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Certain diseases may involve organ systems that cross the boundaries of specialties. For instance, a patient with scleroderma can develop interstitial lung disease, or a patient with relapsing polychondritis can have the clinical manifestation of subglottic stenosis. This book represents a collaboration between specialties, helping clinicians recognize the implications of disease both within their own specialty and in the overlapping specialty. Here, leading experts from the fields of rheumatology and pulmonology provide a masterclass in the care of patients with systemic illnesses that involve the immune system and the lungs.Key Features: Provides an evidence-based clinical approach to the patient with pulmonary manifestations of rheumatic disease Details cutting-edge research with input from the world's leading experts Discusses possible future directions for research and advancement

Greenfield's is the world's leading neuropathology reference. It provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations. The two volume work provides a remarkable text which is clear, comprehensive and precise with exceptional illustrations. The tenth edition features fully updated sections covering CNS tumours, neurodegeneration, skeletal muscle, epilepsy, paediatric and forensic neuropathology.Expert coverage from an international team of Editors and contributors ensures authoritative and up to date content. The two volume set includes a downloadable and easily used e-version. This is a tried and tested reference for scientists, clinicians, researchers, and students who wish to learn more about neurological disease.

Special topic volume with invited peer-reviewed papers only

Traditional and Herbal Medicines for COVID-19 explores promising ways to manage COVID-19, post-COVID, and long-COVID conditions. The management plans are based on anti-virus activity, anti-inflammatory activity, and diverse health benefits of traditional and herbal medicines through a comprehensive summarization of scientific literature by experts in the field. It presents views of the origin of SARS-CoV-2 and emerging variants and pathogenesis, and it proposes renewed strategies of diagnostics, vaccines, and therapies.Features Provides an in-depth analysis to illustrate the impact of traditional and herbal medicines on crucial protein targets responsible for the progress of SARS-CoV-2 infection and symptoms. Presents knowledge of SARS-CoV-2 and variants. Explores strategies to manage COVID-19, post-COVID, and long-COVID by applying traditional herbal medicines. Illustrates molecular aspects of anti-coronavirus activity from traditional herbal medicines. Features information on molecular mechanisms of target proteins involving COVID-19 infection and symptoms. Traditional and Herbal Medicines for COVID-19 serves as an ideal reference for researchers and experts in the fields of virology, epidemiology, drug discovery, and traditional herbal medicine. This book aligns with supporting the Sustainable Development Goals (SDGs) 2030 by the United Nations to establish “Good Health and Well-Being.”

This unique medical guide focuses on scars. The impact of scars is often underestimated and rarely discussed, and they are considered an inevitable side effect of surgery or trauma. Although therapies for distressing scars do exist, many are based on myths rather than evidence. This strongly practice-oriented book provides step-by-step instructions with scales and measuring instruments for assessing scars. Featuring brief abstracts and summaries, this valuable reference resource benefits clinical professionals such as doctors and nurses alike. It will appeal to practitioners who want to understand the nature and background of planned treatments, and to non-experts who simply want to broaden their medical horizons.

This important new book focuses on the involvement of cytokines in specific areas of inflammatory diseases, such as granulomatous responses, lung disease, hepatic dysfunction and the acute phase, arthritis and accompanying bone remodeling, neurogenic inflammation, and shock. The roles of GM-CSF, IL-6, IL-2, TGFb EGF, and LIF are discussed, as well as the medical treatments that affect cytokine activity. The results of approaches important to the biotechnology and pharmaceutical industries, such as the search for endogenous biological response modifiers that control cytokine function or production, attempts to synthesize heterocyclic compounds in the organic chemistry lab, and research regarding second messenger pathways involved in IL-1 and TNF production are examined. This book will provide anyone in cytokine research, especially clinical investigators, pharmaceutical industry researchers, and academic research scientists, with important information on how cytokine research might be used.

Meeting the needs of professionals in this growing specialty, Atlas of Reproductive Physiology in Men summarizes some of the latest research in the field. Packed with tables, color illustrations, and photographs, the book covers laboratory techniques and morphological, anatomical, biochemical, immunological, hereditary, and microbiological parameters and their clinical applications. A comprehensive and well-referenced resource, the atlas bridges the gap between basic and clinical science.

Hemostasis represents a group of balanced activities that keep the blood flowing It is a complete response system which has developed to guarantee blood fluidity and to limit blood loss after wounding, and adapts after exposure to infectious micro-organisms The failure of this control system causes ischemia, severe damage to the distal tissues and, ultimately, death This book provides an up-to-date and comprehensive account of the control of hemostasis by vascular cells It is an indispensable guide for researchers in hemostasis and vascular biology, from the post-graduate level onwards It will also be of great interest to clinicians in vascular medicine and cardiology Topics covered include: hemostatic properties of the vessel wall; anticoagulant properties of the vessel wall; other aspects of coagulation; and changes in vascular hemostatic properties

This volume provides a state-of-the-art survey of developments in the field of NK cell-cancer cell interactions, activation, and oncolytic signaling. Specific topics discussed include NK cell receptors and adhesion molecules, signal transduction and activation, and mechanisms of cytotoxicity. The book will be an excellent learning tool and reference resource for scientists, clinicians, and students.

Human papillomavirus (HPV) is a major cause of cervical cancer. Human Papillomavirus Infections in Dermatovenereology pulls together the diverse disciplines of clinical, molecular biological, socio epidemiological, and immunological research to bridge the gap between the clinical aspects and basic biology of HPV. This volume provides a much-needed overview of the scientific and clinical data of HPV and HPV-associated diseases, exploring opinions on current therapies and diagnostic methods. It critically reviews the most frequently used molecular biologic methods, evaluating their potential in HPV detection. Specialists in dermatology, genitourinary medicine, gynecology, urology, as well as pathologists, microbiologists, epidemiologists, and virologists will appreciate this timely examination of the ubiquitous pathogen, HPV.

