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nerve; subsequently, however, they concluded that the recordings had been from aberrant cells of the cochlear nucleus lying central to the glial margin of the VIII nerve (GALAMBOS and DAVIS, 1948). The first successful recordmgs from fibres of the cochlear nerve were made by TASAKI (1954) in the guinea pig. These classical but necessarily limited results were greatly extended by ROSE, GALAMBOS, and HUGHES (1959) in the cat cochlear nucleus and by KATSUKI and co-workers (KATSUKI et at., 1958, 1961, 1962) in the cat and monkey cochlear nerve. Perhaps the most significant developments have been the introduction of techniques for precise control of the acoustic stimulus and the quantitative analysis of neuronal response patterns, notably by the laboratories of KIANG (e. g. GERSTEIN and KIANG, 1960; KIANG et at., 1962b, 1965a, 1967) and ROSE (e. g. ROSE et at., 1967; HIND et at., 1967). These developments have made possible a large number of quanti­ tative investigations of the behaviour of representative numbers of neurons at these levels of the peripheral auditory system under a wide variety of stimulus conditions. Most of the findings discussed herein have been obtained on anaesthetized cats. Where comparative data are available, substantially similar results have been obtained in other mammalian species (e. g. guinea pig, monkey, rat). Certain significant differences have been noted in lizards, frogs and fish as would be expect­ ed from the different morphologies of their organs of hearing (e. g.

Please note: This is a companion version & not the original book. Book Preview: #1 Dr. Michael Moskowitz is a psychiatrist-turned-pain-specialist who has often been forced to use himself as a guinea pig. He and another psychiatrist-turned-pain-specialist, Bobby Hines, have set up a pain clinic in Sausalito, California, which treats West Coast patients with intractable pain. #2 The brain can turn off pain because the function of acute pain is not to torment us but to alert us to danger. As long as Moskowitz didn't move, he was in no danger, so his brain turned off his pain. #3 The traditional scientific view of pain is that when we are hurt, our pain nerves send a one-way signal up to the brain, and the intensity of the pain is proportional to the seriousness of our injury. #4 The brain controls how much pain we feel, according to the gate control theory of pain. The brain can close a gate and block the pain signal by releasing endorphins, the narcotics made by our bodies to quell pain.

Advances in Medicine and Biology. Volume 157 opens with a study wherein the authors use guinea pig airway smooth muscle to demonstrate that testosterone blocks L type voltage dependent Ca2+ channels. Furthermore, in vivo experiments with sensitized guinea pigs show that bronchospasm induced by antigenic challenge was abolished by testosterone and its 5α and 5β-dihydrotestosterone metabolites. Following this, the authors evaluate the structural features of skeletal muscles in children and adults with various pathologies of the musculoskeletal system based on ultrasonography, considering periods of natural growth and involutive changes. An overview of the current state of research on fluoxetine for the treatment of anxiety alone or combined with depression is provided, along with its possible side effects. Also provided is scientific information is regarding the neurobiological bases of depression and therapeutic effects of fluoxetine during the different periods of menopause. This information could be useful in pharmacological strategies for the treatment of depression occurring in the menopausal women. One chapter focuses on how improved direct access to the liver protected inside the rib cage can be obtained in laparoscopic liver resection using its specific “Caudal approach”, decreasing the risk of refractory ascites and liver failure, especially in hepatocellular carcinoma patients with chronic liver diseases. The nucleolus is packed with proteins involved in ribosome function and biogenesis, as well as other proteins involved in cell-cycle regulation, senescence and stress response. However, little is known about the molecular mechanism of protein turnover in the nucleolus. As such, the authors discuss the nucleolus-localized protein degradation pathway, which is essential to ribosome production and cell-cycle progression. The concluding chapter focuses on the dye Congo red, which is used as a stain in microscopy to detect an abnormal material called amyloid. Amyloid consists of misfolded proteins that form fibrils which bind molecules of Congo red and orientate the molecules parallel to the long axis of the fibrils.

You may be amazed as you read about the extent of the disagreement among many doctors, the lack of medical ethics in modern practice, the alarming rise of specialists who constantly fleece the public by charging unnecessarily high fees. You may gasp as you learn how the public is experimented on, in guinea pig fashion, with every passing treatment and drug. You will be shocked at how uncertain the medical profession really is as to the final effects in years to come of so many of the current innovations like cortisone, early ambulation, penicillin, etc., and at how the unwarranted publicity given these untried medical fads and fancies in newspapers and magazines endangers human life! You may be startled and incredulous when you begin, but when you lay this book down you will have a new and more discerning approach to your medical problems.Now for the first time, here is an unbelievably frank story of what really goes on behind the medical screen - here for the very first time is a picture sometimes painful, but always accurate, of how most physicians feel, think and behave when stripped of their professional veneer.

