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This book teaches foundations of epidemiological design and statistical methods, as well as including topics applicable to new areas of research. Since the publication of the first edition, Biostatistics and Epidemiology has attracted loyal readers from various specialty areas in the biomedical community. The Fifth Edition includes coverage of fixed and random effects and mixed effects models; Poisson regression; constructing confidence intervals for U-shaped relationships; analysis of rare variants; Mendelian randomization; and aspects of machine learning and big data analytics. Biostatistics and Epidemiology was written to be accessible for readers without backgrounds in mathematics. It provides clear explanations of underlying principles, as well as practical guidelines of'how to do it'and'how to interpret it.'Key features include a philosophical and logical explanation at the beginning of the book, subsections that can stand alone or serve as reference, cross-referencing, recommended reading, and appendices covering sample calculations for various statistics in the text.

Introduction to Epidemiology is a comprehensive, reader-friendly introduction to this exciting field. Designed for students with minimal training in the biomedical sciences and statistics, this full-color text emphasizes the application of the basic principles of epidemiology according to person, place, and time factors in order to solve current, often unexpected, and serious public health problems. Students will learn how to identify and describe public health problems, formulate research hypotheses, select appropriate research designs, manage and analyze epidemiologic data, interpret and apply results in preventing and controlling disease and health-related events. With real-world examples in the form of case studies and news files in each chapter, Introduction to Epidemiology is an accessible and effective approach to learning epidemiology. Carefully revised throughout, the Ninth Edition offers: New chapters on Epidemiology Study Plan (5) and on Social Epidemiology (13)

Dieses Buch ist eine kompakte klinische Einführung in die Lyme-Borreliose für Ärzte aller Fachrichtungen, die Patienten mit Verdacht auf B. burgdorferi-Infektion betreuen, sei es im Krankenhaus oder in der Allgemeinpraxis. Das Buch bietet viele praxisorientierte Informationen zu Symptomatik, Diagnose, Behandlung und Prophylaxe mit besonderem Schwerpunkt auf der Situation in Europa. Gleichzeitig beschreibt es den aktuellen wissenschaftlichen Kenntnisstand so detailliert, wie es für das Verständnis der pathogenetischen Zusammenhänge und deren Relevanz für die medizinische Versorgung erforderlich ist. Die Autoren sind Mitglieder einer interdisziplinären Expertengruppe von Epidemiologen, Biologen, Mikrobiologen und Klinikern, die seit vielen Jahren auf dem Gebiet der zeckenübertragenen Krankheiten tätig sind. Die persönliche Erfahrung jedes einzelnen Autors, die er durch die tägliche Arbeit mit Patienten in Spezialkliniken oder durch die Konfrontation mit komplizierten Fragen der Grundlagenforschung, Epidemiologie und Labordiagnostik der Lyme-Borreliose gesammelt hat, stellt eine wichtige Stütze des Buches dar. Aus dem Blickwinkel des klinischen Managements und der praktischen Problemlösung geschrieben, wird diese aktuelle Monographie den Kliniker bei der Bewältigung diagnostischer Herausforderungen und der angemessenen medizinischen Versorgung von Patienten mit Lyme-Borreliose unterstützen.

Strategic decision-making focusing on economics is the fundamental requirement to generate efficiency and improve productivity in any manufacturing environment. In the 21st century, the science of drug development is an established field that requires a dedicated and synergistic partnership between various subject matter experts. Unfortunately, pharmaceutical research is complicated, time-consuming, attritive, and costly, with development costs ranging from $4 billion to $11 billion per commercialized drug. There are more than 750 biotech and big pharma companies in the US that are developing new drug products for a vast number of therapeutic indications. Due to the high attrition rate in clinical trials, a small percentage of these drugs get commercialized. Still, a very high amount of resources are being spent on drug development from a societal perspective. Despite being an economically intense activity, the current state of drug product development makes a limited effort to integrate economics into product design and development. For example, pharmaceutical scientists are excellent at a data-driven decision-making process that requires technical elements and a few strategic elements. However, there is minimal integration of financial valuation elements (commonly employed in other high-tech industries such as fine chemicals, automotive, aerospace, etc.) into pharmaceutical drug development. Unfortunately, this hurts the sustainability of the health system of which these products will be a part in the future. A desirable future state integrates fundamentals of economics in product design and development so that the decision-making is parameterized, the cost of goods can be lowered, wastage can be reduced, patient-centricity is built into the design, and manufacturing/distribution efficiencies can be gained. The financial benefits of such an approach could allow for these savings to be passed on to the stakeholders and improve the value proposition of pharmaceuticals, which is critical to maintaining the innovation potential. This book hopes to introduce the reader to this desired future state of pharmaceutical drug development.

Výukové texty pro bakalářské studium zdravotnických oborů obsahují tradiční témata hygieny a epidemiologie jako biomedicínského základu primární prevence nemocí v novém pojetí. Pro potřeby praxe je zpracována epidemiologie nevýznamnějších skupin nemocí (kardiovaskulárních, nádorových, infekčních) a závislostí (návykové látky), problematika epidemiologických studií a očkování. Zvláštní kapitoly tvoří hygienické požadavky na provoz zdravotnických zařízení a rizika práce ve zdravotnictví. Texty slouží k uvědomění a k pochopení komplexních souvislostí mezi působením životního i pracovního prostředí a možným vznikem nemocí u jedince i v populaci s akcentem na využití poznatků v každodenní zdravotnické praxi.

This book provides deep insights into the ecology of the plague bacterium Yersinia pestis in natural foci, its diversity, genetic variability and the function of the vector, thus painting a holistic picture of how plague pandemics have evolved and how the bacterium has adapted perfectly to its environment over such a long period of time. The book reviews studies of several generations of scientists from the countries of the former Soviet Union where plague foci are found and presents them for the first time to a global audience. In addition, the book provides comprehensive information on historical plague pandemics and explores future strategies for managing the disease.

