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This book serves as a reference work on pediatric HIV infection and covers the full bandwidth of topics from an introduction to pathogenesis and epidemiology, over the transmission of the HI virus, to clinical manifestations, treatment, and prevention strategies. Diseases and disorders occurring in HIV infected persons are discussed in detail. The book covers special populations, such as neonates born to an HIV positive mother and adolescents and examines the specific ways of managing HIV disease in these patient groups. This is the first book to cover palliative care as well as ethical, legal and social issues of HIV infection.

In its updated and expanded second edition, this helpful guide offers a wealth of information for people living with HIV and for people caring for HIV-positive loved ones. All aspects of HIV/AIDS are discussed, including opportunistic and associated infections, dental care, exercise and nutrition, substance use and abuse and emotional treatment. New information will help the newly diagnosed adjust to their illness and long-term survivors to improve their quality of life. Up-to-date discussion of the latest medications covers the growing practice of using HIV drugs as preventatives. Essential Internet resources are provided that help patients live a longer, healthier life.

This edited volume presents a detailed portrait of couples living with mixed HIV status, where one partner is HIV-positive and the other negative. Readers will come to understand the various and complex ways in which these mixed-status, or serodiscordant couples build a life together within the shadow of HIV-related stigma. Spanning the globe, coverage explores serodiscordance as a negotiated practice and process, inseparable from the social context in which it is situated. The book shows how couples draw on diverse and sometimes contradictory cultural discourses of medicine, romance, and “normality” to make sense of and manage their mixed HIV status and any perceived risks, not uncommonly in ways that depart from prevailing HIV prevention messages. Throughout, compelling personal stories accompany the empirical research, sharing the firsthand experiences of men and women in serodiscordant relationships. Bringing together research from diverse disciplines and geographical regions, this book contributes important insights for future HIV health promotion as well as offers new knowledge to scholarship on the cultural intersections of illness and intimacy. It will appeal to a broad audience working across the fields of HIV, health, gender, sexuality, development, and human rights.

This book presents the history of HIV/AIDS in China, which over the last three decades has been a gripping tale of exclusion and fear, and then, by turns, of involuntary tragedy, cautious experimentation and finally vigorous response. It discusses the occurrence, development and epidemic studies and also introduces China's policies and measures to conquer this epidemic, offering readers valuable insights into China's approach to prevention in this field.

Frontiers in Clinical Drug Research – HIV is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of acquired immune deficiency syndrome (AIDS) and other

Frontiers in Clinical Drug Research – HIV is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of acquired immune deficiency syndrome (AIDS) and other

The book focuses on HIV/AIDS prevention and treatment strategies in resource-poor settings. Contributors include HIV/AIDS researchers and public health administrators from the US, Africa, China, and Thailand. Several chapters, written by local health officials, take a close look at AIDS prevention and treatment in China at the community level. Other chapters cover issues of treatment scale-up, drug resistance, and mother-to-child transmission in Southern Africa and Thailand, and offer lessons learned for researchers in other developing countries. Overall the aim of this book is to bring some of the latest issues to the fore, and to foster exchange and collaboration between AIDS researchers in developing countries. This book grew out of an annual conference held in China and organized by the Harvard School of Public Health, and could possibly become the first volume of a series.

Handbook of HIV Medicine provides a concise guide to all aspects of HIV management in the context of sub-Saharan Africa. Contributing author: F Venter

The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus qualify for disability benefits. In this report, the Institute of Medicine (IOM) makes several recommendations for improving SSA's capacity for determining disability benefits more accurately and quickly using the HIV Infection Listings.

Dendritic cells play the most vital part in inducing anti-viral immune responses in HIV and AIDS among many other viruses. Research on dendritic cells (DCs) is emerging as a fundamental aspect for the comprehension of the mechanisms underlying the pathogenesis of viral diseases as well as for the progress on the development of prophylactic and therapeutic vaccines. This volume focuses on the role of DCs in the pathogenesis and immunity of HIV-1 infection. It has recently been clarified that DCs are important targets and reservoirs of HIV and may play an important role in virus spreading to T cells. Interestingly, HIV can exploit many of the cellular processes responsible for the generation and regulation of the adaptive immune responses to gain access to its main target cells, i.e. the CD4+ T lymphocytes. Thus, the central role of DCs in stimulating T cell activation not only provides a route for viral transmission, but also represents a vulnerable point at which HIV-1 can interfere with the initiation of primary T cell immunity. Recent studies have revealed that several HIV proteins can profoundly influence the phenotype and functions of DCs even in the absence of a productive infection, often resulting in an abnormal immune response. While this knowledge has resulted in the identification of some major mechanisms involved in the pathogenesis of HIV-1 infection, the recent progress on DC biology has opened perspectives in the research on new adjuvants (selectively acting on DCs) and on novel strategies for the in vivo targeting of antigens to DCs, which appear to be highly relevant for the development of HIV vaccines. Of note, defects in the number and functions of DCs have been observed in the course of HIV infection and during disease progression, thus suggesting that DCs play an important role in the immune control of viral replication and virus-induced dysfunctions. The development of therapeutic vaccination strategies to be combined with HAART is thought as an important step for an effective control of HIV infection in patients. In this context, the use of autologous DCs may represent an attracting strategy. Notably, DCs are now regarded as a valuable approach for the development of cancer vaccines and several clinical trials have explored the efficacy of different DC preparations as cellular adjuvants in inducing a potentially protective immune response. Recent data in animal models provide the background for the clinical testing of DC-based vaccines in HIV-1-infected patients. Now that we start to understand the complex interactions between HIV and DCs in the pathogenesis of AIDS and we are learning how to prepare potentially effective DCs from lessons on cancer vaccines, we may reasonably assume that DC-based therapeutic vaccines can represent a topic of increasing interest in protocols of clinical immunotherapy of HIV-1-infected patients.

