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This textbook provides an invaluable resource for multidisciplinary medical professionals performing structural heart interventions. Chapters contain clear, easy-to-follow guidance on the use of multi-modality imaging and clinical decision-making. Detailed information is given on intraprocedural monitoring and post-procedural evaluation for successful therapeutic intervention. The use of cardiac imaging technologies including three-dimensional echocardiography, cardiac computed tomography (CT) and magnetic resonance imaging (MRI) are presented with images, illustrations, and video material, along with learning objectives, imaging pearls, and key points to reinforce the key concepts described, facilitating a deep understanding of the value of cardiac imaging in line with the latest guidelines. Cardiac Imaging in Structural Heart Disease:A Textbook for the Heart Team comprehensively discusses the use of the latest methodologies and technologies available in this field of medicine. This Springer Nature Flashcard augmented book is an essential resource for all members of the structural heart team including adult and pediatric cardiologists, anesthesiologists, cardiac sonographers, radiologists and cardiovascular technologists. Additional questions and answers via app: Download the Springer Nature Flashcards app free of charge and use exclusive additional material to test your knowledge.

Written and edited by world-renowned experts in the field, including Dr. Shoei K. Stephen Huang, a pioneer of radiofrequency catheter ablation procedures, Huang's Catheter Ablation of Cardiac Arrhythmias, 5th Edition, provides authoritative, comprehensive information on these increasingly used electrophysiology procedures. This outstanding resource is packed with cutting-edge content in every area of this fast-changing field, including anatomy, diagnostic criteria, differential diagnosis, mapping, and ablation. Ideal for practitioners who need a definitive, user-friendly ablation text for the electrophysiology lab or office setting, it offers quick access to practical content, using detailed tables and high-quality images to help you apply what you learn in your practice.Reflects all the latest technology, including the new pulse field ablation (PFA) procedure, new balloon technologies (RF, laser, and PFA) for pulmonary vein isolation, and high-resolution 3D mapping systems.Offers expert guidance on atrial tachycardia and flutter, atrial fibrillation, atrioventricular nodal reentrant tachycardia, tachycardias related to accessory atrioventricular connections, ventricular tachycardia, transseptal catheterization techniques, ablation for pediatric patients, and patient safety and complications.Contains new chapters covering Biophysics and Clinical Applications of Laser Ablation, Biophysics and Clinical Applications of Pulse Field Ablation, Multiple Strategic Approach to Ablate Atrial Fibrillation, Ablation of Challenging/Difficult Accessory Pathways, Ablation of Ventricular Tachycardia in Arrhythmogenic Ventricular Cardiomyopathy, and more.Contains 450 figures, including ECGs, intracardiac recordings, 3D mapping, ultrasound, fluoroscope, and ablation images.Includes numerous tables and boxes that provide quick access to key points, arrhythmia mechanisms, diagnostic criteria, target sites for ablation, use of special equipment, complications, and troubleshooting problems and their solutions.Provides access to 20 video clips, including transseptal access to the left atrium, intracardiac ultrasound, and techniques of pericardial access.Any additional digital ancillary content may publish up to 6 weeks following the publication date.

