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Clinical information about Hepatitis C is quickly outdated, so Dr. Poordad has assembled expert authors to provide state-of-the-art clinjcal reviews for hepatologists. This issue is uniquely organized to present articles based on therapeutic regimens for certain types of patients: Regimens for the Treatment-Naïve Patient; Regimens for Treatment of the Interferon-Failure Patient; Regimens for DAA Failure Patients; Regimens for the Cirrhotic Patient; Regimens for the Peri-Transplant Patient; Regimens for the HIV-Co-Infected Patient; and Next-generation Regimens: The Future of HCV Therapy. This presentation will be very clinically relevant for the practicing hepatologist.

Written by leading experts from all across the globe, this comprehensive yet concise textbook offers up-to-date summary in the field of Obesity and its Surgical Management for a wide range of healthcare professionals involved within a Bariatric Multidisciplinary Team including Surgeons, Dieticians, Metabolic Physicians, Anaesthesiologists, Psychologists, Psychiatrists, Radiologists and Nursing staff. The book also serves as a reference manual for General Physicians, General Surgeons & General Practitioners.

Effectively apply the latest techniques and approaches with complete updates throughout including 4 new sections (Abdominal Imaging, The Spine, Oncological Imaging, and Interventional Radiology) and 28 brand new chapters. Gain the fresh perspective of two new editors—Jonathan Gillard and Cornelia Schaefer-Prokop -- eight new section editors -- Michael Maher, Andrew Grainger, Philip O'Connor, Rolf Jager, Vicky Goh, Catherine Owens, Anna Maria Belli, Michael Lee -- and 135 new contributors. Stay current with the latest developments in imaging techniques such as CT, MR, ultrasound, and coverage of hot topics such as: Image guided biopsy and ablation techniques and Functional and molecular imaging. Solve even your toughest diagnostic challenges with guidance from nearly 4,000 outstanding illustrations. Quickly grasp the fundamentals you need to know through a more concise, streamlined format.

Human Ageing: A Unique Experience explores the biology of human ageing focusing on the individual. The book begins with the premature ageing disorder Hutchinson-Gilford Progeria syndrome and spins a web of interconnected biological domains involving lamins, telomeres, alternative splicing, genetics, epigenetics, and molecular clocks. The profound influence of culture is explored since cultural inheritance and genetic inheritance are the two intertwined processes driving human evolution. An empirical framework is developed to describe human ageing at the individual level and the implications of this framework on the whole concept of diseases are discussed.

This text book has been received enthusiastically by the medical profession since its first publication in the year 2002.The book is primarily targeted to diabetologists, endocrinologists and physicians involved in diabetes care. The third edition of the book is a fully revised edition, incorporating all newer advances on the subject. The book contains 94 chapters covering basic physiology, ethiopathology, epidemiology, genetics and immunology of diabetes. The clinical sections include clinical profile, management of diabetes and its complications. The last sections cover diabetes at different phases of life, living with diabetes and diabetes healthcare delivery. The last chapter gives an extensive insight into the shape of things to come in the near future. Above contents include comprehensive accounts of each subject and are written with great accuracy and lucidity. Although the previous editions focused on the diabetes in the developing world, the present edition has shifted its focus to whole world, thus enhancing the utility of the book to the readers anywhere. This book is expected to fulfill a vital role in promoting the understanding of diabetes.

Hepatocellular carcinoma (HCC) is the most common disease in the primary malignant tumor of the liver. It is considered that the therapy for HCC is very troublesome because most of the HCC occur from the injured liver such as chronic hepatitis or cirrhosis. If the patients with HCC receive proper therapy for their stage of HCC and liver function, a long survival is expected. In this book, the up-to-date contents of etiology, diagnosis techniques, and various kinds of therapies for HCC are described. This book is very helpful for the medical staff that takes care of the patients with HCC. The contents of this book include precise descriptions of the following: i) the etiology and epidemiology of HCC, ii) the diagnosis technique of CT and MRI, and the indications and results of the treatments, i.e., iii) radiofrequency ablation, iv) molecular-targeted therapy, v) surgical resection, vi) transplantation, vii) trans-arterial chemo-embolization, and radiotherapy. In addition, viii) proton beam therapy is introduced, which is a less invasive therapy for localized HCC.

This issue of the Endocrinology and Metabolism Clinics, guest edited by Drs. Leonid Poretsky and Emilia Pauline Liao, will focus on Diabetes Mellitus: Associated Conditions. Articles in this issue include Metabolic syndrome; The role of glucocorticoids and insulin resistance in adipose tissue function and lipid metabolism; Cardiovascular disease; The Relationships between Cardiovascular Disease and Diabetes: Focus on Pathogenesis; Interventions for coronary artery disease; Peripheral Arterial Disease; Hypertension; Sleep apnea; Osteoporosis; Vitamin D deficiency; Diabetes and cancer; Dementia; Depression; and Polycystic Ovary Syndrome.