Since the emergence of 2022's monkeypox virus (MPXV) outbreak, it has been the heading of news and research articles that MPXV is being involving non-endemic areas after about its 80-year presence in endemic areas. Efforts are concentrated on understanding how MPXV has evolved to cause an epidemic. The book provides a comprehensive compendium of chapters on poxviruses in different domains. It concludes that the main problem we should deal with is not to address how MPXV has overcome the distance between non-endemic and endemic areas, but it is the non-cooperativity of logistics, research, and science in managing poxviruses'outbreaks.

This Handbook on cancer biology comprehensively reviews the current status of the oncobiology of major cancer types, cancer detection and treatment strategies, principles and processes of cancer drug development, and nanomedicine and other emerging cancer medicine applications to cancer diagnosis and treatment. The book also provides practical and implementable nutritional guidance in cancer prevention, treatment, and quality of life for cancer survivors. It discusses pharmacogenetics strategies for predicting cancer prognosis and treatment exposure, response, and toxicity. Further, it presents bioinformatics approaches for predicting anti-cancer drugs and drug combinations based on the multi-omic data, including transcriptomics, toxicogenomics, functional genomics, and biological networks. The Handbook also examines major factors and pathways that regulate cancer stem cells development and discusses potential targeted therapy for cancer stem cells. The book explores the application of the CRISPR/Cas9-based gene-editing technique in basic cancer research, diagnosis, and treatment of cancer. This Handbook is an invaluable source for oncologists, researchers, public health specialists, epidemiologists, and policy makers.​

This book introduces all common errors in medical science fields and the ways to control them. Systematic errors could be controlled both during study design and statistical analysis. Some errors have been presented in small segments but not in a comprehensive book. It covers many common errors that usually affect the research proposals, final reports, theses, and scientific presentations in the field of medical sciences as well as the rejection reasons on scientific papers. It will help researchers to control common errors using epidemiological and statistical methods.

This book comprehensively reviews the epidemiology and surveillance strategies of Visceral Leishmaniasis, and the latest developments in disease diagnosis, drug discovery, and vaccine development. The initial chapters cover the epidemiology features and spatial distribution of Visceral Leishmaniasis. The book further discusses the manifestations of HIV-Visceral Leishmaniasis infection on the immunopathogenesis, diagnosis, and therapeutic response. It analyzes the role of different proteomic technologies in understanding the parasite development, survival, drug resistance mechanisms, host-pathogen interactions, and the development of new therapeutic approaches. The book concludes by discussing recent advancements in vaccine development for Visceral Leishmaniasis. It discusses the promising vaccine candidate, their developmental status, current challenges, and prospects for rational vaccine development against Leishmania. This book is an invaluable source of information for students, and researchers working to understand the Leishmania biology, and drug development.

Die Simulation des menschlichen Herzens, die Vorhersage des morgigen Wetters, die Optimierung der Aerodynamik eines Segelboots, die Suche nach der idealen Garzeit für einen Hamburger: Bei der Lösung dieser Probleme können Kardiologen, Meteorologen, Sportler und Ingenieure auf mathematische Hilfe zählen. Dieses Buch führt Sie zur Entdeckung einer magischen, aus Gleichungen bestehenden Welt, die für eine Vielzahl von wichtigen Problemen unseres Lebens nützliche Antworten liefern können.Die Übersetzung wurde mit Hilfe von künstlicher Intelligenz durchgeführt. Eine anschließende menschliche Überarbeitung erfolgte vor allem in Bezug auf den Inhalt.

The Applied Genomic Epidemiology Handbook: A Practical Guide to Leveraging Pathogen Genomic Data in Public Health provides rationale, theory, and implementation guidance to help public health practitioners incorporate pathogen genomic data analysis into their investigations. During the SARS-CoV-2 pandemic, viral whole genome sequences were generated, analyzed, and shared at an unprecedented scale. This wealth of data posed both tremendous opportunities and challenges; the data could be used to support varied parts of the public health response but could be hard for much of the public health workforce to analyze and interpret, given a historical lack of experience working with pathogen genomic data.This book addresses that gap. Structured into eight wide-ranging chapters, this book describes how the overlapping timescales of pathogen evolution and infection transmission enable exploration of epidemiologic dynamics from pathogen sequence data. Different approaches to sampling and genomic data inclusion are presented for different types of epidemiologic investigations. To support epidemiologists in diving into pathogen genomic data analysis, this book also introduces the analytic tools and approaches that are readily used in public health departments and presents case studies to show step-by-step how genomic data are used and evaluated in disease investigations.Despite the breadth of scientific literature that uses pathogen genomic data to investigate disease dynamics, there remains little practical guidance to help applied epidemiologists build their ability to explore epidemiologic questions with pathogen genomic data. This handbook was written to serve as that guide. Including case studies, common methods, and software tools, this book will be of great interest to public health microbiologists or lab directors, bioinformaticians, epidemiologists, health officers, academics, as well as students working in a public health context.

This new edition builds upon the foundational knowledge covered in the first edition, covering the epidemiology, pathogenesis, and clinical presentation of atopic dermatitis in both pediatric and adult patients. It provides an overview of the mechanism and presentation of atopic dermatitis and focuses on the management methods experienced dermatologists have used to successfully manage atopic dermatitis. The book includes new chapters describing the special considerations for atopic dermatitis in skin of color patients, dedicated chapters on topical and oral prescription management reflected the latest FDA-approved treatments, and also a chapter covering the updated guidelines from the American Academy of Dermatology. A final chapter includes updates on the future of atopic dermatitis treatment. This book provides physicians with insights into the management of atopic dermatitis, such as alternative treatments for pruritus, psychosocial impact on patients and families,assessing patient compliance, and patient resources.

This book aims to compile the latest scientific information on hand, foot, and mouth disease (HFMD), including its epidemiology, etiology, pathology, immune response and vaccine development. Interestingly, the authors shared their own research experience and offered distinctive insights into the pathogenesis of HFMD and vaccine development. The intended audience, including university researchers, graduate students, and vaccine engineers, is well defined. The book is positioned as a resource that not only presents current knowledge but also has the potential to inspire further research in understanding immune pathogenesis and advancing vaccine development for HFMD.