This 2 volume set comprises of the 4th edition of Volume 1 and the 5th edition of Volume 2.The fifth edition of Volume 1 of Handbook of Obesity written by global experts covers the basic science aspects under the broad topic areas of epidemiology, etiology, and pathophysiology of obesity. Divided into 5 sections and detailed in 66 chapters, this edition covers the important advances occurring over the past decades. With a focus on science of obesity and factors participating in the etiology of obesity, this topic is studied from biological, behavioural and environmental perspectives.Volume 1 is structured into 5 parts: Part 1 focuses on the history, definitions, and prevalence of the obesity. It identifies the historical references to excess weight, obesity in art and literature, direct and surrogate measurements of adiposity and obesity related traits, epidemiology of obesity around the globe, and age, sex and ethnic variation completes this part of the volume.Part 2 explains the biological determinants of obesity. It explains the bioenergetics, energy dissipation mechanisms and exposure to experimental overfeeding, genetic and epigenetic evidence, metabolic rates, energy expenditure and energy partitioning, and the evidence on infections and adiposity.Part 3 describes the behavioral determinants of obesity. It deals with chapters related to food, beverages, and ingestive behavior, dealing with smoking, breast-feeding, and sleep duration and pattern, and sedentary behavior, occupational work, and leisure-time physical activity and obesity.Part 4 comprises of chapters explaining the environmental, social, and cultural determinants of obesity. The chapters in this section focus on the role of agriculture and the food industry in the current obesity epidemic, social and economic aspects of obesity, and ethnic and cultural differences and environmental pollutants.Part 5 of this volume discusses the health consequences of obesity. The chapters address important topics such obesity and heart disease, lipoprotein metabolism, insulin resistance and diabetes, metabolic syndrome, cancer, hepatic biology, pulmonary functions, and arthritis and gout, mental health and quality of life, growth and health disorders in pediatric populations, and on bias and discrimination affecting the obese persons.Volume 2 of the 5th Edition of the Handbook of Obesity spotlights on clinical applications for evaluation, diagnosis, prevention, and treatment of obesity. It covers on the several major developments occurred between the previous and the new edition, including the effect of SARS-CoV-2 on people with obesity, the concept of'Precision Medicine', and new medications approved by USFDA aiding patients with obesity weight loss of 15 to 20%.This volume is structured into 5 parts:Part 1 provides insights from evolution on changes in diet and physical activity, and the implications and results for preventing obesity, health care costs associated with obesity and the cost-effectiveness of obesity prevention and treatment.Part 2 deals with evaluation of overweight patients, approaches for classifying obesity and using this knowledge to evaluate patients, and addressing ethnic and racial considerations in evaluating patients with obesity.Part 3 explains the impact of lifestyle in managing obesity, which include behavioural management, diet, dietary composition, and meal timing, and the effects of physical activity and exercise in weight loss and weight loss maintenance.Part 4 is focused on medications in the management of obesity. This includes drug selection, various classes of drugs, combination of drugs affecting weight loss, effect of herbal agents on weight loss and treatment of obesity in pediatric populations, genetic diseases causing obesity and the role of drugs in treating the dyslipidemias.Part 5 discusses bariatric surgery, its history, procedure

A high-yield guide for interventional radiologists on venous thromboembolic diseaseEpidemiological analyses estimate venous thromboembolism (VTE) impacts as many as 600,000 individuals annually in the United States, and it is the leading preventable cause of in-hospital mortality. Diagnosing VTE based on clinical symptoms is generally unreliable due to nonspecific signs, while patient management is influenced by thrombosis severity, location, and underlying risk factors. Venous Thromboembolism: A Practical Guide in Interventional Radiology by renowned radiologists Jeffrey Weinstein, Jeet Minocha, and Joshua D. Dowell focuses on helping clinicians improve VTE diagnosis, decision-making, and procedural outcomes.The first chapter covers interventional radiology basics that lay the groundwork for effective management of patients with VTE, including pathogenesis, patient diagnosis, and medical therapies. Chapters 2 and 3 discuss pharmacologic treatment and imaging of deep vein thrombosis (DVT) and pulmonary emboli (PE), respectively. Chapters 4 to 9 provide practical guidance on patient selection and workup, basic and complex interventional techniques, and management of potential complications for a variety of pathologies and interventions. The final chapter presents a Q&A and VTE-related safety issues.Key features:An authoritative review of VTE by a curated collection of experts in the fieldA reader-friendly primer on the evaluation and management of DVT, PE, and intracardiac thrombus based on evidence-based practicesPractical guidance on deployment and retrieval of inferior vena cava (IVC) filtersThis resource is essential reading for interventional radiology residents and fellows, as well as early-career clinicians who are intricately involved in the management of patients with deep venous disease.

This book provides a comprehensive overview of essential concepts and evidence that guide the practice of contemporary preventive cardiovascular nursing. The sections incorporate a lifespan approach to cardiovascular wellness, and provide perspectives on sources of known and emerging cardiovascular risk factors as well as the spectrum of multidimensional factors including biological, behavioral, psychological and sociocultural influences on cardiovascular wellness, risk, and the evolution of cardiovascular conditions. Unique features address: 1) building resilience across the lifespan such that optimal cardiovascular wellness can be attained within multiple contexts of health states to increase a healthy lifespan and longevity; 2) behavior change skills for risk factor reduction; 3) risk factors and risk reduction approaches with special populations defined by gender,, age and aging, heath states, and health equity issues; and 4) high level roles for cardiovascular nurses as provider - risk assessor, communicator and care provider; educator, leader, patient and health advocate. Relevant case studies are included throughout to facilitate the application of the content. This book fills a gap in that there is no other book on preventive cardiovascular nursing care and roles, and it provides support for the nurse to lead relevant interdisciplinary teams. The book will empower nurses to build knowledge and skills for cardiovascular prevention and to provide leadership for optimal cardiovascular wellness for patients and communities.

Written by pioneers in the field of interventional cardiology, this new edition provides readers with the information and expert guidance needed to perform safe and effective transcatheter aortic valve implantation/replacement (TAVI/TAVR). The book is supplemented by visual aids, including more than 300 illustrations and videos.

