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This book now published in its fully updated second edition comprehensively summarizes the current state of knowledge on malignancies of the gastrointestinal tract and highlights the latest efforts in multimodality treatment options before and after surgery, important ongoing trials as well as future areas of investigation. Dedicated organ-based chapters evaluate current treatments and management and provide information on incidence, etiology and biological characteristics. The state of the art in the radiologic and endoscopic staging of gastrointestinal malignancies is described, and guidance is offered on the role of interventional radiology and interventional gastroenterology in the treatment of these challenging tumors. In addition, the book explores novel and evolving treatments, including Immunotherapy, personalized systemic therapy and minimally invasive surgical and radiology techniques, and addresses patient-reported outcomes and survivorship challenges. It will be of benefit to all surgeons, oncologists and other specialists who treat these malignancies, as well as to trainees looking to increase their understanding of the field.

Survival of patients with metastatic cancer has increased over the past two decades as a result of a progressive improvement of regional and systemic therapies. However, oncologists'estimates of patients'predicted overall survival in metastatic cancer are imprecise. The purpose of this book is to systematize the evidence regarding the prognostic factors of metastatic gastrointestinal tumors, separating the findings with the highest level of evidence among those available for each disease by selecting studies with the highest scientific evidence level.

This book provides an overview of the available evidence surrounding immunotherapy in gastrointestinal cancers, and discusses its future place in clinical practice.Immunotherapy has celebrated some astonishing therapeutic successes in a variety of cancer types and is becoming increasingly relevant in daily clinical practice. Currently, the predominant class of immunotherapeutic drugs is the so-called checkpoint inhibitors, which disengage the physiological brakes on the immune system, enabling a more effective anti-cancer immune response. Malignancies of the gastrointestinal tract, which account for the majority of cancer cases worldwide, are a major cause of morbidity and mortality, creating an urgent need for more effective therapies. A large number of clinical trials have evaluated the efficacy of cancer immunotherapy in gastrointestinal malignancies and demonstrated its potential in certain subsets of patients. This book will appeal to a wide readership, including oncologists, health care professionals in general and biomedical scientists.

Gastrointestinal cancer is one of the most prevalent causes of cancer-related deaths in the world. Recent research demonstrates that phytochemicals are critical in preventing and managing gastrointestinal cancer. The increased intake of phytochemicals could reduce the risk of cancer by inhibiting cancer cell proliferation, inducing apoptosis and autophagy, and suppressing angiogenesis as well as cancer cell metastasis. These mechanisms are also known to counter Helicobacter pylori infection and modulate gut microbiota. There is preliminary data suggesting that daily supplementation with high doses of certain vitamins combined with conventional therapeutic agents may enhance their growth inhibitory effects on tumor cells and protect normal tissues against some of their toxic effects.This book attempts to fill gaps on the role of phytonutrients in the treatment of cancer in the gastrointestinal tract (GIT). It discusses the action of individual vitamins on cellular and molecular parameters and describes how vitamins inhibit protein kinase C activity, increase the production of certain growth factors, and modulate the expression of a number of oncogenes.The book is divided into 2 parts. The first part summarizes the pathophysiology of GIT cancers and introduces readers to anticancer phytonutrients. A chapter on the status of FDA approved nutraceuticals rounds up this section. The second part of the book provides a systematic review on the different plant derived chemicals that can be used to treat GIT cancer. Each chapter in this section focuses on a specific type of phytochemical agent and its molecular mechanisms relevant to the disease.This book will give the reader a holistic view of gastrointestinal cancer treatment and the value of natural compounds in developing functional food and drugs for preventive medicine.

