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Malaria: Volume 3, Immunology and Immunization is a collection of papers dealing with malaria parasites, the methods for measuring the immunological response to plasmodia, and the vertebrates host's immune response to plasmodia. Some papers discuss immunization against sporozoites, against the exoerythrocytic stages of malaria parasites, against asexual blood-inhabiting stages of plasmodia, as well as gamete immunization in malaria. One paper describes various separation methods to isolate malaria parasites and their constituents. Another paper discusses in detail the theory and practice of methods used in measuring antibody responses which occur during plasmodial infections, including the antibody response against sporozoites, exoerythrocytic forms, and in the different blood stages. Another paper explains the vertebrate host's immune response to plasmodial infection as a homeostatic physiological response changing along with the progression of the disease. The changes in the dynamic cellular cascade are different as the disease progresses causing death, than when these lead to recovery. Another paper enumerates the parameters which determine malarial infectiousness from one individual to another such as the time of onset, duration, intensity of the blood infections, as well as the maturity, longevity, and rate of production of gametocytes. Pharmacologists, general medical practitioners, investigators, and laboratory technicians involved in malarial research will find the collection very useful.

Cellular and Molecular Mechanisms of Inflammation: Signal Transduction in Inflammatory Cells, Part A is a collection of papers that discusses the mechanisms of the transduction of signals linking stimulated receptors and cellular function. This book describes the pathways of signal transduction involved in stimulating functions of inflammatory cells connected with host defense and development of inflammatory injury. One paper notes the potential of using fluorescence methodology in analyzing ligand-receptor interactions in living systems during the natural abundance of cell surface receptors. Another paper discusses the structure and function of GTP-binding proteins in neutrophil signal transduction, particularly the role of oligomeric G proteins in signal transduction. One concern in signal transduction research is the physiological significance of the presence of multiple forms of proteins that can have identical functions. One paper reviews phosphatidylcholine breakdown and hormone action in the rat liver, focusing on G proteins and on inositol phospholipid breakdown. This book also discusses calcium translocation in signal transduction, as well as, a novel signal transduction pathway involving phosphatidylinositol 3-kinase. This book can prove beneficial for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology, physiology or oncology.

Processing and Presentation of Antigens brings together the views of immunologists, biochemists, cell biologists, and virologists who have a common interest in the early phases of the immune response. Antigen processing and presentation comprise a series of events that are much more complex and sophisticated than had been thought for a long time, and constitute an essential part of the biology of the immune response to T-dependent protein antigens. The book is organized into seven parts. Part I discusses the major advances and insights in antigen processing, some results on the interaction of antigen with class II MHC molecules, and the precise mechanism involved in antigen processing. Part II presents papers on endosomes, lysosomes, and recycling. Part III deals with studies on presentation in the context of class I MHC molecules. The chapters in Part IV examine interactions of antigens with class II MHC molecules. Part V contains papers on macrophages and dendritic cells as accessory cells. Part VI examines antigen presentation by B cells. Part VII covers studies on T cells.

Speech and Language: Volume 4, Advances in Basic Research and Practice is a collection of papers that deals with the theories, clinical issues, and pathology of language and speech. Several papers discuss nonlinguistic and linguistic processing in children, phonological development in infants, and the development of speech fluency in children. Other papers examine the four major speech production models, the physiological and acoustical aspects of speech adaptation, spatial-temporal model of velopharyngeal function, and variations in the supraglottal air pressure waveform. One paper notes the relationships of two systems of development as follows: language development is dependent upon cognitive products and cognitive development is dependent upon language development. Such relationship leads to the hypotheses that language and cognitive developments are independent, are interdependent, and are both dependent upon some X abilities. One paper suggests that speech clinicians should have as a goal the achievement of speech that is as normal as possible in all respects, and not just for patients to sound normal. The collection will benefit linguists, ethnologists, psychologists, speech therapists, neurologists, neuropsychologists, neurolinguists, or speech pathologists.

Physiology and Toxicology of Male Reproduction is a collection of papers that deals with general reproductive biology and specific aspects of reproductive toxicology, pertaining to the male sex. Some papers discuss testicular organization, reproductive toxicity testing systems, and germ-cell genetic toxicology. The use of in vitro systems by investigators to dissect the male reproductive toxicants can lead to a more scientific approach toward hazard assessment and the development of safer drugs and chemicals. Other papers explain the fundamental reproductive biology of the testis, the neuroendocrine system, the epididymis and accessory sex organs, and spermatozoal evaluation. Toxicological aspects cover the toxicological evaluation of the complete reproductive system, testicular morphology, sperm assessment, and germ-cell mutagenesis. One paper describes alternative methods in toxicology—by using new in vitro systems that should reduce or eliminate the need for tests conducted on animals. In vitro methodology embraces other systems such as from subcellular fractions to isolated intact organs. In relation to target-organ toxicity, the researcher can focus using primary cell cultures. This collection will prove helpful to toxicologists, graduate students and researchers in biology, particularly in male reproductive toxicology and fertility testing.

Methods of Animal Experimentation, Volume V: Nutrition, Aging, and Artificial Organs is a collection of papers that deals with methods to be used in animal experiments to achieve cost effectiveness in their use. This collection discusses laboratory animals used in different experiments such as in nutritional research, aging studies, and artificial organ research. The papers describe the species of animals appropriate for the kind of experiment to be conducted and the criteria that should be followed in choosing a certain species. These criteria include their growth rate, stage of development, as well as existing performance variations. In determining test animals for aging experiments, the book recommends that complete data be available on the genetics of the species, strain, diet history, environmental factors, breeding, and spontaneous diseases to approximate the best test results. The book addresses that the aged are more susceptible to inputs than the young in terms of morphological and functional age. In selecting test animals for artificial organ research, the book notes the importance of animal selection that will be determined, for example, by 1) the size of the prosthesis; 2) the amount of blood flow needed for the device differs in animals and man; and 3) the surgical techniques that will be employed. This book will prove helpful for laboratory workers, veterinarians, and technicians working with laboratory animals. This collection will also be appreciated by researchers designing medical and scientific tests.

