Search

Memory impairment due to aging and various memory disorders represent a great medical challenge to our society. Since the publication of the fifth volume of this collection, the rapid progress in the research fields of Alzheimer's disease (AD) and other types of dementias continues through the intense efforts of research scientists worldwide. This sixth volume contains eight chapters, bringing together a presentation of scientific frontiers in current AD/dementia research. The topics include a discussion on impairments in dementias, memory binding in AD, therapeutic targeting of BACE1 and neprilysin, Tau Immunotherapy, targeting 5-lipoxygenase targets for tauopathy, potential therapeutics for frontotemporal dementia, potential therapeutics for Down's syndrome, and cognitive rehabilitation in multiple sclerosis. Research advances in these areas are presented and discussed in great detail in the chapters. The book will be highly valuable to students and scientists worldwide who are interested in the scientific research and progress in AD and memory disorders. more...

This collection of articles focuses on areas of general medicine which are presented to clinicians at all levels in the profession. Some of the subjects discussed include; vitamin B12 deficiency, viral meningitis, acute altitude illnesses, assessment and management of alcohol use disorders and paracetamol poisoning, non-cardiovascular effects associated with statins and Guillain-Barre syndrome. Some of the other medical issues discussed include managing health problems in people with intellectual disabilities and adults with Down's syndrome and issues relating to sickle cell disease. more...

Understanding Kidney Diseases makes accessible a medical specialty that is commonly regarded by students as difficult. The target audience is undergraduate and non-specialist postgraduate students. The book is unique in combining the reference material normally found in a nephrology textbook with the everyday clinical applicability of a medical handbook. The chapters are structured on the approach that a clinician should take when assessing someone with a possible kidney problem. The factual content is brought to life by over 60 case studies and is illustrated by a high density of figures, many displaying information in a graphical form that avoids off-putting data and text. It is an authored book, written in a consistent style that is deliberately clear, concise and easy to follow. Nonetheless, it is referenced in as much detail as would be expected in a conventional textbook. It explains principles and concepts that help students understand and interpret clinical problems. No other textbook of nephrology combines these features. The book emphasises a patient-centred approach to practice. Students'knowledge can be put it into practice by answering a bank of questions that patients frequently ask, and tested against traditional multiple-choice questions. In summary, Understanding Kidney Diseases gives students confidence in helping someone with a kidney problem. Praised by leading nephrologists, it is the book the authors wish they could have read when they were students. more...

​This book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silico approaches for modern drug repositioning, including signature matching, molecular docking, genome-wide associated studies, and network-based approaches aided by artificial intelligence. Further, the book presents various computational and experimental strategies for better understanding disease mechanisms and identify repurposed drug candidates for personalized pharmacotherapy. It also explores the databases for drug repositioning, summarizes the approaches taken for drug repositioning, and highlights and compares their characteristics and challenges. Towards the end, the book discusses challenges and limitations encountered in computational drug repositioning. more...

Diseases of the heart are the leading cause of death in the Western world. Health professionals and the general public alike eagerly watch advances in the prevention, diagnosis, and treatment of heart disease. Yet the more spectacular aspects of medical progress in the field are often reported prematurely and their potential benefits exaggerated. Written in clear, accessible language, this book presents an authoritative and balanced picture of how heart diseases are recognized and managed. From his many years of experience, Dr. Selzer believes a well-informed patient can cooperate more successfully with a physician, and his book includes information vital to anyone confronting heart problems and cardiac emergencies. This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1992. more...

Introduction to Communication Disorders explores the fields of speech-language pathology and audiology using an evidence-based lifespan perspective. It presents recent advances in the assessment and treatment of communication disorders in a highly readable manner. Each chapter is concise, yet comprehensive, striking a just-right balance of information appropriate for undergraduate-level students. You'll gain a foundation in the areas of anatomy and physiology of speech and hearing, and an overview of the various disorders that affect voice, fluency, articulation, language, cognition, swallowing and hearing across the lifespan. The 7th Edition features a new case-based approach; hundreds of new sources; first-hand perspectives from speech-language pathologists and audiologists; and more. more...

Das Buch für die Kinder- und Jugendmedizin und die Neurologie dient den Behandelnden dazu, ihre Kenntnisse zu erweitern und sensibilisiert sie für transitionsmedizinische Fragen. Die Autoren stellen die entwicklungspsychologischen, versicherungsmedizinischen, soziologischen und ethischen Grundlagen der Herausforderungen dar, die die Transitionsmedizin aufwirft. Aus Sicht von Experten und Betroffenen werden konkrete Forderungen für den Übergang der Kinder und Jugendlichen in die medizinische Erwachsenenwelt formuliert. Das Buch zeigt Wege auf, wie sich der Lebenszyklus des Patienten mit einer chronisch-neurologischen Erkrankung in seiner Versorgung optimieren lässt. more...

