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Chronic Complications of Diabetes Mellitus: Current Outlook and Novel Pathophysiological Insights provides a holistic view of the disease, discussing not only its classical complications but also the under recognized and managed conditions associated with diabetes. Chapters also discuss advances in our understanding of the genomic architecture of diabetes complications and how precision medicine can be used to personalize their management. Endocrinologists, diabetologists, primary care physicians and researchers interested in complications of diabetes mellitus and cutting-edge information will find this to be a comprehensive tome on the topic. Diabetes complications include pathological changes usually related to the vascular system and classical target organs. However, there are also nonclassical complications independent or partially independent from vascular damage that are often overlooked. Describes pathophysiology, clinical aspects and treatment of complications of diabetes, including nonclassical complications such as diabetic bone disease and diabetic cardiomyopathy Addresses and discusses challenges in the management of diabetes complications, including prevention and therapeutic strategies Presents up-to-date, thoroughly referenced information for clinicians, researchers and other healthcare providers

••Selected for Doody's Core Titles® 2024 in Endocrinology/Metabolic Disease••Diagnosis and Treatment of Osteoporosis: A Case-Based Approach is a practical guide that will be useful to a wide range of practicing and in-training clinicians, including physicians, nurse practitioners and physician assistants. With its clinical case and scenario-based approach, readers can quickly decide which clinical problem to address such as the management of osteoporosis of a particular clinical problem (Atypical femoral shaft fractures, Glucocorticoids and bone health, etc.). Each chapter is self-contained with a list of objectives at the beginning and a presentation of clinical cases that encourages self-learning to non-specialized clinical staff. This book is easily accessible to non-specialists, allowing any healthcare provider to learn how to diagnose and manage osteoporosis in the context of their practice.Includes key points at the end of each chapter to provide a succinct summary of each clinical issueProvides multiple-choice questions as an interesting way of testing one's knowledge on the particular issue discussed in the chapterPresents tables and diagrams to elucidate the knowledge outlined in the chapterDevotes a section to therapeutics and an analysis of the results of pivotal and key studies listed in a comparable visual format

Tutorials in Clinical Chemistry is designed for trainee pathology residents, clinical chemists, medical students, and clinical laboratory scientists, in addition to those preparing for board and postgraduate examination. It is helpful to those in training as well as a teaching aid for mentors, faculty, and directors. The book is organized into 17 system-based chapters covering essential pathophysiology, biochemical investigation, and technical aspects of relevance to results interpretation. Tutorials in Clinical Chemistry is a must-have, didactic and essential knowledge as well as practical resource for learning and review.? Facilitates easy access to troubleshooting common questions within a daily practice? Provides the landscape for the required knowledge and competency in clinical chemistry? Presents concise, direct, practical material for clinicians and clinical practitioners reaching out to the clinical laboratoryfor advice and interpretation of findings? Covers all aspects of clinical chemistry fellowship curriculum

This book is a quick-reference guide to osteoporosis that equips the reader with easy-to-follow guidelines for lifelong maintenance of skeletal structure and function, with an emphasis on the diagnosis, therapy and prevention of osteoporosis. Organized into 20 chapters it provides a concise, yet complete evidence-based overview of osteoporosis prevention and management “from paediatrics to geriatrics”. This practical guide is aimed at raising awareness and educate physicians across disciplines about this preventable, treatable and now even curable disease and emphasizing how every doctor can contribute to stop the “osteoporosis treatment gap” recognized over the last ten years. Covering bone biology, pathophysiology, secondary and drug-induced osteoporosis, as well as risk factors, diagnostic measurements, treatment and monitoring strategies, new drugs, management of osteoporotic fractures, and much more, this book is a must-have for all those involved in the prevention and care of this global threat.

General and Comparative Endocrinology: An Integrative Approach, takes a holistic approach to endocrinology, introducing students to the diverse facets of this interdisciplinary science ranging from the medical to comparative domains, while also exploring evolutionary, environmental, and conservation specializations within the field. The textbook is founded on the principle that students interested in the health sciences will benefit from understanding how proficiency in endocrine function among a diversity of organisms contributes to advances in modern medicine. Likewise, students intrigued by comparative physiology will benefit from the wealth of knowledge derived from medical/clinical endocrinology, the historical bedrock of the field. This textbook represents the modern field of endocrinology in its totality by addressing topics and recent advances not currently discussed in other introductory endocrinology textbooks. Key Features Introduces the broad and interdisciplinary scope of endocrinology. Provides clear chapter objectives and key concepts. Includes summary and synthesis questions for each chapter that are suitable for exams and quizzes. Includes a chapter devoted to endocrine-disrupting chemicals. Describes the roles played by the endocrine system in important health challenges related to appetite regulation, obesity, diabetes, and other diseases stemming from ‘mismatches to modernity'. Integrates evolutionary and comparative approaches to hormones and health.

