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This book discusses in detail the pathological aspects associated with alterations in the gut microbiota and the pathogenesis of different disorders related to dysbiosis. The volume describes the impact of dysbiosis on organs other than the gut and brain, such as metabolic diseases, cancer, gynecologic disorders, aging, or pediatric pathologies. Additionally, it associates the mechanisms and metabolic signaling pathways related to gut microbiota homeostasis and alterations with their clinical impact, highlighting the importance of translational research on dysbiosis.The volume is divided into 12 chapters: the first two chapters present diagnostic methods and therapeutic options, including prebiotics and probiotics. The remaining ten chapters specifically focus on diseases of different organs. Moreover, the relevance of these findings to precision medicine will be discussed. The book provides biomedical professionals, basic researchers, and clinical practitioners, especially those specialized in Precision Medicine and Integrative Medicine, with information about the effects of dysbiosis on the physiopathology of various diseases. It also includes updated evidence on the impact of dysbiosis on numerous pathologies, such as metabolic diseases, cancer, gynecologic disorders, aging, or pediatric pathologies, going beyond gastrointestinal and central nervous system diseases typically covered in many publications.Furthermore, the book addresses the translational aspect of dysbiosis. It starts with the basic research knowledge on dysbiosis and disease and aims to provide a translational approach applicable to clinical practice. By combining the fundamental knowledge of biomedical researchers with the clinical applicability of healthcare practitioners, this book bridges the gap between theory and practice.

This book now published in its fully updated second edition comprehensively summarizes the current state of knowledge on malignancies of the gastrointestinal tract and highlights the latest efforts in multimodality treatment options before and after surgery, important ongoing trials as well as future areas of investigation. Dedicated organ-based chapters evaluate current treatments and management and provide information on incidence, etiology and biological characteristics. The state of the art in the radiologic and endoscopic staging of gastrointestinal malignancies is described, and guidance is offered on the role of interventional radiology and interventional gastroenterology in the treatment of these challenging tumors. In addition, the book explores novel and evolving treatments, including Immunotherapy, personalized systemic therapy and minimally invasive surgical and radiology techniques, and addresses patient-reported outcomes and survivorship challenges. It will be of benefit to all surgeons, oncologists and other specialists who treat these malignancies, as well as to trainees looking to increase their understanding of the field.

This book covers the diagnosis and treatment of various types of gastric cancer, and details the clinical process of gastric cancer treatment. Authors collects 37 clinical cases, which are typical gastric cancer cases with complicated disease or metastasis. In each case, the patient's gastroscopic results, abdominal CT images, pathological results and treatment process were analysed in detail. Combined with the expert's precise comments, the surgical treatment method and postoperative radiotherapy and chemotherapy and other treatment schemes of each case were clearly explained in an orderly manner.

This book is an accessible, evidence-based, succinct and practical reference for those providing hands-on care to patients with acute pancreatitis. It represents the most updated results of clinical science and offers the frameworks that underpin the disease and its management. The first part of the book presents the latest clinical science and illustrates a clear indication of what is known, and what are the gaps in our understanding of the disease. The second part provides practical clinical management guidelines. The chapters are designed to bring recommendations, practical points to facilitate navigation, easy access of knowledge, and highlights key decision points and options.Acute Pancreatitis - A Practical Guide for Clinicians is relevant to not only clinicians involved in patient care but medical, nursing and dietitian students, surgical and gastroenterology researchers, companies and agencies. The book comprehensively covers acute pancreatitis, associating it with local pancreatic complications, systemic inflammation and organ failures, also providing management algorithms. This practical reference book is an introduction to disease management, indicating why topics addressed in each chapter are essential, providing valuable guidance for day-to-day treatment by professionals globally.

This book provides an overview of the available evidence surrounding immunotherapy in gastrointestinal cancers, and discusses its future place in clinical practice.Immunotherapy has celebrated some astonishing therapeutic successes in a variety of cancer types and is becoming increasingly relevant in daily clinical practice. Currently, the predominant class of immunotherapeutic drugs is the so-called checkpoint inhibitors, which disengage the physiological brakes on the immune system, enabling a more effective anti-cancer immune response. Malignancies of the gastrointestinal tract, which account for the majority of cancer cases worldwide, are a major cause of morbidity and mortality, creating an urgent need for more effective therapies. A large number of clinical trials have evaluated the efficacy of cancer immunotherapy in gastrointestinal malignancies and demonstrated its potential in certain subsets of patients. This book will appeal to a wide readership, including oncologists, health care professionals in general and biomedical scientists.

