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The material in this monograph was obtained by the authors in years of research carried out at Kursk State Medical University, Russia. This original, evidence-based research studied the behavior and effects of peptide hormones (melanocortins) and corticosteroids on the excitability and interaction of brain structures. Multiple objective indicators of brain functioning were recorded, taking into account behavioral, motor and visceral manifestations; stereotactic technique, electroencephalography, electrocardiography, electromyography, neuropharmacological and structural-functional analysis were used. The mechanisms of hormonal influence on integrative brain activity that ensure the selection and maintenance of biologically adequate behavior and adaptation have been established. Due to the findings of this research, this book explores the origin of mental disorders in diseases of the pituitary and adrenal glands and during hormonal therapy, and to substantiate the purposeful synthesis of active oligopeptides as new drugs. The book will be of use to physiologists, pathophysiologists, endocrinologists, neuropathologists, psychiatrists, university students, and doctors taking upgrading courses.

A state-of-the-art and concise resource presenting the clinical management of pediatric endocrine diseases and disorders, this third edition of the highly regarded textbook covers the most common and challenging conditions seen by practicing endocrinologists and primary care physicians, including growth, hypothalamic, pituitary, adrenal, thyroid, calcium and bone, and reproductive disorders, as well as metabolic syndromes. This expanded third edition includes new topics such as conditions of overgrowth, low bone density and its management, endocrine issues related to sexual identity, mineralocorticoid disorders and endocrine hypertension, and endocrine emergencies. Some existing chapters are expanded to take into account recent advances in the field. Each chapter contains key points, an introductory discussion of the problem, a review of the clinical features that characterize it, the criteria needed to establish a diagnosis, and a comprehensive therapy section delineating the risksand benefits of the best therapeutic options available. New to this edition are concluding sections in each chapter containing relevant case material and multiple choice review questions. Pediatric Endocrinology: A Practical Clinical Guide, Third Edition is a comprehensive resource for all clinicians concerned with the myriad endocrinologic disorders seen in children and adolescents.

Pediatric endocrinology has made great advances in the nearly thirty years since the last edition of this text in 1965. Genetics has become a most important field in understanding endocrine disorders, and cytogenetics and molecular genetics continuously reveal the finer aspects of genetic regulation. The descriptional aspects of growth and pubertal development have made tremendous progress, and more and more of the regulation of growth and puberty is understood. Immunology and the biologies have significantly increased the understanding of the pathophysiology of endocrine disorders and have added greatly to our therapeutic armamentarium. All of these aspects, as well as technical aspects such as imaging technics, are fully covered in the present new edition. Over thirty experts in their respective endocrine specialties have contributed to this edition. They have included many clinical descriptions that will be helpful to pediatricians, pediatric en-docrinologists, housestaff, and students. The organization of the book into text and illustration (atlas) components has been retained. In this way the theoretical aspects and clinical aspects of endocrine disorders are fully retained. In summary, the book covers much wider aspects of pediatric endocrinology and neighboring fields than any other book in pediatric endocrinology and still keeps the original flavor of the clinical teacher, Lawson Wilkins.