This book aims to provide scientific information about hormones. Hormones are chemical compounds that transmit specific information between organs and thus regulate the body's work. As a group of biologically active signaling molecules, they belong to the four main groups of organic chemical compounds. The 36 chapters present the characteristics of exemplary hormones. The prepared monograph is a description of the most popular hormones. In this volume, one can read about the biochemical pathways of adrenaline, adrenocorticotropic hormone (ACTH), aldosterone, antidiuretic hormone (vasopressin), cholecystokinin, corticosteroid, corticotropin releasing hormone (CRH), cortisol, endocrine disorders, endocrine system, epinephrine, erythropoietin, estrogen, follicle-stimulation hormone (FSH), ghrelin, glucagon, gonadotropin releasing hormone (GnRH), growth hormone (GH), growth hormone releasing hormone (GHRH), hepcidin, human chorionic gonadotropin-β, humoral factors, importance of a correct hormonal balance for the psychological well-being of women, insulin, insulin-like growth factor (IGF), luteinizing hormone (LH), insulin, oxytocin, parathyroid hormone (PTH), progesterone, prolactin, thyroid-stimulating hormone (TSH), serotonin, thyroid hormone, thyrotropin releasing hormone (TRH) and prolactin.

Steroids in the Laboratory and Clinical Practice covers both basic chemistry and therapeutic application of steroids in a single source. The comprehensive reference addresses the specificity of steroid determinations to clarify confusion arising from the laboratory results. The book covers important advancements in the field and is a valuable addition in the literature addressing all existing knowledge gaps. This is a must have reference for pathologists, laboratorians, endocrinologists, analytical/clinical chemists and biochemists. Addresses the normal production of steroids and concentrations found in biological fluids and tissues Presents the changes in steroid concentrations at life events as reference points for clinical investigations Reviews the genetic disorders of steroids in relation to specific enzyme changes and clinical presentation

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of endocrine pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Endocrine is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.Provides essential knowledge in all areas of endocrine pathology, including thyroid, parathyroid, pituitary, adrenal, paraganglia, pancreas, skin, neuroendocrine neoplasms, and inherited tumor syndromes—more than 150 diagnoses in allOffers a wealth of new information based on recently recognized and discovered endocrine diseases, as well as tumor types with important implications for patient careIncludes new content on thyroid lesions and tumors now associated with DICER1 gene mutations; the correlation of newly characterized genetic abnormalities in endocrine tumors associated with responses to targeted therapies; and newly recognized syndromes, such as multiple endocrine neoplasia type 4 and type 5, glucagon cell hyperplasia and neoplasia, and othersMeticulously edited by Dr. Vania Nosé with contributions from renowned pathologists to ensure that common/classic endocrine diagnoses as well as newly recognized diseases and unusual cases, are well coveredFeatures nearly 2,200 high-quality images in print and online, including clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosisIncludes updated criteria, terminology, and classifications for a wide range of tumors according to the latest literature, including the 2022 WHO Endocrine and Neuroendocrine Tumors classificationEmploys consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of careIncludes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

Now in a revised and expanded third edition, the aims of The Active Female are threefold: first, to increase the awareness of wellness and fitness issues for active females and their family members; second, to provide an avenue for medical practitioners, allied health professionals, health educators/providers, and certified individuals in sports medicine/athletics to gain critical, updated knowledge of a field specific to active females; and third, to introduce the concept of obesity as a growing health concern even for normal weight individuals. Part I of the book offers a foundation for understanding the interrelationships between female physiology, body image and other psychological issues, the female reproductive cycle, and the musculoskeletal anatomy and physiology of females that makes their health risks and concerns unique. In Part II, the concepts of eating disorders from a global perspective and the health disparities and inequities in women's health are discussed in detail. Part III describes the prevention and management of common musculoskeletal injuries in active females across the lifespan, including the management of osteoporosis. Appropriate exercise and nutritional guidelines and recommendations for active females are discussed in detail in Parts IV and V. Part VI is a new addition to the book and highlights the obesity epidemic and co-morbid diseases associated with obesity even for normal weight obese individuals. Each chapter is bookended by clear learning objectives and review questions for additional pedagogical appeal. An invaluable addition to the literature, The Active Female: Health Issues throughout the Lifespan, 3e will be of great interest to all clinicians and allied health care professionals concerned with women's health and related issues, from sports medicine and family practitioners to endocrinologists, gynecologists and orthopedic surgeons.

This book is a must-read to obtain a comprehensive understanding of all aspects of hyperthyroidism, and is a useful practical guide in decision-making in the management of hyperthyroidism as it sheds light on all modalities of treatment such as medicine, nuclear medicine, and surgery, including minimally invasive surgery.

Endocrinology Enables readers to form an integrated understanding of endocrine physiology by examining the mechanisms of action of medical therapies Endocrinology: Pathophysiology to Therapy is a comprehensive resource on medical therapies; in each chapter, the relevant endocrine physiology of the medical therapy is presented, followed by a review of the detailed mechanism of action of selected medical interventions. Where applicable, emphasis is placed on clinical pharmacology pearls, such as side effects and therapeutic monitoring guidelines. Supplementary chapters address additional topics, including immune checkpoint inhibitor-related endocrinopathies, anabolic steroid abuse, pseudo-endocrine conditions, and dynamic tests in clinical endocrinology. Rather than emphasizing guideline-defined treatment protocols, this??book directs attention towards the pathophysiology and fundamental principles of endocrine therapies. Categories of therapies covered in Endocrinology include: Pituitary gland therapies, including Cushing's disease, Acromegaly, Prolactinoma, adult growth hormone insufficiency, central diabetes insipidus, and syndrome of inappropriate ADH secretion Thyroid gland therapies, including Hashimoto's thyroiditis, Graves'Disease, Thyroid Eye Disease, Riedel's thyroiditis, Thyroid hormone resistance, and RSH secreting tumors Adrenal gland therapies, including primary adrenal insufficiency, primary hyperaldosteronism, classic congenital adrenal hyperplasia, and nonclassic congenital adrenal hyperplasia Pancreatic gland therapies, including diabetes mellitus, neuroendocrine tumors, and hypoglycemia syndromes such as somatostatin analogs and calcium channel blockers Discussing the rationale for using various therapies and enabling readers to appreciate complex concepts in a clinically relevant manner, Endocrinology is an essential reference for practitioners in related fields looking for an accessible and comprehensive resource on the subject.