Common Pediatric Diseases: An Updated Review informs the reader about common diseases in children that are encountered by pediatricians and family physicians. Each of the 14 chapters in the volume presents updated information for readers with the aim to give them a current perspective on the topic. This book is a handy and practical compendium for medical students and healthcare professionals involved in general practice and pediatric clinics.The text starts with a quick introduction to pediatric diseases, before progressing towards specific diseases in children. The list of topics in this book includes pediatric rheumatological diseases, common oral diseases, pediatric metabolic syndromes, pediatric epilepsy syndromes, pediatric demyelinating disorder, genetic epileptic encephalopathies (with an algorithmic diagnostic approach), Henoch-Sch amp;amp;ouml;nlein purpura, atopic dermatitis, childhood-onset systemic lupus erythematosus, Severe Combined Immunodeficiency, PFAPA, aphthous stomatitis, pharyngitis, cervical adenitis syndrome and pediatric hepatoblastoma.[Series Intro]Updates on Pediatric Health and Disease is a comprehensive series of books on infant and adolescent health and diseases. The series features volumes that update readers on current understanding in basic information and advanced clinical practice in pediatric medicine. Neonatology as well as different diseases in all subspecialties of pediatrics, including allergy and immunology, cardiology, endocrinology, gastroenterology, hematology, infectious diseases, nephrology, oncology, pulmonology, rheumatology, neurology, psychiatry and dermatology are represented in each volume. more...

Biomarkers in Medicine is a comprehensive guide to understanding the current and future status of biomarkers. The book features 27 chapters focusing on disease biomarkers for diseases such as cancer, neurodegenerative diseases, cardiac diseases, metabolic conditions and much more.This book supplies readers with the unique insight of experts in multiple specialties in medicine and life sciences who have extensive experience in diagnostics and clinical laboratories. The book includes case studies and practical examples from different classes of biomarkers on different platforms, including new data for biomarkers in different therapeutic indications. In addition to presenting biomarker information, each chapter covers the relevant pathology and also emphasizes on preclinical and clinical manifestation of the disease process.Clinicians managing patients or clinical trials, clinical researchers, clinical laboratories, diagnostic companies, regulatory agencies, medical school graduate students, academic students, and the general public involved in healthcare delivery will all benefit from information presented in this book. more...

Bringing together professional and lived experience, this collection of expert voices frames dementia practice with an occupational justice lens. It provides a focus for learning and development in practice for occupational therapists and allied health workers working in dementia care, incorporating the voice of people living with dementia. more...

This book examines the process of cure discovery and the economic impact of cures across varying diseases. It is the first time anyone has attempted to examine the [economic] returns across a wide spectrum of disease categories, using a common frame of reference. more...

This book offers a comprehensive review of the most common infectious diseases that affect the nervous system. Written by international experts, it provides a guide to clinicians for accurately diagnosing and treating these challenging syndromes. Organized into six sections, the book presents didactic, up-to-date information on the following topics relating to central nervous system (CNS) infections: diagnosis and evaluation of the patient, bacterial, viral, fungal and mycobacterial infections, disorders of the spinal cord, and a myriad of miscellaneous infections. Chapters specifically reflect and look to resolve the common obstacles clinicians face in the field, such as having unknown etiologies on the majority of CNS infections, insensitive and slow microbiological techniques, an increasing number of immunosuppressed individuals with atypical presentations and pathogens, and a lack of standardized diagnostic algorithms. A complex yet accessible addition to the Current Clinical Neurology Series, Neurological Complications of Infectious Diseases invaluably examines a wide range of infections that have neurological complications and sequelae. more...

As the comprehensive textbooks of Dermatology grow longer and more specialized, there is a need for a text to cut the subject back to the essentials a medical professional needs to know. This concise text from an internationally respected editor presents the most important points about the most significant topics in disease of the skin, hair, and nails; any medical professional will find here the material for a solid grounding in the subject.•Covers the range of dermatology in a consistently manageable level of detail •Answers the need for a reliable concise guide for medical professionals in all specialties •Offers a straightforward and approachable synopsis of the subject more...

In this edition, we have introduced four new chapters—skin and systemic diseases and cutaneous malignancies, psychodermatoses, primary immunodeficiency disorders and skin, and principles of vaccination in immunosuppressed children. The topic of ‘patient/parents'education and counseling'has been elaborated further. About 100 new entities and 1000 new illustrations have been added to it. The ‘Suggested Reading'has been added and the ‘Index'has been updated. Altogether, a new set of quotable quotes cater to more than 500 pages of the book. more...

The word Adolescence is derived from the Latin word Adolescere. It means to grow or to mature. There are very conspicuous physical and mental changes at this age in the boys and girls. These normal physical and mental changes sometimes get abnormal or subnormal diversions, which may need help of parents or health worker to get through. Such subnormal changes are experienced in girls often frequently than boys. The common health issues faced by the girls are menstrual disorders, anemia, polycystic ovarian disease (PCOD), psychosocial problems, sexual problems and many more. Also there are many conditions or diseases in the girls which can affect the future fertility of a girl in various forms, if not taken care at right time. She may face infertility, abortions, premature deliveries, intrauterine growth restriction (IUGR), intrauterine death (IUD) or other complications in pregnancy. This book is all about the diseases or disorders which can affect the future fertility of an adolescent girl. more...