This book provides clinicians with the information needed to effectively interpret the literature from observational and interventional cardiovascular outcomes studies. The book begins by providing a historical context of cardiovascular epidemiology, followed by chapters addressing key concepts in the study of cardiovascular disease such as the types of cardiovascular outcomes studies, basic and evolving design and statistical considerations, current guidelines for reducing atherosclerotic cardiovascular disease risk, surrogate markers of cardiovascular disease, challenges in developing evidence-based recommendations for non-pharmacological interventions, an overview of the pharmaceutical development process, and a detailed discussion of the clinical evidence supporting several factors and their relationships with atherosclerotic cardiovascular disease (lipids, inflammation, hemostasis, heart rhythm, blood pressure, diabetes, obesity, and chronic kidney disease). Cardiovascular Outcomes Research is a must-have resource for physicians and other clinicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.

This comprehensive book covers all aspects of cardiovascular health and disease. It begins with sections on cardiac diagnostic approaches like electrophysiology, ECG interpretation, cell death mechanisms, and myocardial perfusion imaging. A large section examines various cardiovascular diseases and related conditions, including gastroesophageal reflux disease, testosterone deficiency, multimorbidity, valvular disease, and rheumatic fever. Treatment strategies are covered next, with chapters on blood management techniques, infections of cardiac devices, anaesthesia for cardiomyopathies, and radiation safety in nuclear cardiology. The book then delves into advancements in the field such as artificial intelligence applications, cardiac resynchronization therapy, stress adaptation mechanisms, and more. Additional sections explore peripheral artery disease, patient cares like nursing for cardiac procedures, molecular pathways in myocardial hypertrophy, cardiac radiology, and mechanical cardiomyopathies. With its comprehensive scope and up-to-date information, this book serves as an invaluable tool for cardiologists, cardiothoracic surgeons, nurses, and any medical professional involved in caring for patients with cardiovascular disease. It also provides a solid foundation for students and residents training in the field.

Acute pulmonary embolism is an emergency diagnosis and major cause of vascular death. It also presents one of the most missed diagnosis with heterogenous clinical presentation. The individual patient and health care burden of pulmonary embolism is increased in the era of increased prevalence of cancer associated pulmonary embolism, high risk pregnancy, underline thrombophilia's, cardiovascular disease and in the last two years, COVID-19 infection. This book comprehensively reviews the etiology, pathophysiology, symptoms, diagnostic approach, imaging, risk stratification and contemporary treatment for pulmonary embolism in several patients'scenarios. The chapters also cover treatment of deep vein thrombosis, the role or pulmonary embolism response teams (PERT), catheter interventions in pulmonary embolism as well as all challenges in chronic thromboembolic pulmonary hypertension (CTEPH). The book's purpose is helping different physician profiles to properly treat often complex profiles of pulmonary embolism patients. The chapters are supported by figures and tables to help the readers understand mechanisms, guide diagnosis and treatment of pulmonary embolism in different clinical settings.

This book is the first board review atlas in Pediatric Cardiology. Chapters cover high-yield and image-based board-style questions with full explanations. This book utilizes images from fetal echocardiography, transthoracic echocardiography, transesophageal echocardiography, cardiac computed tomography, cardiac magnetic resonance, 12 lead electrocardiogram, ambulatory ECG monitoring and intracardiac electrophysiology tracing. This highly illustrated atlas will be an excellent resource not only for board certification and recertification but also as a clinical guide in Pediatric Cardiology. Board Review Atlas of Pediatric Cardiology is a valuable resource for pediatric cardiologists, pediatric cardiology fellows, pediatric cardiac surgeons, and pediatric radiologists and residents.

This book serves as a clinical guide for the growing number of Advanced Practice Clinicians (APC) who care for stroke patients. It covers the entire spectrum of stroke care: acute, inpatient, and outpatient, as well as fundamental topics like neuroanatomy and radiology. Each chapter succinctly reviews crucial topics designed to guide APCs of any experience level with clinical decision-making. To further enrich the text, we incorporated guidelines, relevant trial data written in plain language, decision-making algorithms, clinical pearls, and case vignettes. Since this is a book for APCs, each chapter is written in a clear, clinically focused manner by an experienced APC with a collaborating physician. We hope this is a helpful resource not only for APCs in neurology but also for those practicing in other specialties, primary care, and students learning about stroke care.