Clinical Obesity in Adults and Children A comprehensive and incisive exploration of obesity in society and the clinical setting In the newly revised Fourth Edition of Clinical Obesity in Adults and Children, a team of expert medical practitioners deliver a comprehensive exploration of the increasingly widespread disease of obesity. The book discusses topics such as the causes of obesity, the disease-model of obesity, the management of adult and childhood obesity, and policy approaches to obesity. Designed to enable readers to better understand the full complexity of obesity — both within society and in the clinical setting — the book discusses a disease that is the leading cause of ill health around the world. The editors have included contributions from leading international experts in their respective fields that address every major aspect of this often misunderstood disease. Readers will also benefit from the inclusion of: Introductions to the history and scale of the obesity problem across the world and its epidemiology and social determinants Comprehensive explorations of those affected by obesity, including fetal and infant origins, genetic causes, bias and stigma encountered by those affected by obesity, and the psychobiology of obesity Practical discussions of obesity as a disease, including its co-morbidities of dyslipidemia, fertility, cardiovascular consequences, and obstructive sleep apnea In-depth examinations of the management of obesity in adults and children, including contemporary approaches to clinical and dietary management, and behavioral treatments Perfect for doctors and allied health professionals who regularly work with patients suffering from obesity, Clinical ;Obesity in Adults and Children will also earn a place in the libraries of health researchers and scholars studying obesity and nutrition, dieticians, nutritionists, and anyone else with a professional interest in an increasingly prevalent health problem.

Falls, fractures, frailty, osteoporosis and sarcopenia are highly prevalent in older persons. While the concept of osteosarcopenia is new, it is a rapidly evolving and cross-disciplinary problem. Prevention and treatment are challenging and a combined therapeutic approach is needed. Osteosarcopenia provides evidence-based information on how to prevent and treat these conditions at multiple settings, including multiple illustrations, care pathways and tips to easily understand the pathophysiology, diagnostic methods and therapeutic approach to these conditions. This work evaluates the potential for a link between osteoporosis, sarcopenia and obesity. Presents diagnostic and therapeutic tips that facilitate the design and implementation of new care pathways, impacting the wellbeing of our older population Provides cross-disciplinary understanding by experts from the bone/osteoporosis field and the muscle/sarcopenia field Covers muscle and bone biology, mesenchymal stem cells, age-related changes and cross-talk between muscle, fat and bone, falls and fracture risk, glucose metabolism, diagnosis, imaging, and genetics of osteosarcopenia

Developed by a renowned group of international authors, this engaging, case-based title once again offers readers a wide range of thought-provoking case studies that reflect contemporary, challenging, hands-on clinical care. Expanded and fully updated, Endocrinology and Diabetes: A Problem Oriented Approach, 2nd Edition addresses the complete range of endocrinologic problems found in patient care, offering the reader a convenient and pointed way to solve clinical problems in a timely manner. Due to its comprehensive coverage and practical focus, this title has developed a special place in the field of endocrinology and will again be of great interest to endocrinologists, diabetologists, internal medicine physicians, family physicians, fellows, and residents. The enthusiastic reception and warm welcome of the first edition of this book was overwhelming and gratifying. Despite many standard texts that cover physiology and clinical aspects of endocrinology, this book found a special place because it focused on patient care and practical aspects of endocrine practice. In the current volume we were fortunate to again have the honor of collaboration by international authors who pride themselves foremost as clinical endocrinologists. We hope our readers will find this updated, improved edition worthwhile, and use it for the benefit of their patients.

This book provides easy-to-understand, scientifically backed answers to readers'questions about hormones, helping them understand the many important roles they play, particularly during adolescence.Especially during the teenage years, people are quick to blame raging hormones for everything from acne to rebellious behavior. But hormones play vital and varied roles throughout our lives, driving such basic processes as growth and metabolism and orchestrating sexual maturation and reproduction. But for many, hormones are mysterious and misunderstood. How much do you really know about hormones, how they affect our health, and how what we do can affect them?Books in Greenwood's Q&A Health Guides series follow a reader-friendly question-and-answer format that anticipates readers'needs and concerns. Prevalent myths and misconceptions are identified and dispelled, and a collection of case studies illustrate key concepts and issues through relatable stories and insightful recommendations. Each book also includes a section on health literacy, equipping teens and young adults with practical tools and strategies for finding, evaluating, and using credible sources of health information both on and off the internet—important skills that contribute to a lifetime of healthy decision making.

