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Hemostasis represents a group of balanced activities that keep the blood flowing It is a complete response system which has developed to guarantee blood fluidity and to limit blood loss after wounding, and adapts after exposure to infectious micro-organisms The failure of this control system causes ischemia, severe damage to the distal tissues and, ultimately, death This book provides an up-to-date and comprehensive account of the control of hemostasis by vascular cells It is an indispensable guide for researchers in hemostasis and vascular biology, from the post-graduate level onwards It will also be of great interest to clinicians in vascular medicine and cardiology Topics covered include: hemostatic properties of the vessel wall; anticoagulant properties of the vessel wall; other aspects of coagulation; and changes in vascular hemostatic properties

Greenfield's is the world's leading neuropathology reference. It provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations. The two volume work provides a remarkable text which is clear, comprehensive and precise with exceptional illustrations. The tenth edition features fully updated sections covering CNS tumours, neurodegeneration, skeletal muscle, epilepsy, paediatric and forensic neuropathology.Expert coverage from an international team of Editors and contributors ensures authoritative and up to date content. The two volume set includes a downloadable and easily used e-version. This is a tried and tested reference for scientists, clinicians, researchers, and students who wish to learn more about neurological disease.

Whether you're a clinician concerned with patient management, a technician involved in diagnostic testing, or an investigator studying fibrinogen structure and function, you'll find that the 1994 Index of Variant Human Fibrinogens. is a valuable resource. It contains not only the most comprehensive compilation of the world literature and research on dyfibrinogenemia, but also includes a synopsis for health professionals and expert guidance for the diagnosis and treatment of dysfibrinogenemia, the study of genetically abnormal human fibrinogens. Furthermore, this book provides the latest DNA and protein sequences (including the AaE chain) and listings of available PCR primers and anti-fibrinogen antibodies. Add to this a set of 263 Dysfibrinogen Reports tracking more than 30 different characteristics for each variant, plus 9 summary tables and a comprehensive bibliography, and the result is an authoritative companion for the diagnosis and management of this multifaceted and complex disease.Compare your patient's laboratory profile, clinical manifestations, or molecular defect with virtually all others in the literature. Consider all the options for treating bleeding or thrombotic complications. Determine if your data from a newly identified variant are unique. Spend an hour with this book and see if it doesn't save many hours of literature searching and summarizing!

Musculoskeletal MRI covers the entire musculoskeletal system and related conditions, both common and rare. The text is neatly divided into sections based on the major anatomic divisions. Each section discusses anatomic subdivisions or joints, keeping sections on normal anatomy and pathologic findings close to each other, allowing radiologists to easily compare images of normal and pathologic findings.With more than 4000 high-quality MR images, information is presented in an easy-to-read bulleted format, providing the radiologist with all the information required to make an informed diagnosis in the clinical setting. The new edition also includes a complimentary eBook as well as access to image downloads. Comprehensive and user-friendly in its approach, the book provides every radiologist, both consultant and trainee, with increased confidence in their reporting.

A impressão desta obra é plenamente justificada, diante do exíguo número de contribuições literárias neste segmento. A mesma vem contribuir substancialmente, oferecendo à comunidade científica de estudos em saúde, um novo conhecimento da classificação descritiva das veias do gastrocnêmio em redes, facilitando assim o entendimento dos leitores e estudiosos.

Adding to a vitally important cycle of publications covering the latest research developments in our understanding of neoplasms affecting the human central nervous system, this edition focuses on numerous aspects of pineal, pituitary, and spinal tumors. As with the previous volumes in the series, this latest work addresses a central imperative in cancer research—the need to standardize classifications, written definitions and investigative guidelines in order to achieve a measure of shared objectivity among academics engaged in one of the most important medical endeavors of our era. It brings together the very latest work by oncologists, neurosurgeons, physicians, research scientists, and pathologists, providing the medical community with a wealth of data and results that, taken together, will advance the cause of cancer research. The volume synthesizes work on diagnosis, drug development, and therapeutic approaches that are typically scattered in a variety of journals and books. It features promising recent work in applying molecular genetics to clinical practice and evidence-based therapy, covering molecular profiling of tumors as well as a number of surgical treatments such as resection and radiosurgery. Together with its counterpart publications, it represents a much-needed central resource that will inform and guide future research efforts.