Across the last fifty years, epidemiology has developed into a vibrant scientific discipline that brings together the social and biological sciences, incorporating everything from statistics to the philosophy of science in its aim to study and track the distribution and determinants of health events. A now-classic text, the third edition of this essential introductory textbook gives an overview of the core concepts that form the underpinnings of epidemiology and epidemiologic research. Rather than focusing on statistics or formulas, Epidemiology presents the underlying epidemiologic principles and concepts in a coherent and straightforward exposition. This core content is supplemented with historical notes, a discussion of scientific inference, details about infectious disease epidemiology, and some advanced topics--including how to deal with missing data, the use of causal diagrams, and quantitative bias analysis techniques--that serve as an on-ramp into further study for those who elect to pursue it. By emphasizing a unifying set of ideas, students will develop a strong foundation for understanding the principles of epidemiologic research.

This is a pioneering book that delves into the intersection of artificial intelligence (AI) and healthcare, specifically focusing on the detection and prevention of infectious diseases. Authored by leading experts in the field, this book offers a comprehensive overview of the latest advancements, challenges, and applications of AI in combating infectious diseases. With a unique emphasis on big data, wearable data, and computer vision, the book presents original research works that showcase innovative approaches to leveraging AI for disease surveillance, screening, and severity stratification. Through a combination of review chapters summarizing the current state of the field and novel applications of AI technology, readers gain valuable insights into the potential of AI in addressing major life-threatening infectious diseases identified by the UN Sustainable Development Goal 3. The book's structure ensures a balanced blend of theoretical foundations and practical applications, making it accessible to both researchers and healthcare professionals. By exploring cutting-edge methodologies and case studies, the book equips readers with the knowledge and tools needed to harness the power of AI in the fight against infectious diseases, ultimately contributing to global efforts to improve public health outcomes. With its interdisciplinary approach and focus on AI-driven solutions,'Surveillance, prevention, and control of infectious diseases: An AI perspective'serves as an invaluable resource for researchers, practitioners, and policymakers seeking to stay abreast of the latest developments in this rapidly evolving field. Whether exploring the role of wearable devices in disease monitoring or examining the potential of computer vision for early detection, this book offers a comprehensive overview of AI applications that have the potential to revolutionize infectious disease management and prevention strategies.

​Die auftretenden Varianten von SARS-CoV-2 beschleunigen durch ihre höheren Übertragungsraten die globale COVID-19-Pandemie, wodurch dringend neue therapeutische Angriffsziele benötigt werden. Hierbei wurde die antivirale Wirkung von Fluoxetin - einem Antidepressivum - gegen SARS-CoV-2 entdeckt. Mithilfe biochemischer und bildgebenden Methoden wurde der antivirale Wirkmechanismus von Fluoxetin näher analysiert und die saure Ceramidase als SARS-CoV-2 Wirtsfaktor charakterisiert. Veröffentlichte Studien zeigten, dass auch Aspirin eine antivirale Wirkung gegen Erkältungsviren, wie Rhinoviren und Influenzaviren zeigt. Diese antivirale Wirkung wurde in Bezug auf SARS-CoV-2 in Zellkultur und einem patienten-nahen 3D-Infektionsmodell untersucht und bestätigt. Um die Pathologie einer SARS-CoV-2-Infektion zu verstehen, wurde der Eintrittsweg des Virus in das Gehirn untersucht. Im Gegensatz zu anderen Viren überwindet SARS-CoV-2 die Blut-Hirnschranke ohne T-Zellen oder Makrophagen. Ebenso wurdeder Einbau eines lipophilen Fluoreszenzfarbstoffs in die Virusmembran etabliert, womit die direkte Markierung verschiedener Viren trotz ihrer unterschiedlicher Membranzusammensetzung möglich ist. Mit superauflösender Mikroskopie (SIM) wurde der virale Eintritt verschiedener umhüllter Viren visualisiert.

This book assembles a wide range of explanatory perspectives on social inequalities in health. Everywhere in the world, those with less advantage die younger and suffer more illness than the wealthy. Decades of research have documented this reality and yet we lack a comprehensive understanding of the mechanisms through which social circumstances ultimately influence the biological processes that lead to disease. Explanations have been proposed from various disciplines – economics, psychology, behavioral science, geography, and neuroscience – and each sheds light on parts of the overall process. But very few texts assemble these insights into an overall explanatory paradigm.Through a review of concepts and theories from a wide range of disciplines, the author outlines how these may be woven together to offer a more complete picture of how social influences'get under the skin'to affect health and disease. As well as understanding individual health, the book assembles explanations for social disparities in health. It concludes with a proposal for a set of explanatory models that cross disciplinary boundaries. Topics explored include:Social Inequalities in HealthExplanation and Causal Models for Social EpidemiologySocial and Economic Theories to Explain Patterns of DiseaseBiological Pathways Linking Social Determinants to HealthTheoretical Models of Health BehaviorWork Environment and HealthSocial Networks, Social Support and HealthPositive Influences on Health: Coping and ControlThe Relationship Between Personality and HealthUnderstanding Health Determinants: Explanatory Theories for Social Epidemiology is a textbook for graduate students in epidemiology, health sciences, health policy, and psychology, as well as social science students who are studying health. It will also be of interest to general readers, and can serve as a reference for researchers in epidemiology and the health sciences who are planning studies of the social determinants of health. The book reviews theories that could be tested in such studies.

In diesem Buch erläutern Experten praxisnah die wichtigsten Fakten zu Diagnostik und Therapie von Infektionen mit multiresistenten Erregern wie MRSA, VRE, MRGN und MDR-TB. Sie zeigen auf, welche diagnostischen Verfahren sinnvoll sind und welche Antibiotika bei welchen Infektionen greifen. Die Autoren beschreiben, durch welche Hygienemaßnahmen und Präventionskonzepte des Antiotika-Stewardship, sich Infektionen und Resistenzen vermeiden lassen. Auch auf die psychologischen Aspekte im Umgang mit Patienten, Angehörigen, medizinischem Personal und der Öffentlichkeit bei Infektionen durch MRE gehen die Autoren ein. Das Werk wendet sich an alle Ärzte in allen Einrichtungen des Gesundheitswesens, die Patienten mit Infektionen durch multiresistente Erreger betreuen. Die 3. Auflage erscheint komplett aktualisiert und fasst nun auch die therapeutischen Aspekte in einem Werk zusammen.

