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Diabetes mellitus ist die chronische Erkrankung mit der höchsten Inzidenzrate weltweit. Neben Risikiofaktoren wie Bewegungsmangel und Übergewicht spielen vor allem die deutlich gestiegene Lebenserwartung und damit auch das parallel steigende Diabetesrisiko die Hauptrolle. Der multimorbide und gehandicapte Mensch, d. h. der geriatrische Mensch mit Diabetes, zeigt im Gegensatz zum jungen, nicht-geriatrischen Menschen mit Diabetes deutlich andere körperliche, seelische und kognitive Voraussetzungen. Die sich daraus ableitenden Einschränkungen im Alter erfordern ein im Gegensatz zur herkömmlichen Therapie teilweise konträres Handlungskonzept in Bezug auf Diagnostik und Therapie. Beispiel: Ernährung: Adipositas verhindern beim jungen Diabetiker vs. Mangelernährung verhindern beim geriatrischen Menschen mit Diabetes. Die sonst wichtigste Säule in der Diabetestherapie, die Selbsttherapie des Patienten, ist mit den herkömmlichen Methoden nicht mehr erfolgreich umsetzbar. Oft muß die Umgebung, in Form von Angehörigen oder Helfern, diese Therapieaufgabe unter ganz anderen Prämissen, als dies im ärztlichen und pflegerischen Kontext möglich ist, übernehmen. In diesem Buch vermitteln anerkannte Experten aus der klinischen Praxis, basierend auf Fallbeispielen, einen sehr differenzierten, interaktiven Einblick in die Welt des älteren Menschen mit Diabetes mellitus.

The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin secretion are fundamental to the pathogenesis and progression of obesity-associated type 2 diabetes. There is a need to explain how new drugs can counter insulin resistance and insulin deficiency to a broad range of professionals, from clinical scientists active in early (and later) phase drug development to specialist physicians and increasingly primary care doctors who must tailor drug regimens to the individual patient. Clinical research methods for measuring insulin action and insulin secretion have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. The purpose of the book is to aid the selection of the most appropriate techniques for assessing insulin action, insulin secretion and body composition in humans (with particular reference to new drugs) in phase 1 and 2 studies and aid the understanding of drug effects and non-drug treatment strategies on key biochemical-hormonal defects of obesity and type 2 diabetes. The book will assume a working knowledge of human physiology relating to glucose metabolism and will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

​At a time when clinicians are bombarded with masses of clinical information from numerous sources, and the wide variety of changes/advances in diabetes management, there is a need for a concise, easy-to-read book that provides an up-to-date review of the major advances in management of diabetes, with an evidence-based approach. This book is a collection of short chapters, each focused on a subject related to the management of diabetes and its complications. The chapters are written by acknowledged experts in the field, who are also clinicians dealing with diabetes on a day-to-day basis. The text is highly evidence based and well referenced with reviews of relevant trials. It includes the latest developments in diabetes management, prospects for future therapies and avenues of research, as well as therapies currently undergoing clinical trial. In order to facilitate ease of reading, it has a user-friendly appearance, with multiple headings, illustrations and summary boxes. The primaryaudience is clinical, including all healthcare professionals involved in the management of diabetes and its complications. This encompasses diabetologists and endocrinologists, family practitioners with an interest in diabetes, specialist nurses, dietitians and podiatrists.

Both sub-groups of diabetes mellitus - types 1 and 2 - are, for different reasons, difficult or impossible to adequately control. This is the first book for nearly 20 years to deal with the problem of severely unstable diabetes. As well as brittle type 1 syndromes, the scope of instability has been extended to the notoriously problematic issue of o