Environmental conditions and processes are one of the major pillars on which the human well-being rests. It is the core responsibility of the society to preserve and enhance better conditions for the human well-being. Indeed, there are several evolving unmet needs in public health. Emerging and re-emerging infectious diseases and a surge in the incidence of non-communicable diseases, including cardiovascular diseases (CAD), chronic respiratory diseases, and metabolic diseases have been impediments to sustainable well-being. Many factors are critical in the global surge in the rate and incidence of cardiovascular diseases. These include the shift from acute to chronic conditions, the shift from single risk factor vs. multiple influences, aging population, global health disparities, exposure to lower harmful influences over a longer period, etc. However, the epigenetic factors due to unhealthy environment play a most significant role in the underlying pathogenesis of cardiovascular diseases. Unfortunately, this has been ignored for a long time and realized lately to expand and disseminate knowledge to general population, expand research activities to investigate the cellular and molecular mechanisms, and develop better preventive and treatment strategies. The most significant environmental impoverishment in the pathogenesis of cardiovascular diseases include different genetical, chemical, physical, and biological influences, but not limited to, socio-economic status and lack of nutrients, nutritional aspects including habits, diets and additives, inhaled and ingested pollutants, exhaust gas and gasoline products, tobacco smoke, water pollution, alcohol consumption, soil and mineral pollution, solvents, pesticides, microplastics, non-critical usage of drugs, climate change, extreme atmospheric conditions, extremes in noise and temperature, electromagnetic influences, microwaves and radiation, outdoor light pollution, mental stressors, lack of or over exercise, microbiota and microbiological agents like SARS CoV-2 virus, etc.

This two-volume manual covers the most relevant protocols in pediatric cardiac care to serve as a practical guide that matches and reflects the high level of accumulated knowledge and expertise in this clinical field. It includes 179 chapters and offers comprehensive, precise, and up-to-date practical tips with specific care protocols to provide the most efficient strategies for high-quality care in patients with congenital heart disease (CHD). This book simplifies learning with many tables, flowcharts, graphs, and algorithms for easy access and fast action. Volume II covers many vital sections, such as ethical considerations in pediatric cardiac patients, pediatric cardiac surgery, pediatric cardiac intensive care unit (PCICU) guidelines, clinical pharmacy guidelines, adults with congenital heart disease, appendix (with normal values/reference tables/graphs/scores and various calculated indexes used and needed for proper pediatric cardiac care).This manual is a must-have resource for pediatricians, neonatologists, clinical pharmacy specialists, pediatric intensive care physicians, pediatric cardiologists, pediatric cardiac intensive care physicians, pediatric cardiac surgeons, and/or surgeons interested in pediatric cardiac surgery.

This two-volume manual covers the most relevant protocols in pediatric cardiac care to serve as a practical guide that matches and reflects the high level of accumulated knowledge and expertise in this clinical field. It includes 179 chapters and offers comprehensive, precise, and up-to-date practical tips with specific care protocols to provide the most efficient strategies for high-quality care in patients with congenital heart disease (CHD). This book simplifies learning with many tables, flowcharts, graphs, and algorithms for easy access and fast action. Volume I covers many key sections, such as prenatal morphogenesis and physiology of the human heart, fetal cardiology, neonates and congenital heart disease, cardiac imaging, pediatric cardiac catheterization, pediatric cardiac electrophysiology, critical events and emergency procedures in pediatric cardiac care, management of specific cardiac conditions, general pediatric and subspecialty issues related to children with CHD, follow-up standards in pediatric outpatient cardiology clinic, prophylaxis in children with CHD, quality aspects, professional conduct and training in pediatric cardiac care. This manual is a must-have resource for pediatricians, neonatologists, clinical pharmacy specialists, pediatric intensive care physicians, pediatric cardiologists, pediatric cardiac intensive care physicians, pediatric cardiac surgeons, and/or surgeons interested in pediatric cardiac surgery.

Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the obesity and metabolic syndrome epidemics, which this up-to-date book deals with comprehensively. The contents outline disease mechanisms, diagnostic tests, management, varying manifestations, and special populations. It covers the mechanistic pathways that contribute to NAFLD development, including the role of genetic variants and the gut microbiome. It elaborates on noninvasive diagnostic tests to screen for NAFLD, determine its severity, and monitor response to lifestyle intervention and pharmacologic treatment. This book helps clinicians diagnose and treat this common and potentially deadly disease. Key Features: Reviews current drugs in development and provides practical advice to clinicians on the diagnosis and management of fatty liver. Proves attractive to primary care providers who are on the front line of managing patients with NAFLD, to gastroenterologists and hepatologists who would benefit from updated data on how to risk-stratify patients and identify those who will be eligible for pharmacologic treatment, and other specialists such as cardiologists, endocrinologists, and nephrologists who will find this book to be a useful reference on the extrahepatic manifestations of NAFLD. Focuses on extrahepatic manifestations and new insights on the mechanistic drivers of the disease.