Recent Progress in Hormone Research, Volume 30 presents the proceedings of the 1973 Laurentian Hormone Conference held at Mont Tremblant, Province of Quebec, Canada on August 26-31, 1973. The book presents papers on the regulation of the gonadotropins in primates, their neutralization by specific antibodies, and their role in oocyte maturation. The text also includes papers on the enzymatic interconversion of estrogens and on the concept of the mechanism of steroid hormone action. Papers on the thermogenic action of thyroid hormone related to active sodium transport are also considered. The book further tackles papers on the structure, heterogeneity, and activity of many of the lesser known hormones or hormone-like substances, such as the somatomedins A, B, and C, the epidermal growth factor, the insect hormones, parathyroid hormone, 1,25-dihydroxycholecalciferol, and prostaglandins. Endocrinologists and physiologists will find the text invaluable.

Anxiety: Current Trends in Theory and Research, Volume I, seeks to facilitate a more comprehensive understanding of anxiety phenomena. This volume emerged from a symposium on Anxiety: Current Trends in Theory and Research held at Florida State University in the spring of 1970. The symposium brought together persons who have made important contributions to the understanding of anxiety phenomena and provided them with an opportunity to react to each other's ideas. One of the main goals of the symposium was to stimulate confrontation among opposing views with the expectation that this would, at least, provide clarification of terminology and eliminate the semantic confusion plaguing the field. The volume is organized into three parts. Part I presents an overview of the unique theoretical perspective and research objectives with which each contributor has approached the topic of anxiety. It also provides background information and historical perspective for the reader with limited familiarity with this area. Part II contains papers focusing on the nature and measurement of anxiety. Part III deals with the neurophysiological and biochemical aspects of anxiety. This work is intended primarily for psychologists and students of psychology, but it should be of interest to any behavioral or medical scientist concerned with a more comprehensive understanding of personality and psychopathology.

Regulatory Aspects of Carcinogenesis and Food Additives: The Delaney Clause is composed of papers and discussions presented in the seventh meeting of the International Academy of Environmental Safety regarding the philosophy of the Delaney Clause. The Delaney Clause became a part of the Food and Drug Law in 1958. It states in part'that no additive shall be deemed to be safe if it is found to induce cancer when ingested by man or animal, or if it is found after tests which are appropriate for evaluation of safety of food additives to induce cancer in man or animal. This book covers the different views of the meeting's participants on the interpretation of the Delaney Clause. It presents list of points that should be considered in making decisions with respect to safety. Many other factors that should be taken into consideration are also discussed in this reference.

Developmental Biology Using Purified Genes is a compilation of papers presented at the 1981 ICN-UCLA Symposia on Developmental Biology Using Purified Genes, held in Keystone, Colorado. Contributors representing a wide range of disciplines explore the mechanisms underlying gene control of development and explain how purified genes are transcribed in cells, how DNA sequences and non-DNA molecules regulate development, and how gene-control molecules or other developmental determinants are unequally distributed among embryonic cells. Organized into nine sections comprised of 54 chapters, this volume begins with an overview of the mechanism by which gene activity is regionally controlled and its role in development. It then proceeds with a discussion on eukaryotic genes and their structure, including the collagen gene and the albumin gene family. The next chapters focus on the transcription and translation of yolk protein mRNA in the fat bodies of Drosophila, the organization and expression of the actin multi-gene family in Dictyostelium, the cDNA clones encoding mouse transplantation antigens, and the role of double minute chromosomes in unstable methotrexate resistance. The book also introduces the nucleosome core particle, regulatory factors involved in the transcription of mouse ribosomal genes, and developmental control of 5S RNA gene expression before concluding with a chapter on synthetic oligodeoxyribonucleotides and their use in the isolation of specific cloned DNA sequences. This book will be of interest to microbiologists, molecular biologists, embryologists, geneticists, and researchers working in the fields of genetics and developmental biology.

Speech and Language: Advances in Basic Research and Practice, Volume 10 is a compendium of articles that discuss a wide range of topics on speech and language processes and pathologies. This volume contains seven papers presenting a broad range of topics on speech and language. The book provides various articles discussing topics on the articulatory and perceptual characteristics associated with apraxia of speech; prevention of communicative disorders in cleft palate infants; and the relationship between normal phonological acquisition and clinical intervention. Topics on the role of auditory timing in the diagnosis and treatment of speech and language disorders; categorical perception; and the theoretical and clinical implications of speakers'abilities to control the output of their speech mechanism are presented as well. Linguists, speech pathologists, and researchers on language development will find the book very insightful and informative.

Human Lymphokines: The Biological Immune Response Modifiers is a collection of papers presented at the Third International Symposium on Human Lymphokines held on October 15-17, 1981 at the Wadley Institutes of Molecular Medicine in Dallas, Texas. Contributors explore the role of human lymphokines in immune responses and their applications in immunotherapy. The focus is on lymphokines that have either entered clinical trials or are nearing clinical evaluation. Some of the activities of possible immediate significance, such as Glia cell stimulating factor and polyclonal B-cell activator, are also described. This volume is organized into six sections encompassing 56 chapters and begins with an overview of assay systems, touching on topics such as the activation of macrophages by interferon to produce plasminogen and macrophage activation by lymphokine factors. The next sections turn to the production, purification, and biological and chemical characterization of lymphokines. The discussion then shifts to the mechanisms of action of lymphokines in vitro and the use of animal models in lymphokine investigations, including lymphokine fractions in a mouse tumor model and enhancement of natural killing activity by different types of interferon. A great deal of emphasis is placed on macrophage migration inhibitory factor, lymphotoxins, gamma interferon, and interleukins. The book concludes with chapters devoted to the immunoregulatory effects of lymphokines and clinical studies.

