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This book presents original results on the leading edge of cancer research. Chapter One reviews the most recent advances in the management, analyses the best possible treatment in each scenario, and discusses the future research direction on brain metastases from non-small cell lung cancer. Chapter Two discusses the positive effects of microscopic complete resection on controlling the local recurrence of a single brain metastasis. Chapter Three encapsulates the trends of the computer-aided diagnosis (CAD) development for the estimation of tumor malignancy. Chapter Four examines dendritic cells cross talk with cytomegalovirus pp65-specific cytotoxic T cells, Vγ9γδTγ cells, and invariant NKT cells in patients with glioblastoma multiforme. Chapter Five addresses CD8+ T cell activation and regulation in the skin, paying special attention to what it is known about CD8+ T cell activity and its link with SCC development. Chapter Six discusses knowledge of the molecular basis of anti-cancer drug resistance and the mechanisms through which triterpenoids modulate ABC transporter-mediated multi drug resistance. Chapter Seven reviews cancer and heparan sulfate alterations. Chapter Eight focuses on Ganoderma lucidum targeting apoptosis. Chapter Nine examines the integrated model of cAMP-dependent DNA expression which reveals an inverse relationship between cancer and neurodegeneration. Chapter Ten studies the prognosis of male breast cancer.

Le complicanze neurologiche nel malato oncologico sono relativamente frequenti, compaiono maggiormente nella fase avanzata di malattia e possono avere un impatto negativo sulla qualità di vita del paziente. Alcune di queste complicanze sono curabili, con conseguente miglioramento dei sintomi in un malato spesso già pesantemente compromesso, e quindi vanno identificate e trattate il prima possibile. Rivolto principalmente agli oncologi, ai neurologi e ai medici di famiglia, il testo esamina le complicanze legate in modo diretto o indiretto alla malattia tumorale o derivanti dai trattamenti e rappresenta un utile strumento per la gestione del malato oncologico, in tutte le fasi della malattia: diagnostica, di cure attive e di cure palliative.