The science of drug safety and pharmacovigilance has rapidly evolved in the 21st century. The knowledge and principles it contains are of increasing importance in clinical and practice settings. The aim of this book is to deal with the gap in knowledge about pharmacovigilance and drug safety, including the application of pharmacovigilance knowledge to individual patient cases in clinical practice. A holistic approach is taken with each chapter written from the perspective of a practitioner, industry personnel, researcher, or regulator, creating a synergy between drug safety, pharmacovigilance, and clinical practice. Chapters offer key material on adverse drug reactions, medication errors, prescribing safety, pharmacovigilance as well as data sources used in drug safety and pharmacovigilance. Each chapter is structured as a self-contained learning resource, with learning objectives, and worked cases. The book is suitable for undergraduate healthcare professions, postgraduate students, researchers, clinical practitioners – including those with prescribing responsibilities. It will also be useful for professionals moving from a clinical practice role to a specialist pharmacovigilance role. For those already in a pharmacovigilance role, the book offers insight into the theory and practice of drug safety and pharmacovigilance in clinical settings.

Renowned as the essential reference for all venous specialists, phlebologists, vascular surgeons, and vascular medicine physicians, the fifth edition of the Handbook of Venous and Lymphatic Disorders: Guidelines of the American Venous Forum covers the investigation, prevention, evaluation, and treatment of venous and lymphatic disorders.The full spectrum of acute and chronic venous disorders, chronic lymphedema and chylous complications are included. New or entirely revised chapters discuss in detail basic considerations, diagnostic evaluation, management of acute venous thrombosis, and chronic venous disorders, including deep venous disease and venous ulcers. Medical treatments, including compression therapy, veno-active compounds, and new oral antithrombotic medications, are discussed. Minimally invasive endovascular techniques to treat deep vein thrombosis and pulmonary embolism with catheter-directed thrombolysis, pharmaco-mechanical, mechanical thrombectomy, and venous stenting are presented.Few areas in medicine have progressed as fast as minimally invasive outpatient treatment of chronic venous disease. Endovenous therapies include laser and radiofrequency ablation, liquid and foam sclerotherapy, minimally invasive surgery, cyanoacrylate embolization, mechanico-chemical or ultrasonic ablations, among others.Written by the world's foremost venous experts, leaders of the American Venous Forum, and international authorities, the Handbook has become the most important reference for both day-to-day management and investigation of venous and lymphatic disorders.

This book provides a thorough examination of the correlation between nutrition and stroke. It delves into the interplay between nutrition and brain functions, neurogenesis, and cognitive functions. Additionally, it investigates how various types of nutrition relate to stroke. Moreover, it discusses recent progress in recognizing the significant therapeutic role of different nutrients in addressing stroke. Finally, it offers an overview of nutrients as neuroprotective agents and outlines the fundamental principles of nutrigenomics.

Obesity is a global pandemic rising beyond the status of a lifestyle disorder, and its consequences include impaired metabolism, energy disruption, and abdominal fat deposition and storage. Body Recomposition: A Comprehensive and Metabolic Alternative to Weight Loss presents information on body recomposition, which emphasizes the approach of losing fat while gaining muscle. It contains vast research on topics including factors that influence fat accumulation, strategies for weight management, healthy diet and eating patterns, physical exercise, and lifestyle strategies in healthy weight management.Features: Influence of non-alcoholic fatty liver disease (NAFLD) on stored fat accumulation and its treatment Harnessing the gut microbial arm in combating obesity Roles of leptin, ghrelin, NPY, cortisol, and diverse neurotransmitters in appetite suppression and regulation Genetic predisposition and genetic addiction obesity risk assessment and therapies Gut–brain axis role in metabolism and body recomposition Efficacy of phytochemicals in weight management and roles of drugs and natural supplements in weight management Importance of physical exercise and manageable lifestyle factors Existing commercial weight loss strategies can fail to achieve and maintain sustainable weight loss or enhance greater healthy fat loss. This book provides an improved alternative for dietitians/nutritionists, health practitioners, and clinicians, as well as food and nutrition scientists.

The fourth edition of Dr. James Rippe's classic Lifestyle Medicine textbook continues to lead and inform the rapidly growing field of lifestyle medicine. This is the discipline that focuses on the impact of daily habits and actions on both short- and long-term health and quality of life.The first edition of this comprehensive work named the field of lifestyle medicine in the academic medical literature. The fourth edition continues to span and expand the field and offers extensive evidence-based literature in virtually every aspect of lifestyle medicine. This Textbook, edited by cardiologist Dr. James Rippe, who is a leading lifestyle medicine researcher, represents the combined wisdom and recommendations of over 325 experts in virtually every aspect of lifestyle medicine. Chapter authors have been chosen because of their background as leaders in various aspects of lifestyle medicine.Lifestyle Medicine, Fourth Edition contains extensive sections on the treatment and prevention of coronary heart disease,stroke, cancer, diabetes, obesity, substance abuse, dementia, and many other clinical conditions. Key lifestyle modalities such as physical activity, nutrition, weight management, sleep, stress reduction, and positive connections with other humans are supported by detailed discussion and state-of-the-art evidence. The expanded section on behavioral medicine provides an important framework for these discussions. Every chapter has been completely revised and many new topics added, such as lifestyle medicine for nursing, psychiatry, and preventive neurology.The fourth edition of this classic text continues to serve as the leading, comprehensive textbook in lifestyle medicine. The original has been called the “indispensable bible” of lifestyle medicine, and the fourth edition of this work continues to justify this designation.There is no longer any serious doubt that daily habits and actions have a significant impact on multiple aspects of health. The fourth edition of Lifestyle Medicine provides the scientific evidence to support this assertion and will serve as an invaluable reference and guide, not only to lifestyle medicine practitioners but to all primary care physicians, subspecialty physicians, nurses, and other healthcare practitioners.

