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Standardizing Pharmacology: Assays and Hormones, Volume Two in the Discoveries in Pharmacology series, presents selected articles from historic discoveries that are enhanced with commentary from contemporary scholars who present discussions on the importance of each chapter, along with an updated bibliography on the subject and contributions from a Nobel Prize winner and other pioneers in pharmacology. Academic and industry researchers in pharmacology and medicine, as well as advanced students will find this series a useful teaching tool and launch to new discoveries. Sections cover key discoveries in receptor theory, pharmacological methods and the development of hormone therapy, including J. Parascandola on the development of receptor theory, R.S. Yalow on radioimmunoassay, M. van Rossum and J.T L.A. Hurkmans on bioassays, M. Tausk on androgen therapy and C. Djerassi on oral contraceptives, with commentaries from experts such as T. Hökfelt and V.C. Jordan. - Contains primary-source documents currently unavailable elsewhere - Presents the science behind major pharmacological breakthroughs by those who discovered them - Includes commentary contextualizing the importance of discoveries and related readings

Alcohol is one of the major risk factors for negative health outcomes worldwide. It accounts for more than 60 alcohol-related diseases, ranging from addiction, through liver cirrhosis, to cancer. Collectively, these conditions account for mortality and morbidity that make alcohol use one of the leading preventable causes of disability adjusted life-years (DALYs) lost globally. In this book, an international faculty covers all aspects of alcohol-related disorders, ranging from addiction/alcohol use disorders (AUD) to alcohol-related diseases of other organs such as liver, heart or cancer. A special focus is to reach out to primary care physicians who are in the front line of this major health problem. The book also provides an update for addiction specialists, as well as specialists in internal medicine, gastroenterology and hepatology. The book is divided into sections that include epidemiology, alcohol use disorders and addiction, alcohol-related liver disease, alcoholic hepatitis,primary care and interdisciplinary approaches and other alcohol-related diseases. Besides current diagnostic measures and treatment strategies, the book deals with the many underlying molecular and genetic mechanisms of alcohol toxicity. Novel insights include prospective data on all-cause mortality and the emerging major role of alcohol-mediated hemolysis and enhanced red blood cell turnover. The book also aims at guiding policy makers to handle the topic of alcohol in our society more responsibly.

There have been many advances in the diagnosis and treatment of cancer, but it is still a feared disease with a lot of work left to be done. The importance of gastrointestinal cancer as a frequently occurring disease goes without saying. It accounts for half of human cancer cases but differs from other forms of cancer. Complete prevention is possible through proper treatment of precancerous lesions. There is still no comprehensive book about prevention, early diagnosis, and proper treatment of precancerous lesions and new developed diagnostic modality, and treatment such as endoscopic treatment and minimal invasive surgery and chemotherapy and immunotherapy. Also, this book will contain conservative treatment methods for patients suffering from diverse complications. There will be plentiful clinical cases including endoscopic findings, radiologic images, pathology and treatment outcome in this book. For these reasons, this book will give very valuable information to many gastroenterologists, oncologists, surgeons and general physicians.

Irritable bowel syndrome is a type of functional bowel disorder causing symptoms of abdominal pain and altered bowel habits such as diarrhoea (IBS-D) and constipation (IBS-C). This book uses the'whole evidence'approach to give an overview of the available evidence for Chinese medicine treatment for irritable bowel syndrome, particularly subtypes IBS-D and IBS-C.The book starts by summarising the conventional understanding of irritable bowel syndrome, including its subtypes, aetiology, diagnosis and current available treatments. Data from Chinese medicine classical literature and clinical studies are then discussed. Evidence from clinical studies are evaluated using high-quality and rigorous scientific methodology. For IBS-D and IBS-C, evidence from treatment modalities including Chinese herbal medicine, acupuncture and combination Chinese medicine therapies are presented. The findings are analysed and potential implications for clinical practice and research are explored. Experimental studies that describe the potential mechanisms of action of key herbs are summarised. In the final chapter, current evidence of Chinese medicine for IBS-D and IBS-C are synthesised, recommendations for contemporary clinical practice and future research are also offered.The book is a helpful guide for clinicians and students of Chinese and integrative medicine, offering a comprehensive synthesis of both classical and contemporary knowledge that can integrated into their clinical practice for people with irritable bowel syndrome.

A must-have reference for both beginning and experienced endosonographers, Endosonography, 5th Edition, coves the full spectrum of endoscopic ultrasound (EUS) in a single, convenient resource. Concise, easy-to-navigate chapters keep you abreast of changes in this dynamic field, and nearly 150 procedural videos reinforce techniques of common, clinically relevant procedures. Covering both standard and newer techniques, this authoritative reference covers everything you need to know—from basic applications to advanced interventions. - Guides you step by step through both introductory and advanced techniques, covering everything from interpretation and accurate diagnosis to treatment recommendations. - Employs a user-friendly, templated format to cover all topics from basic applications to advanced interventions, with procedures organized by body system. - Includes a new chapter on Endo-Hepatology, and an increased focus on using EUS for interventions. - Features 20 new procedural videos covering topics such as esophageal and gastric cancer; mediastinal lesions and lung cancer; pancreatic tumors; and bile duct, gallbladder, and ampullary lesions. - Covers recent improvements and new applications in guided fine-needle EUS for diagnosis and cancer staging. - Features high-quality images with correlative illustrations, diagnostic algorithms, examination checklists, and key points boxes throughout. - Provides nearly 150 how-to-videos of both diagnostic and therapeutic procedures performed by expert endosonographers that demonstrate effective techniques and the proper use of equipment. - Provides practical information on establishing an endoscopic practice, from what equipment to buy to effective cytopathology services.

Rumination syndrome (RS) is a condition characterized by repeated, effortless regurgitation of material (usually food). RS is classified as both a disorder of gut-brain interaction, and as a feeding and eating disorder. Not only can the experience of RS be distressing, it can severely impact a patient's medical functioning and ability to live a full life. RS is unfortunately an overlooked (and thus under-treated) condition, as individuals with RS may often describe their symptoms as “reflux” or “vomiting.” RS can also co-occur with other gastrointestinal and eating disorders, further complicating the clinical picture. The good news is that RS can be successfully treated. This book offers a comprehensive treatment approach for RS, for use with children, adolescents, and adults. With evidence backing its use, Cognitive-Behavioral Therapy for RS (CBT-RS), is designed for clinicians (behavioral health or medical) to use with patients in their own clinical settings. With case examples and a practical stepwise approach, clinicians are able to take CBT-RS into their own clinical settings to increase treatment access for RS.