This book provides comprehensive and practical guidance for the management of esophageal cancer. It presents a detailed review of the pathophysiology, clinical staging, treatment, and outcomes of patients with esophageal cancer. Chapters cover the epidemiology of the disease, latest diagnostic and staging tools, systemic therapies, and the current open and minimally invasive surgical techniques including transhiatal, Ivor Lewis and McKeown esophagectomy. Esophageal Cancer: Diagnosis and Treatment compiles experience gained across a variety of medical disciplines, with contributions from world renowned surgeons, gastroenterologists, and medical oncologists. Thanks to its multidisciplinary authorship, this book represents a unique resource for anybody who takes care of patients with esophageal cancer.

This book is structured in three major parts and the first part is a comprehensive overview of IBD-related intestinal cancer. The second and third parts provide rare and important cases on ulcerative colitis (UD) and Crohn's disease (CD) presenting the macroscopic image of the resected specimen and analyzing the endoscopic and the pathological image to explain how to find the IBD cancer. It also delivers a detailed analysis of the histological structure of cancers. This book tries to clarify the critical but yet to be answered questions such as “Why is it so difficult to find out?”, “Why so flat?” and “How to name superficial lesion with invisible margin?” and so on.Atlas of Inflammatory Bowel Disease-Associated Intestinal Cancer is designed to serve all endoscopists and gastroenterologists managing IBD patients. It also is valuable reading for pathologists who are diagnosing gastrointestinal lesions. This book is designed to assist these medical professionals to find cancers in the early stage and stay up-to-date on image-enhanced endoscopy techniques. This book is a translation of an original Japanese edition. This has been facilitated using machine translation (by the service DeepL.com) followed by editors and authors revising, editing and verifying the translated manuscript.

This textbook provides a practically applicable resource for understanding the surgical oncology management of pancreatic cancer. It discusses relevant aspects of anatomy and pathophysiology along with the latest diagnostic techniques. Insightful descriptions are then provided detailing how to perform critical surgical procedures when treating these patients. Relevant perioperative management strategies and emerging themes in cancer biology critical to understanding and treating the disease are also described. The need for cross-discipline collaboration to facilitate and enhance innovation within the discipline is reinforced throughout the text. Each chapter presents the relevant current clinical standards along with areas of controversy in both research and clinical practice within “pearls and pitfalls” sections. Textbook of Pancreatic Cancer: Principles and Practice of Surgical Oncology is a detailed work covering the basic material important to trainees as well as advanced curriculum for established specialists in the field from a multi-disciplinary perspective. Therefore, it is crucial resource for all practicing and trainee professionals who encounter these patients in their day-to-day clinical practice.

This book highlights the importance of understanding gastric and colon cancer metabolism in guiding diagnosis and drug discovery. It summarizes the correlation between adiponectin and matrix metalloproteinase with colorectal cancer. The book also evaluates the divergent role of hypoxia-inducible factor 1 in colorectal cancer growth and metastasis. After discussing the role of genetic polymorphisms in alcohol metabolizing enzymes and EPHX1 with the onset of colorectal cancer, it reviews the molecular mechanisms of chemoresistance in gastric cancer and novel therapeutic strategies to reverse the chemoresistance of tumors. In addition, the book explores the theranostic role of nanoparticles and therapeutic potential of phytochemicals with regard to colorectal cancer. Given its scope, the book offers a valuable guide for oncologists, academic researchers, pharmaceuticals practitioners, and students who are involved in research and treatment of cancer.

This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and'omics'technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancertreatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.

This book provides up-to-date information on all aspects of gallbladder disease. After an introductory section on laboratory findings, pathology, and diagnostic methods, it focuses on specific conditions and their management, covering gallbladder stones, acalculous cholecystitis, gallbladder lesions associated with IgG4-related disease and with anomalous pancreaticobiliary ductal union, and dyskinesia of the gallbladder. Moreover, it discusses incidental gallbladder carcinoma in detail, including epidemiology, risk factors, gene mutations, diagnostic imaging methods and treatment modalities. The book also features a section exploring important current issues, such as the diagnosis and therapy of polypoid lesions and gallbladder wall thickening, and the role of prophylactic cholecystectomy in patients with concomitant gallstones following removal of common bile duct stones by ERCP. It also compares endoscopic gallbladder drainage with percutaneous transhepatic gallbladder drainage. Lastly, the book offers stimulating future perspectives.