Forty years ago, the age-old battle against infectious diseases as a major threat to human health was believed close to being won. However, by the late twentieth century, the increase of emerging and reemerging infectious diseases was evident in both low and high income countries. About 30 new infectious diseases have been identified in the last 20 years. Among the'new'diseases, and most importantly, the Human Immunodeficiency Virus (HIV) epidemic, with 40 million persons infected and 25 million deaths since its first description, presents one of the most significant health, societal and security challenges facing the global community. The interaction of HIV/AIDS with tuberculosis, malaria and bacterial infections have increased HIV-related morbidity and mortality, and in turn, the HIV pandemic has brought about devastating increases in tuberculosis. Understanding the population impact and the dynamics of infection diseases in the most affected region is critical to efforts to reduce the morbidity and mortality of such infections, and for decisions on where to use limited resources in the fight against infections. This book aims to contribute to these efforts by offering a demographic and epidemiological perspective on emerging and reemerging infections in sub-Saharan Africa.

In June 1981, the Centers for Disease Control and Prevention reported the first evidence of a new disease that would later become known as Acquired Immunodeficiency Syndrome (AIDS). HIV and AIDS: Basic Elements and Priorities is a concise collection of all aspects of this disease, and is a source of readily available knowledge. All currently advocated preventive measures such as health education, condom use, safer sex practices, and treatment of sexually transmitted infections have been incorporated. The key elements of this volume are: - up-to-date information on multiple dimensions of the HIV/AIDS epidemic, - discusses new anti–retroviral therapy / drugs, new drugs under clinical trials and preventive HIV vaccine, - covers current ethical, legal and social issues related to HIV/AIDS, - evaluates general public awareness about HIV/AIDS, - includes a global perspective and information about HIV/AIDS. This volume is an excellent reference for science graduates and post graduates, medical students, research scholars and scientists across the world. This book is recommended by the World Health Organization Eastern Mediterranean Region Office (WHO-EMRO) as a basic resource for medical faculty libraries.

A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world.

Based on the current care guidelines from the CDC and elsewhere, this book addresses the current emphasis on managing the side effects of HIV/AIDS such as lypodystrophy, redistribution of body fat, cardiac risks, and vulnerability to other ailments. Combining the latest medical advice with the ideas of hundreds of people living with HIV/AIDS, the book is particularly helpful for friends, family members, and others who make up the support network for anyone struggling with HIV/AIDS.

AIDS and Development in Africa: A Social Science Perspective is the first book-length treatment of both the impact of AIDS in Africa and an assessment of intervention strategies in varying cultural situations. Developed from revised selected papers from the nineteenth Southern African Universities Social Science Conference, AIDS and Development in Africa will be of interest to counselors, medical and development practitioners, Africanists, and AIDS researchers. From this book, you will find wide analytical coverage of the issues and country case studies related to the contributory factors and development impact of the HIV/AIDS pandemic in Africa. You will also explore the ability of countries to willingly promote and cope with the pandemic in the context of their different economic circumstances.Specifically in AIDS and Development in Africa, you will read about: socioeconomic context of AIDS social scientific explanations of the AIDS pandemic in Africa HIV/AIDS and the status of women in Botswana and Swaziland sexual abuse and HIV/AIDS law and HIV/AIDS orphans of the AIDS pandemic media and the African context of social construction human resource development and training in relation to HIV/AIDS in ZambiaAIDS and Development in Africa uses a multidisciplinary social science perspective in case studies of such countries as Botswana, Swaziland, Zimbabwe, South Africa, Malawi, and Zambia to reveal contributory factors and the developmental impact of HIV/AIDS in Africa. This book demonstrates the human consequences of AIDS and the efforts being made by governments, individuals, families, villages, communities, and national government organizations to respond to the pandemic. For example, you will learn about information campaigns and peer education approaches that are successfully increasing transmission awareness and condom use. You will read beyond the usual analysis of demographics and receive much more substantial assessments and analyses of the burden on people, economies, and health care systems of the African countries. AIDS and Development in Africa is indispensable to anyone who is involved with HIV/AIDS prevention/intervention in Africa. This comprehensive book provides you with essential and up-to-date research on the many issues surrounding Africa's HIV/AIDS pandemic.