In diesem Praxisbuch haben Experten auf diesem Gebiet das aktuelle Wissen zur Differenzialdiagnostik und zur Therapie - konservativ bis operativ - zusammengefasst.Das klinische Bild der Refluxkrankheit ist sehr vielfältig. Neben den klassischen Symptomen Sodbrennen und Schmerz hinter dem Brustbein können auch atypische Beschwerden wie Asthma, chronischerer Husten und Heiserkeit als Folge der Refluxerkrankung auftreten. Im schlimmsten Fall kann sich auch als Folge eines langjährigen Refluxes Speiseröhrenkrebs bilden. Insbesondere bei atypischen Symptomen ist aber die Diagnostik erschwert. Hier muss die klinische Expertise durch differenzierten Einsatz von apparativer Diagnostik ergänzt werden. Dieses Praxisbuch leistet eine Hilfestellung in der Funktionsdiagnostik und erläutert mögliche Diagnoseverfahren. Im Therapieteil werden konservative wie auch operative Optionen mit notwendigen Indikationen aufgezeigt. Kapitel zu den Besonderheiten bei Kindern mit Refluxund einem Auftreten bestimmter Symptome während der Schwangerschaft runden das Buch ab. Die Inhalte orientieren sich an der aktualisierten Leitlinie „Gastroösophageale Refluxkrankheit“.Neben der hohen Prävalenz und der deutlichen Einschränkung der Lebensqualität liegt die Bedeutung der Erkrankung im breiten klinischen Spektrum an Symptomen, Komplikationen und Folgeerkrankungen mit Relevanz für zahlreiche Fachdisziplinen auch außerhalb der Gastroenterologie. So bietet dieses Buch einen kompakten Wissenstranfer zum Krankheitsbild - nicht nur für Gastroenterologen.

The chapters in this book are based on the Visceral Pain conference in Adelaide, Australia, under the auspices of the International Federation for Neurogastroenterology and Motility in 2021. This is one of the hottest fields of science and includes mechanisms involving how the microbiome communicates with the brain and how, when disordered, these mechanisms contribute to clinical diseases such as Irritable Bowel Syndrome and Inflammatory Bowel Disease. Researchers from around the globe presented their latest findings as a review of the current state of the art in the field from both the clinical and scientific points of view. These systems are now appreciated as being critical for shaping our well-being and their disorders underlie chronic clinical conditions of significant morbidity and mortality. The author team includes long-established authorities who significantly contributed to the advances in visceral pain research over the past two decades and the new generation thatwill continue to contribute to advancing our understanding of the field.

Helicobacter pylori, a gram-negative bacterium is a common infection in the developing world. The discovery of H. pylori has been associated with gastric problems and, in severe cases, gastric cancer. Across the world, millions of people are suffering from peptic ulcer, which may progress to gastric cancer. The pathogen is generally transmitted through contaminated food and water sources or from an infected person to others. The prevalence of H. pylori infections arises chiefly in developing countries, because many of these countries suffer extremely from a test and treatment approach.This book details the pathophysiology, symptoms, complications, and treatment of H. pylori, and will address the need of students and healthcare workers who want to learn more about this subject. It covers the brief history, taxonomy and virulence factors of H. pylori, as well as its mechanism of transmission, pathogenicity, resistance, isolation, culturing, and possible treatment.

Hepatology and Transplant Hepatology Board Review Hepatology and Transplant Hepatology: Board Review with Multiple Choice Questions is the only source you will need to pass the American Board of Internal Medicine (ABIM) transplant hepatology examination. Written by two highly experienced hepatologists, this indispensable study guide covers all the main topics tested on the exam: pre-transplant, perioperative, post-transplant, and transplant immunology. 261 multiple-choice questions with answers, including questions based on the authors'real-life cases, are designed to mimic the clinical scenarios you will encounter in hepatology practice. Questions testing your medical knowledge, clinical insight, and management skills are supported by brief topic overviews, key references, high-quality images, pathology slides, and cholangiograms. Throughout the book, “Pearls” and “Must-Know Facts” sections emphasize testable points that are likely to appear on the ABIM board examination. The first hepatology-specific study aid of its kind, Hepatology and Transplant Hepatology: Board Review with Multiple Choice Questions is a must-have for medical professionals preparing for the hepatology boards, as well as practicing gastroenterologists and hepatologists who want to refresh their knowledge and test their proficiency in both fundamental and advanced hepatology topics.

The Liver in Systemic Disease A practical guide for non-hepatologists who encounter abnormal liver test results in patients The Liver in Systemic Disease is an easy-to-use and authoritative guide for non-hepatologist health care professionals who need guidance on the management of patients with abnormal liver tests. The book provides definitive advice for when further investigation, or changes in management, are indicated. With a practical focus throughout the text, the editors explore when and how to investigate and manage patients whose primary disease is non-hepatic, but whose liver tests are unexpectedly abnormal. The Liver in Systemic Disease provides substantial flow diagrams and advice on the process, together with updates on the liver diseases non-hepatologists are most likely to encounter. Take-home primers included in the book shine a light on best practice and recommended procedures when dealing with abnormal liver test results. The book also provides: A thorough introduction to evaluate the liver, including serum liver tests, liver imaging, and liver biopsy Comprehensive discussions of practical issues in patients with liver abnormalities, including the diagnosis of drug induced liver injury, prescribing in patients with abnormal liver tests, and more Practical discussions of the management of patients with unexplained abnormal liver tests in primary care In-depth examinations of secondary care management of patients with unexplained abnormal liver tests, including intensive care, and the care of infectious and immunosuppressed patients The Liver in Systemic Disease is an indispensable resource for non-hepatologist medical practitioners seeking to understand the implications of abnormal liver tests and who wish to know when further investigation or alteration of management is indicated.

