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Das kolorektale Karzinom (KRK) ist mit jährlich über 60.000 Fällen das am zweithäufigsten diagnostizierte Malignom beider Geschlechter in Deutschland und weltweit eine der Hauptursachen für krebsbedingte Todesfälle. Eine Vielzahl an systemischen Therapien ist beim KRK verfügbar, doch hängt deren Anwendung und Kombinierbarkeit von einer ganzen Reihe unterschiedlicher Faktoren ab, die bei der personalisierten Therapieplanung unbedingt berücksichtigt werden müssen. Die Neuauflage dieses Kompendiums präsentiert die Differenzialtherapie des KRK auf dem aktuellsten Stand und zeigt dem Leser auch Perspektiven und Forschungspfade für potenziell neue Wege in der Behandlung auf.

ECAB Adjuvant and Neoadjuvant Therapy in Gastrointestinal Cancer - E-Book

Molecular Pathology of Neoplastic Gastrointestinal Diseases reviews the molecular aspects that characterize the spectrum of neoplastic conditions that affect the gastrointestinal tract, providing the reader with current up-to-date knowledge. For each disease entity chapters provide reviews on:the molecular basis of the individual diseasemolecular testing approaches currently available or in development for diagnosis or for gene target characterization for selective targeted therapiesrecommended guidelines for clinical application of molecular tests are included whenever availablemolecular testing for hereditary predisposition or disease riskanimal models and cell culture models of disease

Gastrointestinal Oncology is an evidence-based, practical reference intended to assist in the diagnosis and management of patients with gastrointestinal malignancies. It is designed to be as user friendly as possible and is distinguished by the extremely practical, concrete nature of the information presented and by the multidisciplinary approach adopted. In addition to disease-oriented chapters spanning sites from the esophagus to the anus, non-anatomic subjects such as modern imaging techniques are also addressed. Translational science is supplied where useful in the decision-making process. All of the authors are internationally recognized experts. This book is an ideal resource for oncologists, surgeons, gastroenterologists, and primary-care providers looking for the latest and best information on how to deal with a wide variety of gastrointestinal neoplasms.

Genetic susceptibility refers to how variations in a person's genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.