Written by a cadre of experts, this new edition provides a comprehensive, authoritative, and international view of gestational diabetes mellitus and will be invaluable to maternal-fetal medicine specialists, diabetologists, neonatologists, and a growing number of gynecologists and general physicians concerned with the management of noncommunicable diseases in pregnancy. Offers a comprehensive and authoritative guide to all aspects of the subject internationally Presents an invaluable resource for all working in diabetes, maternal-fetal medicine, and obstetrics Shows the latest developments in research in genomics and in practice with the digital clinic

This monograph brings together the proceedings of a workshop held in Geneva, Switzerland in March 2000 under the joint sponsorship of the University of Sheffield and F Hoffmann La Roche Ltd. Chapters by leading scientists present the latest research on biochemical markers of bone remodelling as well as their clinical applications in the management of osteoporosis. The text focuses on four major areas of interest: 1) potential candidates for markers of bone remodelling, 2) sources of biological bone marker variability, 3) use of biochemical markers in monitoring treatment of osteoporosis, and 4) use of biochemical markers in the prediction of bone loss and fractures. The book also includes transcripts of the lively panel discussions from the Geneva workshop.

Haematology encompasses a broad range of topics ranging from common and relatively benign conditions such as iron deficiency anaemia, hereditary diseases such as thalassaemia, to haematological malignancies that are often life-threatening. Burgeoning information arising from technological advances in recent years has made these subjects particularly challenging for medical students and non-specialist medical practitioners. This book aims to highlight the pathophysiology, clinical presentations and basic principles in the investigations and managements of haematological diseases that are prevalent in Asia. Each chapter begins with a real-case clinical scenario, followed by a set of questions and is complemented by photomicrographs, data charts and illustrations. Readers will have a grasp of the basic knowledge in haematology and the book will be a useful reference in their academic study and clinical encounters.

Pain is ubiquitous to human experience. When pain becomes chronically persistent after acute injuries are repaired or as diseases progress, health systems are challenged to reduce pain's negative impact on an individual patient's life trajectory and chronic pain's collective impact on public health. Pain Management in Vulnerable Populations presents a diverse set of chapters that examine this challenge through the lens of vulnerability. There are special considerations for patients who are considered pain-vulnerable with respect to assessment and treatment and the variability of their access to good care. Medicine's practices, while increasingly being guided by evidence-based algorithms from large data, are also becoming more personalized and tailored to individual patient needs. Each vulnerable group demands a unique approach - this book reveals the details behind the history, examination, and therapeutic options for vulnerable patients in pain. Individual chapters explore conceptual models of vulnerability to pain across the lifespan, beginning in infancy, and in specific clinical populations defined by age, gender, sexual orientation, clinical condition, and healthcare setting. Topics examined range from genomics to sociomedical contexts affecting care such as medical ethics, racial disparities, adverse childhood experiences, disability and workers'compensation, incarceration, torture, military, youth sport, and LGBTQ identity. Challenges to the management of the trajectory of pain are considered in settings ranging from emergency room, palliative and end-of-life care, and nursing homes, prisons, the battlefield, and developing nations. Chapters on illnesses such as sickle cell disease, substance use and mental illness, dental disease, obesity, suicide, HIV, COVID-19, and GI disease discuss personalized treatment plans for each patient's unique needs. Pain Management in Vulnerable Populations serves as an invaluable resource for pain physicians and will also appeal to primary care physicians as pain is one of the most frequently stated reasons for seeing a primary care physician.

This book draws together important facts, in particular areas of vascular biology, and allows the generation of hypotheses and principles that unite an area and define newer horizons. It is designed for scientists and physicians interested in immunology, inflammation and cardiovascular diseases.

Established as the definitive reference for the IVF clinic, the sixth edition has been extensively revised, with the addition of several important new contributions on clinical topics, including The use of digitalization and precision medicine in the IVF clinic, The environment and reproduction, The use of gonadotropin-releasing hormone agonists and the efficiency of IVF, Controlled ovarian stimulation for freeze-all cycles, Immunology in ART, Home monitoring of ART cycles, Luteal-phase support in ART, The POSEIDON stratification of ‘low prognosis'patients in ART, Controlled ovarian stimulation for low responder patients, Adjuvants for poor responders, Innovative therapies in diminished ovarian reserve and primary ovarian insufficiency patients, and Fertility options for transgender and nonbinary individuals. As previously, methods, protocols, and techniques of choice are presented by IVF pioneers and eminent international experts.