In recent years, the study of the human intestinal microbiota and its relationship with the brain has expanded enormously in the scientific field. It has been shown that changes in nutritional habits, apart from producing changes in the host microbiota, can affect the central nervous system, contributing to the development of neurological pathologies such as Parkinson's, Alzheimer's and motor neuron disorders. Several studies have shed light into the role of exercise as a preventive factor against various diseases; however, exercise can also produce stress on the body. This book discusses the relevance of an individual's health state, type and duration of exercise, and diet as contributing factors to the microbiota-gut-brain axis. Also, this book presents findings regarding the relationships between epigenetic modifications and the gut microbiota as well as between epigenetics and cognitive function.

Abdominal pain is one of the frequent reasons for admission to emergency departments in hospitals. Diagnosis in patients presenting abdominal pain is a challenge for physicians owing to several indications, and a lack of contraindications. Delay in diagnosis and misdiagnosis is a common problem even for the most experienced emergency physician or general surgeon. Disruptions that may be related to ancillary services such as radiology and biochemistry also increase the difficulty.Abdominal Pain: Essential Diagnosis and Management in Acute Medicine is a definitive diagnosis guide that serves as a quick reference that supplements medical examinations. It gives physicians involved in a range of medical specialties (emergency medicine, family medicine, gastroenterology, general surgery) an understanding of how to apply procedures to expediently relieve pain where possible, after evaluating and recording the initial vital signs and findings on systemic examination.Key Features- Covers abdominal pain diagnosis and patient management patient in a systematic and structured manner in 12 chapters- Chapters are dedicated to specific topics- Presents an individualized approach tailored for the patient to address common problems- Gives general working knowledge for specific diseases in the list of possible diagnoses- Provides a guide to situations involving trauma and surgery

Over the last two decades, there have been major advances in imaging, endoscopy, and laparoscopy in the field of gastrointestinal (GI) surgery. GI surgery is the newest sub-specialty branch of general surgery, where enhanced expertise and high-volume centres have made a difference to the outcomes of complex operations. Surgeons can now perform difficult procedures with low morbidity and mortality rates, and greatly improved overall results. This volume provides detailed and comprehensive information on diseases of the pancreas. The pancreas continues to fascinate clinicians and researchers worldwide, due to its anatomical location deep inside the abdominal cavity and the various functions of the gland, some of which are well understood but others remaining ill-defined. Last but certainly not least, pancreatic surgery, along with liver surgery, remains the final frontier for the vast majority of GI and hepato-pancreato-biliary surgeons. The information explosion in this era has resulted in cutting-edge developments in acute pancreatitis, chronic pancreatitis, and pancreatic cancer. Comprising evidence-based contributions from recognized leaders in pancreatology, this book covers contemporary issues in acute and chronic pancreatitis and pancreatic cancer to help practicing surgeons and pancreatologists with the most up to date concepts in management. It will be a valuable resource for pancreas specialists, general surgeons with an interest in pancreatic diseases, researchers, and medical students.

This extensively revised second edition of this essential work provides a comprehensive overview of Gastroesophageal Reflux (GER) in children. It contains detailed insight into the epidemiology and pathophysiology of the condition. Relevant diagnostic methods and treatment techniques are also covered. Heavily revised chapters discuss issues associated with GER in special patient populations and current approaches to GER diagnosis and management. New chapters cover relevant aspects of the microbiome, how nutrition can be key to successful treatment and the adverse effects of the latest therapeutic drugs presently available. Colic in infants, and differential diagnoses in eosinophilic esophagitis are also described. The first part of the book is dedicated to introducing the condition, discussing epidemiology, symptoms and diagnosis. This is followed by addressing issues of the condition encountered in special patient populations such as in preterm infants, apnea, neulorogic patients and cystic fibrosis, among others. The final part of the book is dedicated to therapeutic approaches from medication to surgery and alternative approaches such as complementary medicine and hypnotherapy. The approaches and challenges in endoscopy are also detailed.Gastroesophageal Reflux in Children, Second Edition is edited by a leading world expert in the topic and written by a global team of authors from a range of associated disciplines, making the work a critical resource for pediatricians, gastroenterologists to pulmonologists, otolaryngologists and neurologists.

Reclaim Your Life from IBS teaches a number of skills that can directly reduce the impact of gastrointestinal symptoms in a person's life. The book explores the differential diagnosis of irritable bowel syndrome (IBS) and the current scientific models of what causes IBS. It teaches the reader the cognitive model of stress management using cognitive-behavioral therapy and helps readers learn to identify their negative beliefs and reframe them more accurately. It also guides readers to reduce avoidance and helps them understand how to use dietary modifications and medications wisely, rather than reactively. In this second edition, numerous case examples throughout illustrate the application of these core CBT skills to IBS-related thoughts and experiences, and new material is included on exercise, diet, and medications. This book is a proven self-help book for people with IBS, as well as being useful as a treatment manual for clinicians who work with patients with IBS.

The book covers all aspects of endoscopic biopsies of the stomach inclusive of gastritis and gastropathies. It highlights the best way of handling of endoscopic biopsies in the endoscopic room by the gastroenterologist. It elucidates various steps involved in processing of the biopsy, tissue embedding and paraffin sectioning, approach to interpretation, various precautions that require to be taken while interpreting the biopsies, and the essential background knowledge of the interpreter. The book highlights the importance of the little things for a proper reading like matching of the tissue fragments received and the number of tissue present on a slide after the paraffin section.Chapters cover various forms of gastritis, and the easiest approach for daily routine by avoiding the cumbersome classifications and staging formulated for gastritis. It also discusses the utilization of the right nomenclature for acute and chronic gastritis and various other subtypes of gastritis. Chapters include various rarer and infrequently come across conditions of both acute and chronic gastritis, special form of gastritis and infective conditions. It also includes unusual forms of non-neoplastic gastric pathologies such as, a condition, where the gastric mucosa is affected not only by direct exposure to various irritants but may also be affected by many systemic diseases. It also highlights the frequently observed changes in chronic renal and liver failures. The book is targeted to all the practicing pathologists as well as graduate and post graduate students who are keen to learn about non-neoplastic gastric pathology at various levels.

