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In the second half of the twentieth century, the medical community adopted the scientific method as a basis for practice. It seemed that after thousands of years the way was paved for a regulated process: from the laboratory through the clinical trial to the patient's bed. But it soon became clear that the road is neither straight nor continuous. Clinical research only offers unequivocal answers in a few cases. The balance between benefit and risk does not end with a statistical calculation; A significant part of the consideration of the factors that determine the change of medical practice is based on values, worldview and interests. Many factors are involved in the path leading from the laboratory to the patient: scientists, doctors, pharmaceutical and technology companies, politicians, regulators, and at the end of the path stand the patients themselves. Each of these factors uses the means at its disposal to influence the final result - the diagnosis, treatment and follow-up of the patient. The path of progress from the laboratory to the patient is also not continuous: sometimes the intervals between steps are large, sometimes sudden jumps occur after a prolonged period of slowing down and even stopping. Scientific and clinical research depends on the initiative, skills and determination of the researchers, and not a little on coincidences and has no fixed timetables. This book is dedicated to revealing the evolution of medical practice, to identifying fundamental changes in practice and to describing the winding way in which they were accepted and assimilated into the body of medical knowledge and the mutual relationship between the doctor and the patient.

This concise, easy-to-read pocket guide offers medical trainees, researchers, and clinicians at every level the perfect resource on Evidence Based Medicine (EBM). Based on the author's many years of experience teaching EBM to medical students and medical residents at Columbia University, this handy title addresses not only all the basic concepts and issues in EBM, but also takes an example-based approach and is replete with numerous illustrations. This brief book provides readers with all the tools needed to tell the good from the bad in healthcare research. It discusses every type of study design, from the assessment of diagnostic tests to clinical trials and meta-analysis. The work also introduces readers to novel methods, such as the Bayesian analysis of clinical trials. In addition, to help readers better retain the information, the guide includes thought-provoking review questions and answers in an appendix. In all, Pocket Evidence-Based Medicine: A Survival Guide for Clinicians and Students is an ideal resource for anyone who encounters statistics in their studies or career, including clinicians, researchers, trainees in medicine and graduate students in a wide range of other disciplines

Designed for busy clinicians struggling to fit the critical issue of nutrition into their routine patient encounters, Nutrition in Clinical Practice translates the robust evidence base underlying nutrition in health and disease into actionable, evidence-based clinical guidance on a comprehensive array of nutrition topics. Authoritative, thoroughly referenced, and fully updated, the revised 4th edition covers the full scope of nutrition applications in clinical practice, spanning health promotion, risk factor modification, prevention, chronic disease management, and weight control – with a special emphasis on providing concisely summarized action steps within the clinical workflow. Edited by Dr. David L. Katz (a world-renowned expert in nutrition, preventive medicine, and lifestyle medicine) along with Drs. Kofi D. Essel, Rachel S.C. Friedman, Shivam Joshi, Joshua Levitt, and Ming-Chin Yeh, Nutrition in Clinical Practice is a must-have resource for practicing clinicians who want to provide well-informed, compassionate, and effective nutritional counseling to patients.

The inaugural volume of the 50 Studies series, 50 Studies Every Doctor Should Know presents key studies that have shaped the practice of medicine. Selected using a rigorous methodology, the studies cover topics ranging from dieting to cardiovascular disease, insomnia to obstetrics. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implications for practice. Brief information on other relevant studies is provided, and an illustrative clinical case concludes each review. A section of review questions and answers is included at the back of the book to ensure that readers take away the key messages from each study. For this new edition, the contents were reorganized to include ten new studies, and the references, guidelines, and implications of existing studies were thoroughly updated. This book is a must-read for health care professionals and anyone who wants to learn more about the data behind clinical practice.

The main aim of this book is to offer an easy tool to read a scientific article with greater awareness, to understand and evaluate it more thoroughly, and to better plan research. Today, in the era of evidence-based medicine, both research and daily patient-focused clinical practice are no longer possible without a thorough knowledge of the literature and its continuous updates.Written by surgeons for surgeons, this practical book makes the basic concept of statistics and research methodology easy to understand and apply for young surgeons and researchers, students and residents.