The fifth addition of this classic text that focuses on the diabetic foot continues the tradition of the previous four editions. More specifically, it includes contributions from a distinguished panel of clinicians and researchers, who have either participated in previous editions or are new, who provide up-to-date information on the pathophysiology and management of diabetic foot ulceration. As with the previous editions, it is divided into three sections: the first part focuses on clinical features and diagnosis; the second on pathophysiology; and the third on the management of diabetic foot problems. The main emphasis of the clinical part is on the multidisciplinary approach that has been mainly developed by the world-renowned Joslin-Beth Israel Deaconess Foot Center, which pioneered the management of diabetic lower extremity problems. Also like previous editions, the author panel includes diabetologists, podiatrists, vascular surgeons, infectious disease specialists,orthotists, plastic and orthopedic surgeons, the majority of whom work at the Joslin-Beth Israel Deaconess Foot Center. In addition, the fifth edition not only describes the state-of-the-art current methods in clinical practice but also includes a thorough update of all research progress during the last five years. This updated edition of this timely text will be of significant value to all physicians and researchers with interest in a comprehensive understanding of the diabetic foot.

This book discusses the epidemiology and the known cardiotoxic effects of chemoradiation agents in addition to newer therapies in hematopoietic stem cell transplantation (HSCT). Recent expert consensus statements from cardiology and hematology/oncology societies are reviewed in regard to risk stratification of the patient based on the type of treatments they are undergoing. Finally, gaps in knowledge are identified with proposed avenues of research that allow for more accurate risk assessment, prediction and potential treatment of the HSCT patient in attenuating the risk of developing cardiovascular comorbidities.Cardiovascular Considerations in Hematopoietic Stem Cell Transplantation reveals a picture of effective management of these patients in order to optimize both short- and long-term outcomes of HSCT. It is of considerable interest to all involved or training within this rapidly growing area of cardiology and oncology.

Trauma is a serious public health problem worldwide and is the leading cause of death among adults and children. Physiotherapists play a key role in the interdisciplinary team caring for patients with physical injury after a traumatic event. The aim of Cardiopulmonary Physiotherapy in Trauma: An Evidence-based Approach is to encourage quality evidence-based physiotherapy management of adult and paediatric survivors of trauma in an acute care setting on a global level.The first edition of the book was written by South African physiotherapy academics and clinical physiotherapists with expertise in trauma care. This new edition involves the South African writers from the first edition as well as a team of international experts in trauma care across health care disciplines (including surgeons, nurses, occupational therapists, dieticians, pain experts, and social workers). The information shared in the first edition has therefore been updated with more clinical expertise and the latest available evidence. The new content in this latest edition aims to make physiotherapists more aware of the importance of considering how pain influences patients'participation in therapy sessions, and of a team approach to patient care (e.g. managing pain and planning of care) to ensure the best possible outcomes for adult and paediatric patients with traumatic injury, at hospital discharge.

The adoption of aortic valve repair is exponentially increasing, and patients and cardiologists are demanding this with more enthusiasm. This is a current subject of great interest, and contemporary results are already present, and more are awaited. The book ‘ElKhoury's Textbook of Aortic Valve Repair'describes the whole journey through the set-up of an aortic valve repair program, pertinent investigations, patient selection, different approaches, cardio-pulmonary bypass, re-operations, and its application with combined surgery. This book is directed to all training cardiac surgeons and cardiologists, consultant cardiac surgeons and cardiologists, anaesthetists, intensive care specialists and perfusionists. This is the first book authored exclusively on this subject. The 3 editors (esp Prof. ElKhoury) are leading authorities on this subject in the world and are mentors for many surgical programs. Every chapter is authored by champions in the particular aspect of aortic valve repair surgery. These are mainly from USA and Europe.

Syncope is a common condition related to transient loss of consciousness due to global cerebral hypoperfusion and caused by a variety of aetiologies. Although it is self-limited, and usually benign, syncope can be the harbinger of life-threatening heart rhythm problems due to cardiac conditions. A multidisciplinary approach is practical for its evaluation and treatment, requiring the expertise of cardiologists, neurologists, emergency medicine specialists, and other clinicians. This book provides a detailed review of etiopathogenesis and a state-of-the-art update on therapeutic options offering recommendations based on the guidelines and experience of experts while discussing procedures and tests with their indications, methodology, interpretation, and limitations.Key Features: Discusses new diagnostic tools, and therapeutic modalities including video monitoring. Provides up-to-date recommendations regarding the indications for and appropriate interpretation of non-invasive and invasive cardiac testing, for cardiologists and internists. Places particular emphasis on diagnosing and treating reflex and arrhythmic syncope.