Written by a cadre of experts, this new edition provides a comprehensive, authoritative, and international view of gestational diabetes mellitus and will be invaluable to maternal-fetal medicine specialists, diabetologists, neonatologists, and a growing number of gynecologists and general physicians concerned with the management of noncommunicable diseases in pregnancy. Offers a comprehensive and authoritative guide to all aspects of the subject internationally Presents an invaluable resource for all working in diabetes, maternal-fetal medicine, and obstetrics Shows the latest developments in research in genomics and in practice with the digital clinic

The latest data on the pathogenesis of ulcer disease is presented in this text, with the emphasis that an understanding of the pathogenesis and etiology of ulcer diseases represents the most rational approach to pharmacology - the prevention and treatment of ulcer disease. Early and late biochemical and functional changes, morphologic stages of the injury and healing phases, as well as vascular factors in ulceration are highlighted. In addition, new pathogenetic elements on neuroendocrine and other endogenous modulators and circadian rhythms in ulcerogenesis are covered. The section on new pharmacology consists of several chapters presenting new animal models of gastric, small intestinal and colonic ulcers because in vivo models represent the basis to test and accurately detect new antiulcer drugs. A large series of chapters cover new drugs for ulcer prevention and treatment. This book is indispensible to investigators in basic and applied research, academic and industrial pharmacologists and clinicians in gastroenterology.

Immune System Accessory Cells provides a comprehensive survey of all types of antigen-presenting and accessory cells. Macrophages are emphasized through descriptions of different types of endocytosis, other major properties, and all basic and new information concerning macrophages as antigen-presenting cells. Other topics covered include the impact of the immunodeficient state on accessory functions, the evolutionary emergence of accessory functions, and the role of various cell types in defense reactions in major assemblages of Metazoa. The book also presents a chapter describing the phylogenetic aspects of accessory functions, which traces the first accessory cells during the evolution of living matter.Immune System Accessory Cells is an excellent reference for immunologists, cell biologists, and others interested in developing an understanding of the roles of accessory cells in all facets of immune reactions.

This important new book presents critical information on the clinical and morphological aspects of various endocrinological disorders of the gut and pancreas. Topics include a historical perspective and broad overview of the neuroendocrine component of the gut; hyperplastic proliferations of gastrointestinal endocrine cells; pancreatic endocrine cells and their non-neoplastic proliferations; tumors and lesions; and endocrine differentiation in nonendocrine tumors. The book stresses clinical and pathological aspects of these topics, as well as the pathogenesis, clinicopathological correlations, and diagnostic approaches. Gastroenterologists, pathologists, internists, surgeons, endocrinologists and others interested in endocrinological disorders of the gut and pancreas will discover that this book will be a welcome addition to your reference library.

This volume is a comprehensive introduction to the analysis, binding, uptake, metabolism, kinetics, modeling, distribution, occurrence, toxicity and chelation of metals and fluoride in the body, with special reference to mineralized tissues. Both toxic and relatively harmless polyvalent cations and anions are considered. Included are some which are stable, and others which are radioactive. While a number are essential trace elements, others have no known metabolic role. Most chapters are concerned with the uptake of bone-seeking ions by the living skeleton, but aspects of the post-mortem uptake of metals and the process of fossilization are also considered. Highlighted are the utility of modern analytical techniques and the more important bone-seeking elements including aluminum, lead, cadmium, fluorine and the radioactive heavy metals including uranium and plutonium. This important publication is of particular value to those in the fields of biochemistry, radioactive waste, geology, physiology, dentistry, orthopedics, radiology and nuclear medicine, urology, industrial hygiene, pharmacology, anthropology, paleontology, and archeology.

his book provides a comprehensive summary of data from basic research on characterization, regulation, and function of heme oxygenase in mammalian systems. The book also includes a major section that covers the currently used clinical methods to suppress neonatal jaundice with emphasis on the newly developed use of synthetic metalloporophyrins. This book will be welcomed by researchers and students in pharmacology, biochemistry, pharmacy, neonatology, hematology, internal medicine, and endocrinology.

Epidermal Langerhans Cells focuses on epidermal Langerhans cells (LCs) and the important role they play in the induction of contact hypersensitivity and graft rejection. This in-depth work discusses how these antigen-presenting cells are modulated by various physicochemical agents (such as UV light) and how they can be infected by the AIDS virus. It also reveals that cytokines mediate their development into potent T cell-stimulatory dendritic cells. This comprehensive review covers important experimental details and methods, and fascinating information on LCs. It also provides an overview of the immune system as it relates to the skin in health and disease. This up-to-date publication is an indispensable resource for all investigative and clinical dermatologists, as well as immunologists interested in antigen-presenting cells.

Molecular and Cell Biology of the Liver features the latest research findings regarding liver structure and function. A unique feature of the book is the brief science reviews that are included in each chapter which provide essential background information to allow readers to better grasp the subject matter within a chapter. The book covers liver biology from the molecular level to groups of liver cells and explains how groups of hepatocytes interact in similar microenvironments. Other important cell types found in the liver are also examined. Illustrations ranging from electron micrographs to fully rendered drawings act as visual aids to help readers understand complex structural-functional interactions. Molecular and Cell Biology of the Liver will benefit hepatologists, gastroenterologists, cell biologists, anatomists, toxicologists, and other researchers interested in liver structure and function.