Newly updated with the latest information on inflammatory bowel disease, Curbside Consultation in IBD: 49 Clinical Questions, Third Edition contains brief, practical, and evidence-based answers to the most frequently asked questions that are posed during a “curbside consultation” between surgical colleagues. Drs. David T. Rubin, Sonia Friedman, and Francis A. Farraye are joined by an expert group of contributors, offering advice, preferences, and opinions on tough clinical questions commonly associated with IBD. With a unique Q&A format, this text provides quick access to current information. Numerous images, diagrams, and references are included to better illustrate IBD.Some of the questions answered inside the Third Edition include: What are the new approaches to using and minimizing steroids? What is the evolving role of calcineurin inhibitors in IBD? Where should anti-IL-23 therapy be placed in the therapeutic algorithm for Crohn's disease and ulcerative colitis? What should the clinicians and patients know about biosimilars? What are JAK inhibitors? And when should they be used in IBD? What is the approach to loss of response to biological therapy? How should we screen our patients with IBD for depression and anxiety? With information basic enough for trainees and expert practical advice that even high-volume clinicians will appreciate, Curbside Consultation in IBD: 49 Clinical Questions, Third Edition is a must-have. Gastroenterologists, surgeons, IBD nurses and advanced practice providers, and medical and surgical trainees at all levels will benefit from the user-friendly format and up-to-date advice for complicated cases.

Viral hepatitis is a global health care challenge. It affects almost every part of the world and the World Health Organization reports that 354 million people worldwide live with hepatitis B or C. However, there have been recent changes in the treatment of acute and chronic hepatitis, as its management is a key issue in clinical medicine.This book provides up-to-date information about the treatment of acute and chronic hepatitis. From hepatitis A to E, it summarizes the treatment of viral hepatitis to guide clinical practice. After exploring the treatment of each virus, a separate chapter details the clinical pharmacology of all the drugs used in acute and chronic hepatitis. This book will be a great resource to students, internists, infectious diseases physicians, gastroenterologists, microbiologists, and clinical pharmacists.

Bile duct injuries (BDI) are considered the most serious surgical complication associated with cholecystectomy. According to different reports, its incidence has remained constant over the years, ranging from 0.1% to 0.9%. BDI is associated with a greater risk of perioperative morbidity and mortality, a reduction in the quality of life, and a decrease in long-term survival. Also, this complication is a concern to surgeons since its progression is uncertain and may lead to demands on professional responsibility ('malpractice') and emotional and physical consequences ('second victim').Given that injuries in a high percentage of patients are initially unsuspected, the postoperative recovery may be prolonged, and the possibility of a successful repair reduced. Several surgical, endoscopic, and percutaneous procedures may be necessary to manage the lesions and to treat coexisting complications. BDI patients often undergo several repair attempts before successful resolution. This affects their quality of life and has a high psychological, physical, and mental impact due to the prolonged, complex, and unexpected nature of the injury. This currently represents a frequent problem in specialized referral centers or hepatobilopancreatic surgery units, where patients arrive with the sequelae of previous inadequate treatments. Usually, these patients require more elaborate procedures such as reoperations, liver resections and liver transplantation. The prevention, early diagnosis, and adequate treatment in the first approach is of crucial importance to ensure good long-term results. Therefore, this book is an essential resource for surgeons who perform cholecystectomy or treat BDI patients. It provides practical information and a comprehensive review on prevention and proper management, including complex cases. Readers will find contributions by experienced authors from a multidisciplinary and reference team in the management of BDI patients.

Sex/gender - specific medicine (SGM) is defined as the practice of medicine based on the understanding that biology and social roles are important in men and women for disease prevention, screening, diagnosis, and treatment. Current research demonstrates differences in disease incidence, symptomatology, morbidity, and mortality based on sex and gender. Sex/gender-specific medicine is a fundamental aspect of tailored therapy and precision medicine. Therefore, the variables must be considered in medical education and practice as well as in research models ranging from human participants, animals and cells. Gastroenterology is very big and important division of Internal Medicine, which include esophagus, stomach, small and large intestine, pancreatobiliary tract and liver. Nowadays estrogen is known to play a key role in the prevention of colon cancer and progression of liver cirrhosis and hepatocellular carcinoma, especially in women. This book covers the sex/gender-specific medicine inthe area of gastrointestinal (GI) tract in the adults as well as in the pediatrics and in the gut microbiota.

Worried about how allergies will affect your children? From conception through pregnancy and the first two years, this authoritative guide from a leading gastroenterologist shows you how to prevent allergies and optimize gut health in your baby. For many families, eczema, asthma, hay fever and food allergies are constant anxieties, sometimes with devastating consequences. But what if there was a way to prevent allergies from the start? What if early lifestyle changes could change your baby's life? In The Healthy Baby Gut Guide, Dr. Vincent Ho lays out a simple yet effective plan for optimizing your baby's gut health in the first 1000 days after conception. Dr. Ho shares sensible advice, surprising scientific discoveries from the exploding medical field of gut health, and a nutritionist-approved nine-week infant meal plan. Practical, easy-to-follow, and eye-opening, this book is essential reading for every parent and parent-to-be.

Optimal performance of the liver and gastrointestinal tract is vital for general human health. The gastrointestinal system is the main site of nutrient digestion and absorption, and therefore has substantial effects on providing energy and growth for the body. All nutrient and non-nutrient components have an impact on the gastrointestinal system, either locally or systemically. Undeniably, gastrointestinal disorders, with increasing lifetime prevalence, have a profound effect on human health and reduce the quality of life. Nowadays, therapeutic options are limited to medical therapy, including pharmacologic approaches and surgical intervention or lifestyle changes aimed at dietary modifications and increased physical activity. Certainly, dietary modifications can be effective in preventing, treating, and alleviating associated symptoms and complications. In addition to improving whole dietary patterns, the components of foods, collectively or independently, also have a substantial role in their therapeutic features. These components, particularly bioactive compounds, confer unique health benefits and aid in management of various diseases. Recently, investigators have paid much attention to chemopreventive activity of bioactive dietary compounds in the treatment and prevention of gastrointestinal diseases. Fruits, vegetables and edible plants are the main source of biologically active compounds with anti-inflammatory, antioxidant, and protective properties. Most importantly, no major side effects have been reported for these compounds until now. Therefore, this book offers novel targets for prevention, treatment and management of liver and gastrointestinal diseases by providing evidence of effectiveness of bioactive compounds of functional foods. Furthermore, intracellular and molecular pharmacological mechanisms of action of bioactive compounds will also be discussed. It seems that bioactive compounds bring new hope for patients with gastrointestinal disorders through their anti-inflammatory and anti-oxidative potential. The editors hope that the book will be a useful reference for researchers, product developers, health professionals and students.

