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This issue of Endocrinology and Metabolism Clinics of North America is devoted to Reproductive Endocrinology. Guest Editors Peter Lee, MD and Christopher P. Houk, MD have assembled a group of expert authors to review the following topics: Fertility Among Females and Males with Congenital Adrenal Hyperplasia (21-Hydroxylase Deficiency); Reproductive Issues for Turner Syndrome; Fertility and Reproduction Among Childhood Cancer Survivors; Fertility After Crypotochidism; Male Obesity and Fertility; Fertility Issues among Transgender Individuals; Fertility Preservation in Pediatrics; Polycystic Ovary Syndrome (PCOS); Fertility Issues for Patients With Delayed Puberty (Constitutional Delay, Functional Delay, and Hypogonadotropism); Varicocele; Testis Development and Reproduction in Klinefelters Syndrome; and Fertility Issues Among Those With Disorders of Sex Development.