This contributed volume convenes selected, peer-reviewed works presented at the BIOMAT 2021 International Symposium, which was virtually held on November 1–5, 2021, with its organization staff based in Rio de Janeiro, Brazil. In this volume the reader will find applications of mathematical modeling on health, ecology, and social interactions, addressing topics like probability distributions of mutations in different cancer cell types; oscillations in biological systems; modeling of marine ecosystems; mathematical modeling of organs and tissues at the cellular level; as well as studies on novel challenges related to COVID-19, including the mathematical analysis of a pandemic model targeting effective vaccination strategy and the modeling of the role of media coverage on mitigating the spread of infectious diseases.Held every year since 2001, the BIOMAT International Symposium gathers together, in a single conference, researchers from Mathematics, Physics, Biology, and affine fields to promote the interdisciplinary exchange of results, ideas and techniques, promoting truly international cooperation for problem discussion. BIOMAT volumes published from 2017 to 2020 are also available by Springer.

This essential presents infectious diseases of humans and animals that occur or can become endemic in Germany and Europe. These include current threats, African swine fever, avian influenza and COVID-19. In addition, the biology of mosquitoes is described. Globalisation and global warming favour the establishment of new mosquito species that can transmit viruses of the tropics and subtropics, e.g. chikungunya, dengue and West Nile virus. The Schmallenberg virus, which is of veterinary relevance, shows how rapidly new pathogens are spreading in Europe.

This book provides a selection of modern and sophisticated methodologies for the analysis of large and complex univariate and multivariate categorical data. It gives an overview of a substantive and broad collection of topics in the analysis of categorical data, including association, marginal and graphical models, time series and fixed effects models, as well as modern methods of estimation such as regularization, Bayesian estimation and bias reduction methods, along with new simple measures for model interpretability. Methodological innovations and developments are illustrated and explained through real-world applications, together with useful R packages, allowing readers to replicate most of the analyses using the provided code. The applications span a variety of disciplines, including education, psychology, health, economics, and social sciences.

This book comprehensively reviews the disease dynamics, distribution, surveillance, epidemiology, diagnosis, control strategies, and management of the desert malaria. It highlights the potential risks of unstable but often exacerbated malaria conflagration as epidemics in the middle of duned desert, a desert oasis, and desert-fringe regions. Further, it reveals the factors inveigled into desert environments due to extensive anthropogenic activities such as canalized irrigation projects, high-yielding new agriculture practices, human concentration, and increased trade. It addresses the impact of irrigation on the malarial dynamics and its coupling to the climate forcing. The book also offers a model for desert transformation into malaria heaven under the changed climatic conditions including high rainfall, humidity, and depletion in temperature. Lastly, it offers insight into malaria epidemiology and disease control in the desert's arid environments. This book is an essential resource for medical entomologists, parasitologists, epidemiologists, and public health researchers.

In the wake of the COVID-19 pandemic, the MPox epidemic, recent outbreaks of Ebola, and a growing focus on the role of social determinants in health disparities, and more, there is increasing motivation and need to learn about epidemiology. Friis'Epidemiology 101, Third Edition is a clear and accessible resource designed to provide students with a solid foundation in basic epidemiologic concepts while also demonstrating how these concepts can be applied to problems in everyday life. In keeping with the prior editions, this non-technical text is written for students with little or no background in health and biostatistics, and offers numerous case studies, text boxes, vignettes, exhibits, photographs, figures, and illustrations to engage readers.

Die Beiträge der Wissenschaft in der Corona-Krise waren vielfältig. Sie reichten von der Impfstoffentwicklung über Aerosolforschung bis hin zu Modellierungen. Es gab viele Erfolgsmeldungen. Virologen wurden zu Medienstars. Wissenschaft, Politik und Medien sprachen zeitweise mit einer Stimme – ein Siegeszug der Wissenschaftskommunikation? Es gab aber auch überzogene Versprechungen, dünnhäutige Reaktionen bei Kritik und Einseitigkeit in der Politikberatung – ein kommunikatives Desaster für Wissenschaft, Politik und Medien?Dieses Sachbuch möchte die Diskussion zur Corona-Kommunikation in Wissenschaft, Politik und Medien anregen. Es basiert auf Fallstudien, die aus verschiedenen Perspektiven beleuchtet werden, ordnet Beispiele entlang der Kriterien etablierter Wissenschaftsorganisationen ein und formuliert Fragen an die künftige Wissenschaft und ihre Kommunikation.Ist dies eine Studie, Materialsammlung oder Streitschrift? Alles. Aber hauptsächlich ein Plädoyer: Gegen unantastbare Wahrheiten, Meinungshomogenisierung und Ausgrenzung. Für Transparenz, Pluralität und Dialog in Wissenschaft und Kommunikation.

What do the movements of molecules and the migration of humans have in common? How does the functionality of our brain tissue resemble the flow of traffic in New York City? How can understanding the spread of ideas, rumors, and languages help us tackle the spread a pandemic? This book provides an illuminating look into these seemingly disparate topics by exploring and expertly communicating the fundamental laws that govern the spreading and diffusion of objects. A collection of leading scientists in disciplines as diverse as epidemiology, linguistics, mathematics, and physics discuss various spreading phenomena relevant to their own fields, revealing astonishing similarities and correlations between the objects of study—be they people, particles, or pandemics. This updated and expanded second edition of an award-winning book introduces timely coverage of a subject with the greatest societal impact in recent memory—the global fight against COVID-19. Winner of the 2019Literature Prize of the German Chemical Industry Fund and brainchild of the international and long-running Diffusion Fundamentals conference series, this book targets an interdisciplinary readership, featuring an introductory chapter that sets the stage for the topics discussed throughout. Each chapter provides ample opportunity to whet the appetite of those readers seeking a more in-depth treatment, making the book also useful as supplementary reading in appropriate courses dealing with complex systems, mass transfer, and network theory. Chapter “Neolithic Transitions: Diffusion of People or Diffusion of Culture?” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This applied clinical medicine and public health text introduces the fundamental concepts in epidemiological investigation and demonstrates how to integrate emerging research on epigenomics into practice.Epidemiology has a vital strategic role in facilitating and leading evidence discovery in all aspects of human health, with the intent of improving patient and public health through disease control and health promotion practices. It emphasizes what we now know about the transformation the human body and the ecosystem undergo as a result of social structure, environment, daily challenges and mutation. The first part of this text explores the origin of epidemiology, its relationship with medicine and public health, and its role in assessing disease distribution as occurrence or frequency, risk factors, treatment and management. The main direction of this text is to explore the assessment of how gene and environment interactions, termed epigenomic modulations, aberrantly predispose to morbidity, prognosis, survival and mortality at the individual as well as the specific population level.This text presents a novel approach based mainly on epigenomic modulations in the application of epidemiologic investigation in disease incidence, morbidity and mortality at a specific population level for graduate education in public health and clinical sciences as well as medical education.