The book has imperative and up-to-date information on the basics to advanced therapeutic approaches against various life-threatening diseases including vector and parasite-borne diseases, COVID-19, Mucormycosis, and cancer as well. The book harbors extensive knowledge about the applications and effective utilization of advanced personalized medicines, target-based nanoencapsulated phytochemicals, and herbal nanomedicines against life-threatening diseases including cancer, thereby having implications in the cancer biology field encompassing pharmaceutical and life science sectors considerably. Moreover, the proposed book would provide a strong platform for delineating the complex mechanism underlying the disease therapeutics along with the potential therapies countering the existing menace of drug resistance, especially concerning cancer. More so the book will showcase the recent advances in the use of nanocomposite films and molecular-mediated drug delivery for therapeutic applications. The uniqueness of this book is to provide all the possible information from basics to advanced nano-therapeutics at a single platform making it a valuable informative source to the graduates of various universities across the globe to understand multifaceted therapeutic applications against life-threatening diseases. The book is an outstanding compilation comprising comprehensive information on therapeutic advances at a single platform. The book is apt to the present needs and well aligned with the offered curricula in Universities across the globe for UG, PG, and Ph.D. programs encompassing life sciences, medical, paramedical, and pharmaceutical courses. The diversity of chapters in the book are going to covers various aspects of the parasites, pathophysiology, and pathogenesis along with the pivotal role of nanotechnology in drug discovery and nano-biosensors for the detection of coronavirus as well. Moreover, the book has interesting elements of futuristic personalized medicines in combating coronavirus along with remedial therapeutic measures against coronavirus-induced mucormycosis. Another chapter deals with multifaceted therapeutic advances in life-threatening human diseases from traditional, complementary, and integrative medicine to nano-based targeted drug delivery. In the end, the authors have shed light on understanding oncogenesis and cancer and finding an amicable therapeutic nanomedicine solution paving the way towards individualized medicine therapeutics against cancer. With the advent of newer technologies such as combinatorial chemistry high-throughput screening, next generation sequencing, it is now possible to consider that nanotherapeutics and personalized medicines could be the sound death knell for a variety of dreadful diseases including cancer and also to deal with the growing menace of drug-resistance. Once again, our sincere thanks to all the contributing authors who worked like a team to let us complete this book. Special thanks to the Editorial team of the publishing house who were available all the time to impart their valuable input and assistance. Words of appreciation also go to the whole Production Team as well.

This volume is an accessible introduction to RNA viruses and the infectious outcomes that they cause in the central nervous system (CNS). Chapters cover the major RNA viruses, their impact on the CNS, and the similarities and differences in pathological outcomes that can be observed. Neuroscientists, be they students, researchers, or clinicians, will benefit from the timely coverage provided.Our understanding of viruses, and specifically RNA viruses and their pathological impact, is rapidly evolving. For example, the close molecular interaction of viruses with the CNS cell types in the human host is poorly understood. Readers can use the book to understand clearly the cellular and molecular mechanisms governing pathological outcomes of RNA virus infection in the cell types of the human brain (e.g., neurons, endothelial cells, astrocytes, resident immune cells) based on summarized case studies, and gain insight into how cell type-specific defects affect brain function and cause poor clinical outcomes.The book is aimed primarily at neuroscience students and postgraduates wishing to learn about virology and professionals who are interested to learn more about virus-associated neuropathology. A basic knowledge of cell and molecular biology is assumed; however, readers across the disciplines of science, technology, engineering, and mathematics will find this topical and timely publication of value.

The Classic Text—Expanded, Updated...More Authoritative than Ever!Cutaneous Melanoma is the definitive and most authoritative textbook on melanoma used worldwide. This 5th edition provides the most up-to-date and comprehensive information needed for the clinical management and scientific study of melanoma. Written by the leading melanoma experts from the United States, Australia, and Europe, this new edition collectively incorporates the clinical outcomes of more than 60,000 patients treated at major melanoma centers throughout the world.Comprehensive Coverage—from Prevention to Advanced TreatmentThis new edition provides in-depth coverage, ranging from precursors of melanoma to advanced stages of metastatic disease; from melanoma genes to population-based epidemiology; and from prevention of melanoma to all forms of multidisciplinary treatments. Basic principles of diagnosis and pathologic examination are combined with treatment approaches for the many clinical presentations. Clinical management is supported by statistical data about natural history, prognosis, and treatment results. The latest information on staging and prognosis, as well as randomized prospective clinical trials involving surgical treatment and systemic treatments, is included. This volume presents a balanced perspective of the risks and benefits involved in each treatment modality. The book also contains: 1) a comprehensive color atlas of melanoma and its precursors, 2) illustrated surgical and perfusion techniques for every stage and anatomic location of melanoma, and 3) complex genetic and molecular pathways involving melanoma biology. Every drug and biologic agent in use today is described with indications and efficacy.Entirely Revised and UpdatedSeven new chapters discuss the emerging clinical data on the use of biomarkers, adjuvant therapies, targeted therapies, and immune modulation as well as significant clinical research a

Sex/gender-specific medicine (SGM) is defined as the practice of medicine based on the understanding that biology and social roles are important in men and women for prevention, screening, diagnosis, and treatment. Current research demonstrates differences in disease incidence, symptomatology, morbidity, and mortality depending on sex and gender. Sex/gender-specific medicine is a fundamental aspect of tailored therapy and precision medicine. Therefore, the variables must be considered in medical education and practice as well as in research models ranging from human participants, animals and cells. This concept could be applied in the whole clinical areas from Neuroscience, Psychiatry, Gastroenterology, Cardiology, and Rehabilitation, etc. Nowadays estrogen is known to play a key role in the prevention of colon cancer and in the resistant progression of liver cirrhosis and hepatocellular carcinoma, especially in women. This book covers the sex/gender-specific medicine in the whole clinical areas in the adults as well as in the pediatrics. In addition, research results of basic science are also introduced in the colon cancer and Alzheimer's disease.