Browse's Introduction to the Symptoms & Signs of Surgical Disease is essential reading for all medical students learning the fundamentals of history taking and patient examination, when undertaking a surgical rotation, when preparing for their surgical exams and as they transition to postgraduate studies. Maintaining the engaging and readable style so central to Sir Norman Browse's early editions, the sixth edition of this classic text retains all the features beloved by generations of students while being fully revised and updated throughout in line with current surgical practice.Key Features: Current – fully revised and updated Accessible – highly structured and consistent layout, supplemented by tables and revision panels for rapid reference in the pressured run up to qualifying exams Beautifully illustrated – packed with an unrivalled collection of colour photographs and explanatory line diagrams, refreshed for this new edition Expert editors – with a wealth of clinical and teaching experience, supported by contributors new to this edition bringing a fresh approach Companion website – visit www.routledge.com/cw/gossage for digital resources to supplement this textbook including self-assessment material, video animations and an image library Now supplemented by online resources for the complete learning and revision package, this sixth edition remains indispensable for the clinical years of undergraduate study to postgraduate surgical training and beyond. more...

Aluminium is a chemical element present in earth's crust and it is a known environmental toxin which has been found to be associated with various neurological disorders. Aluminium has been found to be a very strong risk factor for the development of Alzheimer's disease. Biochemical Mechanisms of Aluminium Induced Neurological Disorders explains the association of aluminium with neurological disorders. The book introduces the reader to sources of aluminium exposure, followed by an explanation of pharmacokinetics of aluminium and the different biochemical pathways that cause neurological effects. Chapters cover the typical mechanisms associated with aluminium neurotoxicity such as synaptic impairment as well as recent topics of interest such as the role of aluminum in impairing blood-brain barrier functions. Separate chapters which cover clinical evidence of aluminium toxicity and its management are also included in the book. Biochemical Mechanisms of Aluminium Induced Neurological Disorders is a concise, yet informative reference on the subject of aluminium neurotoxicity for all readers, whether they are students of biochemistry, pharmacology and toxicology, clinical neurologists, environmentalists interested in metal pollution or general readers who want to learn about the toxic effects of aluminium in humans. more...

Recent developments in diagnostic and therapeutic aspects of cardiac and neonatal issues have advanced the care of the newborn. In order to achieve excellence in cardiac care, however, close interaction and collaboration of the pediatric cardiologists with neonatologists, pediatricians, general/family practitioners (who care for children), anesthesiologists, cardiac surgeons, pediatric cardiac intensivists, and other subspecialty pediatricians is mandatory. This book provides the reader with up-to-date, evidence-based information in three major areas of neonatology and prenatal and neonatal cardiology. First, it offers an overview of advances in the disciplines of neonatology, prenatal and neonatal cardiology, and neonatal cardiac surgery in making early diagnosis and offering treatment options. Secondly, it presents a multidisciplinary approach to managing infants with congenital heart defects. Finally, it provides evidence-based therapeutic approaches to successfully treat the fetus and the newborn with important neonatal issues and congenital cardiac lesions.This second volume specifically explores issues related to individual cardiac defects, cardiomyopathies, and hypertension and presents a summary and conclusions of both volumes. more...

A primary concern of rare disease diagnosis is the lack of accurate information that may lead to delayed interventions, administering inaccurate treatments, and social consequences. Health communication continues to be one-way and rely on the expertise from the health practitioner. In such a broad spectrum of rare diseases, patients may find it difficult to obtain timely information, accurate diagnosis, and appropriate treatments, surgeries, medications, or psychological counseling in their own countries. The use of information and communication technologies can create new communication channels that address this lack of knowledge. Communicating Rare Diseases and Disorders in the Digital Age is an essential reference source that uses computer-mediated communication to improve patient knowledge when afflicted or dealing with rare health conditions. Featuring research on topics such as support networking, eHealth management, and social computing, this book is ideally designed for health practitioners, physicians, patients, medical administrators, nurses, surgeons, infectious disease educators, hospital directors, world health organizations, academicians, students, and researchers seeking coverage on current advances in health communication, computer science, and epidemiology. more...

This book provides a unique tool for approaching cranio-vertebral junction (CVJ) surgery. Following a brief introduction to the relevant anatomy and biomechanics of CVJ, it explores the field of cranio-vertebral junction lesions and their management. Furthermore, individual chapters cover endovascular surgery, endoscopic skull base techniques, navigation and robotics, ensuring that surgeons stay up-to-date. A chapter addressing the consequences of CVJ surgery with regard to sagittal balance is of particular importance. The book is structured according both to the type of lesion involving the CVJ (tumor, trauma), and to the type of surgical approach (anterior, posterior). Further, it reflects innovative treatment modalities that have improved patient safety and efficacy rates for surgery involving the CVJ, and covers both open and minimally invasive surgical methods, enabling surgeons to hone their skills in both areas. more...

This volume provides a state-of-the-art review of the key aspects of HBV. It covers our current understanding of the HBV genome and lifecycle, liver-enriched factors in the regulation of HBV transcription and translation, HBV protein structures and biological functions, and the immunology and pathogenesis of HBV. It also provides an update on cell and animal models, as well as molecular approaches. The respective chapters also cover the clinical management of hepatitis B and discuss future research directions, in particular, the identification of molecular targets for pharmacological intervention. Given its scope, the book offers a valuable resource for students, researchers, clinicians, and health practitioners in the fields of virology, infectious disease, public health etc. Dr Hong Tang is a Professor and Director of the Center of Infectious Diseases, West China Hospital of Sichuan University. more...