Airway smooth muscle plays a dominant role in bronchial asthma, as well as a significant role in various pulmonary diseases, such as chronic bronchitis, cystic fibrosis and emphysema. Myogenic, neurogenic, and humoral factors control airway smooth-muscle tone. This text provides a state-of-the-art summary and critical discussion of airway smooth muscle from a multidisciplinary point of view. Topics discussed include morphology, biochemical regulation, mechanical and electrophysiological behavior and reflex control of smooth muscle; the epithelium-derived relaxing factor; and methods to measure smooth muscle function in vivo in humans and experimental animals, as well as in vitro in isolated airway tissues. Also discussed are calcium and potassium channels and receptors for adrenergic, cholinergic and histaminergic systems in modulating receptor-response coupling in airway smooth muscle. Airway Smooth Muscle: Modulation of Receptors and Response provides essential information for researchers, teachers, pulmonary specialists and allergists, and students interested in learning about airway smooth muscle.

A concise, in-depth analysis of the status of the sympathetic system in heart diseasesThis book summarizes the functional status of the sympathetic neural system in cardiological diseased states and highlights aspects of sympathetic neural activity that are important to an overall understanding of the pathophysiology process. Critical reviews of methods for evaluating sympathetic activity are discussed, existing data is closely scrutinized, and attempts are made to delineate the factors derived from increased sympathetic activity. The book provides a physiologically and clinically based approach to the investigation of the involvement of catecholamines in cardiovascular diseases, which makes it a valuable addition to the reference collections of researchers, clinical scientists, and graduate students.

Postgraduates and researchers in the study of allergies, clinical immunology, chest diseases, pharmacology, physiology and biochemistry.

Thyroid Diseases: Clinical Fundamentals and Therapy provides a wide-ranging examination of all clinically significant areas of thyroid diseases. Underlying physiological principles are closely linked to the clinical situation and practical therapeutic interventions. The book examines the clinical course, therapy, and final outcome of thyroid diseases, particularly the bimodal and transient evolution of several thyroid diseases. It also discusses the medical, surgical, and radiometabolic therapy of thyroid diseases, stressing the pros and cons of each therapeutic modality. More than 80 acknowledged experts from North America, Europe, and Japan have contributed to this exceptional reference volume, making it essential for physiologists, clinical endocrinologists, radiologists, researchers in nuclear medicine, oncologists, and radiotherapists.

Cell Interactions in Atherosclerosis covers the scientific foundations of the most important disease inflicting the developed world today. It presents a collection of topical aspects on the general theme of cell interactions in atherosclerosis, providing authoritative, up-to-the-minute accounts of how new developments in cell biology have advanced our understanding of these cellular interactions. The book is amply illustrated with electron micrographs and light micrographs incorporating modern cytochemical procedures. Cell Interactions in Atherosclerosis will interest all medical and scientific professionals dealing with atherosclerosis and heart disease.

The microneedle field has been expanding exponentially with innovative designs and various applications, thus capturing the interest of academic industry and regulatory sectors.Microneedles: The Future of Drug Delivery equips readers with a comprehensive understanding of microneedles: from percutaneous absorption to microneedles production, characterization, applications in drug delivery and diagnosis, to practical perspectives on the development, manufacturing, regulatory issues, and commercialization of microneedles. This book is written by a single author and thus provides complex information in a simple, elegant, and cohesive style.The book is intended for graduate students, researchers, scientists, and engineers working in the pharmaceutical, medical, cosmeceutical, and biotechnology industry.

Les scandales provoqués par des pratiques inhumaines lors d'expériences médicales ont permis la naissance et l'évolution des normes modernes encadrant et réglementant l'éthique de la recherche biomédicale en général et des essais cliniques en particulier (Code de Nuremberg, DoH, rapport Belmont, CIOMS/OMS, directives des BPC de l'ICH, CHRB…). Ces normes ont évolué d'une approche éthique centrée d'abord sur le médecin puis vers le patient, puis finalement la transition s'est faite vers une éthique servant les intérêts des industries.Leur évolution conceptuelle, les controverses soulevées, leur caractère non contraignant, leur considération par la communauté médicale comme étant trop restrictives pour la pratique de la recherche ont mené à une application incohérente ou inexistante de ces normes. Ainsi, les violations des règles d'éthique demeurent fréquentes, avec de graves préjudices pour les volontaires et les patients.On enregistre particulièrement ces dérives non éthiques, les accidents graves y afférents et leurs conséquences scandaleuses au cours d'essais cliniques largement industrialisés, sous-traités et délocalisés, échappant ainsi à un contrôle réglementaire sérieux.