For nearly 50 years, Sleisenger & Fordtran's Gastrointestinal and Liver Disease has been the go-to reference for gastroenterology and hepatology residents, fellows, physicians, and the entire GI caregiving team. Now in a fully revised 11th Edition, this two-volume masterwork brings together the knowledge and expertise of hundreds of global experts who keep you up to date with the newest techniques, technologies, and treatments for every clinical challenge you face in gastroenterology and hepatology. A logical organization, more than 1,100 full-color illustrations, and easy-to-use algorithms ensure that you'll quickly and easily find the information you need. - Features new and expanded discussions of chronic hepatitis B and C, Helicobacter pylori infection, colorectal cancer prevention through screening and surveillance, biologic agents and novel small molecules to treat and prevent recurrences of inflammatory bowel disease (IBD), gastrointestinal immune and autoimmune diseases, and more. - Offers reliable coverage of key topics such as Barrett's esophagus, gut microbiome, enteric microbiota and probiotics, fecal microbiota transplantation, and hepatic, pancreatic, and small bowel transplantation. - Provides more quick-reference algorithms that summarize clinical decision making and practical approaches to patient management. - Employs a consistent, templated, format throughout for quick retrieval of information. - Includes monthly updates online, as well as more than 20 procedural videos. - Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Handbook of Gastrointestinal Cancers is a practical guide to the management of colorectal, pancreatic, hepatocellular, gastric, and esophageal cancers as well as other cancers of the upper and lower gastrointestinal tract. Edited by a multidisciplinary group of oncologists from leading institutions, this book is an essential day-to-day reference for evidence-based treatment and patient care. The handbook focuses on treatment strategies and approaches to cancerous gastrointestinal tumors that are transforming the recent oncological landscape, including expert-given guidance on methods such as neoadjuvant and adjuvant chemotherapy, surgical transplant, radiation therapy, molecular diagnostic testing leading to molecularly targeted therapy, and immunotherapy.With so many advances in the current field, it is increasingly difficult for early-career practitioners to grasp the entirety of practices and for seasoned oncologists to keep up with newly approved therapies, side effects to treatments, and special clinical management considerations, but this handbook addresses it all. Organized by major gastrointestinal disease sites and featuring “How I Treat” case vignettes from world experts for common and uncommon management considerations, the handbook brings an experience-based perspective to these tough-to-treat areas. The treatment strategies and applications set forth in the chapters are pertinent to situations and decision-making encountered in practice. Handbook of Gastrointestinal Cancers is a valuable resource for medical oncologists, radiation oncologists, and surgeons treating and managing gastrointestinal cancers as well as trainees in medical, radiation, and surgical oncology programs needing an accessible point of care resource.KEY FEATURES:Provides treatment plans and recommendations for each stage of a range of gastrointestinal cancers, including colorectal, pancreatic, and hepatocellular cancers plus moreIncludes “How I Treat” patient vignettes told from the physician's point of view within each clinical chapterOutlines special considerations for the elderly and for survivors of gastrointestinal cancersHighlights important clinical guidance on nutritional and palliative concerns commonly seen in patients with gastrointestinal cancers

This textbook discusses core principles and practices in gastrointestinal oncology and covers a wide range of practice areas such as pathology and radiologic images, epidemiology, genetics, staging, multidisciplinary management of specific gastrointestinal cancer, and pathology for each primary tumor site. The comprehensive coverage makes Textbook of Gastrointestinal Oncology a useful resource for the practitioner wishing to gain a greater understanding of the principles of managing malignant gastrointestinal disease, as well as medical oncology fellows, surgeons, radiation oncologists, gastroenterologists and fellows, and residents.

This book is a comprehensive guide to rectal cancer care that will provide general and colorectal surgeons details regarding the latest developments in the field. The book aims to cover the dynamic shifts in rectal cancer care that have taken place over recent years. Management approaches, such as watch-and-wait and transanal approaches, are evaluated and assessed by experienced physicians to give readers a full understanding of the available treatment options. Chapter summaries are included to give a clinical overview of each approach and to assist the understanding of each topic covered, and make the book applicable to both general surgeons and specialist practice nurses, as well as rectal cancer specialists.

This volume provides an overview of the current evidence-based medical and surgical practice in emergency conditions in colorectal cancer patients. It offers a multidisciplinary perspective, taking into account the specific characteristics of colorectal cancer patients, the necessary pre-operative assessment, the endoscopic and radiological management, and the surgical treatments. Each chapter is supplemented with tables, figures, key-point boxes, schematic representations, and decision-making trees that serve as easy-to-use tools to apply in the different scenarios requiring acute care. Recommendations for best practice and the main reference articles are included for each topic, as well as numerous illustrated clinical cases with cilnical and empirical evidence regarding the surgical management of colorectal cancer. Specific technical aspects of the different surgical interventions and approaches (e.g., open surgery, laparoscopy, and robotics) are also detailed. This book is intended for residents and emergency surgeons, as well as all practictioners who treat colorectal cancer patients, such as gastroenterologists, oncologists, and radiologists.