Carotid artery disease causes approximately 10 to 20% of strokes, and appropriate intervention is important for secondary and primary stroke prevention. Aggressive treatment of modifiable risk factors for carotid atherosclerosis is central to stroke prevention. This book discusses the risk factors, prognosis and management of carotid artery disease. Topics include medical and behavioral intervention for carotid atherosclerotic disease; intracranial carotid artery stenosis diagnosed with CTA; carotid artery atherosclerosis in patients with inflammatory joint diseases; the impact of obesity on carotid artery disease in obese adolescents; and asymptomatic carotid disease.

Fatty liver disease is the most common type of liver disease seen in the world today, affecting 20% of the population. Written by experts and based on the most current information available,'Healing Fatty Liver Disease'is the indispensable guide for anyone living with fatty liver disease. There is extensive information on the causes of NAFLD, the symptoms and signs, and treatment options. Because diet plays a major role in managing the condition, 100 specially selected recipes are also included.

Nearly 100 of the world's leading medical researchers and clinicians share their expertise on the diagnosis, treatment, and care of people with diabetes mellitus. This newly revised sixth edition is a comprehensive guide to type 1, type 2, and gestational diabetes. New diabetes treatment strategies include medical nutrition therapy with diabetes diet and exercise programs. This guide covers the latest research on diabetes medication and technology with insulin-pump therapy, insulin secretagogues, incretin mimetics, and medications for obesity, as well as advances in diabetes prevention. Family care topics include diabetes in pregnancy, diabetic ketoacidosis, childhood obesity, and type 2 diabetes in children. Other topics include glycemic control, diabetes complications and comorbidities, diabetes mellitus therapy in different patient groups, and much more. This is an excellent resource for physicians seeking to provide the most current treatment for their patients. Therapy for Diabetes Mellitus and Related Disorders is the most comprehensive clinical reference work available on the disease.

The field of adipose tissue biology has been expanding at a very rapid pace in the last few years. Numerous advances have been made since publication of the first edition of this book, in terms of basic adipocyte biology, understanding of the determinants of obesity, distribution of body fat and weight loss, as well as the mechanisms linking excess adiposity to various co-morbidities. Adipose Tissue and Adipokines in Health and Disease, Second Edition contains updated chapters from the previous volume but as the field has evolved, some areas covered in the first edition have been refocused to address the new knowledge. The volume is divided in four sections: the first two deal with basic adipose tissue and adipokine biology, while the last two address the problem of obesity and alterations in adipose tissue function from an epidemiological and clinical standpoint. The chapters are written by experts in their fields and include the most up to date scientific information. Adipose Tissue and Adipokines in Health and Disease, Second Edition is a useful resource for physicians interested in adipose tissue biology and basic scientists who want to know more about applied aspects of the field. The book targets endocrinologists, residents and fellows, internists, nutritionists and general practitioners who are exposed to an ever-expanding obese population.

Hepatitis C: Global Status is one in a series of GIDEON ebooks which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON database (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing exhaustive search of the medical literature. Chapters are arranged alphabetically, by country name. Each section is divided into five subsections. 1. Descriptive epidemiology 2. Summary of clinical features 3. Global status including distribution map 4. Status of the disease in a specific country 5. References

Hepatitis B: Global Status is one in a series of GIDEON ebooks which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON database (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing exhaustive search of the medical literature. Chapters are arranged alphabetically, by country name. Each section is divided into five subsections. 1. Descriptive epidemiology 2. Summary of clinical features 3. Global status including distribution map 4. Status of the disease in a specific country 5. References

Gastrointestinal (GI) bleeding is one of frequent emergencies that clinicians frequently manage in their clinical practices. This book contains several chapters dedicated to the diagnosis and management of gastrointestinal bleeding. This book includes current updates on all areas of GI bleeding including upper GI, lower GI, and small bowel bleeding. It fully covers the different symptoms and signs of gastrointestinal bleeding that can occur in different conditions. The outline of the many dilemmas faced by clinicians in their approach to their patients like diagnostic predictors of clinical outcome, and risk stratification in lower GI bleeding and for upper GI bleeding. There is a dedicated chapter for the diagnosis and management of Dieulafoy lesions (DLs) which are uncommon, yet they are often an under-recognized cause of life-threatening GI bleeding occurring in both the adult and pediatric population. This book also gives a comprehensive overview of the various imaging modalities used for the diagnosis of GI bleeding with emphasis on the role of MDCT in the care of patients with GI hemorrhage. The initial management of significant GI bleeding with focuses on early identification, hemodynamic stabilization, close monitoring in the proper setting, and timely workup and intervention is described. A dedicated chapter discusses the wide range of endoscopic therapies that are now available to treat GI bleeding, with an emphasis on the new advances in endoscopic therapy. There is detailed discussion on the role of transcatheter arterial embolization, which remains an important available treatment modality in the armamentarium for management of non-variceal GI bleeding. A review of the primary prevention of variceal hemorrhage, management of acute variceal hemorrhage, and secondary prevention of variceal hemorrhage is presented. A comprehensive discussion on the surgical and endovascular management of variceal bleeding using transjugular intrahepatic porto-systemic shunt (TIPS) as well as surgical shunts is included in this book. This book will be of great value to many clinicians in different specialties including general practitioners, general internal medicine, gastrointestinal medicine, interventional radiologists and gastrointestinal surgeons.