Mutagenicity: New Horizons in Genetic Toxicology provides an overview of the various applications and studies in the field of genetic toxicology and environmental mutagenesis. The book is composed of selected scientific papers written by experts in the field. The text presents topics on naturally occurring mutagens; occupational carcinogen; and evaluation of cooking methods. Experiments on mammalian cell mutation; chromosomal aberrations; and organisms that can be used as environmental monitors of toxicity are discussed as well. Ecologists, environmental and sanitary engineers, toxicologists, and anyone interested in environmental mutagenesis, genetic toxicology, occupational health, or the regulation of toxic substances will find the book a good source of insight.

Microaerosols: Physiology, Pharmacology, Therapeutics presents a summary of the experimental and technical data on aerosols. This book focuses on the production, measurement, sampling, and biological importance of submicroscopic and submicronic air-borne particles and to their pharmacological, therapeutic, and physiological effects after their deposition in the respiratory tract. Organized into 22 chapters, this book begins with an overview of the process of obligatory liquid filtration. This text then examines the factors that affect the sizing and numbering of aerosols, including the duration of the aerosol dispersion into a closed space, the duration of aerosol sampling, and the location of the particles. Other chapters consider the authenticity of the penetration of aerosols into the pulmonary depths. This book discusses as well the recommendations for preparations of airway dilating solutions. The final chapter deals with the effects on the lungs of airway constricting substances dispersed in aerosols. This book is a valuable resource for physicians.

Epilepsy: Its Phenomena in Man is a 16-chapter text that covers the wide field of the phenomena of epilepsy in man. This book emerged from the manuscripts presented by the scientific program of an alumni reunion of the Brain Research Institute of the University of California, Los Angeles. The introductory chapters review the role of electricity in the exploration and elucidation of the epileptic seizure, as well as the role of synaptic organization of the cerebral cortex in epilepsy. The succeeding chapters deal with the neuroglial impairment hypothesis, the particular forms of experimental epilepsy in man, and their corresponding surgical treatment. These topics are followed by discussions of the problem of synchronization in the spread of epileptic discharges leading to seizures and the behavioral correlations of generalized spike-wave discharge in the electroencephalogram. Other chapters explore the common anatomy of psychomotor epilepsy and schizophrenia; time of occurrence of seizures; the clinical ictal patterns and electrographic data in partial seizure cases; and the problems of analysis and interpretation of electrocerebral signals in human epilepsy. The concluding chapters consider the developments in direct recordings from epileptogenic regions in the surgical treatment of partial epilepsies. These chapters also examine the golgi survey concerning hippocampal pathology in temporal lobe epilepsy and the structural substrates of seizure foci. This book will prove useful to neuroscientists and the workers in biomedical fields critical for the understanding of epileptogenesis.

Schizophrenia: A Life-Course Developmental Perspective covers research findings and ideas concerning the entire life course of schizophrenia. The book discusses research on life-span development in schizophrenia; the genetic and perinatal factors in the etiology of schizophrenia; as well as the neurobehavioral development of infants at risk for schizophrenia. The text also describes the early social and affective development in schizophrenic offspring; the clinical presentation, onset, early developmental patterns, course, and treatment of childhood-onset schizophrenia; and the prediction of psychiatric disorders in late adolescence. The cognitive and linguistic functions of adolescent children at risk for schizophrenia; longitudinal studies of premorbid development of adult schizophrenics; and the ontogenetic implications of sex differences in schizophrenia are also considered. The book further tackles emotion and attachment in families of schizophrenics; late-onset schizophrenia; and the development of liability to schizophrenia. The text then encompasses the developmental trajectories in schizophrenia. Psychiatrists, psychologists, and people working on the research about schizophrenia will find the book invaluable.

Advances in Cognitive–Behavioral Research and Therapy, Volume 2 provides information pertinent to the fundamental aspects of cognitive–behavioral approaches to psychotherapy. This book presents the developments in the study of cognition, personality, learning, social interaction, and behavior therapy. Organized into seven chapters, this volume begins with an overview of cognitive schemata and cognitive processing as significant theoretical concepts for cognitive–behavioral therapy. This text then provides an analysis of self-mastery and the role of self-schemata in processing therapeutic information. Other chapters provide clinical guidelines for helping clients in changing their self-view and behavior. This book discusses as well the increasing influential role of fundamental cognition and social cognition in cognitive–behavioral interventions. The final chapter deals with the applied developments in the treatment of performance anxiety. This book is a valuable resource for research and applied psychologists. Researchers and clinicians struggling with the interplay of behavior, cognition, and emotion will also find this book useful.

Fears and Phobias reviews and synthesizes the different viewpoints of learning theory, psychoanalysis, ethology, and clinical psychiatry with regards to fears and phobias. The causes and treatment of phobias are examined, with due regard for relevant biological and psychological issues. Topics covered range from the etiology of fear to clinical syndromes such as agoraphobic syndrome, animal phobias, social phobias, illness phobias, and obsessive phobias. Comprised of four chapters, this book begins with an overview of the historical aspects of phobias and the components of phobias, followed by a discussion on the etiology of fear. Experimental studies on fear that focus on innateness, maturation, and learning are examined, together with genetic aspects of timidity; the kinds of situations that are feared; and the physiology and learning of fear. The next chapter deals with clinical syndromes and the classification of phobic disorders such as the agoraphobic syndrome, specific animal phobias, and social phobias, along with illness phobias, obsessive phobias, autonomic equivalents to phobic disorders, and children's fears and phobias. The final chapter is devoted to prevention and treatment of phobias, including desensitization, and psychiatric management of phobic patients. This monograph will be of interest to psychiatrists and psychologists.