While there are some books that include discussions of individual causes of hypercalcemia, there are none that provide basic guidance on the approach, diagnosis and treatment of hypercalcemia, while also offering an in-depth, detailed, state-of-the-art review of the individual causes by world-renowned experts in the field. Topics discussed include pathophysiology, differing diagnostic strategies for both the pediatric and adult patient, the various forms and causes of hypercalcemia as well as current treatment regimens and algorithms. Selected chapters are enhanced with illustrative cases, thereby complementing theoretical matter with real-world applications to the practice of medicine, and tables and figures allow the reader to solidify concepts in an easily digestible format. By integrating an evidence- and guideline-based framework along with an up-to-date, research-based summary of each cause, Hypercalcemia is relevantfor expert clinicians and up-and-coming medical students alike.

Thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology, DeGroot's Endocrinology, 8th Edition, remains the comprehensive, international reference of choice for today's endocrinologists and fellows. A full peer review of the previous edition, conducted by a largely new group of renowned editors, was used to update this trusted, two-volume resource. In-depth coverage of both basic and clinical aspects of endocrinology and up-to-date information on the treatment and management of endocrine disorders are provided by a diverse group of expert contributors from six continents. A full-color format and helpful algorithms summarize clinical decision-making and practical approaches to patient management. Organizes content by all the glands that regulate the endocrine system while integrating basic science and clinical presentations of disease. Includes new chapters: Anatomy and Physiology of the Hypothalmus and Pituitary, Differentiated Thyroid Cancer, Medullary Thyroid Cancer, Drugs that Affect Thyroid Function, Genetic Disorders of the Adrenal Cortex, Adrenal Pathology, Primary Aldosteronism, Transgender Healthcare, Erectile Dysfunction, Prevalence and Causes of Male Infertility, Sexual Dysfunction in the Female, Glucose Toxicity and Oxidative Stress. Emphasizes basic science and evidence-based practice throughout. Features extensive updates to content on thyroid and adrenal disfunction, endocrine-disrupting chemicals and human disease, clinical management of diabetes, and advances in genetics. Includes algorithms to outline effective treatment protocols. Contains new emphasis boxes that highlight key points in each chapter. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

The book offers a comprehensive overview of all parathyroid gland disorders both, benign and malignant. It emphases established concepts, presents the ongoing controversies, challenges and debates on diagnosis and treatment of different parathyroid gland disorders, with a view of clarifying some uncertainties, making suggestions to resolve others, and establishing strategies to reach therapeutic success.In addition to general information on parathyroid gland embryology, surgical anatomy, histology and physiology, the chapters explore hyperparathyroidism, osteitis fibrosa cystica, hypoparathyroidism, hungry bone syndrome, the importance of calcium in the human body and differential diagnosis of hypercalcemia. The last chapters investigate post-thyroidectomy hypocalcemia, thyroid cancer, recent intra-operative localizing tools, and illustrate new techniques of parathyroidectomy, as well as parathyroid transplantation. The book will be an invaluable and indispensable source of knowledge and reference for all specialists and trainees entrusted with the care of patients suffering from parathyroid disease.

Best of Five MCQs for the Endocrinology and Diabetes SCE is a dedicated revision guide designed to assist candidates in preparing for the Endocrinology and Diabetes Specialty Certificate Examination (SCE). It contains 350 best of five questions covering the main themes of the specialty curriculum. The questions mirror the format that the candidates can expect to find in the exam and cover all of the key topics, including pituitary gland and hypothalamus, thyroid gland, parathyroid gland and bone disease, adrenal glands, reproductive endocrinology, and diabetes and lipid metabolism. Explanatory answers include references to the most up to date NICE and international guidelines as well as other literature to enable further reading and study. This second edition has been fully updated, with 20 extra questions added to the diabetes chapter to reflect the new exam weightings. Providing a thorough assessment of the reader's endocrinological knowledge, this is the only revision book candidates will need to pass the Endocrinology and Diabetes Speciality Certification Examination first time.

Comprised of clinical cases of patients with osteoporosis, this concise, practical casebook will provide clinicians with the best real-world strategies to properly diagnose and treat the various elements of the disorder they may encounter. It presents a detailed cross-section of patients across all age groups, with different etiologies of the disease and possible complications, to present sensible management scenarios to physicians treating patients with osteoporosis. The cases presented include considerations for screening and diagnosis, assessment tools, nutrition and lifestyle choices, medical treatments, specific populations including men, the elderly and athletes, and more. Pragmatic and reader-friendly, Osteoporosis: A Clinical Casebook is an excellent resource for primary care providers, endocrinologists, rheumatologists, and other clinicians caring for patients with this disease.

This book delivers comprehensive explanations of normal hormonal physiology during pregnancy and descriptions of the hormonal pathology associated with various endocrine disease states. In addition, it serves as a relevant and synoptic resource for the clinical management of endocrine disorders in pregnancy and the prepartum and postpartum periods. Evaluation and management of endocrine disorders including, but not limited to, diabetes mellitus, thyroid disease, and various endocrine tumors are discussed. It provides readers with a detailed overview in a compact and easy-to-read format. This book serves as essential reading for Endocrinology fellows and Obstetrics and Gynecology residents.KEY FEATURES Explains normal physiology of pregnancy in addition to the physiology, evaluation, and management of endocrine diseases in pregnancy and in the prepartum and postpartum periods Explores from a clinical standpoint with practical applications; useful for students, residents, fellows, mid-level providers, and practicing physicians Discusses special considerations and emerging topics including pregnancy in transgender men, obesity and metabolism, and endocrine emergencies