Internationally renowned experts present topics related to obesity, nutrition, and liver disease in this issue. In the first article, the epidemiology of obesity and its association with liver disease are covered. The following two articles focus on the roles that visceral adipose tissue and microbiota potentially play in the pathogenesis of obesity-related liver disease. The next article focuses on the hepatic pathology seen in patients with obesity-related liver disease and those with malnutrition. The next five articles are focused on NAFLD and provide in-depth data on the natural history and treatment strategies for patients with NAFLD. The next six articles deal with the impact of obesity on other liver diseases and on special populations including children and liver-transplant recipients. The final article provides the most updated information regarding genomics and genetic targets that may provide better prognostic and diagnostic biomarkers and more personalized treatment targets for patients with NAFLD. Cutting-edge information in this issue will help readers gain better understanding of the natural history and pathogenesis of primary and secondary liver diseases associated with obesity. As the information about obesity-related liver disease expands, clinicians will be able to provide more targeted therapeutic options for these patients and develop more accurate diagnostic and prognostic biomarkers.

Striking changes have occurred in the world since the publication of the last edition of Viral Infections of Humans. The global population is rapidly approaching 8 billion; climate change is leading to the introduction of new hosts, vectors and virus diseases heretofore never seen in many parts of the world; technological advances have revolutionized the ability to recognize and characterize viruses new and old; vaccines are altering the epidemiological landscape of the diseases they target, in some cases raising the hope of their eradication and remarkably powerful computational tools are enabling not only detection of outbreaks of disease much sooner than in the past but also, through complex mathematical modeling, more accurate prediction of their potential impact.The new Fifth Edition of Viral Infections of Humans captures the both the excitement and frustration of the dynamic struggle between humankind and the viruses that continue to cause immense suffering. It presents the latest concepts, methods and technologies in epidemiology, detection, investigation, modeling and intervention. Updated and entirely new chapters by dozens of experts across the field provide analytic summaries of current knowledge of viruses and prions causing acute syndromes, chronic illnesses and/or malignancies. In sum, this ambitiously expanded volume offers a uniquely comprehensive perspective on viruses in humans, from agents of classic diseases (e.g., hepatitis, measles, polio, rabies and yellow fever), to those with greatest pandemic impact (e.g., influenza and human immunodeficiency virus), to those discovered relatively recently (e.g., henipavirus, metapneumovirus and norovirus).The new Fifth Edition of Viral Infections of Humans is an invaluable reference for students, fellows and established professionals in the fields of microbiology, public health and infectious disease epidemiology, medicine and health policy.

This book comprises proceedings from the Third International Conference on Advances in Nutrition and Cancer, held in Naples in May 2012. This highly multidisciplinary meeting analyzed “nutrition and cancer” from different perspectives and on the basis of distinct and up-to-date experimental approaches. Knowledge on the relation between lifestyle, diet, and cancer is explored in a number of contributions, and the role of dietary intervention in cancer patients is discussed. Issues of vital interest to the research community, such as epidemiological and experimental oncology (genetics, epigenetics, and the mechanisms of action of natural compounds in the diet), receive detailed consideration. A further key topic is the emerging molecular technologies (the “omics”) that can cast light on the interplay between nutrition and human malignancies. Chapters take the form of reviews that include sections presenting expert opinions.

For nearly 25 years, Ferri's concise, pocket-sized resource has served as the go-to reference for practical, clinical information among students, residents, and other medical professionals. Formerly known as Practical Guide to the Care of the Medical Patient, this volume continues to provide a fast, effective, and efficient way to identify the important clinical, laboratory, and diagnostic imaging information you need to get through your internal medicine clerkship or residency.Consult this title on your favorite device, conduct rapid searches, and adjust font sizes for optimal readability. Benefit from the expert guidance of Dr. Fred Ferri, a leading teacher, clinician, and author. Confidently manage patients with the latest clinical information, drug therapies, and lab tests.Apply the latest knowledge and techniques with this updated and streamlined title, which still stays true to the Ferri name. Quickly find important information with content organized into three major sections: Section I, titled'Surviving the Wards,'contains information on charting, laboratory evaluation and formulary; Section II provides the differential diagnosis of common signs and symptoms likely to be encountered in the acute care setting; Section III has been completely revised and subdivided into 11 specialty specific diseases and disorders.

In the last few years, human metabolic disorders have become some of the most prevalent and prejudicial diseases worldwide. Hepatic steatosis, among many health problems, has several risk factors related to the disease prognosis such as obesity, nutritional problems, diabetes, hypertension, hyperuricemia and even sleep apnea. Alcohol abuse also can lead to a severe liver-steatosis state. The progression of hepatic steatosis can lead to complications such as cryptogenic cirrhosis and hepatocellular carcinoma. Drug therapy has instead been focused on the mitigation of risk factors, however, new potential therapeutic perspectives are being discussed. This book presents the origins, diagnosis and epidemiology of hepatic steatosis with new perceptions. The authors also aim to show the molecular basis and signaling involved in liver disorders, discussing the inflammatory process, lipid metabolism and angiogenesis mechanisms. The role of nutrition in the treatment and development of steatosis was also presented and new advances were highlighted. Recent studies revealed the need for the use of bariatric surgery, functional foods and the modulation of endogenous systems, such as the sirtuins and renin-angiotensin systems, to treat liver disease. In this context, we aimed to introduce, review and discuss one of the most widespread metabolic disorders in the world: hepatic steatosis and its repercussions.