This book describes the various procedures, including surgery through the abdominal wall, through a transanal access or by the union of both, using an open, laparoscopic, or robotic approach. Worldwide pioneers for each technique are invited as authors and portray in step-by-step detail about each procedure. Of the 32 chapters, 23 are dedicated only for the surgical procedures. Each chapter is enriched by numerous figures, which complement the text, permitting the understanding of each surgical technique from its beginning until the last step. Eight additional chapters are dedicated to the clinical and anatomical aspects of rectal cancer.In the last decade there has been an impressive evolution in the treatment of patients with rectal cancer, with a focus not only on the preservation of a cancer-free life, but the quality of that life. This book has been written to be useful for everyone involved in rectal cancer management. From internists, gastroenterologists, endoscopists,oncologists, radiotherapists and radiologists involved in the treatment of rectal cancer during their daily practice, to surgeons specialized in colorectal surgery, to junior faculty to trainees, all interested in new and innovative techniques.

This book focuses on early diagnosis and multidisciplinary treatment, which is the key to preventing the occurrence of the liver metastases in colorectal cancer, and to increasing the resection rate of the liver metastasis foci and the 5-year survival after surgery. This book is divided into five parts: the introduction, basics, diagnosis, treatment and prevention. It has 20 chapters in total, covering the latest advances in colorectal cancer liver metastases epidemiology, pathogenesis, molecular diagnostics, marker screening, imaging technology, surgery, chemotherapy and prevention, etc. It provides professionals with up-to-date and comprehensive information on colorectal liver metastases. This book is relevant for senior surgeons and physicians working in oncology, general surgery, chemotherapy, digestive medicine, liver medicine and hepatic surgery.

Das kolorektale Karzinom (KRK) ist mit jährlich über 60.000 Fällen das am zweithäufigsten diagnostizierte Malignom beider Geschlechter in Deutschland und weltweit eine der Hauptursachen für krebsbedingte Todesfälle. Eine Vielzahl an systemischen Therapien ist beim KRK verfügbar, doch hängt deren Anwendung und Kombinierbarkeit von einer ganzen Reihe unterschiedlicher Faktoren ab, die bei der personalisierten Therapieplanung unbedingt berücksichtigt werden müssen. Die Neuauflage dieses Kompendiums präsentiert die Differenzialtherapie des KRK auf dem aktuellsten Stand und zeigt dem Leser auch Perspektiven und Forschungspfade für potenziell neue Wege in der Behandlung auf.

This invaluable book provides an introduction to the development and application of molecular biology with a focus on translational research development in a variety of gastrointestinal cancers.Multidisciplinary Management of Gastrointestinal Cancers will emphasize the multidisciplinary aspects of GI cancer diagnosis, treatment and management, introduce the application of new techniques in GI cancer therapy; guide clinicians/experts to use newly developed evidence-based information and knowledge in patient care.This book will also discuss the role of supportive care and quality of life issues in patients with GI malignancies.

This book is about the manipulation of the immune system as a therapeutic approach to gastrointestinal cancer and its clinical applications, exploring therapeutic approaches which might be taken under the broad banner of immunotherapy.Starting by introducing concepts of modern immunology, the clinical applications of immunotherapy are then discussed. The reader will learn about the three broad classes of immune therapeutic agents: cell-based treatment; antibody therapy; cytokine application and the key effector cells and mechanisms which might cause tumour rejection. The reverse side of this equation, the genetic and molecular mechanisms which the tumour can use to escape immune control and regulation, is also discussed. Through reviewing the most up-to-date evidence, this volume provides an overview of the important scientific lessons learned from past failure of immunotherapeutics in the clinic and highlights more positive recent data, coupled to practical guidelines for clinical usage.Written by a team of worldwide experts, this is an indispensable guide for medical oncologists, surgical oncologists, radiation therapists, pharmacists, oncology nurse specialists.

This up-to-date, hands-on manual offers clear guidance on contouring and treatment planning for both standard and advanced radiation therapy in patients with gastrointestinal cancers and simultaneously draws together the available relevant clinical data for each type of cancer with a view to driving treatment recommendations. The full range of malignancies is covered, including esophageal, gastric, pancreatic, hepatic, biliary, colon, rectal, and anal cancers and pelvic recurrences. Additional chapters are devoted to stereotactic body radiation therapy (SBRT) to the liver for metastatic disease.The management of gastrointestinal cancers with radiation therapy has become increasingly complex. Specifically, the emergence of new techniques such as SBRT and intensity-modulated radiation therapy (IMRT) has further increased the need to understand how to contour targets and organs at risk, how to perform safe treatment planning, and when to apply these technologies. In this context, Radiation Therapy for Gastrointestinal Cancers represents an ideal reference for both established clinical radiation oncologists and radiation oncology residents.

Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format. With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as: Autophagy Notch Pathway P13K/PTEN Signaling in Liver Diseases Sirtuins Hepcidin and Iron Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis Oxidative Stress and Signaling in the Liver. Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom has provided clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge. Signaling Pathways in Liver Disease, Third Edition is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.

Now in its 10th edition, Sleisenger and Fordtran?s Gastrointestinal and Liver Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of gastroenterology and hepatology. Overcome your most complex clinical challenges and make optimal use of the newest techniques, technologies, and treatments?with superb guidance from hundreds of world-renowned authorities. Meticulous updates throughout include the latest approaches and improvements in gastrointestinal and liver disease diagnosis and therapy as well as hundreds of images and 35 new procedural videos.'..one of the most valuable clinical resources in the dynamic field of gastroenterology and hepatology.'Reviewed by Brindusa Diaconu on behalf of the Journal of Gastrointestinal and Liver Diseases, July 2015'..an engaging, educational yet clinically orientated textbook which is relevant to modern clinical practice.'Reviewed by Dr Harry Brown on behalf of glycosmedia.com, April 2015'I can personally attest to the remarkable advances that have been made, as I was author of the chapter on eosinophilic gastroenteritis in the second edition of the textbook, and reading the same chapter in the tenth edition underscores the important advances that have been made in our understanding of the molecular basis as well as the pathophysiology of this and related disorders.'Foreword by Norton J. Greenberger, MD Boston, Massachusetts, June 2015 Consult this title on your favorite e-reader. Get the essential gastroenterology information you need from one authoritative source with an outstanding global reputation for excellence. Zero in on the key information you need to know with a consistent, full-color chapter design. Stay up to date with emerging and challenging topics: enteric microbiota and probiotics; fecal microbiota transplantation; Clostridium difficile colitis; and factitious gastrointestinal diseases. Incorporate the latest findings and improvements in care for liver disease patients—from diagnosis and treatment through post-treatment strategies and management of complications. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.

This book comprehensively summarizes the current state of knowledge on malignancies of the gastrointestinal tract. Dedicated organ-based chapters evaluate current treatments and management and provide information on incidence, etiology and biological characteristics. The state of the art in the radiologic and endoscopic staging of gastrointestinal malignancies is described, and guidance is offered on the role of interventional radiology and interventional gastroenterology in the treatment of these challenging tumors. In addition, the book explores novel and evolving treatments, including personalized systemic therapy and minimally invasive surgical and radiology techniques, and addresses patient-reported outcomes and survivorship challenges. It closes by discussing animal models of gastrointestinal malignancies and examining the significance of the Ras superfamily of GTPases. It will be of benefit to all surgeons, oncologists and other specialists who treat these malignancies, as well as to trainees looking to increase their understanding of the field.

- La AEG (Asociación Española de Gastroenterología), a través de su departamento de docencia, coordina una serie de monografías que recogen la información clínica más novedososa que se está generando en esta especialidad. - El proyecto comienza con una serie de monografías de un elevado nivel ciéntífico y en las que participarán expertos nacionales e internacionales con una acreditada trayectoria tanto clínica como investigadora. - Clínicas Iberoamericanas de Gastroenterología y Hepatología nace con el objetivo de convertirse en un proyecto a largo plazo que recoja publicaciones periódicas que permitan mantener al día al lector en aquellos temas más complejos y a la vez actuales de la especialidad. - Cada una de las monografías estaría integrada por un total de 10 manuscritos orientados para que el lector pueda disfrutar de una visión global de la condición tratada. - En este título, dedicado a las enfermedades comunes del páncreas, los autores hacen una actualización de los últimos avances que se han producido en las principales patologías de origen hepatológico, haciendo especial hincapié en el abordaje de las pancreatitis, cáncer de páncreas y novedades terapéuticas registradas. - El proyecto global de AEG Clinics contará además con dos Directores de renombre que serán los doctores Antoni Castells, del Servicio de Gastroenterología del Hospital Clinico de Barcelona, y Henry Cohen, ex Presidente de la World Gastroenterology Organization. Obra coordinada por la Asociación Española de Gastroenterología (AEG) que recoge la información clínica más novedosa que se está generando en esta especialidad. La obra incluye manuscritos de expertos nacionales e internacionales con una acreditada trayectoria tanto clínica como investigadora y que repasan los últimos avances que se han producido en las enfermedades pancreáticas, haciendo especial hincapié en el abordaje de las pancreatitis, cáncer de páncreas y novedades terapéuticas. El proyecto global de AEG Clinics bajo el que se editan estas monografías está dirigido por los doctores Antoni Castellas, director del Servicio de Gastroenterología del Hospital Clínico de Barcelona y Henry Cohen, Presidente de la World Gastroenterology Organization.