This extensively updated edition provides a comprehensive review of intensive care for neurologically injured patients from the emergency room and ICU through the operating room and post-surgical period in two comprehensive volumes. The Editors of this first volume present a comprehensive textbook that incorporates best practice/evidence-based medicine and performance improvement, while it champions the three characteristics needed in our neuro–ICUs: patient and family centered high-quality care, education, and discovery. This volume concentrates on neuroanatomy, diagnostic assessment and disease management, examining the neurological problems most frequently seen in intensive care, and describes the various types of neurosurgery and critical features of the management of patients. General issues are discussed across the textbook, such as cardiac care, fluids and electrolytes, nutrition, and monitoring as well as more specific conditions and complications including elevated intracranial pressure, seizures, and altered mental states. Listening to an injured brain is not easy. It takes knowledge, dedication, and understanding of the critically ill patient and their family. Textbook of Neurointensive Care Volume 1: Neuroanatomy, Diagnostic Assessment, Disease Management provides the reader with a detailed resource for studying this most complex area of medicine. It is thus essential reading for all trainees and professionals in critical care, neurosurgery, anesthesia and neurology.

A woman-centered approach to pregnancy must be flexible enough to address the variety of women's experiences around the world, encompassing medical conditions, cultures and family structures. It must also include women who choose not to carry a pregnancy or experience a miscarriage. This unique woman-centered text explores all these issues and more

Bewegungsmangel gilt als wichtiger Risiko- und Realisationsfaktor für die Entwicklung von de facto fast allen chronischen Erkrankungen, wie z.B. Adipositas, Diabetes, Arteriosklerose, Arthrose oder auch neurodegenerativen Veränderungen. Zur Hauptursache - der physischen Inaktivität - kommt häufig noch eine kalorische Über- und Fehlernährung hinzu. Als gemeinsamer Ausgangspunkt für die Entstehung solcher Erkrankungen wird die Dekonditionierung gesehen, die bei längerem Bestehen über Funktionsstörungen zu Änderungen in der Struktur führt. Das Buch geht den Ursachen der Krankheitsentstehung auf den Grund und zeigt auf, welche physiologischen bzw. pathophysiologischen Vorgänge im Organismus ablaufen, wenn er längerfristig aufgrund eines sedentären Lebensstils nicht ausreichend bewegt wird. Es diskutiert dabei die wichtige Rolle der Muskulatur und des sensomotorischen Systems, die mit Querverbindungen zu fast allen Organen vernetzt sind. Neue Erkenntnisse zu den Reaktiven Sauerstoffspezies (ROS) und den Myokinen unterstreichen die Bedeutung einer ausreichenden körperlichen Aktivität zur Erhaltung der Gesundheit. Präventive und therapeutische Konsequenzen werden ständig abgeleitet! Das Buch richtet sich an alle Berufsgruppen, die degenerative Erkrankungen aufgrund mangelnder Bewegung behandeln und mehr über den physiologischen Zusammenhang der Krankheitsentstehung und die aktiven Konsequenzen erfahren möchten.

This volume contains eight chapters that detail advances in health and disease. Chapter One provides a comprehensive review on the physicochemical, pharmacological and pharmacokinetic properties of paracetamol. Chapter Two reports about simulated microgravity, its effects on different organs of a healthy body, and its role in various types of diseases. Chapter Three discusses vitamin D and its relationship with nephrotoxic drugs. Chapter Four describes the epidemiology, pathogenesis, diagnosis (classification), and treatment of patients with hypertrophic pachymeningitis related to antineutrophil cytoplasmic antibody associated vasculitis. Chapter Five reviews the current scientific data regarding the genetic causes and novel genes involved in various abnormalities of sex development disorders. The authors in Chapter Six report their clinical experience with poly-methyl-methacrylate for a novel in vivo bone defect closure in various neurosurgical operations. Chapter Seven provides a detailed comparison of multiple studies that were conducted using a variety of approaches with the goal of preventing drug-drug interaction (DDI) responses, which are a form of adverse pharmaceutical reactions. Lastly, Chapter Eight covers upcoming nanotechnological methods and updates on liposomal research.

This book presents a collection of chapters on Covid-19 topics, with focus on the metabolomics and diagnosis. The chapters report on diagnostic tests for detection of SARC-CoV-2 virus and related proteins as well as post-Covid omics. This book covers Fourier-Transform Infrared spectroscopy and spectromicroscopy applied to Covid-19 studies and Carbon Nanomaterials as Covid-19 Electrochemical sensors. Moreover, the reader will find content on 3D printing for virus diagnosis, as well as organ-on-a-chip models for viral infection proteomics interaction.

Contains patterns of allergic reactivity for disorders such as asthma, atopic dermatitis, urticaria, and anaphylaxis. Written by leading experts in the field, Inflammatory Mechanisms in Allergic Diseases covers non-anaphylactic drug disorders; synthesis and formation of IgE antibodies; new treatments using allergenic peptides, immunostimulatory oligonucleotides, and pharmacogenomics;recent advances targeting effector mechanisms; hypersensitivity reactions to drugs and more! With over 3100 references, tables, drawings, and micrographs, Inflammatory Mechanisms in Allergic Diseases is an essential reference for allergists, pulmonologists, immunologists, dermatologists, ophthalmologists, otolaryngologists, internists, pediatricians, family practitioners, and medical students in these disciplines.

Psychiatric, or psychosocial, palliative care has transformed palliative medicine. Palliation that neglects psychosocial dimensions of patient and family experience fails to meet contemporary standards of comprehensive palliative care. While a focus on somatic issues has sometimes overshadowed attention to psychological, existential, and spiritual end-of-life challenges, the past decade has seen an all encompassing, multi-disciplinary approach to care for the dying take hold. Written by internationally known psychiatry and palliative care experts, the Handbook of Psychiatry in Palliative Medicine is an essential reference for all providers of palliative care, including psychiatrists, psychologists, mental health counselors, oncologists, hospice workers, and social workers.