Best-selling book by subject specialist. Thoroughly updated with all recent questions. Includes new AIIMS pattern questions. Updated with NIMHANS 2019 questions. Based on Kaplan's and Sadock's Comprehensive Textbook of Psychiatry, 9th edition and Short Oxford Textbook of Psychiatry, 6th edition. Fully updated with International Classification of Diseases- 11 (ICD-11). Updated with recently asked topics like mental health care act. Concise theory. Genuine questions with explanations. Controversial questions fully explained. Includes Image-based questions. Written in a simple and easy-to-understand language. Latest questions with explained referenced answers. more...

This well-illustrated book covers the full range of lung and pleural diseases from the pathologic standpoint. It has been updated from the first edition by including the most recent molecular data for the different lung diseases, tumor as well as non-tumor ones. New diagnostic tests are included, new aspects for the understanding of diseases have been added. Both diseases of adults and pediatric lung diseases are presented. The chapter on lung development has been expanded due to the many new findings being reported since the first edition.The book will serve as an excellent guide to the diagnosis of these diseases, but in addition it explains the disease mechanisms and etiology. Genetics and molecular biology are also discussed whenever necessary for a full understanding. The author is an internationally recognized expert who runs courses on lung and pleural pathology attended by participants from all over the world. In compiling this book, he has drawn on more than 30 years'experience in the field. more...

This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress. more...

This book is an ideal reference guide for clinicians seeking to improve their decision making and treatment outcomes when placing dental implants in medically compromised patients, in whom conditions for osseointegration and soft tissue healing may be unfavorable. Up-to-date information is provided on the potential impacts of a wide variety of diseases and disorders on dental implant treatment and the factors that need to be considered when deciding on the feasibility of such treatment. More specifically, for each condition possible disease-related changes in the oral environment are explained and key treatment issues are identified, including surgical and prosthodontic aspects and pharmacological considerations. The book will help general dentists, periodontists, and oral surgeons to reduce the risk of treatment failure and complications and to ensure that the implant therapy is successful in achieving excellent quality of life and functional benefits, thereby improving patient satisfaction. more...

Once thought uncommon, cases of Hashimoto's thyroiditis are becoming much more commonplace through the increasing use of needle biopsy and serologic tests for antibodies that have led to much more frequent recognition. It is currently one of the most common thyroid disorders with the possibility that it may be increasing in frequency. As diagnostic methods improve, it is imperative that quick treatments are administered to improve the quality of life of patients. Diagnosing and Managing Hashimoto's Disease: Emerging Research and Opportunities is an essential publication that provides critical reference material for diagnosing and treating Hashimoto's Disease in a clinical environment. Featuring research on topics such as spontaneous hypothyroidism, papillary thyroid carcinoma, and differential diagnosis, this publication is ideally designed for clinicians, therapists, doctors, nurses, hospital administrators, researchers, educators, academicians, and students looking for the most up-to-date research on treating Hashimoto's Disease. more...

Join'Mr. Aluminum,'a scientist who has made the study of aluminum his life's work, on a journey of discovery, reflection, and the science of aluminum. Professor Christopher Exley is a firm believer that science is only useful when it is properly communicated. Scientific papers are difficult vehicles for the wider communication of science and thus he has always endeavored to tell the story of his scientific research as widely as possible through myriad blogs, presentations, and interviews. Through a series of easy-reading entries written for non-scientists, Exley will educate readers about his lifelong scientific passion: aluminum. In scientific circles, aluminum—in relation to human health specifically—has gone the way of the dinosaurs (though, unlike dinosaurs, there has not yet been a popular revival!). Yet aluminum is also the greatest untold story of science. But why do we all need to know a little bit more about aluminum? Do we need a self-help guide for living in what Exley has coined'The Aluminum Age'? What is it about aluminum that makes it different? What about iron, copper, or any of the so-called'heavy metals,'like mercury, cadmium, or lead? Why must we pay particular attention to aluminum? Because its bio-geochemistry, its natural history, raises two red flags immediately and simultaneously. These two danger signals are easily missed by all of us and easily dismissed by those whose interests are conflicted by aluminum's omnipresence in human life and consequently, are purposely blind to its danger signals. First, aluminum, in all of its myriad forms, is super abundant; it is the third most abundant element (after oxygen and silicon) of the Earth's crust. Second, aluminum is super reactive; it is both chemically and biologically reactive. However, these two red flags identify a paradox, as the abundant and biologically reactive aluminum has no biological function either in any organism today nor in any extinct biota from the evolutionary past. This means in practical terms that when we encounter aluminum in our everyday lives, our bodies only see aluminum as an impostor, something foreign, and something for which we have not been prepared through biochemical evolution. This in turn means that all of our encounters with aluminium are adventitious, random, and chaotic. And potentially dangerous. Imagine You Are An Aluminum Atom: Discussions With'Mr. Aluminum'examines the science of aluminum and human health and makes them understandable to all. Within the science you will find personal recollections of events, as well as opinions and reflections upon how the politics of aluminum have influenced and interfered with doing and reporting the science. It is at once both a personal recollection of Exley's life in aluminum research and a guide on the dangers of the constant exposure to aluminum we as humans face during this'Aluminum Age.'It will inform, it will provide the means to question the science, and it will, if the reader is prepared to participate, answer those frequently asked questions on aluminum and human health. more...

