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Dieses Buch bricht mit klassischen Lehrbuchkonzepten, indem es sich auf ausgewählte Kapitel der Inneren Medizin konzentriert und die ärztliche Alltagserfahrung von Ärzten der Klinik für Gastroenterologie, Hepatologie und Infektiologie der Heinrich-Heine-Universität Düsseldorf in den Vordergrund rückt. Pathophysiologische Grundlagen und Überlegungen werden dabei nur kurz angesprochen, während das praxisorientierte Handeln auch bei der Vielzahl sehr seltener Krankheiten, die üblicherweise in Lehrbüchern keine Erwähnung finden, in den Vordergrund gerückt wird. Schwerpunkte sind dabei nicht nur die Gastroenterologie, Endoskopie und Hepatologie, sondern auch die gastroenterologische Onkologie, Infektionskrankheiten, Tropenmedizin und seltene angeborene Stoffwechselkrankheiten. Die pragmatische Behandlung dieser Krankheitsbilder ist Ausdruck des Alltags einer Klinik der Maximalversorgung.

The field of hepatobiliary diseases has advanced enormously in the past 3 decades. The incorporation of new diagnostic and therapeutic interventions in clinical hepatology as well as liver transplantation has exponentially grown and specialty fields have emerged within the liver disease arena. Interventional procedures play a critical role in the management of patients with hepatobiliary diseases as they offer diagnostic and definite treatment options for an array of conditions. Interventions include those that directly measure portal pressure, perform transjugular liver biopsy and place transjugular intrahepatic portsosystemic shunts as therapy for complications of portal hypertension. Other commonly performed intervention is digestive and hepatobiliary endoscopy which offers not only diagnostic but also therapeutic choices in various areas such as portal hypertension and hepatobiliary disease. Endoscopy plays a fundamental role in the management of patients with almost all types of liver disease. Additionally, both the fields of hepatology and endoscopy have become very specialized and thus a thorough knowledge of the indications, findings, therapeutic possibilities and complications that arise from endoscopic interventions is a must for the practicing clinician. The rising incidence of liver cancer has also placed radiofrequency ablation and chemoembolization of liver lesions at the forefront of interventional therapies for hepatocellular carcinoma. Finally the management of acute liver failure has certainly evolved with new therapeutic options such as liver assist devices that can help manage these patients in the intensive care unit. This issue of Clinics in Liver Disease devoted to Interventional Hepatology is a timely and unique one. The Guest Editors have assembled an outstanding group of experts in several fields that can provide practitioners with state of the art and evidence based articles that help manage patients with hepatobiliary disease.

Hepatitis B: Global Status is one in a series of GIDEON ebooks which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON database (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing exhaustive search of the medical literature. Chapters are arranged alphabetically, by country name. Each section is divided into five subsections. 1. Descriptive epidemiology 2. Summary of clinical features 3. Global status including distribution map 4. Status of the disease in a specific country 5. References