Manual dirigido a profesionales y estudiantes de las ciencias de la salud. El lector obtendrá conocimientos y habilidades en Medicina Basadas en la Evidencia (MBE) y en el análisis, interpretación y apreciación crítica de los diferentes diseños de investigación clínica, asimismo, podrá adquirir las herramientas básicas mediante el conocimiento de la estructura de los diferentes ensayos clínicos y de la estadística simple en la presentación de los resultados. Así podrá comenzar a realizar su propio proyecto de investigación.

Johannes Köbberling plädiert leidenschaftlich für eine Beachtung der Wissenschaftlichkeit in der Medizin und stellt heraus, dass dies nicht nur vereinbar mit einer menschlichen Medizin ist sondern geradezu eine Voraussetzung hierfür darstellt. Einer seiner Kernsätze lautet'Die Unwissenschaftlichkeit ist der Boden der Inhumanität'. In diesem Buch verbindet der Autor dieses Plädoyer mit biografischen Notizen und einer Schilderung seiner eigenen Tätigkeit in Forschung, Klinik und Lehre der Inneren Medizin. Im Vordergrund seiner 50-jährigen Berufstätigkeit stand dabei immer die Suche nach wissenschaftlichen Belegen für das ärztliche Handeln.

How partisanship, polarization, and medical authority stand in the way of evidence-based medicineThe U.S. medical system is touted as the most advanced in the world, yet many common treatments are not based on sound science. Unhealthy Politics sheds new light on why the government's response to this troubling situation has been so inadequate, and why efforts to improve the evidence base of U.S. medicine continue to cause so much political controversy. This critically important book paints a portrait of a medical industry with vast influence over which procedures and treatments get adopted, and a public burdened by the rising costs of health care yet fearful of going against'doctor's orders.'Now with a new preface by the authors, Unhealthy Politics offers vital insights into the limits of science, expertise, and professionalism in American politics.

This book focuses on evidence based labor and delivery management. Labor and delivery are for us magical moments, when a new life comes into being, but it requires a lot of careful management, as complications can occur. Evidence based labor and delivery management is an easy to-read book to guide management in labor and delivery. It is based on the best evidence, which usually comes from randomized controlled trials (RCTs) and from meta-analyses of RCTs. This book comprised of 3 sections that include labor, cesarean delivery, and special labor, which are further divided into 27 chapters. Section 1 covers the preparation before labor and delivery, prediction of the onset of labor, place of labor and delivery, first stage of labor, second stage of labor, intrapartum fetal monitoring, operative vaginal delivery, and trial of labor after cesarean or myomectomy. Section 2 covers the indications and optimal rate of cesarean delivery, and cesarean delivery technique. Section 3 covers the induction of labor, labor complications, malpresentation and malposition, and breastfeeding and contraception. The ultimate goal of this book is to improve the health of women going through labor and their babies.

This book bridges the gap between theory and practice, evidence-based practice and practice-based evidence, and the science and artistry of speech-language pathology. It takes a critical look at areas related to wellness, professional development, and growth that can impact the personal self along with the professional self. It examines each area through an overview of inter-disciplinary research in addition to personal narratives illustrating key principles and strategies and offers the reader a professionally balanced perspective.

Teaching Clinical Research Methodology by Example has two principal objectives: (1) to tell the story of the research process in action and to provide a glimpse into the minds of the researchers responsible for some of the major advances (and setbacks) in modern medicine; (2) to explain the principles of evidence-based medicine by reviewing the research methods required to prove or disprove a theory. This text is written in a style accessible to health professionals who do not have a background in clinical epidemiology. The first section of the book, Causation, begins with an explanation of “casual” and “coincidental” associations and follows with examples: Smoking and lung cancer Dietary fats and coronary heart disease Cause and cure of peptic ulcers Viral infection and cancer of the cervix Vaccination and autism Venous obstruction as the cause of multiple sclerosis. The second section of the book explores prevention, treatment, and the ethical principles of clinical trials. Treatments presented include surgery for breast cancer, acute lymphoblastic leukemia, use of Viagra, stem cells in breast cancer, and the use of aspirin to treat heart attacks. Preventive measures discussed include vaccines, peri-menopausal hormone therapy, aspirin in the treatment of heart attacks, prevention of sudden death after heart attacks, stroke prevention, preventing fatal pulmonary embolism in surgical patients. Includes a chapter on assessing net clinical benefits of a treatment. Closes with a glossary of methodological terms.