This volume gathers together selected peer-reviewed works presented at the BIOMAT 2022 International Symposium, which was virtually held on November 7-11, 2022, with an organization staff based in Rio de Janeiro, Brazil. Topics touched on in this volume include infection spread in a population described by an agent-based approach; the study of gene essentiality via network-based computational modeling; stochastic models of neuronal dynamics; and the modeling of a statistical distribution of amino acids in protein domain families. The reader will also find texts in epidemic models with dynamic social distancing; with no vertical transmission; and with general incidence rates. Aspects of COVID-19 dynamics: the use of an SEIR model to analyze its spread in Brazil; the age-dependent manner of modeling its spread pattern; the impact of media awareness programs; and a web-based computational tool for Non-invasive hemodynamics evaluation of coronary stenosis are also covered. Held every year since 2001, The BIOMAT International Symposium gathers together, in a single conference, researchers from Mathematics, Physics, Biology, and affine fields to promote the interdisciplinary exchange of results, ideas and techniques, promoting truly international cooperation for problem discussion. BIOMAT volumes published from 2017 to 2021 are also available by Springer.

This book addresses current topics on pathogenic Vibrio spp. from a comprehensive and holistic perspective. Here, experts in the field provide timely chapters, ranging from genomics, pathogen emergence, and epidemiology to pathogenesis, virulence regulation and host colonization. Questions addressed include: How does climate change affect the spread of these bacteria? What is the status of current vaccines? Are there novel therapeutic options to treat Vibrio infections? Is there likelihood of emergence of new pathogenic strains or species? Can insights from mathematical models and epidemiology lead to prediction of pathogen outbreaks?Recent decades have seen a steady increase in Vibrio spp. infections originating in aquatic and marine habitats, driven by higher human population densities, warming of polluted oceans, natural and human-made disasters, and mass seafood production. These conditions increase the likelihood of pathogenic Vibrio spp. coming into contact with humans, making their study even more timely and relevant as these problems escalate over time. This book is a valuable resource for health management professionals, experienced microbiologists/ microbial ecologists, and early career scientists alike who want to learn more about these important environmental human pathogens. The ideas and technologies presented in this book for preventing, controlling, and monitoring Vibrio spp. infections contribute to the UN Sustainable Development Goal 3: Good Health and Well-Being.

Tuberculosis have been documented since antiquity and the search of the microbes that cause this disease started more than three hundred years ago. Nevertheless, tuberculosis remains an important global health issue, with millions of people affected per year in addition to millions that remain undiagnosed and untreated. Patients with tuberculosis face the full range of recurrence, reinfection, and resistance due to diagnostic, prophylactic, and therapeutic procedures that are not as effective as they should be. In addition, variability in susceptibility to tuberculosis pose a complex problem with numerous interrelated variables. This volume is devoted to the understanding of Tuberculosis focusing on its heterogeneity, its transmission, manifestations, related conditions, diagnosis, treatments, drug resistance and prevention.

This book is intended to show the great achievements and valuable experience of Chinese public health practices and epidemiological theories and methods. It is conducive to expanding medical workers'practical ability of disease prevention and control, and to bridging the gap between clinical medicine and public health.In part 1, it introduces the progress in epidemiology of 10 infectious diseases. In part 2, it covers 11 non-communicable diseases. The research method and prediction modelling and public health ethics are discussed in the 11 chapters of part 3. The contributors include epidemiologists and public health experts, as well as more clinicians, mathematicians, sociologists, philosophers (ethicists), bioinformatics and so on. Among them, there are not only professors from universities, but also researchers from scientific research institutes, and experts in the front line of disease prevention and control.

Become a disease detective with this easy-to-understand resource Epidemiology For Dummies is packed with key concepts, practical applications, and real-life examples in the study of disease transmission and control. It's a must-have for students in all public-health-related fields, and for curious learners, too. This Dummies guide will help you conquer even the trickiest epidemiological concepts. In this introduction to the fascinating, complex science, you'll learn—in terms anyone can understand—all the basic principles of epidemiology, plus how those concepts translate to public health outcomes and policy decisions. Learn the basic principles and concepts of epidemiology Discover real-world examples and public health threats Understand the complex social factors that influence health Embark on a public health career or just pass your epidemiology courseAnyone who wants or needs to understand the fundamentals of epidemiology and the science behind public health will love Epidemiology For Dummies.