Obesity is now considered a global epidemic. Central obesity is the state of excess adiposity in the abdominal region. It is associated with increased, cardiovascular or cancer mortality. The International Diabetes Federation (IDF) has recommended the assessment of central obesity mandatory for diagnosis of metabolic syndrome. Hitherto, there is a huge gap in our understanding of the role of central obesity as a health risk across different populations around the world. There also exist a vast population variation in the relationship between generalised obesity as measured by body mass index and /or percent body fat and the central adiposity measures. For instance, Asian-Indians have a typical phenotype of higher body fat at lower BMI levels compared to their European counterparts. Development and use of region specific standards of measurement of central obesity is in need until a universal agreement is achieved. With this background, the present volume has been organized with some very informative articles from highly reputed scholars, researching on obesity in general and on central obesity, in particular. We have here articles based on empirical data as well some review articles critically examining some theoretical, epidemiological and clinical aspects pertaining to the theme of this volume. Through the 14 chapters of this volume, we have attempted to cover diverse aspects concerning the paradigm of central or abdominal adiposity / obesity within a broader framework of obesity.

Infectious Diseases of Brazil is one in a series of GIDEON ebooks which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON web application (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing search of the medical literature. Chapters are arranged alphabetically, by disease name. Each chapter is divided into four sections: 1. Descriptive epidemiology 2. Summary of clinical features 3. Status of the disease in Brazil 4. References There are 351 generic infectious diseases in the world today. 252 of these are endemic, or potentially endemic, to Brazil. A number of other diseases are not relevant to Brazil and have not been included in this book. In addition to endemic diseases, all published data regarding imported diseases and infection among expatriates from Brazil are included.

'Infectious Microecology: Theory and Applications'firstly introduces microecology in the study of infection and proposes new anti-infection methods and strategies and then provides a comprehensive and up-to-date overview of research on infectious microecology. It concludes with a new theory for studying infectious diseases. This book presents the basic theories and fundamentals of infectious microecology, covering all the microecological systems relevant to clinical work. It also describes a new strategy and method to combat infectious diseases and provides detailed descriptions of studies and techniques in infectious microecology. The book discusses utilizing 10 years'worth of research and clinical practice, referring to recent literature on the relationship between infection and microecology and combined with the latest research findings on liver microecology. In addition, it outlines the latest advances in the theory and techniques in the field of infectious microecology.It is intended for doctors, researchers and graduate students in the fields of infectious disease and microecology.Dr. Lanjuan Li is member of the Chinese Academy of Engineering, she is also a Professor and Chief Physician at Zhejiang University, China.

Questo volume propone una trattazione esaustiva e completa della sindrome metabolica, sotto vari aspetti, tutti molto attuali. Il volume non solo tratta l'argomento affrontandolo in modo classico ma, per la prima volta, descrivendo aspetti quali la relazione tra sindrome metabolica e malattie epatiche, tra la sindrome metabolica e la sleep apnea o l'impatto della stessa nelle popolazioni pediatriche, offrendo una visione molto moderna del problema. Di estremo interesse per l'approfondimento è inoltre la descrizione dei maggiori trials clinici che si sono occupati dell'argomento. Infine, la descrizione dell'approccio tipo ABCDE (Assessment, Blood Pressure, Cholesterol, Diet, Exercise), elaborato dagli specialisti del Johns Hopkins Hospital di Baltimora (USA), offre un suggerimento pratico per la gestione della sindrome.

Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. Anti-obesity Drug Discovery and Development is focused on this very important area of healthcare research. Fifteen well written reviews make this special volume an excellent compilation of recent developments in anti-obesity treatment. The reviews cover a variety of topics including the development of specific, safe and effective receptor antagonists, the role of epithelial endocrine cells and post operative treatment strategies. This book should be useful to clinicians and medicinal chemists involved in ant-obesity research and therapy.

Frontiers in Clinical Drug Research – Diabetes and Obesity is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research. The first volume of this series features 6 chapters that cover a variety of topics including: -Angiotensin blockers -Agents targeting advanced glycation end products -Drugs and the peroxisome proliferator activated receptors -Topical Drugs for diabetic complications -Research on Liraglutide -Research on MicroRNAs as agents for diabetes treatment

This book is intended as a guide for the diagnosis and management of children with celiac disease. It is an excellent learning resource suitable for students and health care providers in the fields of pediatrics, pediatric gastroenterology and pediatric endocrinology. Celiac disease is discussed in detail; gluten allergy and the so-called non-celiac gluten sensitivity are also briefly described. Besides the clinical aspects of the disease, the reader will find suggestions for the correct diagnosis and follow-up of short stature and other celiac related endocrine conditions. This book provides a thorough and critical update on the current knowledge of this unique autoimmune disease.