How partisanship, polarization, and medical authority stand in the way of evidence-based medicineThe U.S. medical system is touted as the most advanced in the world, yet many common treatments are not based on sound science. Treatments can go into widespread use before they are rigorously evaluated, and every year patients are harmed because they receive too many procedures—and too few treatments that really work. Unhealthy Politics sheds new light on why the government's response to this troubling situation has been so inadequate, and why efforts to improve the evidence base of U.S. medicine continue to cause so much political controversy and public trepidation.This critically important book draws on public opinion surveys, physician surveys, case studies, and political science models to explain how political incentives, polarization, and the misuse of professional authority have undermined efforts to tackle the medical evidence problem and curb wasteful spending. It paints a portrait of a medical industry with vast influence over which procedures and treatments get adopted, and a public burdened by the rising costs of health care yet fearful of going against “doctor's orders.” The book shows how the government's efforts to promote evidence-based medicine have become mired in partisan debates. It also proposes sensible solutions that can lead to better, more efficient health care for all of us.Unhealthy Politics offers vital insights not only into health policy but also into the limits of science, expertise, and professionalism as political foundations for pragmatic problem solving in American democracy.

El diálogo entre clínicos e investigadores es un requisito indispensable para mejorar los servicios de salud y enriquecer el quehacer profesional. Las prácticas basadas en la Evidencia constituyen este espacio de encuentro entre científicos y profesionales. Gracias a este diálogo cada vez más profesionales de la salud guían sus prácticas y decisiones clínicas sobre la base de las evidencias científicas disponibles. Aunque en las últimas décadas este movimiento ha adquirido importancia en la mayor parte de los escenarios de salud del mundo, en nuestro contexto su desarrollo aún es incipiente. La importancia de las prácticas basadas en la evidencia provienen de un principio ético indiscutible: los usuarios de la salud merecen recibir las mejores intervenciones disponibles. Para ello los profesionales debemos garantizar a los usuarios un abordaje efectivo, eficiente y eficaz, mediante una evaluación rigurosa y sistemática de nuestras intervenciones. Las Prácticas basadas en la Evidencia no intentan reemplazar el saber clínico-práctico por la evidencia científica. Lo que se busca es la integración entre la mejor evidencia científica disponible y la experiencia clínica de los profesionales. El presente libro brinda una visión panorámica sobre el movimiento de las prácticas basadas en la evidencia, haciendo especial énfasis en el campo de la psicoterapia. De esta forma especialistas internacionales sintetizan los conocimientos necesarios para interiorizare en este nuevo paradigma. A partir de su lectura se pretende generar una actitud responsable en el quehacer profesional, entendiendo que el uso de la evidencia científica es una responsabilidad ética para todos los profesionales de la salud.

The American Society of Addiction Medicine Handbook of Addiction Medicine is a practical, evidence-based guide to the identification and treatment of substance use disorders. Produced by the largest medical society dedicated to the improvement of addiction care, it begins with screening and brief intervention and an overview of treatment. This is followed by substance-specific chapters covering: alcohol, sedatives, opioids, tobacco, stimulants, hallucinogens, cannabinoids, inhalants, anabolic steroids and prescription drug misuse. Substance-specific chapters cover pharmacology, acute effects and intoxication, withdrawal, medical complications and treatment. The handbook concludes with chapters on the medical care of patients with substance use disorders, psychiatric co-occurring disorders, special populations and ethical and legal considerations. Chapters include practical tools and treatment protocols that can be used in outpatient and inpatient settings. To learn more about the American Society of Addiction Medicine, and its commitment to providing the best resources for addiction clinicians, please visit http://www.asam.org.

This second edition of the Oxford Handbook of Key Clinical Evidence provides an alternative to the growing volumes of trial data for students, trainees and researchers looking for the key evidence affecting medical practice. Written by a team of leading figures across the major specialities, the Oxford Handbook of Key Clinical Evidence carefully selects and brings together key information on some of the most important trials currently impacting clinical practice. With introductory chapters on the history and importance of evidence based medicine complemented by in-depth analysis of the impact of each trial and its practical implications, this text is a definitive quick-reference guide in this increasingly important field. Highlighted boxes identify the study type and evidence-level attained, while analysis of the key message and impacts of the trial firmly place the evidence into a practical setting for the reader. This extensively revised Handbook presents the key data, facts, and evidence informing both medical and surgical specialties. This second edition includes a brand new chapter on paediatrics. It incorporates new landmark trials which are changing clinical practice, and re-reviews previously included trials to ensure consistency with current practice. It is essential reading for everyone with an interest in getting to grasps with the fundamental evidence underpinning modern practice.