Pandemie und Klimakrise rufen die herausragende Rolle der Wissenschaft und des wissenschaftlichen Wissens für Informierung und Orientierung der Gesellschaft sowie für die Beratung der Politik bei der Ausrichtung praktischer Maßnahmen ins Bewusstsein. In diesem Zusammenhang wird die Frage virulent, weshalb der Wissenschaft diese herausgehobene Rolle zukommt. Dass diese Frage trotz der vielbeschworenen Autorität der Wissenschaft alles andere als trivial ist, zeigt sich daran, dass Wissenschaftsskepsis und Relativierung wissenschaftlicher Resultate bis hin zur Wissenschaftsleugnung Einfluss gewinnen, sobald es um konkrete Fragen der Ausrichtung gesellschaftlichen Handelns an der Wissenschaft geht. Wodurch ist also Vertrauen in die durch die Wissenschaft ermittelten Fakten, die in ihren Modellen entworfenen Szenarien und ihre Ratschläge an Gesellschaft und Politik gerechtfertigt? Weshalb soll man der Wissenschaft in besonderem Maße vertrauen und auf ihren Ratschlag hören?Insgesamt sollen die Beiträge des Buches Aufschluss darüber geben, wodurch die Vertrauenswürdigkeit der Wissenschaft in ihrer modernen Form gerechtfertigt ist und an welche Bedingungen ihre besondere Rolle in der Gesellschaft geknüpft ist. Was kann Wissenschaft für die Gesellschaft leisten und wo liegen die Grenzen ihrer orientierenden Rolle? Was heißt es „auf die Wissenschaft zu hören“ und was sind die Bedingungen dafür, dass Menschen in einer demokratischen Gesellschaft sich wissenschaftliche Erkenntnisse aneignen und sie als Richtschnur für ihr Handeln verwenden?

This textbook provides basic quantitative models allowing researchers and decision makers to a) assess viability of threatened populations and evaluate the success of species reintroductions, b) estimate invasion abilities of alien species, c) evaluate the persistence of metapopulations subjected to habitat destruction and fragmentation, d) analyze policies and strategies for the sustainable harvesting of biological resources, and e) assess the course of human and nonhuman diseases and the possible containment measures. Air and water pollution, overexploitation of renewable resources (e.g. marine fish stocks and forests), massive land-use change together with climate change impact the Earth biodiversity and impair the functioning of ecosystems. Globalization increases the risk of diffusion of alien species and new pathogens.A panoply of numerical problems mainly based on real data from the ecological literature enables the reader to practice the presented modelling tools.presented modelling tools.

This book presents the basic theoretical concepts of dynamical systems with applications in population dynamics. Existence, uniqueness and stability of solutions, global attractors, bifurcations, center manifold and normal form theories are discussed with cutting-edge applications, including a Holling's predator-prey model with handling and searching predators and projecting the epidemic forward with varying level of public health interventions for COVID-19.As an interdisciplinary text, this book aims at bridging the gap between mathematics, biology and medicine by integrating relevant concepts from these subject areas, making it self-sufficient for the reader. It will be a valuable resource to graduate and advance undergraduate students for interdisciplinary research in the area of mathematics and population dynamics.

Substance misuse and addictions are a public health issue. They affect the well-being of each community and nation as a whole. It is, therefore, necessary to identify, educate, and treat individuals who are addicted to substances. Policies and procedures go hand-in-hand with public health education and safety. The science behind the public health issues of one drug may be applicable to other drugs as well. However, marshalling all of the aforementioned information into a single source is somewhat difficult due to the wide array of material. The Editors address this by compiling the research in this single reference work that serves as a'one-stop-shopping'approach to everything readers need to know about the scientific basis of public health and addictions and agents of misuse.Apart from active agents that have a plant or chemical basis, there is a need to consider that there are other forms of addiction which may havecommon modes of causality or prevention. These include food addiction, gaming, gambling, and other non-drug addictions. These types of addiction may be related to the addiction of drugs.The Handbook of Substance Misuse and Addictions: From Biology to Public Health offers a holistic understanding of the relationship between public health and substance misuse. The text provides a common platform upon which other forms of addiction or substance misuse can be understood and treated. Addiction processes involve understanding the biological processes as well as behavior, psychology, sociology, and public health, all of which are interlinked. This Handbook is a useful reference for lecturers, students, researchers, practitioners, and other professionals in public health, addiction science, epidemiology, health education, health promotion, and health sciences.

This updated second edition of Molecular Typing in Bacterial Infections, presented in two volumes, covers both common and neglected bacterial pathogenic agents, highlighting the most effective methods for their identification and classification in the light of their specific epidemiology. New chapters have been included to add new species, as well as another view of how bacterial typing can be used. These books are valuable resources for the molecular typing of infectious disease agents encountered in both research and hospital clinical laboratory settings, as well as in culture collections and in the industry. Each of the 21 chapters provides an overview of specific molecular approaches to efficiently detect and type different bacterial pathogens. The chapters are grouped in five parts, covering respiratory and urogenital pathogens (Volume I), and gastrointestinal and healthcare-associated pathogens, as well as a new group of vector-borne and Biosafety level 3 pathogens including adescription of typing methods used in the traditional microbiology laboratory in comparison to molecular methods of epidemiology (Volume II). Comprehensive and updated, Molecular Typing in Bacterial Infections provides state-of-the-art methods for accurate diagnosis and for the correct classification of different types which will prove to be critical in unravelling the transmission routes of human pathogens.

In diesem Open-Access-Tagungsband werden die Erfahrungen mit der Corona-Pandemie durch renommierte Forscherinnen und Forscher wissenschaftlich reflektiert. Neben dem gesellschaftlichen und politischen Umgang mit Covid-19, geht es um vergangene Pandemien sowie zukünftige Infektionsgefahren.Die Akademie der Wissenschaften in Hamburg veranstaltete im April 2022 das Symposium „Infektionen und Gesellschaft – was haben wir gelernt?“. Im interdisziplinären Diskurs ging es darum, die Bedrohung durch Infektionserreger zu eruieren und die Reaktionsmöglichkeiten der Gesellschaft auszuloten. Das Symposium wurde von der Arbeitsgruppe „Infektionsforschung und Gesellschaft“ der Akademie der Wissenschaften in Hamburg konzipiert.

This book deals with the advantages of using artificial intelligence (AI) in the fight against the COVID-19 and against future pandemics that could threat humanity and our environment. This book is a practical, scientific and clinically relevant example of how medicine and mathematics will fuse in the 2020s, out of external pandemic pressure and out of scientific evolutionary necessity. This book contains a unique blend of the world's leading researchers, both in medicine, mathematics, computer science, clinical and preclinical medicine, and presents the research front of the usage of AI against pandemics. Equipped with this book the reader will learn about the latest AI advances against COVID-19, and how mathematics and algorithms can aid in preventing its spreading course, treatments, diagnostics, vaccines, clinical management and future evolution.