An ideal resource for both pediatricians and endocrinologists, Sperling's Pediatric Endocrinology, 5th Edition, brings you fully up to date with accelerating research; new discoveries in metabolic, biochemical and molecular mechanisms; and the resulting advances in today's clinical care. The editorial team of world-renowned pediatric endocrinologists led by Dr. Mark Sperling, as well as expert contributing authors, cover comprehensive and current aspects of both basic science and clinical practice. Whether you're preparing for certification or have extensive clinical experience, this detailed, authoritative reference helps you increase your knowledge and determine the best possible course for every patient. Delivers trusted guidance in every area of the field: including Endocrine Disorders of the Newborn, Endocrine Disorders of Childhood and Adolescence, and Laboratory Tests. Features new topics such as transgender issues in children and adolescents and endocrinology of pregnancy, the fetus and the placenta. Offers expert coverage of hot topics such as disorders of sexual development, molecular basis of endocrine disorders, hypoglycemia in newborns and infants; neonatal and other monogenic forms of diabetes; Type I and Type II diabetes and their treatment with new insulins together with the progress in an artificial pancreas and new medications for T2DM in adolescents; the obesity epidemic and role of bariatric surgery; and advances toward personalized medicine. Includes easy-to-follow algorithms and numerous quick-reference tables and boxes in every clinical chapter, plus interactive questions online for self-assessment. Offers state-of-the-art information and fresh perspectives from new and award-winning authors in such areas as disorders of growth, multiple endocrine tumors, and puberty and its disorders in girls and boys.

According to the United Nations, the number of people aged 60 years or over in the world is projected to be 1.4 billion in 2030 and 2.1 billion in 2050. Endocrinologists and other clinicians face the challenge of caring for the elderly. To do so, they need to incorporate geriatric principles into their clinical practice. Endocrinology of Aging: Clinical Aspects in Diagrams and Images presents chapters in a way that allows the reader to incorporate concepts and main facts of complex subjects in a visual way. As the global population becomes older, the need for a deeper understanding of geriatric pathology increases, and with it, the access to educational resources for the endocrinology and metabolism of aging. Chapters divided according to specific endocrine and metabolic systems, providing evidence-based content regarding what is known about the function of endocrine and metabolic systems altered during the aging process Addresses physiological changes that alter the pathophysiology of the clinical picture, explaining the characteristic pathological expressions of hormonal and metabolic disorders in the advanced age Editors and authors are clinical endocrinologists, geriatricians, internists and endocrine surgeons, with extensive global experience in clinical and experimental gerontology Considers the patient transitioning from young adult to elderly, discussing the endocrinological challenge to discern physiology from pathology Focuses on age as an essential factor for diagnostic and endocrine management Includes many pictures and diagrams, making it a user-friendly reference guide for practicing physicians

Hormones and Aging, Volume 115 in the Vitamins and Hormones series, highlights advances in the field, with this new volume presenting timely topics, including hypothalamic aging and hormones, endocannabinoids and aging-inflammation, neuroplasticity, mood and pain, the impact of hormones and bone loss across the menopause transition, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Vitamins and Hormones series Includes the latest information on Hormones and Aging

Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition presents a catalog of fundamental information on the structure and function of hormones from basic biology to clinical use, offering a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors, signaling pathways, and the biological activities they regulate. The book's stellar editorial board, affiliated with the Japan Society for Comparative Endocrinology, brings together authors that present a compelling structure of each hormone with a consistent presentation that provides a primer surrounding the plethora of hormones that now exist. Comparative endocrinology continues to rapidly expand and new information about hormones is being produced almost daily, making it important to stay up-to-date. Hormone, paracrine, and autocrine factors have been identified as key players in a range of different systems, including immune, musculoskeletal and cardiovascular. Frontiers between disciplines are being blurred and many scientists in fields other than endocrinology are interested in hormones. Scientists now have the unprecedented opportunity to look from invertebrates to vertebrate and identify novel regulatory factors and understand their function and how they determine an organism's physiology and survival. Presents hormones in groups according to their origin so that readers can easily understand their inter-relation Includes 47 new hormones, such as neuropeptides, cytokines, growth hormones, biogenic amines and amino acids that are important for cell to cell communication via endocrine, paracrine and neurotransmitter signaling Summarizes the current knowledge of hormone evolution based on comparative genome resources, such as synteny, genome sequence and comprehensive phylogeny Covers a wide range of information on hormones, from basic information on structure and function across vertebrate and invertebrate phyla to clinical applications Collates key information on 259 hormones and 47 groups/families

Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived factor targeting the kidney, look at FGF23 as a regulator of phosphate metabolism and beyond, and cover research on novel concepts of FGF receptor signaling. Additional sections cover biochemistry, pharmacology and nephrology, making this book an ideal reference source on FGF23. Provides a comprehensive collection of chapters on the diversity of FGF23's actions Highlights truly translational topics, from molecular signaling to physiology and mechanism of disease, discussing cell culture and animal models to study FGF23 Describes FGF23's potential in the clinical setting as a biomarker or even drug target Presents leaders in the field who cover a wide spectrum of research backgrounds and expertise, including clinical and basic scientists who specialize in diseases, endocrinology, genetics, protein biochemistry, cell biology and physiology