This book provides a comprehensive guide for nurses practicing in any area of endocrinology and at any level of expertise. Endocrinology Nursing is a fast-developing specialty with nurses performing advanced roles and expanding their practice to run independent nurse-led services. Supported by the European Society of Endocrinology (ESE) and edited by members of the ESE Nurses Working Group, this is the first book ever published specifically for endocrine nurses. It is also an excellent resource for endocrinology specialty trainees, general practitioners, medical and nursing students, expert patients and nurses working in specialties such as fertility, osteoporosis, oncology, obesity, urology and gynaecology, who look after patients with endocrine-related disorders. This volume includes 13 sections and 69 chapters providing a comprehensive overview of adult and paediatric endocrinology but also a section on advanced practice, role development and nursing research. It has been written by an international team of more than 100 eminent nurses, physicians, surgeons, psychologists and other healthcare professionals, which makes this book a valuable resource for any multidisciplinary team. Many patient advocacy groups have contributed with case studies which emphasises the close working relationships with patients. more...

This book presents up-to-date, practically oriented information on major topics in acute hepatitis. The coverage encompasses epidemiology; diagnosis, including molecular methods; treatment and challenges; and the management of co-infections. The book opens by examining the local and global epidemiology of acute hepatitis. Detailed attention is then paid to each of acute hepatitis A, acute hepatitis B, acute hepatitis C, hepatitis D co-infection, and hepatitis E. Acute Hepatitis will be of high value for general practitioners and specialists in gastroenterology, infectious diseases, and internal medicine. It will be international in scope in terms of both authorship and appeal. more...

• All chapters are adequately covered, revised and updated within a concise volume. • Inclusion of large numbers of clinical and radiographic photographs and several photomicrographs of important cases is the hallmark feature of this edition. • Simple and lucid language for easy understanding. • Concise and comprehensive presentation of each topic will be helpful for both undergraduate and postgraduate students. • Latest classifications of oral diseases, recent grading and staging system of tumors have been added. • New chapters like Diseases of Temporomandibular Joint, Syndromes Related to Oral Diseases, and Important Classification of Oral Diseases have been added. • Relevant Key Points and important Text Boxes have been provided in every chapter wherever required for last minute revision. • Several diagrams, tables and flowcharts have been provided to help students understand the subject better. more...

Identify interventions to plan, individualize, and document care. Here's the resource you'll turn to again and again to select the appropriate diagnosis and to plan, individualize, and document care for more than 850 diseases and disorders. Only in the Nursing Diagnosis Manual will you find for each diagnosis…defining characteristics presented subjectively and objectively • sample clinical applications to ensure you have selected the appropriate diagnose • prioritized action/interventions with rationales • a documentation section, and much more! more...

This book is the first to provide balanced examination of both pediatric liver disease and liver transplantation – two topics that are inherently related, given that most chronic liver disorders eventually require organ replacement. The different forms of liver disease encountered in the pediatric age group are first discussed in a series of disease-specific chapters that have a reader-friendly, uniform structure covering pathophysiology, diagnostic and treatment algorithms, clinical cases, and transition to adult care. Key topics in the field of liver transplantation are then addressed. Examples include indications and contraindications, surgical techniques and complications, immunosuppression, in pediatric liver transplantation, acute and chronic rejection and allograft dysfunction, and CMV and EBV infection in transplant recipients, long-term graft injury and tolerance. A section on pediatric hepatology across the world includes chapters presenting the features and management of pediatric liver disease in South-America, Africa and Asia. A closing section considers what the future holds for pediatric liver disease and its management, including novel genetic testing, cell therapy and gene therapy. Pediatric Hepatology and Liver Transplantation will be of value for a range of practitioners, from residents making their first approach to pediatric liver disease through to specialists working in transplantation centers. more...

For as much as we know about DNA and gene expression, many more mysteries remain to be solved. Epigenetics and epigenomics seek to study heritable modifications in gene expression that do not involve underlying DNA sequences to further human health changes. Examining the Causal Relationship Between Genes, Epigenetics, and Human Health provides innovative research methods and applications of chemical activation or deactivation of genes without altering the original DNA sequence. While highlighting topics including gene expression, personalized medicine, and public policy, this book is ideal for researchers, geneticists, biologists, medical professionals, students, and academics seeking current research on the expanding fields of genomics, epigenomics, proteomics, pharmacogenomics, and genome-wide association studies. more...