Life's Blood: The Story of Hemoglobin encompasses the entire clinically relevant story of hemoglobin, the only molecule we have that captures oxygen from the air we breathe and delivers it to our tissues to generate the energy without which we would not exist. Dr. Rosove covers first the discoveries of oxygen, hemoglobin, and circulation of the blood, then the structure and function of human hemoglobin, together with comparisons to other oxygen transporters in the animal kingdom. He examines the red blood cell and how it protects hemoglobin, with an in-depth look at malaria and the hemoglobin and red cell mutations malaria forced us to make defending ourselves against it, particularly sickle cell disease and the thalassemias. The author also explores adaptations to the oxygen-poor environment of high altitude; lessons from freak hemoglobin mutations; hemoglobin toxins including carbon monoxide and chemicals and drugs that cause oxidant damage; and the quest for a hemoglobin substitute. Life's Blood is a comprehensive resource for physicians, nurses, and other health professionals, at any and every stage of career development. Even seasoned hematologists, internists, and hospitalists will find something new and informative on practically every page. The book's approachable, engaging style will also appeal to science-minded readers who will appreciate being awakened to the workings of hemoglobin, a miraculous molecule.

This important new book focuses on the involvement of cytokines in specific areas of inflammatory diseases, such as granulomatous responses, lung disease, hepatic dysfunction and the acute phase, arthritis and accompanying bone remodeling, neurogenic inflammation, and shock. The roles of GM-CSF, IL-6, IL-2, TGFb EGF, and LIF are discussed, as well as the medical treatments that affect cytokine activity. The results of approaches important to the biotechnology and pharmaceutical industries, such as the search for endogenous biological response modifiers that control cytokine function or production, attempts to synthesize heterocyclic compounds in the organic chemistry lab, and research regarding second messenger pathways involved in IL-1 and TNF production are examined. This book will provide anyone in cytokine research, especially clinical investigators, pharmaceutical industry researchers, and academic research scientists, with important information on how cytokine research might be used.

This comprehensive publication draws together the important aspects of carcinogen-cell interaction. This interesting work describes the regulation of normal cell proliferation, cellular responses to carcinogen damage, the biologic consequences of cellular DNA modification, the structural and genomic changes resulting from carcinogen insult, and the possible involvement of such changes in the conversion of normal human fibroblasts to malignant cells. It presents current reviews with up-to-date literature references and provides critical information from leading investigators that is essential in understanding the biology of human cell transformation. This volume is especially useful to advanced students in genetic toxicology, molecular biologists, and all who are interested in the molecular and macromolecular changes in human cells leading to neoplasia.

Many developments in immunology have occurred over the past 10 years that give us a better understanding of the immune system and its dysfunctions. Refined mapping of the major histocompatibility complex MHC; elucidation of its gene structure and polymorphism, as well as the molecular basis of MHC restriction; the arrangement, expression, and regulation of immunoglobulins; definition of the structure of the T cell receptor and organization of its genes; and the characterization of soluble factors involved in cell/cell interactions and cloning of their genes are among the major accomplishments. Volumes I and II build on these developments in basic immunology to introduce animal models of various diseases, corresponding human studies, and the genetic analysis of autoimmune traits at the patient population level. The book will be a tremendous asset to immunologists, geneticists, and physicians in various areas of clinical subspecialties.

Meeting the needs of professionals in this growing specialty, Atlas of Reproductive Physiology in Men summarizes some of the latest research in the field. Packed with tables, color illustrations, and photographs, the book covers laboratory techniques and morphological, anatomical, biochemical, immunological, hereditary, and microbiological parameters and their clinical applications. A comprehensive and well-referenced resource, the atlas bridges the gap between basic and clinical science.

Hemostasis represents a group of balanced activities that keep the blood flowing It is a complete response system which has developed to guarantee blood fluidity and to limit blood loss after wounding, and adapts after exposure to infectious micro-organisms The failure of this control system causes ischemia, severe damage to the distal tissues and, ultimately, death This book provides an up-to-date and comprehensive account of the control of hemostasis by vascular cells It is an indispensable guide for researchers in hemostasis and vascular biology, from the post-graduate level onwards It will also be of great interest to clinicians in vascular medicine and cardiology Topics covered include: hemostatic properties of the vessel wall; anticoagulant properties of the vessel wall; other aspects of coagulation; and changes in vascular hemostatic properties

Written by established researchers, this two-volume publication provides timely, comprehensive and insightful reviews on recent discoveries in the etiology of hypertension. Structural changes of the blood vessels in hypertension in relation to connective tissue, cerebral vessel structure and innervation, smooth muscle cell hypertrophy and/or hyperplasia, and rarefaction of microvessels are discussed. Also presented are the effects of antihypertensive therapy on vessel structure and function. A unique feature is the inclusion of a chapter on pulmonary vascular changes in pulmonary hypertension, which shows certain changes that are similar to systemic hypertension. This book is of major interest to researchers involved in the study of hypertension and the biology of the blood vessels.