This popular learning and revision aid is designed specifically to help medical students memorise essential clinical facts, invaluable throughout medical studies and particularly useful in the pressured run-up to final exams. Over 100 maps are organised by body system, and include disease definitions and descriptions, pathophysiology, causes, risk factors, investigations, treatments and complications where relevant and applicable.Key features: Proven – new edition of this very well-received and successful book which has helped thousands of medical students around the world to exam success using mind maps, an established tool in education and known to improve memory recall Flexible – ideal primer when coming to a topic for the first time, when reviewing it at the end of a module or attachment, and for making project and revision plans Adaptable – use the maps in the book directly, as a guide to prepare your own or a supplement to personal notes Systems-based – in line with medical course structure Current – thoroughly revised and updated incorporating the latest clinical guides with many maps new to this edition including Breast Disease and expanded coverage of Rheumatological, Haematological and Endocrine conditions

Lifestyle medicine is a practice which adopts evidence-based lifestyle interventions as a primary modality to prevent, treat, and reverse chronic diseases. The six main pillars of this specialty include physical activity, nutrition, stress resilience, cessation or risk reduction of substance use, quality sleep, and connectivity. Lifestyle Psychiatry: Through the Lens of Behavioral Medicine is grounded in the same pillars, drawing upon theories, methods, and empirical findings from health psychology and behavioral medicine.Lifestyle psychiatry is a rapidly emerging area within healthcare informed by rigorous research within the social and biological sciences, public health, and medicine. A volume in the Lifestyle Medicine series, this book uses a comprehensive biopsychosocial approach to prevent and treat psychiatric disorders and promote mental and physical well-being through evidence-based lifestyle interventions.Features: Draws upon theories, methods, and empirical findings from health psychology and behavioral medicine Provides evidence-based research on the bi-directionality of mental and physical health Addresses fundamental neuroscience concepts and applies them to practical aspects of lifestyle practices, mental health, and brain health Appropriate for clinicians, primary care physicians, and those practicing in specialized areas, the information in this book provides users with practical tools to help explain, prevent, and treat psychiatric disorders and associated maladaptive health behaviors in patients.

Die Labormedizin gilt nach Expertenmeinung als ausschlaggebend für rund 70% aller klinischen Entscheide, wird jedoch hinsichtlich ihrer Kosten und des Kosten-Nutzen-Verhältnisses labordiagnostischer Verfahren kritisch betrachtet. Mit diesem Buch veröffentlicht das Institut für Innovation & Evaluation im Gesundheitswesen eine von der schweizerischen Foederatio Analyticorum Medicinalium Helveticorum (FAMH) veranlassten Studie, um den gegenwärtig generierten und zukünftig zu erwartenden Nutzen von Laboranalysen aus der Perspektive von Patienten und Gesellschaft zu untersuchen. Dies ist ein Open-Access-Buch.

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in women and men worldwide and represents a major financial burden to world health care systems. Importantly, CVD has eclipsed cancer as the leading cause of death for women globally. Through advancements in research and clinical testing, the symptoms and risk factors for CVD have been well established for men, but not for women. Consequently, there is an immediate need for new innovative research that will bridge this gap and allow for improved early diagnosis and treatment of CVD in women. This book will serve as a guide for health care providers to better understand the physiological, biochemical, and genetic differences in heart disease in women with the goal of providing improved education, awareness and treatment of cardiovascular disease in women. The book will cover topics such as: sex dependent clinical outcomes of cardiovascular disease, cardiac protection by estrogen, cardiac health during menopause, cardiac rehabilitation programs, fitness and exercise, cardio-oncology, shift work and the CVD risk, and pregnancy related CVD.

This volume contains eight chapters that detail advances in health and disease. Chapter One presents state-of-the-art research of Ovalbumin bioactive peptides (OVA-BAPs). Chapter Two focuses on providing a comprehensive overview of OVA in human nutrition and the food industry. Chapter Three elaborates on an approach to identify critical factors affecting the pharmacokinetics in rats of several formulations of acyclovir. Chapter Four provides a comprehensive review of the literature on the pathophysiology and current therapies of CP-induced hemorrhagic cystitis. Chapter Five focuses on endocrine immune-related adverse events (irAEs), including their pathogenesis, risk factors, diagnostic processes, clinical characteristics, and management. Chapter Six discusses the benefits of beetroot juice in resistance training. Chapter Seven presents the challenges and opportunities in postgraduate medical education. Lastly, Chapter Eight discusses biologically encapsulated nanoparticles, which are used for improving drug interaction to control and cure disease.

This textbook describes several diseases and clinical conditions, from physiopathological mechanisms to main clinical pictures, highlighting the importance of laboratory medicine, with the aim to provide the necessary tools for guiding correct laboratory findings interpretation. Indeed, it is now widely recognized that laboratory medicine has a pivotal role in clinical medicine, significantly influencing clinical decisions. Thus, it is crucial to understand and use laboratory data appropriately. This book has the great advantage of describing each topic exhaustively in order to facilitate its understanding. Specifically, it describes both diseases with a high incidence in the population, such as Diabetes Mellitus, Cardiovascular Diseases, Dyslipidemias, and Autoimmune Diseases, as well as rare diseases, such as Hereditary Metabolic Diseases. In addition, unusual topics are treated, such as Clinical Biochemistry of the Mind, as well as hot topics, such as Biological Drugs, Biobanks, Health Technology Assessment, and Omics Sciences. Finally, the book includes a chapter on the new health emergency, the SARS-CoV-2 pandemic. Two appendices are provided at the end of the book: a table summarizing the reference range and decisional cut-off for the main laboratory parameters and instructions on performing a venous blood sample. The book will be an invaluable tool for medical and biomedical students, as well as for practitioners.