Now in its second edition, this book provides a state of the art overview on basic concepts of epigenetic epidemiology and a comprehensive review of the rapidly evolving field of human epigenetics.Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. Unlike our genetic inheritance, our epigenome is malleable throughout the lifecourse and is shaped by our environmental experiences. Population-based epidemiologic studies increasingly incorporate epigenetic components. These so called epigenome-wide association studies (EWAS) contribute substantially to our understanding of the relevance of epigenetic marks, such as DNA methylation, histone modification, and non-coding RNAs for disease causation.Written by leading experts in the field, the book opens with a comprehensive introduction of the principles of epigenetic epidemiology and discusses challenges in study design, analysis, and interpretation. It summarizesthe latest advances in epigenetic laboratory techniques, the influence of age and environmental factors on shaping the epigenome, the epigenetic clock, and the role of epigenetics in the developmental origins hypothesis. The final part focuses on epigenetic epidemiology of various health conditions such as imprinting disorders, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, metabolic disorder and vascular disease, as well as neurodevelopmental and psychiatric disorders. Given its scope, Epigenetic Epidemiology is an indispensable resource for researchers working in the field of human epigenetics.

This book discusses the impacts that weather and climate have on human physical health, longevity, and mental wellness, and acts as a guide to the application of meteorological science in health care. It provides a background on biometeorology by covering basic concepts of human anatomy and meteorology, and how modern biometeorological science can be incorporated into medical practice through diagnosis, prevention and treatment of physical and mental diseases. The recommendations, advice and preventive measures addressed in this book aim to help people adapt to different weather phenomena and changes to minimize negative health consequences, which is increasingly relevant as climate change and its effects on human health become more pronounced and studied. The book is intended for environmental epidemiologists, medical students, physicians, health care providers, climate scientists, insurance industries and policy makers, but will also appeal to general enthusiasts of atmospheric, climate and medical sciences.

Oral infections mainly affect oral health, but can also affect people's general health in several ways. This book gives an overview of the scientific evidence for linkages between oral infections and other systemic diseases. Much research has been carried out to find the most plausible reasons for associations and possible causal mechanisms in this regard. The last 20-30 years have opened up the field of the infection hypothesis in cardiovascular disease that was first introduced in the nineteenth century. The book also provides a short overview of oral infections and symptoms due to systemic diseases.

This updated second edition of Molecular Typing in Bacterial Infections, presented in two volumes, covers both common and neglected bacterial pathogenic agents, highlighting the most effective methods for their identification and classification in the light of their specific epidemiology. New chapters have been included to add new species, as well as another view of how bacterial typing can be used. These books are valuable resources for the molecular typing of infectious disease agents encountered in both research and hospital clinical laboratory settings, as well as in culture collections and in the industry. Each of the 21 chapters provides an overview of specific molecular approaches to efficiently detect and type different bacterial pathogens. The chapters are grouped in five parts, covering respiratory and urogenital pathogens (Volume I), and gastrointestinal and healthcare-associated pathogens, as well as a new group of vector-borne and Biosafety level 3 pathogens including adescription of typing methods used in the traditional microbiology laboratory in comparison to molecular methods of epidemiology (Volume II). Comprehensive and updated, Molecular Typing in Bacterial Infections provides state-of-the-art methods for accurate diagnosis and for the correct classification of different types which will prove to be critical in unravelling the transmission routes of human pathogens.

This book offers a comprehensive overview of the latest standard medical procedures and surgical techniques for biliary atresia (BA), as well as the perioperative care, long-term follow-up and transitions. Experts on pediatrics in such fields as hepatology, surgery, pathology, and liver transplantation present their research findings and analyses of this rare and intractable disease of unknown etiology. In Japan, shared experience and sound understanding based on conferences and guidelines have led to standardization of management and clinical care and, as a result, better outcomes. Providing insights into improving surgical outcomes, and including special chapters focusing on social support systems for patients and families as well as recent advances in early diagnosis, this book a valuable resource for medical professionals around the globe who are involved in treating biliary atresia. It is especially useful for pediatric hepatologists, pediatric surgeons and transplant surgeons.

Shared diseases among wildlife, livestock and humans, often transboundary, are relevant to public health and global economy, as being highlighted currently relative to the global COVID19 pandemic. Diseases at these interfaces also impact the conservation of biodiversity and must be considered when managing wildlife. While wildlife and domestic livestock have coexisted in dynamic systems for thousands of years, spillover disease risks are higher today than in the past due to global patterns of increasing close contact and interactions among wildlife, livestock and humans in the context of complex, diverse and numerous circumstances. Multidisciplinary studies of animal interfaces, especially those involving wildlife, therefore, must be brought to the forefront so that knowledge gaps can be realized and filled to inform managers and policy makers.In the first part of the book authors illustrate and discuss ecological and epidemiological concepts related to the interfaces, with avision towards socio-ecological system health. In addition, the history of past animal interfaces provides the necessary perspective to focus current questions, better understand present situations, and informs how we can best approach the future. The second part discusses the myriad of similar and differing wildlife- livestock interfaces found around the world from a regional point of view. The third part focuses on how to assess the spatial and temporal overlap between livestock and wildlife, and authors present new technical innovations about how inter-transmissions between wild and domestic populations can be quantified. An overview of main modeling approaches available to quantify multi-host disease transmission at the wildlife/livestock interface, illustrated with specific-case studies, is also presented. Finally, the need for interdisciplinary approaches and a dedicated thematic field to approach the wildlife/livestock interfaces and create opportunities to promote wildlife–livestock coexistence is emphasized. The concluding chapter presents perspectives and directions to better understanding disease dynamics at the wildlife/livestock interface, global change and implications for the future. The changing distribution of interfaces, ongoing human and environmental changes (e. g. climate warming, changes in animal production systems, etc.) and their likely impacts and consequences for the interfaces and disease transmission processes are all discussed.