Assessment Strategies for Cognitive-Behavioral Interventions is a collection of original contributions provided by leaders in the field who consider the theoretical and applied assessment issues related to the expanding field of cognitive-behavioral interventions. Chapters in the present volume, designed as a companion volume to an earlier text, Cognitive-Behavioral Interventions: Theory, Research, and Procedures, focus on the issues inherent in the measurement of cognitive and behavioral events and processes. The book opens with an overview of recent growth in the field. Attention is devoted to examining several goals of the new assessment endeavors, some suggestions related to the proposed methods, and certain problems inherent in cognitive-behavioral assessments. Separate chapters follow that deal directly with a variety of specific content areas. These include a conceptualization of attributions, as well as describing their measurement and speculating as to their role in both the etiology and treatment of psychological disturbance; and suggestions for assessment in clinical interviews and for using psychometric instruments and discusses belief systems and irrationality. Subsequent chapters focus on special populations and procedures.

Biology of the Lymphokines discusses the scope and diversity of lymphokine research. This book focuses on the studies on lymphokines, such as those involving cellular source, chemical nature, purification strategies, and bioassay limitations. The mechanism of lymphokine action, lymphokines in vivo, and value of lymphokine quantitations are also covered. This text describes the repertoire of lymphokines produced by various lymphoblastoid cell lines and its significance for coping with the problem of large scale lymphokine production. The anti-viral and general immunoregulatory properties of interferons and rationale developed for integrating interferons with the family of lymphokines are likewise deliberated. This publication is a good source for students and researchers conducting work on lymphokines.

Monoclonal Antibodies Against Bacteria, Volume II provides the basis for understanding new developments of practical importance in the health sciences within the area of microbiology and infectious diseases, focusing on advances made possible by monoclonal antibodies. This 12-chapter volume starts with the analysis of streptococcal antigens implicated in the causation of rheumatic fever and heart disease to find ways of inducing protective immunity. The next chapters deal with the detection of staphylococcal enterotoxins in foods and treatment of staphylococcal food poisoning, the classification of meningococcal isolates associated with meningitis and related disorders, and the immunology of brucellosis with emphasis on the problem of distinguishing antibrucella antibodies elicited by vaccination of cattle from antibodies elicited by infection. These topics are followed by discussions of the diagnostic and epidemiologic studies of legionellosis; the identification of antigens in gram-negative bacteria; and the development of means to study and control infections by Pseudomonas in cystic fibrosis and other pathologic conditions. Other chapters explore the analysis of toxigenicity and neutralization of botulinum toxin, the pathogenetic role of Escherichia coli's pili, and study of its antigens to understand regulatory networks of the immune system involving antiidiotypic antibodies. The remaining chapters consider the elucidation of antigenic mosaics of archaebacteria and identification of their molecular signatures in their ecological niches and other life forms. These chapters also look into the combination of bacterial genetics with hybridoma technology for elucidating structure-function relationships in membrane molecules, as well as the strategies, methods, quality control, and other practical aspects connected with industrial production of monoclonal antibodies against bacteria. This book will prove useful to internists, pediatricians, surgeons, dentists, veterinarians, clinical pathologists, and laboratory technologists.

Monoclonal Antibodies Against Bacteria, Volume III covers the basis for understanding developments of practical importance in the health sciences within the area of microbiology and infectious diseases, focusing on advances made possible by monoclonal antibodies. This 12-chapter volume specifically considers the basic principles of hybridoma technology. The introductory chapters deal with treponemal antigens of significance for understanding syphilis, yaws, pinta, salmonellosis, and other gastroenteropathies. The subsequent chapters highlight pediatric infections and the strategies for molecular analyses of bacterial antigens, focusing on cell walls, S layers, and sheaths. The remaining chapters examine the bacterial toxins involved in gaseous gangrene and other forms of cell damage, such as diphtheria, caries and periodontal diseases, and bacteria relevant to animal sciences. This book will prove useful to internists, pediatricians, surgeons, dentists, veterinarians, clinical pathologists, and laboratory technologists.

The Antigens, Volume IV is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from the immune reactions of lipids and lipid model membranes to the immunology of antibiotics and protective antigens of bacteria. Antigens of pathogenic fungi are also explored, along with adjuvants and antigenic competition. Comprised of seven chapters, this volume begins with a review of lipids as antigens, followed by a discussion on the immunological aspects of antibiotics. The next two chapters are concerned with more complex antigens, namely, bacteria and fungi, as well as the relationship between immunity and infection. The last three chapters deal with three important areas of immunology: antigenic competition, adjuvants, and lectins. In particular, the chemistry of lectins and their application to immunology are examined. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

Interleukin 3: The Panspecific Hemopoietin contains contributions from immunologists, hematologists, protein chemists, and molecular biologists whose efforts have defined the biology and molecular nature of interleukin 3 (IL-3) in less than a decade. The articles represent personal perspectives rather than exhaustive reviews. They are arranged in alphabetical order rather than thematically because many of the individual articles cover multiple aspects of the molecule. These articles cover topics such as the potential role of IL-3 in the pathology of allergic and inflammatory disease and the role of IL-3 in the genesis of certain myeloid leukemias. A number of articles also highlight an important technical point, namely, that many of the various assays often used for IL-3 are not specific. One article indicates that the''histamine-producing cell-stimulating factor''activity can be mediated not only by IL-3 but also by granulocyte-macrophage colony-stimulating factor. Another deals with the lack of specificity of assays based on the induction of 20a-SDH or factor-dependent cell lines.