Palliative surgery can greatly contribute to improving symptom control and quality of life for terminal cancer patients. Owing to the advanced stage of the disease, however, this type of surgery is also associated with significant morbidity and mortality. It is therefore important for surgeons to have a sound understanding of the medical and scientific background underlying treatment decisions in palliative surgery, a foundation that this book provides. The opening chapters examine the relationship between palliative medicine and palliative surgery and address general issues including pain management and anesthesiological considerations. The role of palliative surgery in a wide range of disease settings is then thoroughly explored, including detailed information on surgical techniques and their indications and outcomes. This book will be an invaluable resource for all who wish to learn more about the emerging role of palliative surgery.

Modern Management of Cancer of the Rectum is intended to provide a comprehensive overview of all aspects of rectal neoplasms. It addresses epidemiology, biology, screening and chemoprevention, the role of imaging in diagnosis, staging and prognosis, radiation therapy, medical and surgical treatment, as well as new modalities of therapy, including laparoscopy, and transanal endoscopic surgery. A greater understanding of prognostic factors, patterns of spread and natural history has occurred during the past decade; together with new diagnostic modalities this has led to significant changes in the management of patients with rectal cancer. This book will be invaluable for all those who treat rectal cancer.

This book is a full colour, highly clinical multi-media atlas focusing on the role diagnostic and therapeutic endoscopy plays in the management of patients with cancer. Conveniently split into sections for each part of the GI tract, each section will follow a consistent structure. With 400 high-quality images and in addition, 21 high-definition videos showing endoscopy from the experts, this book is the perfect consultation and learning tool for all gastroenterologists, endoscopists, GI surgeons and oncologists.

Comprehensive and complete, Shackelford's Surgery of the Alimentary Tract delivers the definitive, clinically oriented, cutting-edge guidance you need to achieve optimal outcomes managing the entire spectrum of gastrointestinal disorders. Make effective use of the latest endoscopic, robotic, and minimally invasive procedures as well as medical therapies with unbeatable advice from a'who's who'of international authorities!Find expert answers to any clinical question in gastrointestinal surgery, from the esophagus to the colon.See exactly what to look for and how to proceed from an abundance of beautifully detailed intraoperative and laparoscopic photographs.

Molecular Pathology of Neoplastic Gastrointestinal Diseases reviews the molecular aspects that characterize the spectrum of neoplastic conditions that affect the gastrointestinal tract, providing the reader with current up-to-date knowledge. For each disease entity chapters provide reviews on:the molecular basis of the individual diseasemolecular testing approaches currently available or in development for diagnosis or for gene target characterization for selective targeted therapiesrecommended guidelines for clinical application of molecular tests are included whenever availablemolecular testing for hereditary predisposition or disease riskanimal models and cell culture models of disease

Dr. Van Dam is an internationally recognized leader in gastroenterology and has been a leader in advances in intervedntional endoscopy. He brings this expertise to the topic of management of benign and malignant pancreatic disease and has selected top experts in the field to provide state-of-the-art clinical information to gastroenterologists. The modern management treatise of each article addresses current diagnostics as well as medical management. Seven articles are devoted to pancreatic cancer and span medical management, surgial mangament, radiologic imaging, endoscopic diagnosis, palliation, and screening. Other important topics addressed are pancreatic transplantation, pancreatic cystic neoplasms, acute and chronic pancreatitis, and autoimmune pancreatitis.