Pregnancy complicated by diabetes is a medical challenge that can be minimized through a program of expert protocols and patient partnerships. This newly revised edition presents a complete package of these protocols that can help produce healthy infants in pregnancies complicated by type 1, type 2, and gestational diabetes. Topics include: --Pre and Inter-pregnancy counceling, assessment, and management --Contraception in diabetes and prediabetes --Nutrition management of preexisting diabetes --Risk assessment, fetal surveillance and delivery in prenancies complicated by diabetes --Neonatal care of infants of mothers with diabetes --Management of gestational diabetes --Diagnostic testing and fetal surveillance --Use of insulin in pregnancy and assessment of glycemic control --Postpartum concerns for women with diabetes more...

Written with enthusiasm and creativity, the text centers not only on increasing fluency but also on the therapeutic journey by describing goals, principles, and techniques for assessment counseling and ongoing management. It will benefit graduate students who are beginning their comprehensive study of fluency disorders, as well as professional clinicians expanding their knowledge of this specialty area. This text provides clinical insights to assist people who stutter with their ability to communicate and enhance their quality of life. more...

This exciting new book explores the dark side of the molecular protein assembly bringing an updated view of how failures in the homeostatic mechanisms that efficiently regulate protein folding leads to the accumulation of structurally abnormal pathogenic assemblies, encompassing an emerging group of diseases collectively known as'Protein Folding Disorders.'This complex and diverse group of chronic and progressive entities are bridged together by their relationship to structural transitions in the native state of specific proteinaceous components, which for reasons poorly understood, convert into polymeric aggregates that generate poorly soluble tissue deposits and which are considered today the culprit of the disease pathogenesis in their respective diseases. Despite the diversity in the amino acid sequence of the different proteins involved in these heterogeneous disorders, all the pathologic conformers can trigger cascades of events ultimately resulting in cell dysfunction and death with devastating clinical consequences in many of the most precious aspects of human existence including personality, cognition, memory, and skilled movements.This book, which is composed of a compilation of chapters authored by outstanding and well-published scientists in the respective fields currently performing active investigations at world renowned universities and research centers, focuses on the growing number of diseases associated with protein misfolding in the central nervous system. Individual chapters are dedicated to the most common neurodegenerative diseases associated with protein aggregation/fibrillization focusing on the nature of the pathogenic species and the cellular pathways involved in the molecular pathogenesis of Alzheimer's, Parkinson's, and Huntington's diseases as well as in Amyotrophic Lateral Sclerosis, and Prion disorders. A group of contributions is centered on the current knowledge of the intracellular pathways and subcellular organelles affected by the different disease conditions, while others are focused in the emerging pathogenic role of misfolded subunits assembled into neurotoxic soluble oligomers, and in the novel notion of the transmissibility of the protein misfolded species, an innovative concept until recently only accepted for Prion diseases. Lastly, a different set of chapters is dedicated to the evaluation of novel therapeutic strategies for these devastating diseases. more...

• The contemporary definitive textbook represents ear, nose, throat, head and neck surgery in all its diversity and targets the medical students, residents and practitioners • Significant addition to the contents as well as clinical highlights offer advanced information and guidelines for the clinical practice • Includes instructive boxes, tables, flow charts, line digrams and photographs to enhance learning • Contains chapter on anatomy of neck, thyroid and parathyroid; bacteria and antibiotics; fungi and viruses; diagnostic imaging, including CT anatomy of ENT; and anesthesia • Clinical highlights for quick revision, especially prepared for answering frequently asked MCQs (PGME, USMLE and PLAB), short-answer questions and oral/viva questions • Appendix having top 101 clinical secrets, problem-oriented clinical cases and miscellaneous key points • Chapters reviewed by many professors of various medical colleges of India. more...

Throughout history, humans have consumed wheat simply to obtain energy from its starch and protein. In recent years, however, additional health-related benefits to wheat consumption have been discovered. In Advances in Health and Disease. Volume 7, the authors open by presenting the results of a randomized clinical trial that show wheat intake improves cognition. The trial was initiated based on the results showing that wheat supplementation improves memory in rodent models of Alzheimer's disease and vascular dementia. Next, this collection reviews the most recent findings regarding to colorectal cancer risk factors. Colorectal cancer onset is related to mutations in specific genes whose etiology may vary. According to the origin of those mutations, risk factors of colorectal cancer can be divided into modifiable and non-modifiable. Keratoconus, the most common corneal ectasia, is also discussed. It is usually diagnosed during puberty with most of the diagnoses being between 10 and 20 years old, and men tend to be more affected than women. Current studies show that keratoconus has a multifactorial origin mixing genetic and environmental influence. Following this, the authors propose that strength training in youth needs to carefully consider specific needs, goals and interests of the pediatric population along with their physical and psychological uniqueness. Additionally, key characteristics of strength training for children and adolescents at various maturational stages are described, along with information on practical implementation in different settings. This collection also analyzes several publications on microcirculation disorders in diabetes mellitus (DM) which restrict the introduction of methods for noninvasive assessing microcirculation in clinical practice. Ways to increase the diagnostic significance of Laser Doppler Flowmetry for non-invasive assessment of microcirculation in patients with DM are discussed. Several protocols were developed in the early and middle 19th century in order to modulate the shape of the iris or to create scar tissue at the cone in order to treat keratoconus. However, the authors propose that the first major revolution in the surgical management of these patients came with keratoplasty, as previous interventions showed unreliable and contradictory results and were gradually abandoned. In conclusion, the authors discuss Rosmarinus officinalis, commonly known as rosemary, a woody, perennial herb with evergreen, needle-like fragrant leaves and white, pink, purple, or blue flowers, native to the Mediterranean region. Rosemary extracts are used in food additives; and in traditional medicine, they have been observed to contain anti-tumor, antimicrobial and antioxidant activities. more...