This book on Medical Jurisprudence & Clinical Forensic Medicine addresses the evolving nature of law and medicine. It updates the medicolegal (ML) systems and discusses the concerns related to digitalization of courts, serving a subpoena through social media, ethical/ML issues in nanomedicine, telemedicine and online prescription practices, toxicology and mass disaster. It fulfils the increased demands of students, forensic medicine specialists, clinicians and lawyers to get authentic medicolegal information in situations of ethical dilemma or during ML urgencies. It features case-based discussions on ML and deontological issues supported by the latest legal/statutory information.Key Features:• Discusses the clinical and applied aspects of forensic medicine through illustrative case scenarios and reports.• Addresses the needs of clinicians and forensic medicine specialists in writing medico-legal reports for specific cases.• Provides evidence-based solutions to medicolegal and ethical dilemma faced during routine practice.

This book contains eight chapters discussing curcumin and its role in health and disease. Chapter One evaluates curcumin's role in cancer prevention. Chapter Two reviews curcumin's function as a natural systemic disease modulator. Chapter Three looks at the effects of curcumin supplantation and exercise training on Alzheimer's disease and age-associated cognitive decline. Chapter Four focuses on the antiviral effects of curcumin, with a special emphasis on COVID-19. Chapter Five examines green extraction techniques for curcumin, synthetic approaches, as well as its anti-inflammatory, anti-oxidant, and anti-neoplastic effects. Chapter Six reviews the possible effects of immune responses to the preventive combined effects of exercise training and curcumin supplementation in chronic disease. Chapter Seven is a mini review of the essential therapeutic effects of curcumin. The eighth and final chapter examines the promises and challenges of curcumin in medical research.

This handbook volume is part of the Reference Series: Micro/Nano Technologies. This individual volume provides a comprehensive, self-contained, and authoritative knowledge in nanomedicine. It covers the theoretical and practical aspects of functionalizations of nanoparticles as nanomedicine, including surface activation, characterization, and microemulsion systems. As a Springer Major Reference Work it is continuously updated online, allowing newcomers and other readers to keep in touch with the most up-to-date information.The book is particularly recommended to undergraduates, postgraduates, researchers, scientists, and field experts. It will inspire innovations in the highly interdisciplinary field of nanomedicine.

The Handbook of Religion and Health has become the seminal research text on religion, spirituality, and health, outlining a rational argument for the connection between religion and health. For the past two decades, this handbook has been the most cited of all references on religion and health. This Third Edition is the most scientifically rigorous edition to date, covering the best research published through 2021 with an emphasis on prospective studies and randomized controlled trials. This volume examines research on the relationship between religion and health outcomes, surveys the historical connections between religion and health, and discusses the distinction between the terms''religion''and''spirituality''in research and clinical practice. It reviews research on religion and mental health, literature on the mind-body relationship, and develops a model to explain how religious involvement may impact physical health through the mind-body mechanisms. It also explores the direct relationships between religion and physical health, covering such topics as immune and endocrine function, heart disease, hypertension and stroke, neurological disorders, cancer, and infectious diseases; and examines the consequences of illness including chronic pain, disability, and quality of life. Additionally, most of its 34 chapters conclude with clinical and community applications making this text relevant to both health care professionals and clergy. This book is the most insightful and authoritative resource available to anyone who wants to understand the relationship between religion and health.

This book focus on COVID-19 topics, with emphasis on metabolomics and diagnosis. The chapters cover the chemical science for prevention and understanding outbreaks of infectious diseases. This book compiles the most widespread methodologies of application of quality statistical tools added to the evaluation of diagnostic tests for detection of SARS-CoV-2, metabolic behavior of COVID infection severity, and trends in rapid test for COVID-19.

This collection of chapters describes in detail the physical therapy research in patients with various types of cancers to help medical professionals and physical therapists help improve the physical function, activity of daily living, quality of life, the survival rate in cancer patients and cancer survivors. It provides not only information on rehabilitation but details on physical therapy cancer research and research methods. The book provides practical skills to treat the patients and to create useful and effective physical therapy programs by giving step-by-step tutorials to help readers learn various techniques. Along with presenting an introduction to physical therapy of cance and new findings, the authors provide recommendations on each cancer therapy. Physical Therapy and Research in Patients with Cancer is aimed at physical therapists and student physical therapists. Undergraduate and postgraduate students also can use our book to understand the basics and get up-to-date information. By sharing the latest research with our readers, the book creates a foundation for further development in this field of study.