A therapist's most profound responsibility is to choose the right treatment for his or her client. Yet despite extensive training, mental health professionals remain susceptible to biases that influence their decisions and can have a dramatic effect on outcome. This book applies the theory and research of decision analytics to mental health, with a particular focus on how to improve clinical decision making. Chapters explore the intersection of decision making and clinical expertise, as well as ways to improve clinical decisions using evidence-based findings, client feedback, ethics, and more.

Essential Clinical Global Health is a brand-new, pioneering, and evidence-based textbook that provides a clinical overview of the increasingly prominent specialty of global health. Originally developed from a course at Harvard Medical School, and now with contributions from nearly 100 world-renowned global health experts from across the globe, this textbook presents vital information required of students, trainees, and clinicians during their international experiences and training. Essential Clinical Global Health introduces readers to the up-to-date knowledge, skills, and approaches needed for productive and rewarding global health experiences. It provides essential clinical information on the diagnosis, management, and prevention of the leading causes of morbidity and mortality in low- and middle-income countries. The textbook also includes practical guidance on topics such as health systems, population-based approaches, cultural awareness and sensitivity, travel preparedness and safety, and career development in global health. With key learning objectives in each chapter, practical clinical advice, setting-appropriate guidelines, personal field experiences from student and clinician contributors, Essential Clinical Global Health is the first global health textbook with a clinical focus for healthcare students, trainees, and providers.A companion website at www.wileyessential.com/globalhealth features self-assessment questions and videos.

50 Studies Every Internist Should Know presents key studies that shape today's practice of internal medicine. Selected using a rigorous methodology, the studies cover topics including: preventative medicine, endocrinology, hematology and oncology, musculoskeletal diseases, nephrology, gastroenterology, infectious diseases, cardiology, pulmonology, geriatrics and palliative care, and mental health. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implications for practice. An illustrative clinical case concludes each review, followed by brief information on other relevant studies. This book is a must-read for health care professionals and anyone who wants to learn more about the data behind clinical practice.

This practical guide, written by experts in mental health nursing, is designed to support healthcare practitioners in checking the physical health of people with severe mental illness (SMI). As life expectancy is reduced by 12 to 19 years in people with SMI, this patient group should receive a physical health check at least once a year. Yet many mental health practitioners have not been trained to assess their physical health needs, and even when such training is offered it may be difficult to access it because of clinical workloads. The Health Improvement Profile (HIP) provides an efficient, effective, evidence- based physical health check tool specifically designed to be used when assessing people with SMI. It supports practitioners in identifying physical health problems and guides them towards evidence-based interventions to address common health issues affecting people with SMI, ranging from cardiovascular disease to lifestyle factors such as diet, alcohol and smoking.

In this book, an evidence-based approach to dietary and lifestyle medicine is taken. An approach known as'epidemiology-based health promotion,'which compiles and presents available evidence that could help physicians, other healthcare professionals and members of the general public make wiser decision about healthcare, is also explored. Within this book, evidence-based practice (EBP) literature is reviewed, including literature on leadership and ethics in the field of internal medicine (compared to surgery) and how they affect the adoption of evidence-based medicine (EBM). A four-stage iterative model to identify procedures for implementing evidence based practices into applied settings is reviewed. The authors of the final chapter compare the cost-benefit and cost-effectiveness of all types of evidence-based medicine, both pharmaceuticals and non-drug complementary and alternative medicine (CAM) for all clinical conditions.

This text provides practitioners with the scientific literacy needed to understand statistical methods in order to increase the accuracy of their diagnoses. It will help readers comprehend how the process of clinical research relates to the scientific method of problem solving. Readers will understand the importance of three key, interrelated tasks involved in a research study: description (why it was done), explanation (what was done and to whom), and contextualization (how the results relate to other bodies of knowledge).