This book draws together important facts, in particular areas of vascular biology, and allows the generation of hypotheses and principles that unite an area and define newer horizons. It is designed for scientists and physicians interested in immunology, inflammation and cardiovascular diseases.

This book provides an updated overview of eicosanoid metabolism. It also presents a timely discussion of eicosanoid metabolism in the process of tumor cell metastasis, in chemoprotection and radioprotection associated with cancer therapy, and in cell differentiation. The book focuses on the role of eicosanoids in the immunology of malignant disease. This includes how various immune cell populations in cancer are affected by the secretion and action of various eicosanoids and metabolites of eicosanoids and how these processes may be affected by various pharmacological manipulations and interventions to augment anti-tumor immunity. Head and neck cancer is covered in great detail to illustrate a cancer in humans where these considerations are particularly relevant. This important volume demonstrates that the principal factor in cancer patient immunologic deficiency is related to excess secretion by monocytes of prostaglandins.

This book addresses a variety of key issues surrounding mental health and the criminalization of certain individuals and groups by the Criminal Justice System and the impact this can have on their mental health. It challenges the assumption that people with mental health problems are in some way a risk or danger to society (and themselves) and therefore have a greater propensity for committing crimes, when in reality they are more likely to become the victims of crime. It argues that the misguided correlations drawn between mental health and crime, as perpetuated by the media, policy makers, clinicians, agents of the criminal justice system, and ultimately the public, lead to the criminalization of the vulnerable. Furthermore, the criminalization, stigmatization, stereotyping, labelling and discrimination endured by people with mental health problems has a devastating effect on their mental health and well-being and has negative consequences for society as a whole. Each chapter focuses on a specific area relating to mental health, identifying key themes and issues, as well as offering recommendations for improvements with regards to the treatment and support for people with mental health problems. In addition, the treatment of offenders with mental health problems who engage with the criminal justice system and its services, such as the police, prison and probation services, is critically evaluated.

This book presents an authoritative review of the research regarding the influences of anabolic-androgenic steroids on metabolism. The book provides a concise description of the biochemistry of these steroids using simple terms and includes methods of separation and their clinical applications. The first section of the book examines the general structure, nomenclature, and classification of anabolic-androgenic steroids. Subsequent chapters explore concepts basic to understanding the pathways of their metabolism in both target and non-target tissues, including the interactions of steroids with receptors and the effects of steroids on the cellular metabolism of skeletal muscle. The changes and molecular base of modifications in metabolism during exercise involving anabolic-androgenic steroids are also described. Finally, a comprehensive review of methods for scanning and identifying anabolic-androgenic steroids in biological fluids is presented, as well as a discussion regarding the applicability and limitations of these techniques. The book provides valuable reference information for all scientists and clinicians engaged in sports medicine, exercise biochemistry, and endocrinology.

This classic ENT textbook has been updated and expanded to reflect the increasing sophistication of diagnostic and management skills. All sub-specialities are covered, with the content grouped into five major sections: Rhinology, Head and Neck, Otology, Paediatric Otorhinolaryngology, Imaging.New material includes:- A new chapter on middle ear devices- Information on recent technical advances, including implant devices, immunotherapy and monoclonal antibodies- Updated coverage of imaging and diagnostic techniquesEach chapter includes key learning points, up-to-date references and suggestions for further reading. Many chapters benefit from updated figures which provide clarity and enhance the effectiveness of the text. ENT trainees and other practitioners with an interest in otorhinolaryngology will find this all-purpose textbook ideal for a thorough understanding of the specialty.From the Foreword by the President of the Royal College of Surgeons of England‘This iconic ENT textbook has guided generations of aspiring ENT surgeons around the world, as well as practitioners from other disciplines seeking a general grounding in the specialty.'‘By bringing together recognised experts in their fields, the editors have ensured that this Twelfth Edition of Logan Turner's Diseases of the Nose, Throat and Ear will remain a definitive text for those working in the UK and also in those many countries around the world in which previous editions of the book have gained popularity.'- Mr Tim MitchellReviews of the Eleventh Edition‘It is a modern, well-illustrated textbook with plenty of illustrations and figures, and the text is clear, well written and broken up into easy-to-read sections. It is also a suitable textbook both for primary and secondary care doctors and has a good depth of coverage. If you want to learn more about ENT and want an established, yet up-to-date book which is not expensive then look no further. It is an excellent general all-purpose ENT textbook which will satisfy a wide audience.'- Dr Harry Brown

This book discusses advances in health and disease, treatment and prevention. Chapter 1 explores how the co-administration of probiotics and prebiotics can enhance survival, colonization, and antimicrobial properties, offering a promising avenue for clinical intervention. Chapter 2 aims to present recent progress in light-based therapies for cancer and infectious disease treatments with a special focus on silica nanoparticle designs. Chapter 3 focuses on presenting the main effects provided by the regular consumption of Lpb. plantarum, in addition to its use in different food matrices. Chapter 4 focuses on acid-based enzyme inhibitors and catalase activity. Chapter 5 discusses in vitro maturation, in vitro fertilization, and polycystic ovary syndrome. Chapter 6 outlines techniques for inducing atrial fibrillation in a laboratory setting and explores the underlying mechanisms responsible for its perpetuation. Chapter 7 analyzes the treatment of prostate hyperplasia. Finally, Chapter 8 focuses on the gravitational mass spectroscopy (GMS) method, studied in the dynamics of RNA genome conformations of the H5N1 and SARS-Cov2 serotypes in the saliva of a proband who was infected with these viruses twice with an interval of two months.