Human Cytogenetics: Clinical Cytogenetics, Volume II presents the general theoretical principles and clinical aspects of cytogenetics, a branch of genetics that deals specifically with the study of the chromosomes. The volume focuses on the clinical cytogenetics of human. It discusses the sex chromosomes and their abnormalities and the abnormalities of sexual development and differentiation; mechanism of sex determination in mammals; major autosomal abnormalities found in human populations; and chromosome abnormalities in relation to human pregnancy wastage and chromosome changes in neoplasia. The book will be a great reference book for geneticists, cytogeneticists, pathologists, clinicians, and medical students.

Cardiovascular Review 1984 is an attempt to assimilate most of the clinically germane English-speaking cardiologic literature in as concise and timely a format as possible. Thus, this textual compendium of individual reports represents as current a summary of cardiologic thinking as the publishing process will allow. With the addition of another 1926 references, this work now consists of about 9000 statements on cardiovascular reports appearing in the English-speaking cardiovascular literature. The table of contents has been constructed to reflect the order in which the preponderance of cardiologic literature appears. Thus, ischemic heart disease, valvular heart disease, arrhythmias, and conduction defects have been assigned a high priority reflected by their location in the first few sections of this book. Thereafter, topics ranging from acromegaly to tumors of the heart have been addressed in alphabetical order.

Novel Approaches to Cancer Chemotherapy compiles theories in tumor biology, emphasizing their potential use in developing therapeutic approaches to cancer therapy. This book emphasizes the unique property of a cancer cell and describes in detail how a novel therapeutic approach can be developed. This compilation consists of 11 chapters. Chapters 1, 2, 5, 6, and 7 deal with emerging areas of cancer therapy, such as the use of interferon, monoclonal antibodies, liposomes, lymphokines, and immunomodulators. The rest of the chapters cover some of the biochemical and enzyme targets in cancer cells, such as polyamines, prostaglandin, thromboxane, leukotrienes, 5a-reductase, aromatase, cell membrane glycoproteins, and sodium flux. The developments in relation to cancer therapy are mentioned in chapters dealing with biochemical approaches. This book is valuable to biologists, biochemists, immunologists, and molecular biologists intending to exploit the unique properties of cancer cells.

Stress, Neuropeptides, and Systemic Disease traces the development of the neuropeptide hypothesis from its anatomical substrate to its functional correlates in animal and pre-clinical human models of stress-induced disease. The book contains articles that discuss the different aspects and findings on the study of neuropeptides such as the histochemical localization of peptide-containing cells and peptidergic receptors; the current concepts in hypothalamo-pituitary-adrenal axis regulation; neuropeptides involved in stress and their distribution in the mammalian central nervous system; and neuropeptide-mediated regulation of the neuroendocrine and autonomic responses to stress. The methods of measuring neuropeptides and their metabolism; stress responses and the pathogenesis of arthritis; brain peptides and gastrointestinal transit; and diminished opioid inhibition of blood pressure and pituitary function in hypertension development are presented as well. Physicians, neurobiologists, pharmacologists, and biological scientists will find the book very interesting.

Clinical Immunobiology, Volume 3 covers a variety of methods used for assaying the immune status of an individual. This volume is composed of 21 chapters and begins with a presentation of the background and issues to which clinical tests would be applied. The succeeding chapters outline the methodological procedures used in the analyses. Other chapters present some examples of the kinds of data that can be generated with the procedures used and provide guidelines for interpretation of the tests. The remaining chapters discuss the value of the immunological test procedures in differential diagnosis and analysis of diseases. These chapters also explore the usefulness of these procedures in prognosis of disease and the consequences of immunological manipulation undertaken for treatment or prevention of disease. This book will be of great value to clinical immunobiologists, biochemists, and researchers.

Clinical Immunobiology, Volume 2 covers the advances in the field being made to apply bone marrow transplantation to the treatment of several diseases. This volume is divided into 11 chapters and begins with surveys of the clinical considerations of bone marrow transplantation. Considerable chapters are devoted to the application of this transplantation to the treatment of various diseases, including aplastic anemia, aregenerative pancytopenia, leukemia, uniformly fatal severe combined immunodeficiency diseases, and Wiskott-Aldrich syndrome. Other chapters examine the cellular engineering in the form of bone marrow and thymus transplantation. The remaining chapters consider the effects of exposure to excessive amounts of radiation or cytotoxic chemicals, as well as the hematopoietic failure based on malfunction of the complex process of normal hematological development and maintenance. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

Clinical Immunobiology, Volume 4 is a 13-chapter text that covers the advances in understanding of the concepts and practical applications of lymphoid subpopulations and the major histocompatibility complex (MHC). The first chapter presents an overview of the problems of various subpopulations of cells involved in the immune system. The succeeding chapters describe the techniques used for cell classification, either by their cell surface phenotype or by their responsiveness to a series of different stimuli. These chapters include surveys of the methods of detection of complement receptors and expression of these receptors on the surface of both normal and leukemic human lymphocytes. A discussion of the evidence that different T-lymphocyte populations differentially express receptor for IgG and IgM is also provided. Other chapters describe the relationship of MHC to serology of cell surface antigens and reactivity in the mixed leukocyte culture test. This work also explores the methods that employ the so-called'proliferative and cytotoxic responses'. The remaining chapters look into the association between HLA antigens and a variety of different diseases. These chapters also discuss other genetic markers in the HLA linkage group. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

Clinical Immunobiology, Volume 1 is a 12-chapter introductory text to the several aspects of immunobiology field. The opening chapters describe the structural and functional development, as well as the molecular and cellular nature of the immune apparatus. The subsequent chapters deal with the relation of structure to function in the lymphoid system and its molecules. These topics are followed by discussions of the fundamental issues of tolerance, inflammation, immunological mediators and amplifiers, and immunogenetics. The remaining chapters explore the immunobiological aspects of transplantation, allergy, tumor immunity, autoimmunity, immunodeficiency, and immunosuppression. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