Now in its third edition, the Oxford Textbook of Endocrinology and Diabetes is an up-to-date, objective and comprehensive text that covers the full scope of endocrinology and diabetes. It contains wide ranging and pragmatic advice on diagnosis and clear guidelines for recommended management, while also covering the scientific principles that underlie the medical practice in this important field. The book has been re-organised into 15 overarching sections, with new sections on Endocrinology of Pregnancy and Management of the Transgender Patient included. All other sections have been extensively updated and restructured. Each chapter is written by an internationally acknowledged expert, relates basic science to evidence based guidelines and clinical management, and where appropriate offers an outline of the controversies in the subject. The textbook has an international focus and deals with subject matter applicable across the globe. The new edition has over 800 images complementing the extensive text and information provided. The book is a'one-stop'text for trainees and consultants in Endocrinology and Diabetes, residents, those preparing for sub-specialty exams and other professionals allied to the area who need to gain an understanding of the field. It acts as both a point of reference for the experienced consultant as well as a trusted training resource. Purchase of the print work also includes full access to the online edition of the textbook for the life of the edition.

Written by leading international specialists, this book provides a comprehensive, state-of-the-art overview of endocrine-based female reproductive disorders. Particularly focusing on the Hypothalamus – Pituitary – Ovary (HPO) axis as the main driver of reproduction in women, it discusses amenorrhea; chronic anovulation and polycystic ovary syndrome as the most common dysfunctions of the HPO axis; endocrine diseases as possible impacts on the HPO axis; uterine disorders related to estrogen/progesterone; and the impact of endometriosis and uterine fibroids on reproduction. It also addresses infertility and menopause as hormone-related disorders in women and endocrine changes during pregnancy and lactation, and in breast disorders. The book is intended as a major reference for endocrinologists, gynecologists, and obstetricians, as well as basic and clinical scientists. It is published as part of the SpringerReference program, which provides access to live editions constantly updated through a dynamic peer-review publishing process.

This book provides a complete review of multiple metabolic disorders and the use of phytochemicals for their prevention and treatment. When describing each metabolic disorder, all authors describe de main health alterations, providing the most current figures and statistics worldwide; medicinal plants used in traditional medicine for its treatment and scientific information related to their potential to prevent or treat each condition. Authors also include a complete scientific background check, complete analysis of all phytochemicals recommended for each disorder, a description of the mechanism(s) of action and in vivo and/or in vitro studies. Within this volume, a series of 3 plant species, recommended to treat or prevent the previously described disorders, are presented with their botanical information, traditional use in different cultures and countries, and the available scientific information validating their health benefits. Besides six main metabolic disorders are described, providing a full scientific background for its general understanding, and three study cases are presented, where metabolic disorders are analyzed and approached from different medical and pharmaceutical angles.

This volume is designed to provide an understanding of current and potential therapies for osteoporosis. The opening chapter introduces the cells of bone and their interactions. Several following chapters describe factors affecting bone including systemic hormones with significant effects on bone, and local mediators including growth factors, prostaglandins, cytokines and chemokines. Topics that have commanded particular attention recently are calcium, FGF-23, nervous system bone interactions. Drugs that cause bone loss provide important information on mechanism as well as therapeutic considerations. An overview of the genetics of bone disorders and a discussion of the pathophysiology of osteoporosis establish the clinical context. The final chapters discuss current and potential osteoporosis treatments.

This reference work provides comprehensive information about diabetic nephropathy. Chapters in the book introduce the reader to the link between diabetes, obesity and chronic kidney disease (CKD) and delve into many topics relevant to treating kidney disease in diabetic patients. These topics include CKD epidemiology, diagnosis, treatment considerations for the elderly patient, post-transplant diabetes, pathophysiology, biomarkers and much more. Special topics such as the incidence of cardiovascular disease in diabetic CKD, nutrition for obese CKD patients and the clinical use of biomarkers for evaluating cases are also included. The broad spectrum coverage of informative topics about diabetic kidney disease make this an essential reference for medical students and clinical residents/healthcare professionals in nephrology, endocrinology, geriatrics, internal medicine and general surgery. Researchers interested in the clinical biochemistry of diabetes and associated disorders will also benefit from the information presented.

Completely revised and updated, and utilizing the most current evidence and practice guidelines for the treatment of osteoporosis, this comprehensive third edition discusses the basic aspects of bone metabolism, the pathophysiology of osteoporosis, current diagnostic techniques and medical treatment strategies. Osteoporosis is a common disorder that is prevalent in over 20 million Americans over the age of 60. One and a half million osteoporotic fractures occur in the United States every year, including 300,000 hip fractures. Mortality rates after hip fracture approach 25%, with another 50% of patients experiencing a major decrease in their prior level of independence and quality of life. Despite the wide prevalence and severe consequences of osteoporosis, it remains a disorder that is severely under-diagnosed and treated. In this context, specialists and primary care physicians alike are having increasing difficulty keeping up with the rapid changes to the field and incorporating these advances to clinical care.In the years since the last edition of this book was published, the osteoporosis field has changed drastically. In addition to revising and updating existing chapters and removing a few that are no longer as relevant, new chapters discuss an advanced understanding of the cellular and molecular mechanisms underlying the disorder, the introduction of new diagnostic imaging techniques, a more nuanced appreciation of the risks and benefits of osteoporosis therapies, and the introduction of two new classes of osteoporosis medications. Following the format of the second edition, and including helpful key points at the opening of each chapter, this text will present a comprehensive overview of both the basic and clinical concepts relating to each topic, when appropriate. Chapter authors were chosen based on their high level of expertise and leadership in the field. Taken together, this text should thus be of great interest to physicians of multiple specialties, allied health professionals, as well as basic and clinical researchers.