This book explains and discusses in simple language the structure and function of botulinum toxin and other neurotoxins as well as the rational for its utility in different disease conditions. Safety, factors affecting efficacy and duration of action, as well as cost and insurance issues are also addressed. Updates to the new edition include information on new indications, new approvals by FDA, new positive information on childhood indications, as well as data on long-term use of botulinum toxins therapy in several medical ailments (particularly migraine) that demonstrate its safety when applied properly and according to the published guidelines, are all included. In addition, two new chapters cover botulinum toxin therapy in dentistry and in veterinary medicine.

«We often speak of the body of text, and Darian Goldin Stahl's excellent and timely book deals with sister-inspired texts of the body. Stahl makes the case, beautifully and powerfully, for the value of artists'books to open us up (like a laparotomy) to illness experience.» (Paul Crawford, Professor of Health Humanities, University of Nottingham, UK) This book investigates how handmade artists'books excite the senses to communicate lived experiences of illness and disability. The combination of text, image, materials, and form, along with the gesture of turning pages, make artists'books a powerful source of expressive potential. These works of art not only enable patients to create meaning from their medical experiences, but also invite healthcare learners to an uncensored read of critiques on Western medicine. Artists'books are increasingly popular among medical institutions in an age of digital screens because of their intimate handheld, multi-sensory expressions of bodily phenomena that may be difficult or impossible to communicate through words alone. By applying a phenomenological practice of sensing and meaning-making, the author provides step-by-step instructions for creating new artists'books as part of health humanities pedagogies. In this way, Embodied Books serves as a philosophical and pragmatic example of why and how experiencing artists'books in healthcare contexts is so important.

Since before the time of our last common ancestor, microbes have been shaping our evolution and our environment, just as we have shaped theirs. This fact has recently gained renewed prominence with wider acknowledgement of the microbiome (part of One Health) and its role in maintenance of human homeostasis. This two-part book titled “Pathogens and Environmental Impact on Life Forms”, highlights the fluid dynamics we share with the microbes within us, including both, arguably ‘helpful'species, and undoubtedly pathogenic ones (pathogen containment, clearance, and optimisation are dwelt on).It also underscores the effects of anthropogenic changes on microbes external to us, and the consequences of the resultant environmental dysbiosis for our continued health and well-being. Prominent examples include indiscriminate industrialisation and urbanisation. Both of these forces, empowered by a culture of consumerism, have led to excessive pollution and several detrimental lifestyle changes, which have culminated in our present obesity crisis and diabetes ‘pandemic'. Finally, this book concludes by emphasising that the way forward for healthcare is not only to be cognizant of the eubiotic microbiome in its diagnoses and treatments, but also to use this tremendous resource to contend with the quickly transforming landscape of infectious diseases.

Companion volume to Cinemeducation Volume 1 Cinemeducation, Volume 2 outlines a comprehensive approach to using film in graduate and medical education. It provides readers with a wide array of film excerpts ready for immediate application in the classroom. Each excerpt includes the counter time, year of release, names of actors, a short description of the movie and the scene being highlighted as well as discussion questions. Entire chapters are dedicated to reality television, mainstream television, music videos, documentaries and YouTube. Clearly structured, this second volume dives deep into human experiences. Authors from five continents have composed 49 chapters devoted to a wide assortment of new topics relevant to medical and postgraduate healthcare education. Some of the specific issues covered include substance abuse, gambling, dealing with tragedy, diabetes, heart disease, chronic illness and obstetrics as well as mental health problems. Some films portray health care professionals both positively and negatively and these are presented with rich detail. A wide variety of specialties and different health careers are covered. All of these areas converge on the common ground of compassion in the medical experience. This book is ideal for the undergraduate or postgraduate classroom. All healthcare educators will appreciate its comprehensive scope and innovative approach, including those in psychology, social services, dentistry and veterinary science.