Ions, Cell Proliferation, and Cancer present the credibility of ions as specific regulators of cell proliferation. This book provides an understanding of the control of cell proliferation and the deregulated proliferation of cancer cells. Organized into three sections encompassing 32 chapters, this book begins with an overview of the important role that ions in animal cells play in a variety of fundamental processes associated with essential cell functions. This text then examines the relationship between ionic events and cellular production, specifically in mammalian cell systems. Other chapters consider the development of atomic absorption spectrophotometry as a method for measuring inorganic cations. This book discusses as well the two widely applicable methods for measuring free concentrations of ions inside cells. The final chapter deals with magnesium ion as the most abundant divalent action in living cells. This book is a valuable resource for animal cell biologists, molecular biologists, and research workers.

Psychoneuroimmunology, Second Edition presents reports on the relationship between the nervous and immune systems. The book is divided into four sections. The first section details the role of neural structures and neurotransmitter signals in communication with the immune system. It documents the extensive neural connections with organs of the immune system; the dynamics of noradrenergic sympathetic innervation of spleen and thymus; and the evidence for immune signaling of the CNS. Part II elaborates the role of hormones in the modulation of immune functions; the basis for bidirectional communication between the neuroendocrine and immune systems; and the potential physiological implications of these neuroendocrine-immune system interactions. The third part addresses behavioral influences on immune response; the effects of conditioning, stress and social interactions in modulating immune responses; and the behavioral consequences of experimentally altered or genetically determined immunologic states. The final section presents the effects of psychosocial factors on immune responses and the potential impact of behavioral interventions in modulating immunity in healthy human subjects and in patients with AIDS. Neuroscientists, endocrinologists, and immunologists will find the book interesting.

Advances in Metabolic Disorders, Volume 11: Gastrointestinal Hormones covers the developments in the study of gastrointestinal (GI) hormones. The book discusses the cytochemical techniques in work with GI hormones; the general aspects and problems for the radioimmunoassays of GI hormones in the 80s; and the response of the GI hormone system to the pathological changes. The text also describes the evolutional aspects of GI hormones; the cell membrane receptors for secretagogues on pancreatic acinar cells; and the synthesis of GI hormones using organic chemical or recombinant DNA techniques. Gastrin is reviewed with regard to its forms and fragments in tissues, circulating components during post- and perisecretory processing, cellular origins and distribution, actions and structure-function relations, metabolic disposal, nervous and chemical control for its release, and its role in human pathology. The book further tackles the chemical, anatomical, and biological studies on gastrin-releasing peptides, as well as the physiological actions of gastric inhibitory polypeptide. Discussions about the vasoactive intestinal peptide, incretin, enteroglucagon, neuropeptide Y, peptide HI, galanin, cholecystokinin-58, neuropeptide K, peptide YY, motilin, somatostatin-28, neurotensin, substance P, and opioid peptides are also encompassed. The text concludes by looking into the investigations on the structure and function of the head activator in hydra and in mammals. Molecular biologists, endocrinologists, histochemists, physiologists, and those involved in the research about GI hormones will find the book invaluable.

Botulinum Neurotoxin and Tetanus Toxin covers the mechanism of action, pathogenesis, and treatment of clostridial neurotoxins. The book is organized into four parts encompassing 18 chapters that discuss the origin, structure, pharmacology, toxicology, immunology, assays, and clinical issues of botulinum and tetanus neurotoxins. The introductory part of the book discusses the discovery and production of neurotoxins in various strains of Clostridium bacteria. This text also describes how specific bacteriophages and plasmids mediate the pathogenicity of some types of Clostridium botulinum and Clostridium tetani. The subsequent part provides an overview of issues related to toxin binding, including toxins that may serve as models for botulinum and tetanus neurotoxins. Discussions on the peripheral and central aspects of poisoning transport in the central nervous system and on the antagonistic drugs for clostridial neurotoxins are provided. The third part of the book addresses the antibodies against botulinum neurotoxin. Bioassay in mice and highly sensitive immunoassays, such as reversed passive hemagglutination, reversed passive latex agglutination, radioimmunoassay, and enzyme-linked immunosorbent assay, are presented. The concluding part covers the animal models for these toxins and discusses the diagnosis and treatment of botulism and tetanus in human. The clinical use of Clostridium botulinum toxin type A in ocular and neuromuscular disease is also examined. This book will be of value to protein chemists, microbiologists, virologists, pharmacologists, immunologists, and clinicians.

Asthma: Physiology, Immunopharmacology, and Treatment is a collection of essays that discusses the clinical signs and symptoms of allergic bronchial asthma and the effects of a number of intricate sequences of biochemical reactions initiated by the combination of antigen and antibody. It presents such topic as the pathobiologic mechanisms of asthma. The book discusses the physiologic changes in the acute asthmatic attack. It focuses on the autonomic regulation of airway smooth muscle and the nervous regulation of respiration. Another topic of interest is the genetic aspects of asthma. The section that follows is a review of the biochemical, pharmacological, and immunological factors in the release of chemical mediators from human lung. The book also presents the characteristics of pharmacologic receptor systems and the role of parasympathetic nervous system in asthma. The text will provide valuable insights for physicians, scientists, students, and researchers in the field of human anatomy.