This book is a guide to help clinicians caring for people with advanced heart failure develop a team approach for a group of people who, despite the increased awareness, remains disadvantaged in accessing support to help them live with, and support them as they die from, this serious illness.

The must-read book for all cardiac surgical practitioners and part of the revolutionary'Key Questions'series of cardiothoracic surgical textbooks, including Key Questions in Thoracic Surgery and Key Questions in Congenital Cardiac Surgery. Key Questions in Cardiac Surgery provides a systematic, evidence-based overview of the important topics in contemporary adult cardiac surgical practice.

This manual defines sex and gender differences in cardiovascular disease and how they have become an important topic within most subspecialities in the field of cardiology. It is now evident that sex differences in biology and lifestyle influence the pathophysiology of heart disease. Consequently risk factors for cardiac disease are modified by sex and gender, and women and men develop partly different variants of the same heart diseases. These facts profoundly influence prevention and management in clinical practice. Good medical practice demands a more tailored and personal care for each individual patient. In addition, the life-course of women has a few unique phases, related to hormonal changes in pregnancy and after menopause, that also interact with individual risk and the development of co-morbidities. As heart disease is now the number one cause of death in women worldwide, a more specific attention to cardiovascular disease in women is justified. Most important advances in gender-specific knowledge are related to ischemic heart disease and its traditional and sex-specific risk factors. Diagnostic pathways have changed, coronary angiography is no longer the gold standard that it used to be. Recent guidelines and position papers have paid attention to these new insights, whereas educational programs urgently need to be adapted. The ongoing paradigm shift in cardiology needs to be updated for the clinician in an easy and accessible manner. Other important topics in which sex and gender differences have been elaborated are heart failure, atrial fibrillation, aortic valve disease and its treatment, cardiac rehabilitation, co-morbidities, cardiotoxicity in cancer treatment and neurology. In addition, female-specific risk factors and socio-economic factors are relevant to women's cardiovascular health. We will invite the best EU experts in this field to contribute to the various chapters. Manual of Cardiovascular Disease in Women has an educational role for established cardiologists and vascular specialists in training, nurses and other allied professionals. It represents an update on the most recent insights in sex- and gender differences in cardiovascular health with a focus on women's cardiovascular diseases. Additional questions via app: Download the Springer Nature Flashcards app for free and use exclusive additional material to test your knowledge.

​The second edition of this book explores different aspects of the relationship between hypertension and brain damage, providing readers with up-to-date information that will be of interest to clinicians and researchers alike. In recent years, numerous studies have been published that have added new evidence on different aspects of the disease. New recommendations and the latest hypertension guidelines on stroke and dementia will be described in this edition, which will include not only updated content but also new chapters on aspects that have recently emerged in relation to hypertension and brain damage. After an introductory chapter on the epidemiology and burden of neurological disease induced by hypertension, the significance of various comorbidities that represent risk factors for brain damage in the context of hypertension is discussed. The effects of hypertension on small and large cerebral arteries and the consequences on brain damage are then examined in detail. Similarly, the association between hypertension and ischaemic stroke, transient ischaemic attack and haemorrhagic stroke is explored in depth, and the evidence and guidelines for reducing hypertension during the acute phase of each form of stroke are summarised. Both primary and secondary prevention of stroke are addressed, with the results of major studies presented. The reader will also find interesting new perspectives on the role of different imaging techniques, including CT and functional MRI, in detecting and diagnosing brain damage in patients with hypertension. The concluding chapters examine the relationship between hypertension and cognitive decline and dementia associated with hypertension, its pathophysiology, the detection of cognitive impairment in daily practice, and its prevention and treatment.

Renowned as the essential reference for all venous specialists, phlebologists, vascular surgeons, and vascular medicine physicians, the fifth edition of the Handbook of Venous and Lymphatic Disorders: Guidelines of the American Venous Forum covers the investigation, prevention, evaluation, and treatment of venous and lymphatic disorders.The full spectrum of acute and chronic venous disorders, chronic lymphedema and chylous complications are included. New or entirely revised chapters discuss in detail basic considerations, diagnostic evaluation, management of acute venous thrombosis, and chronic venous disorders, including deep venous disease and venous ulcers. Medical treatments, including compression therapy, veno-active compounds, and new oral antithrombotic medications, are discussed. Minimally invasive endovascular techniques to treat deep vein thrombosis and pulmonary embolism with catheter-directed thrombolysis, pharmaco-mechanical, mechanical thrombectomy, and venous stenting are presented.Few areas in medicine have progressed as fast as minimally invasive outpatient treatment of chronic venous disease. Endovenous therapies include laser and radiofrequency ablation, liquid and foam sclerotherapy, minimally invasive surgery, cyanoacrylate embolization, mechanico-chemical or ultrasonic ablations, among others.Written by the world's foremost venous experts, leaders of the American Venous Forum, and international authorities, the Handbook has become the most important reference for both day-to-day management and investigation of venous and lymphatic disorders.