This book explores the pathophysiology, clinical assessment and management of the obese patient in the context of serious chronic disease, as well as the political and environmental aspects, including prevention. The book's approach of arriving at an exploration of these issues through the vehicle of assessing the controversies is unique and interesting, attempting to debunk the myths and explore the genuine science whilst demonstrating areas where healthy debate is rife.

In this book, the authors present current research in the study of the causes, treatment options and potential complications of cirrhosis. Topics discussed include optimal medical management of liver cirrhosis without liver transplant; cardiac dysfunction in end stage liver disease; bacterial infections in cirrhosis; asymmetric dimethylarginine (ADMA) and endothelial dysfunction in cirrhosis; surgical risk associated with cirrhosis; the physics of liver fibrosis and cirrhosis; endoscopic obliterative therapy with cyanoacrylate for gastric varices; and surgical resection of hepatocellular carcinoma.

This updated and enlarged second edition is a unique source of information on the diagnosis, treatment, and follow-up of metabolic diseases. The clinical and laboratory data characteristic of rare metabolic conditions can be bewildering for clinicians and laboratory personnel alike – reference laboratory data is scattered, and clinical descriptions can be obscure. The new Physician's Guide with the additional more than 600 diseases now featured, documents 1200 conditions grouped according to type of disorder, organ system affected (e.g. liver, kidney, etc) or phenotype (e.g. neurological, hepatic, etc). It includes relevant clinical findings and highlights the pathological values for diagnostic metabolites. Guidance on appropriate biochemical genetic testing is also provided and established experimental therapeutic protocols are described, with recommendations on follow-up and monitoring. The authors are acknowledged experts, and the book is a valuable desk reference for all who deal with inherited metabolic diseases.Chapter 73 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com

Ce premier'Rapport de recommandations sur la prise en charge des personnes infectées par les virus de l'hépatite B ou de l'hépatite C'est le fruit d'une démarche collective impulsée par la Ministre de la Santé et réalisée sous l'égide de l'Agence nationale de recherches sur le sida et les hépatites virales (ANRS) et de l'Association française pour l'étude du foie (AFEF). Ce rapport a été coordonné par le Pr Daniel Dhumeaux (hépatologue au CHU Henri Mondor de Créteil et président du Programme national de lutte contre les hépatites B et C 2009-2012). Pour produire ses recommandations, il a mobilisé pendant plus d'une année quelque 200 cliniciens, chercheurs, patients et associations de patients. L'élaboration du rapport s'est organisée autour de 22 groupes thématiques d'experts et d'un comité indépendant des experts, fait de personnalités scientifiques et du monde associatif, dont la mission a été d'assurer la validation et la synthèse des textes. Par les mesures qu'il met en avant, ce rapport se propose, selon trois axes : – de relancer la prévention des hépatites B et C, jugée en retard sur plusieurs points (vaccination contre l'hépatite B notamment), – d'articuler les étapes de la prise en charge des patients atteints d'hépatites B et C selon des parcours de soins et des stratégies thérapeutiques spécifiques qui leur sont propres, – de soutenir, à tous les niveaux, les valeurs d'équité dans les soins par des mesures concrètes de lutte contre les inégalités sociales. En émettant ces recommandations, le collectif responsable du rapport a eu clairement conscience de la contrepartie économique des traitements nouveaux, en particulier de l'hépatite C, qui implique des choix et des indications raisonnables. Avec des thérapeutiques dont l'efficacité est désormais proche de 100%, l'éradication de cette infection peut devenir un objectif réaliste. En l'absence de vaccin, elle ne passera que par l'identification et la prise en charge de tous les patients atteints et des coûts de médicaments réduits. Ce premier rapport, destiné aux pouvoirs publics, à tous ceux qui luttent contre ces maladies (professionnels de santé, associations de patients, industriels du médicament) et aux médias, apporte un état des lieux épidémiologique, sanitaire et social de l'épidémie dans notre pays et émet des recommandations fortes pour être plus efficace à tous les échelons de la riposte. Il est souhaité qu'il donne lieu à une véritable mobilisation collective afin que ces hépatites soient maîtrisées à tous les niveaux de notre société, y compris dans les groupes les plus vulnérables et les régions les plus touchées.

Chronic liver diseases progressively destruct liver tissue, leading to fibrosis and cirrhosis. Liver diseases can be caused by viral, autoimmune, or toxic (drugs/alcohol). Most conditions can be managed pharmacologically for indefinite periods of time. The articles in this issue will review best practices for managing and treating patients who present with these chronic problems, like hepatitis, nonalcoholic fatty liver, end stage liver disease, and drug-induced injuries.