This book presents a comprehensive collection of classic cases and problem scenarios encountered as bedside case discussions during ward rounds. It facilitates the practical management of hepatic disorders. The unique aspect of hepatology involves the blend of the basic tenet of clinical medicine applied to liver disease and a multitude of interventional modalities in the management of liver, biliary, and pancreatic diseases. This book takes the reader through the process of ruling in and ruling out possibilities based on clinical data (history and examination) and then traces the logical trajectory of each case from recommended investigations to the analysis of test results and finally to making a syndromic diagnosis. By adopting an evidence-based approach, the book emphasizes analytical and need-based studies to exclude any mimics. This book helps practice hepatologists and gastroenterologists for a systematic approach towards the most common cases.

Now fully revised to include recent advances in the field, the third edition of Gastrointestinal and Liver Pathology Pathology, a volume in the Foundations in Diagnostic Pathology series, is an essential foundation text for residents and pathologists. The popular template format makes it easy to use, and new information throughout brings you up to date with what's new in the field, including advances in molecular diagnostic testing and new diagnostic biomarkers. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice.Key features of this practical text include: - A consistent, user-friendly format that explores each entity's clinical features, gross and microscopic findings, ancillary studies, differential diagnoses, and prognostic and therapeutic considerations. - A focus on specific features of selected neoplastic and non-neoplastic entities, including broad and in-depth differential diagnoses. - Clinical information on treatment and prognosis, enabling you to better understand the clinical implications of the diagnosis. - Nearly 1,000 full-color, high-quality illustrations with extensive figure legends, as well as abundant boxes and tables throughout. What's NEW in this edition: - Advances in molecular diagnostic testing and its capabilities and limitations, including targeted/personalized medicine. - New diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities. - The latest TNM staging and WHO classification systems. - New co-editors Drs. Amitabh Srivastava and Daniela S. Allende lead a team of expert, internationally recognized pathologists who keep you up to date with the latest information in the field.

This book provides a concise overview of the robotic techniques applicable to colorectal surgery. Initially, it describes how to set-up an operating room from an ergonomics perspective. Detailed guidance is then provided on how to apply robotic platforms to the rectum, colon and abdominal wall. Emphasis is placed on describing the latest procedures and how to utilize them in a particular scenario. Instructional picture material and tips and tricks from world leading experts contain tips on how to successfully perform many of the techniques covered, enabling the reader to systematically develop a detailed knowledge of the methodology and how to potentially troubleshoot any issues that may arise.Robotic Colorectal Surgery: Complete Manual of Surgical Techniques describes how to apply the latest robotic techniques in everyday colorectal surgery practice, making it an indispensable resource for trainee and practicing surgeons.

This textbook on the digestive system was developed in collaboration with medical students to meet both students'and teachers'needs and objectives. It is currently the official gastroenterology textbook for undergraduate students in all French medical schools in Canada, and is also used in Europe and Africa. An updated and improved 3rd edition was published in French in 2020; this translation and update make the book available in English for the first time. The text features contributions from GI experts from Quebec, France, French Africa, and from key Canadian GI experts.The first part of the book covers the eight main organs of the digestive system, while the second half discusses the major clinical diseases and symptoms that affect the digestive system. This book is comprehensive and well-organized, and features color-coded and beautifully designed figures and tables that make the book helpful and accessible to students.

Mit diesem Buch für die Kitteltasche oder als eBook auf dem Smartphone behalten Sie die Nerven vor und während Ihres ersten Dienstes auf einer gastroenterologischen Station. Dieser Guide beantwortet alle wichtigen Fragen, die Sie sich vor Ihrem ersten Einsatz stellen: Wann sollte eine Endoskopie durchgeführt werden? Wann muss ich den Oberarzt rufen? Auf welche Notfälle muss ich vorbereitet sein? Von wichtigen Laborwerten über organisatorische Aspekte und Notfallsituationen, bis hin zum Umgang mit Fieber und Dysphagie finden Sie zahlreiche Tipps und Tricks für das ideale Vorgehen. Von jungen Gastroenterologen geschrieben, die wissen, was junge Ärzte für eine gute Vorbereitung ihrer ersten Dienste brauchen. Plus: eBook inklusive.Für jeden Weiterbildungsassistenten, der seine ersten Dienste in der Gastroenterologie souverän meistern möchte!

The main purpose of this book is to create a reference for the indications, contraindications, patient selection, treatment practice, treatment side effect management, and follow-up of radionuclide treatments. Besides standard methods such as surgery, chemotherapy, radiotherapy, and hormone therapy, newly developed biological treatments, targeted treatments, personalized treatments, external beam radiotherapy, and targeted radionuclide treatments have begun to take their place in professional practice. Nuclear medicine, in addition to its role as a tracer of cancer, also assumes the role of treating with radioactive molecules directed to the cancer it traces. These traceable next-generation radionuclide treatments, whose efficacy and reliability have been proven and where diagnosis, treatment, and follow-up are carried out together, are increasingly included in oncology practice together with the new developed radiopharmaceuticals, ensuring a high rate of damage to cancer cells while protecting the surrounding normal tissues. Molecular cancer treatment will become more effective with individualized next-generation traceable radionuclide treatments, which will be shaped by genetic studies in the future. Radionuclide treatments for many cancer types and benign diseases are presented by experienced nuclear medicine experts in the light of their own experience and case studies, while systemic treatments in common cancer types and side effect management of these treatments are summarized by medical oncologists. This book will be of interest to nuclear medicine physicians as well as oncologists.