Recent Progress in Hormone Research, Volume 47 covers the developments in the field of endocrinology and metabolism. The book discusses the molecular mechanism of action of a steroid hormone receptor; neuroendocrine control of human reproduction in the male; and the immortalization of neuroendocrine cells by targeted oncogenesis. The text also describes the neuroendocrine regulation of the luteinizing hormone-releasing hormone pulse generator in the rat; the gonadotropin-releasing hormone pulses; and steroids, receptors, and response elements. The molecular biology of human renin and its gene; the cellular and molecular analysis of pancreatic islet cell lineage and differentiation; and sulfonylurea signal transduction are also considered. The book further tackles the complex hormone response unit regulating transcription of the phosphoenolpyruvate carboxykinase gene, and the structure and molecular regulation of mammalian glucose transporters. Endocrinologists, physiologists, and biochemists will find the book invaluable.

Colon Cancer Cells brings together fundamental research and clinically relevant issues in the cell biology of colon cancer. This book is composed of five parts encompassing 21 chapters that specifically describe the initiation and progression of colon cancer cells. After briefly dealing with the major issues in colorectal carcinoma, this book goes on presenting the in vitro and in vivo models of colon carcinogenesis. This topic is followed by a discussion on the history of the development and characterization of commonly used colon cancer cell lines. The following parts describe the biochemical and immunological features and hormones in the colon. These parts also consider the studies on human colon tumors xenografted into nude mice and the biology and treatment of colorectal cancer metastasis. Discussions on the application of human monoclonal antibodies to tumor detection; the expression of blood group-related carbohydrates by normal, premalignant, and malignant colonic tissues; and the correlation of antigen variability in colon carcinoma with certain diagnostic and prognostic parameters are also included in these parts. The concluding part examines various therapeutic strategies and their potential in improving patient management with advanced colon carcinoma. Researchers, clinicians, and students interested in the biology of colon cancer development and in gastrointestinal cell biology will find this book invaluable.

The Practice of Clinical Engineering deals with clinical engineering, its educational requirements, the requirements for accreditation, and practice, including legislation and liability. The objectives of clinical engineers are discussed, together with clinical engineering internships, insurance and malpractice, and the clinical engineer's role in hospital planning. This book is comprised of 56 chapters divided into eight sections and begins with an overview of clinical engineering as a discipline and how it differs from biomedical engineering. The reader is then introduced to the history of interdisciplinary engineering and the use of technology in clinical medicine. The following sections focus on the education of the clinical engineer, with emphasis on internships and the training of biomedical equipment technicians; professional accreditation and registration; the role of the clinical engineer as an interface in hospitals; and the involvement of clinical engineers in anesthesiology, surgery, and coronary care. The final chapter considers the transfer of technology to the clinical area and the means that can be used in the implementation of advances in medical engineering. This monograph is intended for engineers concerned with clinical medicine and those concerned with the utilization of diagnostic and therapeutic medical instrumentation or systems.

The newly revised edition of this work provides an up-to-date description of the mechanisms of infection and disease production in a clear and logical manner. Dealing in an integrated manner with all microorganisms, the factors common to all infectious diseases are set out. Molecular biology, pathology, and immunology are brought together to explain how an infectious agent causes disease, and how the body reacts to it. - Attachment to and entry of microorganisms - Events occurring immediately after entry - The encounter of the microbe with the phagocytic cell - The spread of microbes through the body - The immune response to infection - Microbial strategies in relation to the immune response - Mechanisms of cell and tissue damage - Recovery from infection - Failure to eliminate the microbe - Host and microbial factors influencing susceptibility - Vaccines

Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIB: Aliphatic and Polyhalogenated Carcinogens covers environmentally and occupationally significant carcinogens of industrial origins. The book discusses the structure-activity relationships, metabolism, and environmental significance of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene pesticides, biphenyls, and related aromatics. The text also describes the structure-activity relationships, metabolism, and environmental significance of the halogenated phenoxy acids, aromatic ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and related compounds. The structure-activity relationships, metabolism, and environmental significance of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and related compounds thiocarbonyl compounds are also encompassed. The book further tackles the structure-activity relationships, metabolism, and environmental significance if fatty acids, detergents, and other surfactants with oncogenic potential. The text then looks into the effect of chemical reactivity, molecular geometry, and metabolism on carcinogenic activity. Chemists, geneticists, and those involved in cancer research will find the book invaluable.

Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIC: Natural, Metal, Fiber, and Macromolecular Carcinogens covers structure-carcinogenicity relationships of carcinogenic mycotoxins, carcinogenic substances generated by plants, carcinogenic metals and metalloids, and foreign-body carcinogens. The book discusses the metabolism and mechanism of carcinogenic action, physicochemical properties, other biological activities (principally mutagenicity and teratogenicity), modification of carcinogenic activity, formation and environmental significance. The text also describes the carcinogenic water-soluble high polymers and explores the intriguing problems of the carcinogenic effect of osmotic imbalance in tissue microenvironment, as well as of spontaneous malignant transformation occurring in cell cultures in vitro. Studies on tumor induction and carcinogenesis modification by nonviral nucleic acids, by nucleases, proteases, histones, and by antigenic stimulation as well as by antibodies are also considered. The book further tackles tumor-released factors as possible modifiers of carcinogenesis. The text will prove invaluable to chemists and people involved in cancer research.

International Review of Experimental Pathology, Volume 33: Progress in Hodgkin's Disease summarizes the progress made in the diagnosis and understanding of the pathogenesis of Hodgkin's disease. The first half of this volume deals with diagnostic aspects, whereas the second half focuses on recent developments in the understanding of the pathogenesis of Hodgkin's disease. The book opens with a chapter on the differential diagnosis between Hodgkin's disease and non-Hodgkin's lymphomas, and provides guidelines on how to deal with the grey areas between these two groups of diseases. Separate chapters follow on the criteria for a prognostically relevant histological grading of the most common subtype of Hodgkin's disease; data on the nodular lymphocyte predominance subtype of Hodgkin's disease; and the various reagents used to define the immunophenotype of Reed-Sternberg cells. Subsequent chapters deal with potential mediators of lymphocyte agglutination to Reed-Sternberg cells; immunological alterations in Hodgkin's disease; molecular genetic studies into the pathogenesis of Hodgkin's disease; and results of studies on Hodgkin cell lines. This book provides data that go beyond those covered in textbooks in pathology and hematology and should be of interest to all pathologists and clinicians dealing with the diagnosis and management of Hodgkin's disease, as well as to lymphoma researchers.