The Mayo Clinic Gastroenterology and Hepatology Board Review book has been designed to provide a review of core essential knowledge in gastroenterology, hepatology, and relevant related areas of radiology, pathology, endoscopy and nutrition to physicians, trainees and other persons caring for patients, gastroenterology fellows in training, medical residents, medical students, gastrointestinal assistants, nurses, and allied health care personnel. While less detailed than encyclopedic textbooks, it provides much more information than outline booklets. Clinical knowledge to enhance patient management, rather than the latest scientific advances is emphasized. For persons preparing for their board examination, certification or recertification, case-based presentations and numerous board examination-type single best-answer questions with annotated answers are provided. Abundant figures, images and tables are also included. The faculty authoring this book are all Mayo Clinic gastroenterologists and hepatologists who spend most of their time caring for patients and teaching in an academic environment.

The metabolic syndrome is a common syndrome affecting about 20% of the adult population in Europe, and probably the prevalence is of the same magnitude in other industrialised countries worldwide. It is mainly caused by western lifestyle resulting in abdominal obesity, but also a genetic predisposition plays a role. This syndrome, which is linked to leisure lifestyle and overeating/obesity, can develop into type 2 diabetes, cardiovascular disease and cancer. Therefore, proper treatment and prevention are heavily needed. This book discusses lifestyle intervention and treatment, specifically with pharmacological compounds, in order to formulate a strategy for treating the metabolic syndrome in the daily clinic.

This book adheres to strict scientific principles and is designed to explore the whole aspect of gallstone disease from the micro world of the genetic profiles, basic metabolisms of bile lipids in cholesterol gallstone patients, to the macro world of clinical triple defects of gallstone patients. It is especially suitable for medical professionals: internists, surgeons, residents, nurses and medical students, and for collection by libraries. This book deals with motor dysfunction in calculous gallbladders as well as reactive oxygen species in relation to gallstone formation. Etiology and pathogenesis of pigment, calcium carbonate and intra-hepatic gallstones are also discussed.

Es ist „normal“, nicht normalgewichtig zu sein.Etwa 60% der Deutschen sind übergewichtig. Die heutigen „Volksseuchen“ – u.a. Diabetes, Fettstoffwechselstörungen und Hypertonie - sind weitgehend durch Übergewicht bedingt.Was sind die Grundlagen und Ursachen?Psychologisch und physiologischVon der genetischen Prädisposition bis zu UmweltfaktorenRegulation von Hunger und Sättigung sowie des EnergiestoffwechselsFolgekrankheitenVom Diabetes bis zu KarzinomenVom Fersensporn bis zur WirbelsäulendegenerationVon der Stigmatisierung bis zur EssstörungWelche Therapie ist sinnvoll?Keine Crashdiäten – langfristige ErnährungsumstellungAdipositasgerechte BewegungstherapieVerhaltensmodifikation, ggf. VerhaltenstherapieBariatrische Chirurgie als ultima ratioDAS Nachschlagewerk, das alle Bereiche der Adipositas umfassend, interdisziplinär darstellt.Eine anspruchsvolle Aufgabe für alle Fachleute, die in Krankenhäusern, Reha-Kliniken und niedergelassenen Praxen mit adipösen Patienten arbeiten: Ärzte (Internisten, Allgemeinmediziner, Pädiater, Gynäkologen, Endokrinologen …), Ernährungsfachkräfte, Klinische Psychologen, Psychotherapeuten, Bewegungstherapeuten, Gesundheitsberater …Unverzichtbar auch für Experten, die sich mit den gesellschaftlichen Perspektiven dieser Epidemie beschäftigen.NEU und erweiterte Kapitel u.a. Psychosoziale Faktoren, Essverhalten, EssstörungenPeriphere und zentrale Regulation der EnergieaufnahmePrävention, Perinatale AdipositasPLUSPraxistipps, Schnellübersichten, hohe AktualitätNach den LeitlinienDAG, Deutsche Adipositas-GesellschaftDGE, Deutsche Gesellschaft fürErnährungDGEM, Deutsche Gesellschaft für ErnährungsmedizinDDG, Deutsche Diabetes-Gesellschaft

Albuminuria may not only serve as an early marker of advanced disease, but may also serve as a predictor of disease progression and poor outcome. This fact makes the current book'Albuminuria: Symptoms, Causes and Treatment Options' very crucial and timely. The book is composed of ten chapters written by experts from seven different countries. It is well classified to serve its purpose, divided in three broad sections. The first section deals with the clinical evaluation and implications of albuminuria. It also covers the molecular, cellular and biochemical basis of albuminuria. The second section is geared towards albuminuria noted in special clinical conditions; diabetic nephropathy, cardiovascular diseases, resistant hypertension and following renal transplantation and exercise. The third and final section covers albuminuria among the extremes of age; both the pediatric and the fastest growing elderly group. The book provides a reference and guide that reviews various aspects of albuminuria to cater to a wide spectrum of readers, ranging from medical students to practicing physicians.