Oxford Desk Reference: Endocrinology provides easy access to evidence-based materials for quick consultation but also provides an in-depth expert reference for clinical practice. It covers the process of diagnosis, investigation, and management, as well as information for patients. Internationally-renowned experts have brought together evidence, guidelines and their clinical expertise to put trustworthy support at your fingertips. The vast spectrum of endocrine disorders are clearly laid out in self-contained topics for easy reference. Chapters build bridges between pathogenesis, clinical presentation, differential diagnosis and investigation to aid understanding. Careful consideration is given to establishing a diagnosis including the recognition, investigation and management of the rarer diagnoses. The practical treatment of everyday endocrine disorders and the management of life-long conditions are outlined in clear protocols. Chapters are organised by endocrine glands, disorders and syndromes and there are sections on the involvement of hormones in other specialities including endocrine oncology. The continuity from childhood to adolescent and adult endocrinology as well as the needs of older patients is explored in specific sections. Dedicated chapters cover the important roles endocrine specialist nurses play in patient management, and dietetic advice. The editors have included a wealth of practical resources including: · A speedy reference section, which provides summaries and quick direction · A patient advice and reference section, which supports face-to-face discussion with patients · A medicolegal chapter, which outlines risk and DVLA regulations Oxford Desk Reference: Endocrinology is the ideal companion for consultants, registrars associate specialists and clinical assistants as well as those from other disciplines who share endocrine clinics including endocrine surgeons, oncologists, gynaecologists and paediatricians. more...

Although the vast majority of diabetes cases (type 1 and type 2) are polygenic diseases, research, funded by the American Diabetes Association, has found that some forms of diabetes, distinct from type 1 or type 2 diabetes, are caused by single gene mutations. It has been estimated that these monogenic forms of diabetes account for up to five percent of all diabetes cases. In addition to monogenic diabetes, there are other atypical causes of diabetes, including: genetic defects in insulin action; diseases of the exocrine pancreas; and endocrinopathies. Given recent advances in our understanding of sub-types of diabetes, the time has come for a book on how to correctly diagnose and treat patients with atypical forms of this disorder. The book will be divided into three parts, each exploring distinct categories of atypical diabetes. Part I: Monogenic Diabetes: Genetic Defects of β-cell development and function; Part II: Insulin resistance, genetic defects in insulin action, and diseases of exocrine pancreas; Part III: Endocrinopathies, Immune-mediated diabetes, Diabetes of Unknown cause, and Other genetic syndromes sometimes associated with diabetes. more...

• Thoroughly revised and updated chapters. • Includes latest evidence of newer anti-diabetic drugs, recently available gadgets. • Contains information regarding latest clinical trials. • Includes a few new chapters including Non-Alcoholic Fatty Liver Disease in Diabetes. • Incorporates more practical examples, clinical pictures and diagrammatic illustrations for better understanding of the reader. more...

This guide to communication disorders blends the format of a dictionary with the contents of a textbook and clinical reference book. With this guide, both the students and the professional clinicians may have, at their fingertips, a single, invaluable resource on the encyclopedic knowledge of the entire range of communication disorders, epidemiology and ethnocultural factors, symptomatology, onset and development, etiological factors, and major theoretical concepts of their profession. more...

Jabbed demonstrates that the medical procedure hailed as the greatest medical advancement in history—vaccines—is a racket run by criminals and gullible believers who have replaced vaccine science with the religion of vaccinology. Vaccine marketers teach believers to fear, shame, and scapegoat anyone foolish enough to question the sanctity of vaccines. Such an environment is not the domain of science; rather it's the breeding ground of tyranny.Jabbed exposes this tyranny. From polio and smallpox to medical journals, medical curricula, congressional hearings, regulatory policies, White House statements, and executive orders, Jabbed shines light on the dark underbelly of Big Pharma, Big Medicine, and Big Government.A vaccine informed public is the only thing that will have the power to stop vaccine industry sociopaths and to hold them accountable for their crimes.Jabbed informs and immunizes against three of the most dangerous epidemics in history: tyranny, greed, and corruption. Once immunized, the growing vaccine-informed community will have the power to stand up and dismantle the vaccine paradigm and program and to punish the perpetrators of what may well be the greatest medical fraud ever perpetrated on the human race: vaccines. more...

This classic text on paediatric neurology is now in its fourth edition. Leading academics from around the world present evidence from their various areas of expertise, placing it firmly in the clinical context. Each chapter covers the basic science of the disorder and relevant genetic advances. New to this edition are chapters on fetal neurology, movement disorders, basal ganglia disease and psychogenic disorders. References at the end of each chapter are thorough, guiding the clinician to relevant further reading. The international team of editors has maintained the clinical approach of the late Jean Aicardi, which distinguishes this book from others in the field. Succinctly given, patient-focused information makes Aicardi's Diseases of Nervous System in Childhood a comprehensive yet readable resource for busy clinicians in paediatric neurology, general paediatrics, neurodisability and all the related medical disciplines. more...