Comprehensive and complete, Blumgart's Surgery of the Liver, Pancreas and Biliary Tract - edited by Dr. William R. Jarnagin and a team of experts- delivers the comprehensive, cutting-edge guidance you need to achieve optimal outcomes in surgery of the liver, biliary tract, and pancreas. Edited by a panel of experts and featuring contributions by many leading authorities, this 2-volume reference brings you the latest information on pathology, diagnostics, surgery, and non-operative intervention all in one source. At www.expertconsult.com you can not only access the complete contents online, but also an abundance of detailed illustrations and step-by-step procedural video clips from the Memorial Sloan Kettering video library that show you how to perform key procedures step by step. Glean all essential, up-to-date, need-to-know information in one comprehensive reference that provides extensive coverage of pathology, diagnostics, surgery, and non-operative intervention as well as hepatobiliary and pancreatic surgery. Deepen your understanding of surgical anatomy to help with diagnosis, surgical operation, interventional radiology, and endoscopy. See how to perform key procedures by watching operative videos from the Memorial Sloan Kettering video library. Apply the most advanced diagnostic and management options for each disease, including interventional techniques. Stay current with the latest knowledge and advancements including minimally invasive techniques in hepatic resection; surgical considerations for congenital disorders of the pancreas; non-surgical therapies for pancreatic cancer; microwave ablation and other emerging technologies; the most recent developments in the rapidly changing area of transplantation; and the newest best practices in pre- and post-operative care and blood transfusion. Get in-depth coverage of the pancreas from the only fully comprehensive text on both hepatobiliary and pancreatic surgery. Learn from the very best. Rely on the trusted guidance of experts, with a fresh perspective from senior editor, Dr. William Jarnigan, who has earned a national and international reputation in the surgical management of diseases of the biliary tract. Access the full text online at www.expertconsult.com, along with image and video libraries, tables, figures, and more! Over 200 additional contributing experts.A single, comprehensive reference that covers pathology, diagnostics, surgery, and non-operative intervention all in one text!

Developed in conjunction with the American Society of Colon and Rectal Surgeons, this comprehensive textbook provides readers with the full scope of surgical practice for patients with diseases of the colon and rectum. Expert surgeons, all active both as educators and with busy clinical practices, have written concise and practical chapters on the most commonly done procedures while providing much-needed insight on less frequently presentations, as well.The ASCRS Textbook is designed to meet the needs not only of colorectal specialists, but also the general surgeon in practice whose caseload includes patients with disorders and diseases of the colon, rectum and anus. Residents and fellows will also find a wealth of hands-on guidance and practical tips and tricks. The ASCRS Practice Parameters are incorporated in the book along with an appendix providing the most up-to-the minute access to best practice guidelines. Patient care and safety are addressed in each chapter.'[The ASCRS Textbook of Colon and Rectal Surgery] is a long awaited textbook for those in the field and it does not disappoint. It is brief and to the point, but does not lack the necessary detail expected from a society-produced publication. [It has an] easy-to-read quality that enhances comprehension for the trainee. It is by no means just a student textbook. The inclusion of'hot'current topics, like the anal fistula plug, makes it fresh and useful for experienced surgeons. This is an excellent addition to the colorectal library.'(Doody's Review)

Gastrointestinal Oncology is an evidence-based, practical reference intended to assist in the diagnosis and management of patients with gastrointestinal malignancies. It is designed to be as user friendly as possible and is distinguished by the extremely practical, concrete nature of the information presented and by the multidisciplinary approach adopted. In addition to disease-oriented chapters spanning sites from the esophagus to the anus, non-anatomic subjects such as modern imaging techniques are also addressed. Translational science is supplied where useful in the decision-making process. All of the authors are internationally recognized experts. This book is an ideal resource for oncologists, surgeons, gastroenterologists, and primary-care providers looking for the latest and best information on how to deal with a wide variety of gastrointestinal neoplasms.

Make optimal use of the newest techniques, technologies, and treatments with Sleisenger and Fordtran's Gastrointestinal and Liver Disease - the indispensable information source in this broad field! Edited by Mark Feldman, MD, Lawrence S. Friedman, MD, and Lawrence J. Brandt, MD, this 9th Edition equips you with the amassed knowledge of hundreds of respected authorities from around the world, helping you to overcome all of your most complex clinical challenges and make the most effective use of the newest techniques, technologies, and treatments. Significant updates on bariatric surgery, Barrett's esophagus, and many other evolving areas keep your practice current. Full-text online access includes downloadable illustrations and links to reference abstracts. The result remains the indispensable core reference in gastroenterology and hepatology. World-renowned experts provide reliable guidance on every area of your field. A consistent, full-color chapter design lets you find information quickly. Significant updates on bariatric surgery, Barrett's esophagus, endoscopic ultrasound, endosonography, treatment of liver disease, and much more keep you current on the latest advances. Many new contributors from all over the world provide you with fresh insights on all areas of gastroenterology and hepatology. Full-text online access via Expert Consult includes downloadable illustrations and links to reference abstracts.