This handbook is designed to help jobbing histopathologists jog their memory and get through more workload in any working day. Rapid access is facilitated by a bullet-point, tabular and diagrammatic style, as well as by handy anatomical diagrams, guidance on the'Cut-Up'with emphasis on core'datasets'and by a special index for frozen section advice, grading systems and scoring systems. The book provides, where useful, differential diagnosis lists and presents diagnostically helpful molecular and immunohistochemical findings. Information is kept up-to-date on a dedicated website ua href='http://www.pathbook.com/'www.pathbook.com/a./u The iDiagnostic Criteria Handbook in Histopathology/i is inot/i designed to be an'exam cram'and neither will it serve as a basic text for beginners. Trainees, however, will still benefit from the sheer breadth of topics covered in this one small volume: from lab management and lab methods, to autopsy practice, cytology and all sub-specialties in surgical pathology. A chapter on exam technique and mnemonics makes the book also an essential companion for those revising for professional exams. So why clutter your precious desk space with multiple sets of heavy two-volume reference works'Give this handy iVade Mecum/i a place next to your microscope and see how much time you could save!

Desde el año 1927, Cecil Tratado de Medicina Interna ha sido la obra de referencia en este campo. Permite comprender de manera óptima cómo diagnosticar y tratar cualquier trastorno médico que se encuentra en la práctica. Integra hábilmente los últimos avances en biología con el diagnóstico y las terapias actuales, basados en la evidencia, incluyendo dosis farmacológicas. Su formato dinámico y bien organizado ofrece un acceso rápido a la información de referencia. Como novedades destancan: la inclusión de un nuevo capítulo de Aplicación de tecnologías moleculares a la medicina clínica, una sección completamente renovada de enfermedades infecciosas y cobertura de las más novedosas técnicas y tratamientos cardiovasculares.Cuenta con multitud de contenidos en linea, en inglés, como figuras complementarias, tablas, algoritmos, referencias, vídeos de procedimientos o casos de estudio.

En su tercera edicion, esta obra trata de los padecimientos gastrointestinales mas comunes, presentados de manera didactica, sencilla y actualizada. Asimismo, presenta las bases legales que gobiernan la practica de la gastroenterologia y la endoscopia en Mexico.

Care for Children Born Small for Gestational Age is a comprehensive handbook that serves to synthesize the extensive recent literature in the area to provide a practical resource aimed at a wide range of healthcare professionals, including obstetricians, midwives, neonatologists, and primary care physicians. This comprehensive handbook includes an in-depth survey of the prevention, diagnosis, treatment and long-term monitoring of children born small for gestational age, as well as related conditions such as intrauterine growth restriction, metabolic syndrome and type 2 diabetes. Additionally, the short and long-term psychiatric and social consequences of this condition are addressed.

This book presents original research results on the leading edge of cancer. Topics discussed include coping mechanisms in patients with head and neck cancer; hepatocellular carcinoma; chronic lymphocytic leukemia; the pathobiology of B-lymphoproliferative disorders from MBL to CLL to SLL; molecular and cellular characterization of chronic lymphocytic leukemia; pain as a consequence in patients with early stage breast cancer treated with intracavity brachytherapy accelerated partial breast irradiation (IBAPBI); the future of anti-tumor immunotherapy; coping with childhood cancer; and the current clinical utility of Everolimus in the treatment of renal cell carcinoma.

The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystophy, adipose tissue was the site of a local low-grade inflammation that involves immune cells such as macrophages and certain populations of lymphocytes. This new information is an important step in the pathophysiology of both obesity and related metabolic and cardiovascular complications. Finally, it is a unique and original work focusing on adipose tissue, covering biology and pathology by investigating aspects of molecular and cellular biology, general, metabolic, genetic and genomic biochemistry.

La obesidad es una enfermedad crónica que provoca alteraciones en diferentes órganos por efectos metabólicos, inflamatorios y mecánicos. El tejido adiposo es un reservorio de energía pero también es un órgano que sintetiza hormonas y donde ocurren fenómenos inflamatorios que participan en diversos procesos patológicos. Este libro escrito por 25 autores, vinculados a la docencia en ciencias médicas básicas y clínicas, hace un recorrido por los eventos que ocurren en el tejido adiposo del sujeto obeso, las señales hormonales y nerviosas desencadenadas por la presencia de alimentos en el tracto digestivo, los circuitos cerebrales de la saciedad y del apetito, y la fisiopatología, diagnóstico y enfoque terapéutico de enfermedades asociadas a la obesidad: diabetes mellitus 2, dislipidemia, hipertensión arterial sistémica, síndrome de apnea obstructiva del sueño, hígado graso, síndrome de ovarios poliquísticos, patologías cutáneas y enfermedades articulares. Revisa, además, síndromes genéticos que se presentan con incremento de la adiposidad, describe mecanismos epigenéticos que intervienen en la obesidad, detalla aspectos de la nutrigenómica relacionados con la síntesis y degradación de grasas en tejido adiposo e hígado. Asimismo, analiza los posibles efectos del exceso de peso sobre la carcinogénesis. Finalmente, además de explicar las recomendaciones dietéticas y de ejercicio físico, y el uso de algunos medicamentos en el tratamiento de la obesidad, describe los principios, indicaciones y complicaciones metabólicas de la cirugía bariátrica.