Doktorarbeit / Dissertation aus dem Jahr 2022 im Fachbereich Medizin - Sonstiges,, Veranstaltung: Doctoral / PhD Program, Sprache: Deutsch, Abstract: In December 2019, a new outbreak of pneumonia emerged in China, which was identified as SARS-CoV-2, which has a rapid spread as it is transmitted mainly through coughing, sneezing, or contact. It presents various symptoms such as fever, dry cough and myalgia. It can affect any age, being mainly mild and with spontaneous resolution, but in older people and/or with comorbidities, and it can present a severe or fatal course. For its diagnosis, it is important to evaluate the presence of fever, perform an epidemiological history, chest CT and laboratory tests such as RT-PCR or respiratory tract samples. Apelin or its receptor agonists have an excellent potential for treating or reducing the spread of the SARS-COV-2 virus. The apelin may represent a novel molecular target that will be able to improve the protective effects of the endocannabinoid signalling in the body. Along with dealing with SARS-COV-2, this may be even able to reduce the amount of lung damage that the virus cause. CBDs regulate apelin and other receptors in the lungs as it helps in improving the lung functions and the reduction of the virus's damage to the body. CBDs are effective when it comes to acting as an anti-inflammatory agent. It may be due to how well it can do due to its interaction with apelin. CBD has been shown to have a wide range of anti-inflammatory effects inside it. Malinoswska et al. (2021) noted that it could help reduce the negative consequences of hypoxia and ischemia within patients. A small dose of CBD may prove to be beneficial when treating children with neonatal asphyxia due to their mothers suffering from the COVID-19 virus. Another mechanism that contributes to the antiviral activity of CBD is the modulation of interferon after activation of the host immune response to the viral pathogen.

Ophthalmic Epidemiology: Current Concepts to Digital Strategies provides a comprehensive guide to graduate students, ophthalmologists, and researchers in ophthalmic epidemiology. It covers recently developed new methodologies, technologies and resources in ocular epidemiological research, such as telemedicine, disease registries, EMR, bio-banks and omics. This book also summarizes recent epidemiological findings and provides up-to-date data on ocular diseases. Furthermore, it introduces and discusses the uses of epidemiology in the evaluation of health services and population screening programs and reviews the application of epidemiology in intervention trials in the communities.Key Features Comprehensive guide to the epidemiology of common eye diseases. Provides updates on the prevalence and risk factors of eye diseases. Outlines how epidemiological techniques can be utilized to evaluate ophthalmic health services and programs.

This ten-chapter volume presents some recent advancements in health and disease. Chapter One explains the increased mortality rate owing to atherothrombosis and cardiovascular diseases. Chapter Two reviews the evidence for all current management strategies for recurrent hypoglycaemia in diabetes. Chapter Three provides information on the relationship between obesity and circulating levels of C-reactive protein. Chapter Four describes high-sensitivity C-reactive protein as a biomarker of diabetes and hypertension. Chapter Five studies the combination of two self-associating biopolymers such as high-molar-mass hyaluronan and chitosan for treatment of skin wounds. Chapter Six outlines an integrated approach to address the issues of high levels of stress and burnout in the workplace. Chapter Seven examines pericoronary adipose tissue as a possible storage and supply site for lipoproteins and apolipoproteins in the human coronary artery. Chapter Eight deals with corneal collagen cross-linking protocols for the management of keratoconus. Chapter Nine discusses free radicals, their formation and catabolism, and their beneficial and adverse effects on cellular activities. Finally, Chapter Ten details various diagnostic tests for vasculitis.

This volume presents some of the latest research updates related to health and disease. Chapter One investigates how traditional Chinese medicine can be leveraged in service of assisted reproductive technology. Chapter Two includes details about several drugs used in the treatment of rheumatoid arthritis. Chapter Three reviews the changing perspective of infection prevention and control measures in maternal and child healthcare settings. Chapter Four examines the role that infection control nurses play in the infection prevention and control teams of healthcare centers. Chapter Five explores some psycholinguistic aspects of illness narratives in patients with pulmonary hypertension as a therapeutic means to lessen patients'disease-related burden and promoting the sense-making of their illness experience. Lastly, Chapter Six highlights the prognostic value of various microRNAs with reference to chronic kidney disease.

The book Nanopharmaceuticals in regenerative medicine is a collective and comprehensive volume of the latest innovations in nanoscience technology for practical use in clinical, biomedicine and diagnostic arena. The term nanotechnology pops up in every segment of modern-day life. The primary aim of this book is to deliver the precise information to students, educators, technologists and researchers. A conglomerate of scientists from various research fields contributed to the chapters, giving detailed descriptions on the most recent developments of nanotechnology in the area of disease management. This book will also be useful for industrial research and development partners, start-up entrepreneurs, government policy makers and other professionals who are interested in nanomedicines.Chapter 8 of this book is freely available as a downloadable Open Access PDF at Nanopharmaceuticals in Regenerative Medicine | Harishkumar Madhyastha, (taylorfrancis.com) under a Creative Commons CC-BY 4.0 license.

The World Health Organization estimates that there are 2.1 billion individuals with obesity globally. Nearly three quarters of adults in the United States are overweight or obese. The average individual with obesity cuts ten years off their life expectancy, yet less than 40% of physicians routinely counsel individuals concerning the adverse health consequences of obesity. Obesity Prevention and Treatment: A Practical Guide equips healthcare practitioners to include effective weight management counselling in the daily practice of medicine.Written by lifestyle medicine pioneer and cardiologist, Dr. James Rippe and obesity expert Dr. John Foreyt, this book provides evidence-based discussions of obesity and its metabolic consequences. A volume in the Lifestyle Medicine Series, it provides evidence-based information about the prevention and treatment of obesity through lifestyle measures, such as regular physical activity and sound nutrition, as well as the use of new medications or bariatric surgery available to assist in weight management. Provides a framework and practical strategies to assist practitioners in safe and effective treatments of obesity. Contains information explaining the relationship between obesity and increased risk of heart disease, diabetes, cancer, osteoarthritis, and other chronic conditions. Chapters begin with bulleted key points and conclude with a list of Clinical Applications. Written for practitioners at all levels, this user-friendly, evidence-based book on obesity prevention and treatment will be valuable to practitioners in general medicine or subspecialty practices.