YAMADA'S Textbook of Gastroenterology For over 25 years, Yamada's Textbook of Gastroenterology has been the most comprehensive gastroenterology reference book, combining an encyclopedic basic science approach to GI and liver disease with the latest clinical thinking, especially in diagnostic and therapeutic developments. It is universally respected across the globe. The original outstanding editorial team was led by Tadataka Yamada, MD, one of the world's leading figures in GI research. This seventh edition of the Textbook features a new set of Editors-in-Chief and a new team of Associate Editors. This new editorial team has made substantial changes and updates to the Textbook, with a greater focus on the human microbiome, obesity, bariatric endoscopy and aging, along with consolidation of many older chapters. Led by Professor Michael Camilleri and Professor Timothy C. Wang, a stellar group of associate editors have once again combined with authors in their respective fields to communicate their vast fund of knowledge and experience to make the 7th edition of this iconic textbook the most comprehensive ever published.

The instant New York Times, Wall Street Journal, and USA Today bestseller!New York Times bestselling author Dr. Will Bulsiewicz offers a groundbreaking cookbook packed with delicious plant-based recipes, as well as a targeted plan for overcoming food sensitivities.Leading gastroenterologist Dr. Will Bulsiewicz, or “Dr. B,” introduced readers to the wonders of fiber with the New York Times bestseller Fiber Fueled—a guide to optimizing the gut microbiome, sharpening immunity, lowering cholesterol, and promoting weight loss through a diet rich in diverse fruits, vegetables, nuts, seeds, and legumes. Rather than restriction, Dr. B's solution is abundance and variety. Now he applies all the principles of the Fiber Fueled diet in a cookbook that's as beautiful as it is practical. This must-have cookbook will inspire you with deeply flavorful, satisfying plant-based recipes that make the Fiber Fueled lifestyle delicious and inviting. But The Fiber Fueled Cookbook is also a revolutionary treatment program for food sensitivity sufferers who have struggled to get a handle on their symptoms. In it you will learn the GROWTH strategy, a groundbreaking approach that helps readers break down what's causing their GI problems, and discover real solutions that are personalized to their individual needs. Whether you are well on your plant-based path, or excited to get started, the 100+ irresistible recipes in this book, including Lemon Lentil Salad, Cheezy Broccoli Potato Soup, Maple Peanut Granola, and Chocolate Cookie Milk, will get you ready to embrace the power of being Fiber Fueled!

Colitis ulcerosa und Morbus Crohn sind chronisch entzündliche Darmerkrankungen, die vorwiegend in der zweiten und dritten Lebensdekade auftreten. Obwohl beide Erkrankungen nicht selten sind, betreuen die meisten Ärzte nur wenige Patienten mit dieser Diagnose. Daraus resultiert eine relativ begrenzte Erfahrung in der Führung dieser Patienten. Dies erklärt vielleicht auch, warum sich die Diagnosestellung nicht selten verzögert und Unsicherheiten bezüglich der Therapie bestehen. Auch die 7. Auflage dieses Kompendiums ist eine kompakte Informationsbasis für alle relevanten Fragen, die sich bei der Behandlung betroffener Patienten stellen. Es berücksichtigt alle aktuellen Entwicklungen auf dem Gebiet der Pathophysiologie, der Diagnostik und der internistischen und chirurgischen Therapie und berücksichtigt dabei die neuen, inzwischen aber gut etablierten Therapien mit Antikörpern und Januskinaseinhibitoren.

This Atlas focuses on surgical techniques used to treat the entire spectrum of esophageal diseases. Surgical “pearls” and tips on how to select and perform the correct operation are included and based both on evidence-based data and the experience of the Editors.Step-by-step descriptions of operative and endoscopic procedures in esophageal surgery are provided. Each chapter describes the current indications, perioperative management strategies, and a detailed operative approach with relevant technical considerations.The description of approaches and surgical techniques used in esophageal surgery are outlined in an easily understandable manner for the specific target audience. This book is written by world-class internationally renowned esophageal surgeons and gastroenterologists

Get relief from your inflammatory bowel disease symptoms Crohn's disease and ulcerative colitis are diseases that disrupt your body's ability to digest food, absorb nutrition, and eliminate waste in a healthy manner. Crohn's And Colitis For Dummies is the ultimate reference to these common forms of inflammatory bowel disease (IBD), including tips on how to recognize and control the symptoms, so you can get your life back. Get ideas for keeping disease in check through diet and lifestyle changes, learn about the various medical and surgical treatment options, and discover healthier living with this friendly Dummies guide. This updated edition covers the latest research on IBD and new therapies that are helping today's Crohn's and colitis patients. You'll also find resources that will help and offer hope as you navigate your diagnosis. Learn about the different forms of inflammatory bowel disease Ask the right questions at the doctor's office Make simple changes that will improve your symptoms Know that there's hope and that you are not aloneThis book is perfect for anyone who has been recently diagnosed with Crohn's or colitis, and for those who suspect they may have an IBD. If you're a caregiver or family member of an IBD sufferer, you'll also love the easy-to-understand information inside.

This book provides an extensive overview of the role of imaging in the detection, diagnosis, management, and follow-up of tuberculosis. Chapters cover the disease's epidemiology and pathophysiology, microbiological diagnosis and pathology relevant to radiologists, and the distinct aspects of imaging tuberculosis at various locations and body systems. This book discusses recent advances in imaging pertaining to tuberculosis, and addresses the approach to patients with tuberculosis and HIV co-infection. The final chapter offers an algorithmic approach to the diagnosis and management steps of tuberculosis. Imaging of Tuberculosis is an updated and comprehensive reference source that covers imaging of tuberculosis in a structured fashion and is valuable for radiologists.

The book provides up-to-date information on all aspects of colonic diverticular disease, particularly common in Western countries. Most people suffering from it remain asymptomatic, while about 20% develop symptoms without complications, experiencing the so-called'Symptomatic Non-Complicated Diverticular Disease'(SUDD). 10-25% of this last group eventually develop diverticulitis, with or without complications. The incidence of diverticulitis and diverticular colon disease is increasing worldwide, and is becoming a significant burden for national health systems in terms of direct and indirect costs, also because its prevalence increases with age. Unfortunately, the disease pathogenesis is relatively unknown and several aetiological factors may play a role in its onset. The first parts of the book will deal with the disease epidemiology and etiopathogenesis, focusing on the roles of inflammation and dysbiosis as part of the pathophysiology of diverticular disease. The clinical spectrum, the diagnostic approach and differential diagnosis, medical and surgical treatments are described in the following sections. Written by experts in the field, the volume will be a unique and valuable resource for all clinicians, residents, and physicians involved in the management of this disease.