This book provides the reader with comprehensive information on the epidemiology, etiology, pathogenesis, pathophysiology, clinical features, prevention, and treatment of diabetes with the aim of empowering health care providers in their daily battle against the disease. Diabetes has been identified by WHO and the United Nations as a medical emergency because of the increase in its global prevalence, which may reach one billion in three to four decades if the trend remains unchanged. Despite improved care that is helping to prolong life, diabetes impacts substantially on the quality of life of those affected and kills or disables several million people each year. The disease is systemic because all organs, tissues, and cells suffer in the presence of hyperglycemia and are damaged by the diabetic milieu. Unfortunately, most patients with diabetes will consequently experience chronic diabetic complications. This book, combining basic science with a practical clinical orientation, willbe of value for all physicians and nurses who care for patients with diabetes. more...

THE DEFINITIVE GUIDE TO INPATIENT MEDICINE, UPDATED AND EXPANDED FOR A NEW GENERATION OF STUDENTS AND PRACTITIONERS A long-awaited update to the acclaimed Saint-Frances Guides, the Saint-Chopra Guide to Inpatient Medicine is the definitive practical manual for learning and practicing inpatient medicine. Its end-to-end coverage of the specialty focuses on both commonly encountered problems and best practices for navigating them, all in a portable and user-friendly format. Composed of lists, flowcharts, and'hot key'clinical insights based on the authors'decades of experience, the Saint-Chopra Guide ushers clinicians through common clinical scenarios from admission to differential diagnosis and clinical plan. It will be an invaluable addition -- and safety net -- to the repertoire of trainees, clinicians, and practicing hospitalists at any stage of their career. more...

This book includes real-time photographical recording and panoramic summary of 105 cases with oral mucosal diseases along with their diagnosis and management. This book reflects the characteristic clinical manifestations through images of each case presented. In addition to the medical history, examination, diagnosis, pathology and management of each case, a comprehensive commentary is introduced in the end of each chapter with an emphasis on the normative clinical train of thoughts and guidelines. more...

The Oxford Handbook of Rheumatology, 4th edition has been fully reviewed and updated to make it into an invaluable guide for students, trainees, consultant rheumatologists, and everyone caring for patients with musculoskeletal disease. With the addition of a paediatric rheumatologist to the editor team, this new edition is a fully functional rheumatology handbook for patients from childhood to adulthood. Practically structured, the handbook focuses first on presenting symptoms and then considers key diseases, emergencies, and rare diseases in detail. There is a comprehensive and updated account of assessment, guidelines, and treatment options. The text has been condensed with bullet points and summary boxes so the reader can focus on the essential information. To aid understanding over half of the images have been updated and the colour plate section has been expanded. Taking a clinical, evidence-based approach, written by experts, and presented in a clear, practical, bullet-point style for rapid reference, this handbook will be your constant companion and a joy to use. more...

The brain is a masterpiece that defines your uniqueness. As you age, though, your brain may be susceptible to a terrible disease. Alzheimer's disease is the most common cause of dementia among older adults. It is considered an irreversible, progressive brain disorder that slowly erases memories and thinking, and eventually eliminates the ability to carry out the simplest of tasks. Alzheimer's disease may rank third, just behind heart disease and cancer, as the leading cause of death for elderly people. Medical science continues to make progress in the search for therapeutic interventions and a cure. Since 1983, hundreds of Alzheimer's-related patents have been granted by the United States Patent and Trademark Office in an effort to eradicate this deadly disease. To better understand these inventions, Michael J. Dochniak has written this book to provide an easy-to-read, brief summary of such patents. Within the summaries are inventor profiles and news articles that are insightful and relevant. Impactful inventors include a Nobel laureate, a soldier and an ex-convict. Pioneering inventors include George Glenner, Barbara Cordell, Birinder Boveja, Joseph Buxbaum, Dale Schenk and Vivian Hook. At the beginning of several chapters, you will experience a personal story about Alzheimer's disease. Most importantly, the book this novel is about keeping your brain healthy as you age. more...

Today, an increasing number of healthcare professionals (including nurses, midwives and members of many allied professions) have to conduct the vital first stage in a patient's journey – taking a clinical history and conducting an effective physical examination. This book offers clear, practical guidance on the fundamentals of clinical examination for any practitioner who wishes to understand their patient's specific needs and to plan appropriate care. Recognising that readers will come from a diverse range of clinical backgrounds and roles, the opening chapter (on consultation and the skills needed to take an accurate clinical history) underpins the systems-based approach. This, combined with the use of case study examples, allows healthcare professionals to focus on the principles of examining the system or systems that are most relevant to their specific area of practice. The book also includes a helpful glossary and list of abbreviations. This new, updated edition contains revised chapters on genitourinary assessment, obstetric assessment and mental health assessment. There is also a completely new chapter on eye, ear, nose and throat assessment, covering the EENT conditions most commonly encountered in primary healthcare. more...