Sandra Lindsay, the first person to receive the COVID-19 vaccine, takes the reader on her journey from humble immigrant beginnings in 1980s Bronx to national health equity advocate and winner of the Presidential Medal of Freedom.Sandra Lindsay immigrated to the United States from Jamaica in 1986 with ambitions of becoming a nurse and living the American Dream. In December 2020, she became the first person to receive the COVID-19 vaccine and was subsequently honored with the Presidential Medal of Freedom. Lindsay tells her inspiring story, from leaving a stable home in Jamaica only to experience years of struggle in the Bronx, NY, as a single mother and struggling student. Her tenacity led to a successful thirty-year nursing career, including her leadership as the director of critical care at Northwell's Long Island Jewish Medical Center during the country's worst health crisis in 2020. In First in Line Lindsay lays out her triumphs and setbacks as a single mother and working student who overcomes barriers with the love of her family and the support of mentors and leaders. Her beginnings as a four-dollar-an-hour grocery store fortified her with the resilience to persevere over decades to become an executive at a globally recognized nationally known healthcare system. Lindsay recounts working through the darkest months of the COVID-19 crisis in 2020 and leading the critical care units at Long Island Jewish Medical Center. The suffering and losses she witnessed ignited Lindsay's passion for seeing an end to inequities in healthcare. First in Line tackles a variety of issues: bias and inequity in healthcare; chronic disease in marginalized communities; maternal, infant, and Black and Brown women's health; and mental health. While Lindsay continues to beat the drum for vaccination as COVID-19 continues to impact our lives, she advocates for a holistic approach for improved, equitable healthcare for all people who live on the margins.

Clinical scientists, embryologists, and reproductive technologists, at all levels, as well as trainees and students interested in assisted reproductive technology and reproductive medicine, will find here a clear synopsis of the best laboratory practice, clinical biology, assisted reproduction techniques, and advanced practical skills they will need to know as clinical practitioners. Expert embryologists and trainers contributed to the essential material as well as a number of advanced topics.Key features: Offers a clear synopsis of the clinical biology, laboratory skills, and best practice for the trainee embryologist Provides the ideal reference resource for those undertaking postgraduate training to become a clinical embryologist Gives access to the views of expert embryologist and trainers

Established as the definitive reference for the IVF clinic, the sixth edition has been extensively revised, with the addition of several important new contributions on clinical topics, including The use of digitalization and precision medicine in the IVF clinic, The environment and reproduction, The use of gonadotropin-releasing hormone agonists and the efficiency of IVF, Controlled ovarian stimulation for freeze-all cycles, Immunology in ART, Home monitoring of ART cycles, Luteal-phase support in ART, The POSEIDON stratification of ‘low prognosis'patients in ART, Controlled ovarian stimulation for low responder patients, Adjuvants for poor responders, Innovative therapies in diminished ovarian reserve and primary ovarian insufficiency patients, and Fertility options for transgender and nonbinary individuals. As previously, methods, protocols, and techniques of choice are presented by IVF pioneers and eminent international experts.

This book takes readers through forty-five challenging scenarios to teach communication skills in medicine. It follows the revised format of the Practical Assessment of Clinical Examination Skills (PACES) exam conducted by the Royal College of Physicians in the UK, which tests communication skills twice in two separate stations. Most scenarios in this book have been created in an acute medical unit setting. Being fully dialogued will improve the clinical communication skills of young doctors, senior medical students, nursing staff, and trainees in internal medicine and general practice at all levels, preparing them for the new format of MRCP PACES. Readers will learn: How to convey abnormal test results and break bad news How to discuss the diagnosis of a chronic disease and negotiate a management plan How to communicate with patients who pose an ethical dilemma How to communicate with challenging patients and relatives What to tell patients or relatives when things go wrong How to communicate with patients and relatives regarding end-of-life issues Key Features: Takes readers through a simple step-by-step approach to skillfully dealing with common challenging communication scenarios they face in their daily practice Guides readers on how to communicate in layman's terms without using medical jargon, as it is fully dialogued, proving particularly helpful to non-UK candidates, whose first language is not English Simplifies several complex ethical and medicolegal principles, such as treatment of patients lacking capacity, dealing with patients who refuse consent, confidentiality, counselling a non-compliant patient, basic genetic counselling, management of patients who demand non-indicated investigations or treatments, open disclosure after a medical error, preparing an advance decision and lasting power of attorney, issues around brain death and organ donation, tube feeding, Do Not Attempt Resuscitation orders and referral to the coroner

Initiation and Promotion in Skin or Liver Neoplasia is the only source of its kind that presents a comprehensive compilation of in vivo initiation/promotion studies that involve neoplastic changes in the skin or liver of experimental animals. The book surveys world literature over the past 65 years from almost 2,000 original studies covering nearly 200 journals in 9 languages. Publications reviewed consist of primary peer-reviewed papers, as well as those abstracts, meeting reports, and review articles, containing original data. Papers measuring both pre-neoplastic or neoplastic changes are included.The summaries for each study included in the book are highly formatted resumes that have four principal components which indicate:1) What was done in the study;2) How the study was done (e.g, methods);3) The precise results obtained;4) Individual critiques using GLP (Good Lab Practice) standards.Initiation and Promotion in Skin or Liver Neoplasia provides an indispensable abstracted reference resource for scientists, toxicologists, cancer researchers, litigators, regulators, environmentalists, policy analysts, and industry-based investigators.