This textbook includes 70 chapters contributed by an exceptional group of experts in all areas of hepato-pancreato-biliary diseases, bringing a multi-disciplinary approach to treatments. The book is designed to cover all aspects of the liver and pancreatic anatomy and pathology, as well as therapy. The topics are comprehensively reviewed, and as well as summarizing the previous works, the authors provide discussions of practice-changing techniques and approaches to therapy of HBP cancers. Treating the diseases in hepato-pancreato-biliary regions is particularly difficult due to the complex anatomy, aggressive biological behavior, and poor prognosis. Therefore, ample illustrations are included to tackle these challenges.The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases aims to update the academic and non-academic medical professionals, such as surgeons, radiation oncologists, medical oncologists, gastroenterologists, interventional radiologists, radiologists, basic scientists. In collaboration with the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO), delivers a valuable and well-organized textbook for medical professionals.

This practical guide provides patients who have inflammatory bowel disease (IBD) with cognitive-behavioral therapy (CBT) strategies for coping with IBD. It teaches a number of skills that can make coping with Crohn's or colitis easier. Chapters provide an overview of Crohn's and colitis as well as the interplay between stress and the gut, before offering strategies on relaxation training, physical activity, managing stress and avoidance, diet and nutrition, and medical treatment options. The book also emphasizes the importance of the doctor-patient relationship and helps patients learn how to think about medical management (including the possibility of surgery) to minimize anxiety from catastrophic thoughts and balance potential risks and benefits appropriately. Dr. Hunt challenges readers to engage in specific behavioral experiments to reduce shame and stigma and highlights practical applications with case illustrations and clinical vignettes. This book can be used as a standalone self-help book or in conjunction with practitioners during in-person therapy.

This book provides a practical overview of the treatment and management of celiac disease. It examines new data which can be merged with clinical aspects to provide a global perspective for the busy clinician. The disease represents 1% of the population and often goes unnoticed for a long time; however, this book aims to reduce the instance of misdiagnoses of symptoms by providing clear guidance in a single book, with contributions from esteemed experts in the field. Advances in Celiac Disease - Improving Paediatric and Adult Care addresses the clinical characterisation of the disease, in both paediatric and adult populations. The clinical symptoms are clearly defined as well as treatment options and follow-up. This book will be an essential resource for clinicians seeking a clear, concise resource to identifying, treating, and managing celiac disease in both adults and children.

There is no other time in life when the provision of adequate and balanced nutrition is of greater importance than during infancy and childhood. During this dynamic phase of life, sufficient amounts and an appropriate composition of supplied substrates are of key importance for growth, functional outcomes, and the metabolic programming of long-term health and wellbeing. This condensed volume was compiled with the aim of providing concise information to readers who seek quick guidance on the practice of nutrition of infants, children, and adolescents. After the great success of the first two editions, the editors prepared this thoroughly revised and updated third edition with a truly international perspective to address challenges in both affluent and challenged populations around the world. This book of outstanding quality will be useful to many healthcare professionals around the world, and it will contribute to further enhancing the quality of feeding of healthy infants and children, as well as enhancing the standards of nutritional care in sick children.

This book is structured in three major parts and the first part is a comprehensive overview of IBD-related intestinal cancer. The second and third parts provide rare and important cases on ulcerative colitis (UD) and Crohn's disease (CD) presenting the macroscopic image of the resected specimen and analyzing the endoscopic and the pathological image to explain how to find the IBD cancer. It also delivers a detailed analysis of the histological structure of cancers. This book tries to clarify the critical but yet to be answered questions such as “Why is it so difficult to find out?”, “Why so flat?” and “How to name superficial lesion with invisible margin?” and so on.Atlas of Inflammatory Bowel Disease-Associated Intestinal Cancer is designed to serve all endoscopists and gastroenterologists managing IBD patients. It also is valuable reading for pathologists who are diagnosing gastrointestinal lesions. This book is designed to assist these medical professionals to find cancers in the early stage and stay up-to-date on image-enhanced endoscopy techniques. This book is a translation of an original Japanese edition. This has been facilitated using machine translation (by the service DeepL.com) followed by editors and authors revising, editing and verifying the translated manuscript.

Over the last two decades, there have been major advances in imaging, endoscopy, and laparoscopy in the field of gastrointestinal (GI) surgery. GI surgery is the newest sub-specialty branch of general surgery, where enhanced expertise and high-volume centres have made a difference to the outcomes of complex operations. Surgeons can now perform difficult procedures with low morbidity and mortality rates, and greatly improved overall results. This volume provides detailed and up-to-date information on diseases of the mesentery, omentum, peritoneum, and retroperitoneum as well as abdominal trauma. As an area of surgery that may often be neglected in traditional teaching, with limited resources to aid clinical decision making, diseases and trauma in this area can lead to situations where even the most experienced surgeon may feel challenged. Managing patients with these diseases successfully warrants a comprehensive knowledge of their anatomy and physiology as well as the pathology involved. The book provides comprehensive coverage of the different conditions and traumas, and includes a final chapter covering abdominal surgery during the COVID-19 pandemic. Written and edited by international experts in the field, this book will be a valuable resource for abdominal, peritoneum and retroperitoneum surgeons and trainees, general surgeons, researchers, and medical students.

Die nicht-alkoholische Fettlebererkrankung gilt als'neue Seuche der Hepatologie', als diejenige Lebererkrankung mit den höchsten Zuwachsraten weltweit. Prognosen sagen eine Zunahme des Phänomens um 50% und eine darauf basierende Verdreifachung der Zirrhoseraten bis 2030 voraus.Dieses Buch dient zum Nachschlagen zu allen Fragen um das vielfältige Krankheitsbild der nicht-alkoholischen Fettleber (NAFLD). Es bildet den aktuellen Stand der Wissenschaft ab mit seinen diagnostischen Verfahren und Therapieoptionen sowie neuen Entwicklungen auf diesem Gebiet.Tabellen, Übersichten und Algorithmen, erlauben ein schnelles Erfassen der wichtigsten Punkte und eine strukturierte Diagnostik und Therapie. Grundlagen zur Pathogenese und Physiologie führen in das Thema ein. Weiterhin werden die Differentialdiagnostik und unterschiedliche Therapieverfahren erläutert. Dabei wird die gesamte therapeutische Bandbreite von der Verhaltensänderung über die Ernährung bis hin zu den neusten Medikamenten dargestellt. Auf spezifische Patientengruppen wie z.B. Kinder oder adipöse Patienten wird gesondert eingegangen. Weiterhin werden auch Komorbiditäten wie z.B. Hepatozelluläres Karzinom bei NAFLD oder NAFLD bei chronischen Lebererkrankungen und der Einfluss von Genussmitteln detailliert besprochen. Für alle Gastroenterologen und Hepatologen sowie für interessierte Internisten und Weiterbildungsassistenten ein praktisches Nachschlagewerk.