This book represents a comprehensive, clinically oriented text covering all aspects of male osteoporosis, from the basic concepts of bone physiology and regulation of bone remodeling in men, the causes and pathophysiological mechanisms responsible for the most frequent causes of osteoporosis, to diagnostic and screening protocols, as well as prevention and treatment approaches. It offers a broad overview of male osteoporosis by specialists involved in research and clinical practice and discusses the practical issues encountered. Filling a gap in the literature, this volume is a valuable resource for general practitioners, clinical endocrinologists, geriatricians and experts in osteoporosis.

Now in its fully revised and expanded third edition, this comprehensive text represents a compilation of the critical endocrinology topics in the areas of sports medicine, kinesiology and exercise science, written by leading experts in the field. As in previous editions, the focus here is on the critical issues involved in understanding human endocrinology and hormonal workings with regards to physical activity, exercise and sport and how such workings impact the full range of medical conditions, overall health and physiological adaptation. Chapters included discuss the effect of exercise on the HPA axis, the GH-IGF-1 axis, thyroid function, diabetes, and the male and female reproductive systems, among other topics. Additional chapters present the current evidence on circadian endocrine physiology, exercise in older adults, exercise and hormone regulation in weight control, and the effects of overtraining in sports. Chapters brand new to this edition present the role of hormones in muscle hypertrophy, the effect of exercise on hormones in metabolic syndrome patients, how exercise impacts appetite-regulating hormones in clinical populations, and the relative energy deficiency in sport (RED-S) condition.

The aim of this book is to focus on the bone and mineral disorders. The new knowledge in the field of bone and mineral metabolism and bone disorders has expanded vastly in the past 25 years. Mineral and bone disorder in CKD occurs when damaged kidneys and abnormal hormone levels cause calcium and phosphorus levels in a person's blood to be out of balance. Mineral and bone disorder commonly occurs in people with CKD and affects most people with kidney failure receiving dialysis. This book consists of 12 chapters, which include skeletal and mineral homeostasis, nutritional aspects of calcium and vitamin D, disorders of phosphorus metabolism, rickets and osteomalacia, parathyroid hormone independent hypercalcemia, primary hyperparathyroidism in the Indian context, hypocalcemic disorders, diagnosis of osteoporosis, management of osteoporosis, and anabolic agents for treatment of osteoporosis. Discovery of novel mechanisms involved in bone resorption through osteoclasts and bone formation through osteoblasts, has allowed the development of effective therapeutic agents for osteoporosis, resulting in reduction of fracture risk and reduced mortality. This book will provide a strong basis for basic understanding of bone and mineral physiology and treatment for disease states.

This work offers a comprehensive reference guide to help clinicians in the field of Internal Medicine addressing common aspects of endocrinological disorders in their daily practice. The exponential growth in our knowledge of biomedicine calls for continuous multidisciplinary approaches across specialists and disciplines. In this volume, recognized experts in each given area explore the complex mechanisms linking endocrinological disorders to abnormalities of the cardiovascular system, kidney, liver and gastrointestinal tract, autoimmune, neuro-psychiatric, rheumatic, and dermatologic diseases. Aspects connected to critically ill and elderly patients are examined as well, helping to enhance daily interactions with the most fragile populations observed in clinical medicine. The individual chapters are designed to deliver timely information while explaining pathophysiological mechanisms with the help of figures, flow-charts, and updated guidelines. The book offers a unique and valuable resource for all clinicians, residents, specialists, and physicians involved daily in the management of complex and multidisciplinary systemic diseases.

The seventh edition of Brook's Clinical Pediatric Endocrinology has been compiled by an experienced editorial team and internationally renowned contributors; it presents basic science and clinical management of endocrine disorders for all involved in the care of children and adolescents. It provides treatments for a variety of hormonal diseases, including diabetes and hypoglycaemia, growth problems, thyroid disease and disorders of puberty, sexual differentiation, calcium metabolism, steroid metabolism and hypopituitarism.

Written in clear, accessible language for not only those living with diabetes, but caregivers, and medical professionals as well, this work will prove invaluable information to the more than 1.5 million people who are diagnosed with diabetes each year.

Epidemiology of Thyroid Disorders provides comprehensive, clinical knowledge to professionals dealing with thyroid disorders. The book focuses on the pathophysiology of thyroid disorders, the prevalence and incidence of various diseases, and their prevention. This focused analysis on thyroid disorders raises awareness of this global problem that, once diagnosed or misdiagnosed, can sometimes lead to over-treatment and cardiovascular complications, especially in the elderly. This succinct, targeted reference gives the reader excellent information on the epidemiology of global thyroid disorders, as well as up-to-date treatment data and a special focus on prevention. Serves as a starting point for medical professionals, addressing the patterns, risk factors, prevention, and treatment of thyroid disorders around the world Discusses the prevalence of thyroid disorders around the world, covering disability and cost burden Covers recent trends, technologies and advancements in the management of thyroid diseases

Glucocrinology is defined as the relationship between the endocrine system and glucose metabolism. Importantly, it not only examines the physiological and pathophysiological role of the entire endocrine system on glucose metabolism by summarizing the most important mechanisms of action of all the hormones, but also explors the effect of glucose metabolism on the endocrine system in a bidirectional way (regulatory circles). This book comprised of 4 sections that include the scope of glucocrinology, glucovigilance in endocrinology, endovigilance in diabetes, and specific issues in glucocrinology, which are further divided into 22 chapters. The structured layout of the book discusses each gland, covering its impact on glucose physiology, and its bidirectional relationship with diabetes, metabolic syndrome and hypoglycemia. The need for endocrine pharmacovigilance, and important topics such as bone and reproductive health are given special attention. Wall structured sections explain the concept of glucocrinology in a basic and beautiful manner, making it easy to understand for the endocrinologist and non-endocrinologist alike.