The Antigens, Volume III is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from microbial polysaccharides and lymphocytic receptors for antigens to antigenic determinants and antibody-combining sites. Allergens and the genetics of allergy are also explored. Comprised of seven chapters, this volume begins with a review of microbial polysaccharides as antigens, followed by a discussion on antigenic determinants and their specific reaction with antibody-combining sites. The reader is then introduced to the reaction of antigens with their specific receptors on lymphocytes. The next four chapters are concerned with several categories of more complex antigens which, in most cases, have yet to be characterized adequately at a molecular level: allergens, histocompatibility antigens, antigens of Mycoplasmatales and chlamydiae, and animal viruses. The book concludes with an analysis of virus infections and the immune responses they elicit. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

Molecular Mechanisms and their Clinical Application in Malignancies is a collection of manuscripts presented at the 12th Annual Bristol-Myers Squibb Symposium on Cancer Research, held in Toronto, Canada on September 26-27, 1989. This symposium reviews the current understanding of the mechanisms of malignant transformation and the application of several technologies to the diagnosis, evaluation, and treatment of malignancies. This book is divided into 14 chapters. The opening chapters deal with the genetic basis of neoplasia and the molecular biology of oncogenes, the regulation of transcription, and the rearrangement of T- and B-cell genes during development and in malignancies. The subsequent chapters focus on the genetic abnormalities detected in specific tumors, such as retinoblastoma, colorectal carcinoma, and lung cancer. These chapters also examine the retinoid and thyroid hormone receptors. Other chapters explore the genetic basis of the cellular response to therapy, drug resistance, cachectin-tumor necrosis factor in the biology of disease, acute myelogenous leukemia, and the stages in tumor progression. The final chapters look into the application of molecular biology to clinical treatment in the form of receptor specific intoxication on tumor cells, the molecular genetic analysis of the phakomycoses, and the structural design of antitumor compounds. This book will prove useful to oncologists, molecular biologists, clinicians, and researchers.

Neurobiology of Cytokines, Part A provides an overview of the effects of cytokines in the brain and in the endocrine system. The book discusses the general aspects of cytokines, including the endogenous agonists and antagonists, their receptors, their second messengers, and transport mechanisms for cytokines across the blood-brain barrier. The text also describes the anatomical localization of cytokines, cytokine receptors, and their respective mRNA in brain and in endocrine tissues. The methods for evaluating the in vivo as well as in vitro actions of cytokines on hormone secretion are also considered. The book further tackles the synthesis and release of cytokines and their central nervous system actions; and the methodology for studying the role of cytokines in human neuropathological conditions.

International Review of Experimental Pathology, Volume 31: Transition Metal Toxicity merges discussions of normal and deranged metabolism of transition metals; redox cycling of metal ions in biological systems; oxidative stress during the metabolic interactions of metal ions; and the actions of oxygen-derived free radicals in the pathogenesis of metal ion toxicity. The book also describes the roles played by chromium and other metals in carcinogenesis; the morphologic pathology of metal toxicosis; and metal ion overload due to inborn metabolic defects, as well as to excessive environmental exposure. Research findings at the molecular, cellular, and organ levels are reviewed. Physiologists, biochemists, pathologists, and biophysicists will find the book invaluable.

Basic Mechanisms and Clinical Treatment of Tumor Metastasis provides information pertinent to the basic mechanism of tumor metastasis and the clinical results with immunochemotherapy of cancer. This book explores the extensive studies of clinical trials of cancer immunotherapy by Japanese investigators who played a significant role in the clinical assessment of different immunomodulating drugs. Organized into five parts encompassing 36 chapters, this book begins with an overview of both the in vivo and in vitro behavior of metastatic tumor cells. This text then examines the pathogenesis of cancer metastasis and its possible modulation by immune cells per se of by those treated with immunopotentiators in experimental animals. Other chapters consider the effects of different soluble immune mediators on tumor cell growth and metastasis. This book discusses as well the immunobiology and immunopathology of human tumor cell metastasis. The final chapter deals with successful and unsuccessful trials with cancer immunotherapy using various biological and chemical compounds. This book is a valuable resource for biologists, oncologists, and clinical researchers.

Cancer and Chemotherapy, Volume III: Antineoplastic Agents is a collection of articles that deals with the treatment of cancer using drugs. The collection describes the various drugs that are used, the therapeutic approaches being taken, and agents that are being developed. Part I is a general review of anti-cancer drugs as regards their action mechanisms, pharmacokinetics, pharmacology, known toxicities, and clinical utility. These drugs include alkylating agents such as mitomycin C and nitrosoureas; plant alkaloids such as maytansine; antibiotics such as anthracyclines; platinum-containing complexes; antimetabolites; and hormones. Part II examines the molecular pharmacology of some major drug classes, namely, bleomycin and anthracycline. The text also discusses the chemistry, mechanism, and any structure-activity relationships found in these drug classes. Part III discusses in detail the clinical pharmacology of some antitumor drugs, for example, cisplatin and nitrosoureas. The text includes the clinical applications, biochemistry, metabolism, and the use of mathematical models in interpreting or describing resulting data. The book is helpful for pharmacologists, molecular biologists, and scientists involved in cancer-research.