This book provides a concise overview of several critically important techniques and their applications within Laparoscopic Common Bile Duct Exploration (LCBDE). LCBDE is rapidly emerging as the preferential management option for treating patients with common bile duct (CBD) stones. Chapters within this book describe how this technique can be applied to manage patients with concomitant gallstones, which aims to increase the exploration of the CBD via the transcystic route. Particular mention is made for the use of energy devices to enable stone fragmentation within the bile duct also known as Lithotripsy-Assisted Bile duct Exploration by Laparoendoscopy (LABEL). Guidance is also provided on how to set-up an acute biliary service which can offer the single-stage management of concomitant gallstones and choledocholithiasis. The concepts of ‘Leveraging Access to Technology and Enhanced Surgical Techniques (LATEST)'in LCBDE and ‘Biliary Surgery 2.0'as the framework through whichthese techniques can be further enhanced are analysed. Laparoscopic Common Bile Duct Exploration features insight into how to perform these increasingly important procedures successfully and set-up a service within institutions that are yet to provide it. Therefore, it is a valuable resource for all medical professionals involved in the care of these patients.

This book is based on the proceedings of the Enteric Nervous System conference in Adelaide, Australia, under the auspices of the International Federation for Neurogastroenterology and Motility. The book focuses on methodological strategies and unresolved issues in the field and explores where the future is heading and what technological advances have been made to address current and future questions. The Enteric Nervous System II continues in the tradition of a popular earlier volume which covered the previous meeting. Many of the same authors are contributing to this new volume, presenting state-of-the-art updates on the many developments in the field since the earlier meeting. The coverage include a wide range of topics, from structure and function of the enteric nervous system through gut motility and visceral pain. The author team includes long-established authorities who significantly contributed to the advances in ENS research over the past two decades and the new generation that will continue to contribute to advancing our understanding of the field.

This book provides a comprehensive analysis of the value of contrast-enhanced ultrasound (CEUS) in the diagnosis of a wide variety of pathologies. Sonography reliably identifies a wide range of diseases, and the efficacy of modern ultrasound has dramatically improved with contrast enhancement. This book covers almost all aspects of CEUS starting from basic principles and ending with features of its application in individual organs. In particular, it explores the diseases of abdominal, retroperitoneal, and pelvic organs as well as superficial structures, highlighting the characteristic features of typical findings. Focal lesions are discussed in depth, with attention to their early detection and differential diagnosis. Besides, a practical approach to the stratification of the risk of malignancies is provided. The authors summarized their own experience with CEUS in oncology, hepatology, gynecology, urology, endocrinology, and other fields of medicine. The role ofCEUS in differential diagnosis of various disorders of the female reproductive system is comprehensively discussed as well. The presentation is clear and concise, and richly illustrated. The book will be a helpful tool for both residents and practitioners approaching ultrasound diagnostics, as well for more experienced radiologists and other professionals.

This fully revised and updated third edition of the Oxford Handbook of Gastroenterology and Hepatology provides up-to-date, pragmatic advice on the management of common conditions and emergencies. An essential resource for all those involved in the care of patients with gastroenterological and hepatological disease, both for specialists and trainees in gastroenterology and hepatology, and also clinicians from other specialties. The handbook includes a problems-based approach, a unique A to Z compendium of conditions, and sections on therapeutic drugs, and emergencies. Thoroughly revised and updated, it now includes such updates as new approaches for the management of eating disorders, and post-liver transplant patients, the latest advances in endoscopy, new therapies, refined advice on how to select between therapeutic options, as well as additional emergency topics on abdominal trauma, bowel obstructions, and major haemorrhage.

Tuberculosis is an important concern in numerous countries across the globe. Training is usually focused on pulmonary tuberculosis, and the nuances of diagnosis and management of extrapulmonary tuberculosis, including abdominal tuberculosis, are not usually emphasized. This book details the varied presentations and mimics of tubercular involvement of the abdomen and the gastrointestinal system..The book provides clear guidance to the clinicians to diagnosis and manage the varied forms of abdominal tuberculosis. The chapters also touch on areas of controversy and confusion. Chapters are focused on each of the sites (intestinal, peritoneal, gastroduodenal, hepatobiliary, and pancreatic), modalities for evaluation (histology, microbiology, radiology, endoscopic ultrasound, nuclear medicine), differential diagnosis, and follow-up including response to treatment. Separate chapters have also been devoted to pediatric abdominal TB, therapy-related hepatitis, and considerations in immunocompromised states such as HIV. Therefore, this book will help practice clinicians and serve as a one-stop resource for graduate students in internal medicine and fellows training in gastroenterology.

In this book the recent advancements in understanding the gut-brain interaction as well as gut microbiome and how this interaction plays a vital role in human health and disease are discussed. Each chapter gives an analysis of questions, research directions, and methods within the field of gut-brain axis. The readers will benefit from the latest knowledge about our understanding about how gut-brain axis and modulation of gut microbiome determines predisposition to neurological disorders. The multidisciplinary book is essential reading for anyone interested in the field of gut-brain axis and gut microbiome: from undergraduates to graduate students as well as scientists and physicians having an interest in the new exciting field of gut microbiome and its relationship with brain function.

Täglich stellen sich dem Kinderarzt und Allgemeinmediziner, dem jungen Assistenten, aber auch dem erfahrenen Arzt in der Pädiatrie Fragen aus der Kindergastroenterologie bzw. -hepatologie und Ernährung. Dieses Buch soll rasche Antworten und praktische Hilfen im Alltag geben.