This extensively revised edition of this important textbook provides a practical approach to the use of nuclear cardiology for the general cardiologist. It is an adjunct to the existing literature in nuclear cardiology, providing a simple case-based approach to understanding the methodology, application and outcomes of the modality, and representing a pocket-sized compendium designed for a clinical cardiology audience. Nuclear cardiology procedures have been a mainstay in noninvasive testing for the diagnosis and risk stratification of coronary artery disease for many years. Although a mature field with a multitude of clinical applications, the advances in the technology and imaging procedures have been remarkable and important to document.Handbook of Nuclear Cardiology: Cardiac SPECT and Cardiac PET reviews the important indications for choosing nuclear cardiology procedures and provides a description of the procedures themselves, including both SPECT and PET imaging protocols, as well as supplying readers with a the key readings resources. It emphasizes how noninvasive testing results can be used clinically and the appropriateness of such techniques using a concise and logical structure, vital for trainees, practicing physicians, nurses and technologists looking for a brief, up-to-date overview and reference volume for nuclear cardiology. It therefore represents an essential reference for a large number of cardiologists internationally looking for information in the field.

This case-based atlas encompasses all aspects of imaging in congenital cardiac defects, cardiac masses, inflammatory and acquired heart diseases, cardiomyopathies and coronary-related pathologies. The chapters begin with a description of the imaging approach, followed by cases comprehensively covering the gamut of clinical scenarios that may be encountered in clinical practice. The atlas provides pertinent information about each discussed disease state, its imaging diagnosis and recent advances, including role of radiology in management, follow up and prognostication. Cases that may pose as imaging differentials accompany the index case, followed by a variety of companion cases illustrating the possible spectrum of abnormalities that the reader may be confronted with while dealing with the index case. It acts as a guide for the cardiovascular radiologist, physician, paediatrician, internist, cardiologist, cardiothoracic surgeon as well as radiology residents for inculcating an evidence-based approach for choosing the right imaging algorithm in the given clinical situation. The highly visual design of the atlas enables it to act as a quick and ready reference.

The ESC Textbook of Thrombosis is the third iteration of Therapeutic Advances in Thrombosis. Now a new addition to the European Society of Cardiology (ESC) publications portfolio, it is informed by the work of the ESC's Working Group on Thrombosis. Written by internationally renowned experts in the field of thrombosis, the textbook presents an up-to-date and in-depth review of all aspects of thrombosis and antithrombotic therapies. Not only does it reflect contemporary European guidelines from the ESC but also it also summarizes the latest evidence from clinical trials. Covering the topic in great detail with thirty-one chapters, the textbook is split into four sections: Pathophysiology of thrombosis, Clinical pharmacology of antithrombotic drugs, Therapeutic strategies, and Special situations. Appealing to the large community of cardiovascular healthcare specialists in Europe and across the world, the textbook is a must read for cardiologists dealing with acute and chronic coronary syndromes, atrial fibrillation, artificial heart valves and pulmonary embolism. It will also appeal to cardiac surgeons, cardiovascular researchers, and general physicians alike.

This book is focused on a clinical-based diagnostic approach of autonomic dysfunctions, highlighting main diagnostic tools and pharmacological and non-pharmacological therapies available nowadays. The autonomic nervous system (ANS) is a subcomponent of the peripheral nervous system (PNS) and dysfunction of one or more subdivisions of the ANS, when accompanying other diseases, is linked to a worse prognosis of the latter. In some circumstances or when severe, dysfunction of ANS itself results in symptoms and disability. A myriad of factors can cause autonomic dysfunction and more than one can concur even in the same patient; due to the expansive nature of the ANS, patients can be affected by a wide range of conditions. Each chapter is characterized by a similar structure and is devoted to a different dysfunction. For each pathology, the book offers the essential information on mechanisms of action, treatments and outcomes. Written by experts in the research of these disorders, the volume addresses primarily Neurologists, but will be a useful tool also for Gastroenterologists, Ophthalmologists, Urologists, Cardiologists and Internal medicine specialists.

