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The Heart in Systemic Autoimmune Diseases, Second Edition, provides an overview on our current understanding of major complications relating to the heart and autoimmune diseases. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations of these important comortbidities. Mortality in autoimmune diseases, in particular, rheumatoid arthritis and SLE, has increased when compared with the general population. This excess mortality is largely due to cardiovascular diseases (CVDs)-particularly those of atherosclerotic origin, such as ischemic heart disease-and is gaining recognition in all branches of medicine, from cardiology, to internal medicine, and from rheumatologists to orthopedics. - Presents an impressive body of well ordered information on the topic of cardiovascular diseases and their relationship to autoimmune illness - Highlights key references - Summarizes the experience of a selected panel of distinguished physician-scientists who are actively involved in the field of cardiovascular disease and systemic autoimmunity

This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed in this compilation include a review on the optimization of the formulations of metronidazole through a different administration route; the use of metronidazole in cancer gene therapy and targeted cell ablation; protective roles of glutathione peroxidases in diabetes; stem cell disorders and bone marrow transplantation; catalase gene mutant mice; what animal models of inflammatory arthritis teach us about bone damage; methylprednisolone use in autoimmune diseases; the clinical use of methylprednisolone in oncology; how pretreatment with methylprednisolone reduces adverse clinical effects of inflammatory response induced by heart surgery and cardiopulmonary bypass; and the potential side effects of methylprednisolone.