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

Disturbances of haemostasis and thromboembolic disorders still constitute a great problem in clinical practice. Increasing insight into the mechanism of blood coagula­ tion has led to more effective therapy and prophylaxis. Particularly, the understand­ ing of the biochemistry of fibrinolysis has provided possibilities for the pharma­ cological interference of these processes, which has resulted in effective haemostatic agents and useful antithrombotic ones. The development of antifibrinolytics for interfering with pathological fibrinolytic processes is nearly complete and has led to the development of drugs essential to the therapy of hyperfibrinolytic bleeding. The search for fibrinolytics for dissolving intravascular thrombi has led to highly effective compounds. This development is still under way and promising results are hoped. Spontaneous dissolution of blood clots is a phenomenon which was described a century ago. First investigations of this process assured that there is in the organism a system capable of removing the fibrin which is formed during blood coagulation after it has fulfilled its physiological function. This fibrinolytic system is specifically adapted to the degradation of insoluble fibrin into soluble degradation products. In the past 30 years, thorough investigation of this system has clarified the fibrinolytic process, its physiological role and its meaning as a pathogenetic principle. A good knowledge of these processes is required for an understanding of the effects and side effects of fibrinolytics and antifibrinolytics, which comprise the basis of methods for the detection of fibrinolytic processes in the organism and of the control of therapy with these drugs.

Photodynamic therapy (PDT) was discovered over one hundred years ago after observing the death of microorganisms upon exposure to dyes and light. It is the combination of non-toxic dyes and harmless visible light that, in the presence of oxygen, produce highly toxic reactive species. The principal medical application during the last century was in cancer therapy but, in these days of rising antibiotic resistance, PDT shows increasing promise as an alternative approach to treating infections. PDT has also been used in blood product sterilization, peridontology, acne reduction, and the treatment of viral lesions such as those caused by human papilloma virus. It may also have potential as an environmentally friendly pesticide. This is the first and only book to comprehensively cover the use of light and photosensitising agents for controlling microbial pathogens. It provides a comprehensive and up-to-date coverage of an emerging field. There are several chapters on the design of antimicrobial photosensitizers, their use to kill pathogenic organisms and their success in treating infections in animal models. It has long been known that gram-positive bacteria are highly susceptible to photoinactivation but the book also discusses means of widening the range of microorganisms that can be tackled by PDT. Edited by two pioneers in the application of PDT to medical and environmental issues, this book covers the basic science, translational research in animals, and the clinical applications in various medical specialities. It represents an indispensable resource for microbiologists and infectious disease doctors as well as dentists, dermatologists, gastroenterologists and transfusion specialists.

Hepato-pancreato-biliary (HPB) surgery is now firmly established within the repertoire of modern general surgery. Indeed, in many major tertiary centres there are now specific teams for both pancreatic and liver surgery. However, in most hospitals outside these major centres the day-to-day management and decision-making for patients with these diso