Up-to-date and evidence-based, Updates on Treatment and Management of Endocrinopathies [correct title?] provides an overview of recent developments regarding the most prevalent endocrine disorders. A concise, easy-to-read reference for endocrinologists and endocrine surgeons, this timely reference includes an overview of each disorder as well as diagnosis, management, treatment, prognosis, and a summary by a renowned expert who has contributed to the most current literature. Addresses endocrine diseases of the thyroid, parathyroid, and adrenal glands as well as familial endocrine syndromes: multiple endocrine neoplasia type 1 and 2 (MEN). Includes both surgical and nonsurgical treatments. Consolidates today's available information on this timely topic into one convenient resource.

This book is devoted exclusively to hyper- and hypoparathyroidism with a focus on clinical practice guidelines explained by experts in the field. The clinical, genetic, biochemical, and pharmacological aspects of the most common parathyroid conditions are discussed comprehensively. The 15 chapters review the various forms of hyperparathyroidism and hypoparathyroidism and present data derived from widely diverse sources. New therapeutic approaches for chronic hypoparathyroidism continue to pique interest in parathyroid diseases and show that more research must be done to optimize care. The aim of this book is to serve as a practical guide to clinical management of common parathyroid conditions and to disseminate knowledge useful to the clinic, both for specialists and general practitioners. Also, under- and postgraduates, specialist nurses, and non-experts in the field will find this book to be a valuable source of current information.

Maternal-Fetal and Neonatal Endocrinology: Physiology, Pathophysiology, and Clinical Management systematically examines the normal and abnormal endocrinology of the pregnant and lactating female and of the fetus and neonate. This reference volume expands coverage of specific disorders and diseases beyond the current endocrinology content on the market, which in most cases has a paragraph or no mention at all about pregnancy or aspects of fetal/neonatal development. Formalized source of maternal/fetal endocrine physiology and pathophysiology Key reference for fellows and residents for rarer endocrine pathologies Integrated presentation of new molecular and genetic causes of endocrine disorders Bridges the experience/knowledge gap of endocrinopathies rarely encountered in pregnancy

This book provides a comprehensive guide for nurses practicing in any area of endocrinology and at any level of expertise. Endocrinology Nursing is a fast-developing specialty with nurses performing advanced roles and expanding their practice to run independent nurse-led services. Supported by the European Society of Endocrinology (ESE) and edited by members of the ESE Nurses Working Group, this is the first book ever published specifically for endocrine nurses. It is also an excellent resource for endocrinology specialty trainees, general practitioners, medical and nursing students, expert patients and nurses working in specialties such as fertility, osteoporosis, oncology, obesity, urology and gynaecology, who look after patients with endocrine-related disorders. This volume includes 13 sections and 69 chapters providing a comprehensive overview of adult and paediatric endocrinology but also a section on advanced practice, role development and nursing research. It has been written by an international team of more than 100 eminent nurses, physicians, surgeons, psychologists and other healthcare professionals, which makes this book a valuable resource for any multidisciplinary team. Many patient advocacy groups have contributed with case studies which emphasises the close working relationships with patients.

This comprehensive book examines the complex interplay between endocrine and kidney disorders, and how this inter-relationship impacts patients with chronic kidney disease. Authored by experts in areas of endocrinology and nephrology, chapters cover a variety of topics, including diabetes, metabolic syndrome, thyroid dysfunction, gonadal disorders, dyslipidemia, mineral bone disorders, obesity, and pituitary disorders. These comorbidities are thoroughly examined and provide the clinician, researcher, and trainee with a greater understanding of the impact of endocrine disorders on kidney disease patients, the ability to identify persistent gaps in knowledge for future investigation, and move closer towards the goal of improving the health and survival of the chronic kidney disease population.

Ortner's Identification of Pathological Conditions in Human Skeletal Remains, Third Edition, provides an integrated and comprehensive treatment of the pathological conditions that affect the human skeleton. As ancient skeletal remains can reveal a treasure trove of information to the modern orthopedist, pathologist, forensic anthropologist, and radiologist, this book presents a timely resource. Beautifully illustrated with over 1,100 photographs and drawings, it provides an essential text and material on bone pathology, thus helping improve the diagnostic ability of those interested in human dry bone pathology. Presents a comprehensive review of the skeletal diseases encountered in archaeological human remains Includes more than 1100 photographs and line drawings illustrating skeletal diseases, including both microscopic and gross features Based on extensive research on skeletal paleopathology in many countries Reviews important theoretical issues on how to interpret evidence of skeletal disease in archaeological human populations