This fully revised and updated seventh edition provides a thorough overview and introduction to hearing science. Covering topics such as conductive and cochlear mechanisms, auditory pathways, and binaural and spatial hearing and including some new and updated diagrams and figures, this book serves as a great resource for both graduate students and professionals working in audiology and other fields like psychology, neuroscience, otolaryngology, and linguistics. This improved edition reflects the ever-changing field of hearing science.

Nanomedicine biotechnology is applied to and used to study drug development, working mechanisms, diagnosis, and therapies. This textbook particularly written for biomedical applications of nanomedicine covers the whole range of disease treatments related to nanomedicine. This book serves the purpose of highlighting the current advancements of nanomedicines-based regimens which may be employed in disease treatment while it also contains the fundamental knowledge for biomedical researchers from all levels. Each chapter starts with an introduction/theory into the specified approaches for various disease states followed by detailed discussions for a comprehensive understanding. This book best suits advanced level students, but also provides an excellent updated material for researchers and healthcare workers related to nanomedicine and diseases treatment.

This volume provides a state-of-the-art survey of developments in the field of NK cell-cancer cell interactions, activation, and oncolytic signaling. Specific topics discussed include NK cell receptors and adhesion molecules, signal transduction and activation, and mechanisms of cytotoxicity. The book will be an excellent learning tool and reference resource for scientists, clinicians, and students.

The book delves into the multifaceted world of migraine pain, offering a profound understanding of its underlying pathophysiology and presenting established treatment strategies for its effective management. It discusses the intricate world of migraine pain, offering valuable insights into its diverse aspects. Starting with an exploration of migraine's epidemiology and etiology and the complex factors contributing to this debilitating headache disorder. This book explores the significance of lifestyle changes and offers practical strategies for incorporation. Furthermore, the impact of diet and nutrients on migraine management is extensively covered, shedding light on their role in alleviating symptoms. This book serves as a comprehensive guide, blending scientific insights with practical approaches, making it an indispensable resource for healthcare professionals, researchers, and individuals seeking a deeper understanding of migraine pain. By addressing both established practices and cutting-edge advancements, it bridges the gap between knowledge and effective management, offering a holistic perspective on this challenging condition.

Dizziness and Vertigo describes the basic knowledge and practical skills necessary for managing patients presenting with common symptoms of dizziness and vertigo. It provides practitioners with a comprehensive overview of these conditions, steps for diagnosing patients and various treatment options.This revised and updated edition provides a framework for the accurate diagnosis and management of patients with dizziness and vertigo, covering clinical assessments and case studies. It also includes new methods for treating Ménière's disease and benign paroxysmal positional vertigo (BPPV) and in the field of vestibular rehabilitation.Dizziness and Vertigo is an essential reference for all those who manage patients in the outpatient setting, including general practice trainees, ear/nose/throat (ENT) specialists and physiotherapists.

Nausea and vomiting are two of the most common side-effects of anti-cancer treatment, and the discovery and clinical application of 5-hydroxytryptamine3 receptor antagonists has transformed the management of these side effects, resulting in a much improved quality of life for cancer patients. This text presents a detailed overview of the management of cancer-treatment induced emesis in a number of different treatment settings, and focuses on the mechanisms and use of 5-HT3 receptor antagonists. Contributions are also included from the points of view of the nurse and the patient.

This unique volume contains reviews by some of the most prominent immunologists in the world. The authors present vital facts for each of their areas of expertise and provide individual perspectives on how their own contributions were developed and how these contributions influenced general immunological thinking and development. This impressive collection of personal reviews by these internationally renowned immunologists makes The Immunologic Revolution an important and lasting contribution to the entire biomedical community.

This up-to-date volume describes the wide variety of available methods concerning percutaneous absorption of drugs and toxins. It discusses in detail the advantages and disadvantages of each method. This unique publication provides a clear, systematic presentation of each aspect which must be considered when designing and performing skin penetration experiments and when interpreting results. It includes specific information regarding necessary supplies and equipment, along with commercial sources for these items. This state-of-the-art book is an ideal instructional manual for investigators uninitiated in performing percutaneous absorption and metabolism studies. Those involved with investigative dermatology, dermatological research, toxicology, and pharmacology will find this reference interesting and indispensable.

Written by established researchers, this two-volume publication provides timely, comprehensive and insightful reviews on recent discoveries in the etiology of hypertension. Structural changes of the blood vessels in hypertension in relation to connective tissue, cerebral vessel structure and innervation, smooth muscle cell hypertrophy and/or hyperplasia, and rarefaction of microvessels are discussed. Also presented are the effects of antihypertensive therapy on vessel structure and function. A unique feature is the inclusion of a chapter on pulmonary vascular changes in pulmonary hypertension, which shows certain changes that are similar to systemic hypertension. This book is of major interest to researchers involved in the study of hypertension and the biology of the blood vessels.