La scoliose idiopathique est une déformation tridimensionnelle de la colonne vertébrale dont l'étiologie exacte reste inconnue. Bien que son traitement demeure une affaire de spécialistes, son dépistage est l'affaire de tous! Il est nécessaire que chaque praticien soit en mesure de la dépister, d'en connaître les modalités évolutives, et de pouvoir orienter le patient vers le spécialiste si nécessaire. De gros progrès ont été réalisés ces dernières années tant sur la compréhension de la déformation que sur les possibilités thérapeutiques. Cet ouvrage est l'occasion de faire le point sur cette pathologie qui concerne aussi bien les enfants et les adolescents que les adultes. Cet ouvrage aborde les aspects cliniques, paracliniques et thérapeutiques à tous les âges du diagnostic de la scoliose. Les traitements sont présentés en détail, de manière à permettre à chacun de pouvoir répondre aux questions des patients et de leur famille. Nous avons également voulu y intégrer des chapitres moins « médicaux » concernant les problématiques rencontrées dans la vie courante et les aspects pratiques de cette pathologie. Actuellement, les patients s'informent par leurs propres moyens sur leur pathologie. Il nous faut donc pouvoir devancer et parfois contredire les informations erronées et éventuellement aider au mieux les patients à s'orienter face aux informations qu'ils rencontrent. Cet ouvrage n'est pas un livre de techniques chirurgicales. Il s'adresse à tous ceux qui sont amenés à voir en consultation des patients porteurs d'une scoliose : pédiatres, médecin de réadaptation et de médecine physique, radiologues, médecins généralistes, chirurgiens orthopédiste non scoliologues.La scoliose idiopathique est une déformation tridimensionnelle de la colonne vertébrale dont l'étiologie exacte reste inconnue. Bien que son traitement demeure une affaire de spécialistes, son dépistage est l'affaire de tous! Il est nécessaire que chaque praticien soit en mesure de la dépister, d'en connaître les modalités évolutives, et de pouvoir orienter le patient vers le spécialiste si nécessaire. Cet ouvrage est l'occasion de faire le point sur cette pathologie qui concerne aussi bien les enfants et les adolescents que les adultes.

This reference discusses best practices for the management of patients with cancers of the esophagus, stomach, colon, liver, and pancreas. Focusing on a wide variety of GI carcinomas by organ and tumor type, this source provides expert coverage of diagnostic, staging, and treatment procedures by seasoned oncologists and radiologists, and offers in-

Although first reported in 1973, immune heparin-induced thrombocytopenia (HIT) remains one of the most potentially devastating and frequent adverse drug reactions encountered by physicians. This Fourth Edition reinforces its standing as the leading guide to the accurate diagnosis and management of HIT by identifying key signs and symptoms of this d

The fourth edition of Clinical Nuclear Medicine highlights the continued growth in clinical applications for PET and other aspects of molecular imaging. With its problem-oriented clinical approach, the book presents relevant topics of current importance to the practicing clinician rather than providing a comprehensive review of all technical a

This is the leading international professional reference text that also serves as a bench book, describing all aspects of the pathology of brain tumours - genetics, molecular biology, epidemiology, morphology, immunohistochemistry, diagnostic criteria and prognosis. Beautifully illustrated in colour throughout and comprehensively referenc

Provides Insight into How Cytokine Action Impacts the Physiology and Pathology of the CNS. As with the first edition of Cytokines and the CNS, this completely updated and revised edition introduces neurobiologists to cytokine biology and immunologists to the unique functions of cytokines in CNS physiology. The dramatically accelera

Tumor Diagnosis - Practical approach and pattern analysis, Second edition, has been thoroughly revised to provide the most up-to-date information for all pathologists, histopathologists and trainee pathologists working in the diagnosis of tumors and tumor-like conditions. Following the success of its predecessor, this will once again prove the most

Taking stock of advances in clinical recognition, laboratory testing, and pharmacologic therapy as well as basic aspects of pathogenesis, the Third Edition of Heparin-Induced Thrombocytopenia reinforces its standing as the leading guide to accurate diagnosis and effective management of this complex condition. Featuring added chapters on bivalirudin

The Delta Receptor spans current research in delta receptor biology, pharmacology, physiology, and chemistry to identify, advance, and inspire the development of novel drug candidates. It demonstrates the potential significance and impact of the delta receptor in the therapy and treatment of medical conditions such as pain, gastrointestinal disorde

Children with brain and spinal tumors account for 20-25% of childhood cancers. Until the early 1990s there had been little progress in the development of new treatments, and outcomes were not improving despite advances seen in other childhood cancers. During the past 10 years, however, there has been a dramatic increase in interest in the subject a

The third edition of this reference has new and fully updated chapters that feature discoveries and breakthroughs in the diagnosis and management of Parkinson's disease.

The Second Edition of Pharmacotherapy for Child and Adolescent Psychiatric Disorders contains new and expanded chapters oncombination therapy pharmacoepidemiology pharmacoeconomics current social, ethical, and legal issues surrounding the administration of psychostimulants and antidepressants to childr