Kirsten rat sarcoma (KRAS)-Mutationen zählen zu den häufigsten onkogenen Mutationen in Tumoren. Mit dem besseren Verständnis der Schlüsselfunktion von KRAS wird beim kolorektalen Karzinom erstmals eine an molekularen Merkmalen ausgerichtete individualisierte Therapie ermöglicht, bei der frühzeitig beurteilt werden kann, welche Patienten von einer hochspezialisierten Behandlung einen besseren Nutzen ziehen können. Dieses Lehrbuch vermittelt die aktuellen Kenntnisse zu KRAS-Mutationen und deren Bedeutung für die Therapie des Kolorektalkarzinoms. Es erläutert die biochemischen Grundlagen und diskutiert den Stellenwert von Biomarkern in der Diagnostik sowie die Konsequenzen für die Therapie mit Anti-EGFR-Antikörpern. Das Buch wurde von namhaften Spezialisten aus dem deutschsprachigen Raum verfasst und richtet sich an alle Personen, die an der medikamentösen Therapie des kolorektalen Karzinoms interessiert sind.

Moderne onkologische Chirurgie ist immer interdisziplinär und umfasst chirurgische, chemotherapeutische und strahlentherapeutische Behandlungsverfahren ebenso wie fundiertes Wissen zu den Grundlagen und zu Nachsorge und Palliativmedizin. Alle Aspekte sind in diesem Band von ausgewiesenen Experten systematisch dargestellt. Die einzelnen diagnostischen und therapeutischen Verfahren sind ebenso beschrieben wie alle Tumoren der Viszeralorgane und benachbarter Organgebiete. Die Kapitel wurden aktualisiert und teilweise neu verfasst; zusätzliche neue Kapitel gehen ebenso auf neue Erkenntnisse zu Tumorwachstum und Metastasierung ein wie auf neue Therapieverfahren (laparoskopische und computerassistierte Tumorchirurgie, biologisch zielgerichtete Therapie, Schwerionen- und Protonentherapie, selektive interne Radiotherapie und Radioimmuntherapie) und auf zusätzliche Krankheitsbilder (Peritonealkarzinose). Das umfassende Buch zur onkologischen Viszeralchirurgie, das auch bei komplexen Fragestellungen immer eine Antwort weiß!

This comprehensive and critical review of current and established treatment modalities for malignant liver tumors is designed to help you sort through the proliferation of competitive approaches and choose the best treatment options for your patient. Dr. Clavien and his contributors consider all the options – radiological, surgical, pharmaceutical, and emerging/novel therapies – and help you find the best single or combined therapy. Building on the success of the previous edition, this extremely thorough revision: features a new section on Guidelines for Liver Tumors, where you will find specific strategies for treating common liver malignancies; the guidelines were prepared by the Associate Editors and take into account national and international society guidelines reflects actual practice by taking a multidisciplinary approach, with contributions from international experts who have extensive experience with this patient population achieves comprehensive and balanced coverage by having each chapter reviewed by the Editor, Deputy Editor, two Associate Editors, and at least one external reviewer includes 16 new chapters that cover liver anatomy, histologic changes in the liver, epidemiology and natural history of HCC, CCC and colorectal liver metastases, strategies of liver resection, and economic aspects as well as novel therapies facilitates the kind of daily interaction among hepatologists, hepatic surgeons, medical oncologists, radiotherapists, and interventional radiologists that is essential when treating patients with complex liver malignancies In 44 chapters organized into six major sections, the book covers the full range of liver tumors. The perfect blend of evidence and experience, Malignant Liver Tumors: Current and Emerging Therapies, 3rd Edition, illuminates the path to better patient care.

L'ouvrage'Post'U FMC-HGE'est publié chaque année lors des Journées nationales de formation médicale continue en hépato-gastroentérologie, qui ont eu lieu à Paris du 20 au 22 mars 2009 dans le cadre des Journées francophones d'hépato-gastroentérologie et d'oncologie digestive.