An indispensable read for all those seeking to address the severe problems of local and global human health and environmental crises The widespread growth of monopolies and big business has led to a fourth industrial revolution focused on producing fast, living fast, and dying fast for the sole benefit of accelerated profit. Despite unprecedented accumulations of wealth and industry, the world has watched as indicators of income inequality--a partial parameter of social inequity--have increased, while big business, with their nearly unrestricted influence, has increasingly distorted advancements in medical research. Bold and incisive, Critical Epidemiology and the People's Health invites readers to the next great paradigm in public health by promoting a progressive, transdisciplinary, intercultural, community-building approach radically divergent from the presiding object-based, empiricist mode of thinking. A concise overview of the Latin American Social Medicine movement, this book introduces the work of leading scientist Jaime Breilh to a global English audience, focusing on key questions such as: What are the real challenges facing critical epidemiology during the current time of immense turmoil and inequity? How can we conduct responsible and sensitive public health research? What role does epidemiology play in addressing the societal ills of both the global North and South? And how can we create a more rigorous, updated, and effective epidemiology? In addressing these questions, Critical Epidemiology and the People's Health offers readers a clear-eyed and much-needed perspective on how to overcome Cartesian reductionism with renewed methodological tools to address the rampant growth of injustices harming our global collective health and to subvert the reigning notions of health prevention and promotion.

This book provides detailed and updated knowledge about medically important ‘Big Four'venomous snakes of India (Indian spectacled cobra, Indian common krait, Indian Russell's viper, and Indian saw-scaled viper). This book essentially covers the snakebite problem in the world with particular reference to Asia and India. It discusses the evolution and systematics of venomous snakes, emphasizing ‘Big Four'venomous snakes of India; the evolution and composition of venoms determined by traditional biochemical and modern proteomic analyses. It also describes the pharmacological properties of enzymatic and non-enzymatic toxins of ‘Big Four'venomous snakes of India. Different chapters discuss exciting topics such as species-specific and geographical differences in venom composition and its impact on pathophysiology and clinical manifestations of snakebite envenomation in India, biomedical application of Indian snake venom toxins; production and quality assessment of commercial antivenom,prevention, and treatment of snakebite in India, adverse effects of antivenom including strategies to combat antivenom reactions inpatient.This book caters to toxinologists, pharmacologists, zoologists, antivenom manufacturers, biochemists, clinicians, evolutionary biologists, herpetologists, and informed non-specialists interested to know about the Indian snake venoms.

This book is the first social epidemiological study of COVID-19 spread in New York City (NYC), the primary epicenter of the United States. New York City spread COVID-19 throughout the United States. The context of epicenter formation determined the rapid, extreme rise of NYC case and mortality rates. Decades of public policies destructive of poor neighborhoods of color heavily determined the spread within the City. Premature mortality rates revealed the'weathering'of policy-targeted communities: accelerated aging due to chronic stress. COVID attacks the elderly more severely than those under the age of 60. Communities with high proportions of prematurely aged residents proved fertile ground for COVID illness and mortality. The very public policies that created swaths of white wealth across much of Manhattan and parts of Brooklyn destroyed the human diversity needed to ride out crises. Topics covered within the chapters include: Premature Death Rate Geography in New York City: Implications for COVID-19 NYC COVID Markers at the ZIP Code Level Prospero's New Castles: COVID Infection and Premature Mortality in the NY Metro Region Pandemic Firefighting vs. Pandemic Fire Prevention Conclusion: Scales of Time in Disasters An exemplary study in health disparities, COVID-19 in New York City: An Ecology of Race and Class Oppression is essential reading for social epidemiologists, public health researchers of health disparities, those in public service tasked with addressing these problems, and infectious disease scientists who focus on spread in human populations of new zoonotic diseases. The brief also should appeal to students in these fields, civil rights scholars, science writers, medical anthropologists and sociologists, medical and public health historians, public health economists, and public policy scientists.

In December 2019, the world witnessed the occurrence of a new coronavirus to humanity. The disease spread quickly and became known as a pandemic globally, affecting both society and the health care system, both the elderly and young groups of people, and both the men's and women's groups. It was a universal challenge that immediately caused a surge in scientific research. Be a part of a world rising in fighting against the pandemic, the Coronavirus Disease - COVID-19 was depicted in the early days of the pandemic, but updated by more than 200 scientists and clinicians to include many facets of this new infectious pandemic, including i, characteristics, ecology, and evolution of coronaviruses; ii, epidemiology, genetics, and pathogenesis (immune responses and oxidative stress) of the disease; iii, diagnosis, prognosis, and clinical manifestations of the disease in pediatrics, geriatrics, pregnant women, and neonates; iv, challenges of co-occurring the disease with tropical infections, cardiovascular diseases, hypertension, and cancer and to the settings of dentistry, hematology, ophthalmology, and pharmacy; v, transmission, prevention, and potential treatments, ranging from supportive ventilator support and nutrition therapy to potential virus- and host-based therapies, immune-based therapies, photobiomodulation, antiviral photodynamic therapy, and vaccines; vi, the resulting consequences on social lives, mental health, education, tourism industry and economy; and vii, multimodal approaches to solve the problem by bioinformatic methods, innovation and ingenuity, globalization, social and scientific networking, interdisciplinary approaches, and art integration. We are approaching December 2020 and the still presence of COVID-19, asking us to call it COVID (without 19).

Epidemiology: A Research Manual for South Africa offers an applied introduction to epidemiological research methods, for students of various health science disciplines who are required to conduct or reference epidemiological research. Directed at readers who are new to epidemiological theory and practice, the text explains fundamental concepts and methods in a manner that is clear and accessible. The text offers a step-by-step guide to the development of a research protocol and the application of epidemiological methods, and addresses specific content areas and methodologies that are important in contemporary epidemiological research. Examples focus on the South African setting, highlighting regional conditions, diseases and health services. This fourth edition is comprehensively revised to reflect current knowledge and practice, and reflects greater emphasis on the complex burden of disease in South Africa as well as the use of routinely available health data for research purposes. The text includes new chapters on reproductive and perinatal epidemiology as well as injury epidemiology, and offers many new, local examples.