When faced with clients who challenge one s boundaries of competence it is important to be able to assist the individual; however, it is equally important to know when one s skills and background may be limited and when outside consultation or expertise is required. Autism Spectrum Disorder is aimed at helping clinicians screen for autism spectrum disorder (ASD), treat higher functioning individuals with ASD, and assist family members. It surveys historical views of the disorder, current diagnostic criteria, co-occurring conditions, etiology, epidemiology, assessment, treatment for affected individuals, and interventions for family members. Author V. Mark Durand uses clinical cases throughout the chapters to give readers consistent examples of the most commonly seen forms of autism and to illustrate the various facets of working with such patients.

This edited volume represents an opportunity to bring together current evidence in the treatment of eating disorders. The book includes contributions from many of the leading international experts in the field of eating disorders, as well as provides a compendium of a wide range of best studied treatments. This second edition is intended to serve as a guide to the clinician searching about how to proceed with treatment while caring for the individual with an eating disorder. The authors generously shared their contributions, in addition to their clinical insight and wisdom. The reader will appreciate and benefit from the expertise of those assembled in this text. Ultimately, patient care relies on the artful clinician who will integrate the evidence to inform the practice and tailor the treatment for each individual. This text may serve as a useful reference, both for beginning and seasoned clinicians. Clinicians across the wide range of disciplines treating individuals with eating disorders may find the chapters in this book helpful to them in their work with patients, whether in treatment facilities, in the community or in private practice. The chapters describe evidence-based or evidence-informed practices for the full range of eating disorders including anorexia nervosa, bulimia nervosa, binge eating disorder and obesity. The chapters also report on the health of a range of individuals across the life cycle; from childhood, to adolescence, to adulthood, and include a special section on males as well. Authors share with the reader their clinical expertise and provide clinical vignettes in order to highlight important treatment considerations. Although the field has already made strides, future research will enlighten our understanding of these complex conditions, including the most effective treatments.

By sharing what evidence-based education (EBE) methods are available, this book seeks to increase the efficacy of clinical education in a variety of fields and at the same time, provide valuable insights to these faculty members as to how they can contribute to the growing body of evidence regarding teaching, often referred to as the scholarship of teaching and learning (SOTL). This text is a valuable resource for faculty and doctoral students teaching in communication sciences and disorders programs. The book introduces those in higher education to the concepts key to SOTL, how to use SOTL for professional development to improve learning outcomes, and how to begin engaging in SOTL. Coverage highlights how instructors can make use of existing SOTL research to improve teaching through the use of specific, evidence-based education strategies described in depth using specific classroom application vignettes.

Evidence-Based Practice in Long Term Care The “how-to” guide for SNF evidence-based practice implementation Successfully implement evidence-based practice (EBP) in your facility with this how-to guide. The authors provide easy-to-understand guidance on the fundamentals of EBP and on how to create a culture of EBP that all staff will embrace. To ensure a smooth transition, you'll get case studies and exercises, helpful checklists to reinforce the text, and examples to help you implement EBP in your own facility. Evidence-Based Practice in Long-Term Care: Solutions for Successful Implementation will help you:Employ strategies to apply EBP through successful case studies presented in the textAchieve organizational support for EBP theory by illustrating tangible resident quality improvementStandardize skilled care with consistent resident treatment, while minimizing the variability in careReview and revisit policies and procedures on a regular basis to ensure your efforts reflect the most recent EBP standardsTable of Contents Chapter 1: What Is Evidence-Based Practice? Chapter 2: Integration of Evidence-Based Practice Chapter 3: Accessing and Appraising Resources Chapter 4: Evidence-Based Practice Becomes a Reality in Long-Term Care Chapter 5: Journal Clubs Chapter 6: How to Answer Questions With Nursing Research Methods Chapter 7: Nursing Excellence and Evidence-Based Practice Chapter 8: Examples of Evidence-Based Nursing Practice Chapter 9: Evidence-Based Practice in Long-Term Care Chapter 10: How Evidence-Based Practice Influences Quality of Care and Culture Change

The clinical management of patients with diabetes is rapidly evolving. Evidence-based Management of Diabetes provides a succinct summary of a range of topics, including areas where there is already well developed evidence for a particular treatment, but also those areas where the evidence is perhaps doubtful or there is some associated controversy or ambiguity. Where possible throughout the book treatment recommendations are given based on the available evidence and practice guidelines. The book also highlights the gaps in evidence where further research is needed. In the practice of diabetes care, there are many issues influencing practitoners currently. This book addresses many of the most pertinent issues concerning delivery of diabetes care. The authors are internationally renowned experts in the field of diabetes care who successfully and succinctly present state-of-the-art reviews based on the medical evidence designed to help the clinician be as best informed as possible in the care of patients with diabetes.