This volume addresses three general themes in the preoperative diagnosis of early-stage esophagus cancer starting. Beginning with detailed observations of diagnosis using Endoscopic Submucosal Dissection (ESD), subsequent sections describe the current medical treatments for various types of carcinoma and conclude with detailed explanations of difficult cases and their diagnoses. The book also includes a wealth of endoscopic and pathological figures, helping scholars understand the diagnosis and treatment visually. Endoscopic Diagnosis of Superficial Esophagus Cancer for ESD is an essential book for clinicians and professionals in the fields of endoscopy and gastroenterology, offering them a comprehensive guide to diagnosis and treatment using ESD. Further, it is a valuable companion piece to the Editor's well-received book Endoscopic Diagnosis of Superficial Gastric Cancer for ESD.

This book offers a comprehensive review of Lynch Syndrome (LS), addressing both the basic and clinical aspects of this condition. Due to the recent advances in our understanding of the genetic mechanism of LS, and to new screening methods, including universal screening and/or multi-gene panel analysis, the standard treatment strategy for patients and family members of LS have been steadily improving. In this book, experts describe the disease's manifestations, discuss state-of-the-art diagnosis and management options, and offer a cutting-edge overview of the genetic and epigenetic basis of the syndrome. Providing essential insights into this new phase in the management of LS, this book is a valuable resource not only for colorectal surgeons, but also for general gastrointestinal clinicians, gynecologists, oncologists and all basic researchers with an interest in LS.

This textbook discusses core principles and practices in gastrointestinal oncology and covers a wide range of practice areas such as pathology and radiologic images, epidemiology, genetics, staging, multidisciplinary management of specific gastrointestinal cancer, and pathology for each primary tumor site. The comprehensive coverage makes Textbook of Gastrointestinal Oncology a useful resource for the practitioner wishing to gain a greater understanding of the principles of managing malignant gastrointestinal disease, as well as medical oncology fellows, surgeons, radiation oncologists, gastroenterologists and fellows, and residents.

This book clearly describes the surgical procedures employed in patients with gastric cancer. The techniques used in the various types of gastrectomy are presented step by step, and the roles of endoscopic treatment and chemotherapy are also discussed. A distinctive practical feature is the provision of accompanying online videos of standard surgical procedures, which will serve as excellent learning aids for novice practitioners and provide ideal teaching material for experienced surgeons. Surgery remains the mainstay in the treatment of gastric cancer. With advances in tumor biology and technical developments, gastric cancer surgery has become more diverse and its outcomes have steadily improved. However, further improvement of certain aspects of surgical procedures and techniques is still required. Surgery for Gastric Cancer will acquaint readers with the state of the art in the field and prove a valuable tool in the quest for optimal practice.

This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

This is the second edition of a well-received book reflecting the state of the art in oncologic imaging research and promoting mutual understanding and collaboration between radiologists and clinical oncologists. It presents all currently available imaging modalities and covers a broad spectrum of oncologic diseases for most organ systems. Today, oncologic imaging faces the challenge of improving and refining concepts for precise tumor delineation and biologic/functional tumor characterization, as well as for purposes of creating individual treatment plans. The concept of radiomics has further advanced the conversion of images into mineable data and subsequent analysis of said data for decision-making support. Since the release of the book's first edition, radiomics has been introduced in oncology studies and can be performed with tomographic images from CT, MRI and PET/CT studies. The combination of radiomic data with genomic features is known as radiogenomics, and can potentially offer additional decision-making support. This book will be of interest to clinical oncologists with regard to the diagnosis, staging, treatment and follow-up on various tumors affecting the CNS, chest, abdomen, urogenital and musculoskeletal systems.

This book offers essential information on basic and translational research in gastric cancer, while also illustrating potential opportunities for its application in clinical practice. Gastric cancer is the fourth-most-common cancer globally and the second-leading cause of cancer deaths. It is known to be a heterogeneous disease with varied responses to “one-size-fits-all” treatments. Expanding our knowledge of cancer cell genetics may help us to explore more effective treatments in gastric cancer. The research on molecular mechanisms and its clinical applications, both presented here, will help readers gain an in-depth understanding of gastric cancer and its effective treatment.The book's four sections cover personalized medicine, precise regional therapy, immunotherapy and nanomedicine in gastric cancer. Each part presents the state of art, recent advances and the authors'experiences. Moreover, several interesting cases are described to demonstrate how gastric cancer patients benefit from translational research. This informative and attractively presented book on precision treatment in gastric cancer, including experimental findings and clinical treatment options, offers a valuable resource for oncologists and graduate students working in the field of gastric cancer.