Medical students and junior doctors are an integral part of the healthcare system. On an academic gastroenterology service, they often initially evaluate the patients that are then staffed by the consulting physician. Like all clinical specialties, the acquisition of medical knowledge is required to gain expertise. There are several resources such as textbooks and evidence-based articles that are available for this purpose. Inspired from patient care, this book offers a fresh approach to clinical teaching. 50 Gastrointestinal Cases and Associated Imaging is a different kind of book. It encompasses a gamut of cases for which gastroenterologists are commonly consulted for in the hospital and outpatient setting. Each case is presented from initial history and workup including imaging (various modalities including endoscopy), followed by a brief discussion on management. Questions are presented to the reader in each case followed by an answer. Since each case is unique, the pertinent teaching points are tested in a question format within the case narrative. Similar to real-life scenarios, this helps the reader to retain the most important information. Why buy this book? Unlike listing facts as most review books do, teaching points are integrated into realistic clinical cases. Medical students to residents/registrars in internal medicine, emergency medicine, GI medicine, radiology and surgery would benefit from this book alike. Secondary audiences will include nurses and general practitioners who want to understand the presentation of common GI cases and associated imaging. Moreover, it could also be potentially used as a training tool – a valuable educational resource for senior colleagues who enjoy teaching. Finally, this book would make an excellent prerequisite prior to starting any gastroenterology rotation.

This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed in this compilation include the management of facial hemangiomas by pediatric surgical laser therapy; pain sensor molecules of the primary afferent nerves and their nociceptive modalities; natural polymeric materials in pharmaceutical formulations; microelectrode arrays in mast cell electrophysiology; fructose synthesis and health implications; medical tourism in the context of the globalization of health services; objective measurement and monitoring of pain; homeopathy services in the National Health Service and other developed countries; axis orientation on visual performance in astigmatic eyes; and pulmonary hypertension and dialysis.

Hepatitis is a disease of the liver which affects millions of Americans each year. For most people, symptoms are mild and are resolved within a few weeks or months. For others, however, hepatitis is life-altering, becoming a chronic problem which causes irreparable internal damage. The diversity of causes--which range from bacteria and toxins to metabolic disorders--and their corresponding methods of transmission have made hepatitis a hard ailment to control. In recent years, vast progress has been made toward the identification, prevention and treatment of this disease. Combining scientific knowledge with practical concerns, this comprehensive guide provides a plethora of information on the broad class of diseases referred to by the collective term of hepatitis. With a view toward patient education, it discusses the history, symptoms, cause and disease course of hepatitis'various forms. Covering Hepatitis A and Hepatitis B as well as more recently discovered varieties, the text examines immune system response to the disease and its effect on liver function. Non-infectious causes such as metabolic disorders are also discussed. Practical information regarding diagnostic laboratory and imaging tests as well as conventional and alternative treatments is provided. The final chapter lists a variety of resources for anyone dealing with the reality of the disease including books, CDC publications, hepatitis organizations and foundations, drug treatment financial assistance and transplant information. An extensive glossary of medical terms and an index are also included.

This monograph offers the reader an integrated point-of-view about the inflammatory response related to injury, infections and tumors. This integration is based on the hypothesis that the multiple pathophysiological mechanisms making up inflammation represent the re-expression of ontogenic mechanisms during early embryo development as well as the recapitulation of ancestral phylogenetic mechanisms. The relevance of the anti-inflammatory treatments is also highlighted with respect to polytraumatic patients, advances in stem cell research, embryology and the wound healing mechanism.Readers of this book will have the chance of gaining a unique perspective about of the pathophysiological mechanisms involved in the multiple inflammatory conditions. This integrative concept about inflammation can be applied in biological investigation, as well as in clinical research and translational medicine.

Offering 171 unique cases, Gastrointestinal Imaging Cases features over 700 high-quality images. The clinically relevant cases cover both benign and malignant conditions and are grouped into 12 sections organized by the parts of the Gastrointestinal System including: the Pharynx and Esophagus, Stomach, Duodenum, Small Intestine, Appendix, Colon, Rectum, and Anus, Liver, Gallbladder, Bile Ducts, Pancreas, Spleen, and Mesentery and Peritoneum. Within each section, the cases appear in a random order to facilitate the self-assessment experience of reading cases as unknowns. Each case is complete with pertinent findings, differential diagnoses, management recommendations, teaching points, and suggested further reading. This comprehensive, yet easy-to-follow, casebook is an ideal tool for the resident preparing for the boards, the fellow for recertification exams, or the radiologist in need of a quick review.

The American Diabetes Association/JDRF Type 1 Diabetes Sourcebook serves as both an evidence-based reference work and consensus report outlining the most critical components of care for individuals with type 1 diabetes throughout their lifespan. The volume serves not only as a comprehensive guide for clinicians, but also reviews the evidence supporting these components of care and provides a perspective on the critical areas of research that are needed to improve our understanding of type 1 diabetes diagnosis and treatment. The volume focuses specifically on the needs of patients with type 1 diabetes and provides clear and detailed guidance on the current standards for the optimal treatment of type 1 diabetes from early childhood to later life.To accomplish the book's editorial goals, Editors-in-Chief, Drs. Anne Peters and Lori Laffel, assembled an editorial steering committee of prominent research physicians, clinicians, and educators to develop the topical coverage. In addition, a Managing Editor was brought on to help the authors write and focus their chapters.