Quanto si può credere agli articoli che riportano i risultati della ricerca clinica? Valutare l'affidabilità dei risultati, saperli correttamente interpretare e applicare ai propri pazienti sono oggi competenze di importanza decisiva per ogni professionista della sanità. Scritto da clinici per i clinici, questo testo serve a formare nel lettore quel nucleo di conoscenze, tecniche e abilità necessario per sfuggire alle trappole e agli equivoci che una lettura ingenua degli articoli che riportano trial clinici può comportare.

Translational Research and Clinical Practice offers a clear and comprehensive introduction to evidence-based medicine. The use of medical literature has always been an integral tool for patient care, yet recently the modern processes of question formulation, literature search, and study evaluation have changed with the advent of the internet and technology. The physician must be able to find empirical evidence from the appropriate study using a searchable question and then determine its impact on patient care. The book provides the general framework for such medical decision making; it covers all kinds of cases and strategies, including questions of diagnosis, therapy, prognosis, differential diagnosis, clinical presentation, and causality. The tested material and approaches in this book are based on a course developed and taught by the author at Temple University School of Medicine. Organized for ease of use, accessibly written, and replete with clinically germane examples, Translational Research and Clinical Practice is a concise guide for medical students and clinicians seeking to effectively interpret and apply medical evidence in daily practice.

Netter's Orthopaedic Clinical Examination: An Evidence-Based Approach, by Joshua Cleland and Shane Koppenhaver, helps you apply best practices to get the most clinically significant information from each physical examination. Classic Netter artwork and anatomy/biomechanics tables provide a handy anatomy and pathophysiology overview, while an evidence-based approach helps you focus on the examination techniques, tests, and measures that have been proven to yield the most meaningful diagnostic findings. Evidence-based information allows you to evaluate the effectiveness of the clinical tests available and review recent studies quickly to determine which test will best predict a specific diagnosis. Netter images and discussions of anatomy and biomechanics enhance your understanding of the orthopedic anatomy and pathology of each joint.A'Summary and Recommendations'table in each chapter helps you review the available clinical evidence at a glance. An assessment of study quality (QUADAS) appendix and icons identifying study quality draw your attention to top quality studies and help you understand why some studies were included and others omitted. A scale added to reliability tables makes it easy to focus on approaches and tests with the highest reliability. A concise tabular approach to terminology and statistics makes terms and equations easier to understand. Information has been organized to parallel the structure of a clinical orthopedic examination.

The clinical management of patients with epilepsy and the associated medical literature are rapidly evolving. Evidence-based Management of Epilepsy differs from other epilepsy textbooks by focusing specifically on topics where the available evidence is sufficiently well developed to be synthesized into straightforward summaries of proven therapies. When evidence is missing or there is doubt, controversy or ambiguity, the distinguished authors offer treatment recommendations based on practice guidelines or consensus statements that span the gaps in evidence while pointing to those areas where further research is needed. The initial chapters cover critically important aspects of antiepileptic drugs (AEDs) and surgical treatment such as when to start and stop AEDs, how to monitor their effectiveness, special considerations in women who become pregnant, and when to consider surgery to alleviate seizures. The following chapters cover the therapy of seizures when they develop after traumatic brain injury or stroke, and the treatment of concomitant depression and anxiety in patients with epilepsy. The final chapters discuss emerging topics in epilepsy: the treatment of the postictal state, technologies to predict and detect seizures, strategies for closing the treatment gap and sudden unexpected death in epilepsy. The contributors are renowned experts in their fields who successfully and succinctly present state-of-the-art reviews based on the medical evidence designed to help the clinician be as best informed as possible in the care of patients with epilepsy.

The treatment of hypertension is now evolving into a decision-making process of ever greater complexity. Not only has the range of drugs available increased but so too has our knowledge of the diversity of individual patients'responsiveness to therapy, and the need to tailor their treatment with reference to a wide variety of additional factors. In order to provide effective patient care, the clinician needs to be aware of all the options available, but also of the evidence supporting their use and the extent to which that evidence justifies the choices made. In this new volume, leading authorities in their fields draw on the available evidence to provide answers to a series of key clinical questions facing the clinician treating hypertension: Should we treat prehypertension? How does the choice of therapy change in the presence of comorbidities such as obesity, ischemic heart disease, left ventricular hypertrophy, diabetes or cerebrovascular disease? Evidence-based Management of Hypertension provides answers to these and many other questions, as the authors present an expert analysis of the available evidence and offer authoritative recommendations for treatment planning. In each chapter, tables highlight evidence from a variety of sources, and every chapter concludes with a series of key practice points that present a summary of evidence-based recommendations for best practice, graded according to the quality of that evidence. For any clinician concerned with the care of the hypertensive patient, this volume will be a valuable aid to treatment planning and long-term management.

Practising evidence-based medicine necessarily depends on the clinician having access to the best evidence available, but in a fast-moving field, keeping up to date with the latest developments is a challenging prospect. In this new volume, leading experts focus on the most important clinical issues associated with the management of lipid disorders, evaluating and interpreting the evidence available to provide the reader with a reliable summary of our current knowledge. Topics covered include therapeutical strategies for managing hereditary lipid disorders, including familial hypercholesterolemia, both in adults and children, and familial combined hypercholesterolemia. The authors also evaluate the evidence for a link between inflammatory disease and cardiovascular risk; the metabolic syndrome and the interconnections between dyslipidemias and diabetes. They also look at therapeutic challenges such as the management of patients who are statin resistant, and the control of lipid levels in those suffering renal insufficiency. Tables highlight important data, evidence from trial results and expert reports, and each section concludes with a series of key points that present a summary of evidence-based recommendations for best practice, graded according to the quality of that evidence. Evidence-based Management of Lipid Disorders provides the busy clinician with a unique analysis of the data supporting current therapies and will help the reader formulate effective strategies for treating their own patients.

'A Beginner's Guide to Evidence Based Practice in Health and Social Care is for anyone who has ever wondered what evidence based practice is or how to relate it to practice. It presents the topic in a simple, easy to understand way, enabling those unfamiliar with evidence based practice to apply the concept to their practice and learning. Using everyday language, this book provides a step by step guide to what we mean by evidence based practice and how to apply it. It also provides an easy to follow guide to searching for evidence, explains how to work out if the evidence is relevant or not, explores how evidence can be applied in the practice setting, and outlines how evidence can be incorporated into your academic writing.'--Publisher's description.

This practical handbook provides a clear and comprehensive evidence-based guide to the care of women in primary care, intended for general and family practitioners, nurses, physician assistants, and all those who practise primary care of women. It emphasizes preventive and well-woman care throughout the life-cycle of a woman, including sexuality, contraception, medical care in pregnancy, and psychological and important medical concerns. This second edition, revised and updated throughout with several new contributing authors, incorporates the latest evidence and research-findings on a wide range of problems for which women seek medical guidance. There is an expanded section on menstrual problems and menopause-associated conditions, including clear guidance on the use of hormone replacement therapy.

British Medical Association Book Awards 2009 - First Prize Winner, Primary Care Category Evidence-Based Diagnosis in Primary Care provides guidance on diagnosis in general practice, from the patient's first presentation with a symptom to the final establishment of a diagnosis or referral for further investigation. The book is divided into two parts: • Symptoms; which details the steps necessary to reach a provisional diagnosis when a patient presents; and • Disorders; in which the more detailed assessment of that initial diagnosis is described. This is the first book to be written about diagnosis in primary care that attempts to base its guidance on the research evidence. Enough information is provided on each symptom, or condition, to decide on the pre-test probability of each possible disorder, and how the symptoms, signs and investigations alter those probabilities to allow a conclusion to be reached about the most likely diagnosis. Evidence-Based Diagnosis in Primary Care also explains the principles of evidence-based diagnosis – with special emphasis on the issues raised by attempting an evidence-based approach in primary care – and clearly demonstrates the power, and the difficulties, of an evidence-based approach. Many chapters also feature ‘red flags'– elements of the history or examination that should alert the practitioner to the possibility of serious disease, which is vital for general practice.

De patiënt van nu mag ervan uitgaan dat de huisarts een gedegen, academische opleiding achter de rug heeft. Een opleiding die zich voortdurend aanpast aan en vooruitloopt op de veranderingen in het beroep, zoals het werken in grotere samenwerkingsverbanden, en in de maatschappij (bijvoorbeeld de vergrijzing). Alle facetten van de huisartsopleiding nemen hiertoe deel aan een continu kwaliteitsproces. Niet alleen moet de kwaliteit van het opleidingsinstituut als organisatie optimaal zijn, maar ook dat van de opleidingspraktijken en de stage-instellingen, van de daar werkzame opleiders, de docent.

Title from PDF title page (viewed on Sept. 9, 2008).

This book aims to supplement the reader's clinical experience with a carefully designed series of commonly encountered clinical problems in general surgery to simulate the clinical decision-making approach. Each clinical topic includes: a problem-solving approach; system-based essential core knowledge; concise explanations of relevant basic sciences; management pathways (based on the most up-to-date guidelines); FAQs; self-assessment (EMQs, SBAs, T/F). This book, primarily aimed at undergraduates and junior doctors, will guide and stimulate the reader to recognise, recall and apply the relevant facts to given clinical situations and also enhance success at clinical examinations.'Standard textbooks can be daunting. This book is different. I believe that students and young doctors will find this an easy read and will be able to translate the scenarios into an understanding of how clinical pathways are constructed. By asking questions through the pathways students are encouraged to develop their own ideas - a form of problem-based learning rather than learning by rote. Retention of facts is so much easier when they form part of a story.'David Cade FRCS, Consultant Surgeon

Description based on print version record.

Chronic diseases - the major causes of premature adult deaths in all regions of the world - have been generally neglected on the international health and development agenda. WHO is launching a global report on chronic diseases, which will present the latest scientific information and make the case for increased and urgent action for chronic disease prevention and control. The report will review the burden of chronic diseases, major risk factors and associated trends. It will be an authoritative and state-of-the-art guide to effective and feasible interventions. The primary audience of the report will be health planners and decision-makers as well as stakeholders who can influence multisectoral government action. (Product Description).

Clinicians from all disciplines and specialties require up-to-date information in order to deliver the best possible care. It is imperative that information is relevant, valid, and obtainable in a realistic fashion. Information mastery is the applied practice of evidence-based medicine. Information Mastery: Evidence-Based Family Medicine, Second Edition outlines the techniques and resources necessary for clinicians to incorporate an evidence-based approach to the care of patients. This second edition uses “Usefulness Equation” as a guide to the Information System, whereby the usefulness of information varies directly with the relevance of information and the validity, divided by the work it takes to obtain the information. This text focuses on all three factors: learning how to obtain valid information from journal articles, reviews, CME, experts, practice guidelines, decision analysis, and pharmaceutical representatives; how to focus on relevant information – POEMS (Patient Oriented Evidence that Matters) – in order to provide more effective patient care and that which has the potential to change clinical practice; and finally, how to access this information quickly and efficiently. This edition also focuses on “Point of Care”, stressing the use of computer-based systems, especially hand-held computers. Special to the accompanying CD-ROM are instructions for teacher to aid in effectively conveying key concepts.

This publication takes a critical, evidence-based look at the efficacy of diagnostic tests which are increasingly being used to evaluate organ damage and dysfunction. The use of biomarkers is growing, with a steady stream of products being brought out by the pharmaceutical industry. Some of these assist in diagnosis, others provide a means of monitoring the state of progression of disease and the effectiveness of therapeutic options. However, in many cases the evidence which supports the use of these methods as opposed to traditional biochemical tests has not yet been demonstrated, and it is intended that this volume will help clarify the strengths and weaknesses of using these biomarkers across a wide range of applications and in the various organs of the body. This approach will provide pathologists, clinical biochemists and medical laboratory scientists with an invaluable overview of the diverse applications of biomarkers in medicine.

Includes bibliographical references and index.

In this lucid, readable book Trisha Greenhalgh provides the basics of evidence based medicine: how to find a medical research paper, assess it for its scientific validity, and where relevant, put the findings into practice. Written for anyone, medically qualified or not, who wishes to understand and apply evidence based medicine, How to Read a Paper makes seemingly obscure concepts clear and relevant, using practical examples and considering all the main types of research paper. This book is a comprehensive introduction to the usefulness and potential applications of evidence based medicine in the clinical setting.