This textbook assembles the wealth of clinical experiences across multiple medical specialties and offers clinical pearls that will result in better patient care and are highly relevant to daily practice. This book has been compiled by many renowned clinicians, medical educators, and researchers who are experts in their respective disciplines across Australia, New Zealand and the United States. The chapters provide multiple cases in vignette format, illustrating the clinical pearls, and finish with a discussion and practical tips. This format will allow the reader to easily understand how the clinical pearls can be applied in clinical practice. Evidence-based medicine and clinical guidelines help us choose the best management and treatment options for our patients. However, many questions in medicine have not been researched or are not readily amenable to research. In fact, there is more to the art and mastery of practicing clinical medicine than the evidence-based approach. Information gained over years of reflective clinical practice and cumulative wisdom adds value to evidence-based clinical medicine. With experience and clinical gestalt playing an equal, if not a more prominent role than what evidence can offer in a physician's approach to solving clinical problems, this book offers unique perspectives on the practice of medicine.Beyond Evidence-Based Medicine: Clinical Pearls from Experienced Physicians will be valuable for later-year medical students, medical educators, doctors in training, and consultant physicians alike. Aiming to improve the day-to-day medical practices of professionals, the Editors have invited experienced physicians to share their expertise culminating in a unique book with broad applicability and appeal.

This book is the first authoritative and comprehensive text dedicated to the understanding of how cholesterol triggers vascular inflammation and mechanical injury that leads to heart attacks, strokes as well as other organ and tissue pathology. It includes chapters on the background of cholesterol crystal formation and methods for their detection as well as a description of the physiochemical transformation of metastable ‘liquid'cholesterol to a solid flat plate crystalloid within the cellular and extracellular environment resulting in volume expansion. Chapters also discusses cholesterol crystals and other crystalloid molecules found in atherosclerotic plaque. In addition, the book examines how cholesterol crystals can induce similar injurious processes in other organs including the retina of the eye to cause blindness, in solid cancers causing further tumor growth and in the brain of patients with Alzheimer's. And lastly, the book addresses various potential therapeutics that disrupt the physiochemical transformation of cholesterol from a liquid to a solid, inhibit its role in triggering inflammation and tissue injury while ushering a path towards targeted therapies.Cholesterol Crystals in Atherosclerosis and Other Related Diseases will be of interest to cardiologists as well as individuals in various fields of science including crystallography, basic and clinical imaging, cardiac oncology, and drug discovery.

Biological sex and gender have a tremendous impact on the efficacy and safety of pharmacological interventions in virtually every disease state. This book presents a comprehensive and up-to-date overview on how sex-specific information is guiding the diagnosis and treatment of diseases affecting men and women, as well as of disease states that disproportionally affects women. Experts in various fields discuss both preclinical and clinical research that is contributing to a better understanding of the impact of sex in the presentation, etiology, treatment, and disease outcomes. Also discussed are the challenges encountered in implementing this growing body of knowledge into practice, as well as possible avenues to recognize and reduce health disparities between men and women so that therapeutic interventions are tailored and improved.

Part of the renowned Braunwald family of references, Hypertension: A Companion to Braunwald's Heart Disease provides today's clinicians with clear, authoritative guidance on every aspect of managing and treating patients who suffer from hypertensive disorders. An invaluable resource for cardiologists, endocrinologists, and nephrologists, this one-stop reference covers all the latest developments from basic science to clinical trials and guidelines related to the treatment of common to complex hypertension. Now fully updated from cover to cover, the 4th Edition offers unparalleled coverage of hypertension in an accessible and user-friendly manner. - Thoroughly covers new treatment guidelines related to recent research and the latest physiologic understanding for a wide range of patients with hypertension and related co-morbidities. - Includes new chapters on Hypertension in Women, Mineralocorticoid Receptor Antagonists, Exercise and Hypertension, and Telemedicine/Digital Health. - Contains new or expanded content on epidemiology, pathophysiology, immunology, clinical findings, laboratory testing, invasive and non-invasive testing, risk stratification, clinical decision-making, prognosis, and management. - Provides new chapter summaries and a new focus on clinical and actionable content using a streamlined, narrative format. - Covers behavior management and prevention as an integral part of hypertensive and pre-hypertensive treatment plans. - Highlights combination drug therapies and management of chronic complications of hypertension. - Offers expert guidance from worldwide experts in cardiology, endocrinology, and nephrology, and integrates the most recent guidelines from leading organizations around the world. - Any additional digital ancillary content may publish up to 6 weeks following the publication date.

The book is a compact yet comprehensive practical resource that highlights all must-know information on non-alcoholic fatty liver disease (NAFLD). Covering the major issues dominating the field, this book offers a broad vision on NAFLD using key data for a deep and thorough understanding of the latest diagnostic methods, treatment options, potential complications, and disease management strategies to improve patient outcomes. The volume bridges the trans-disciplinary divide between hepatologists, cardiologists, nephrologists, psychiatrists, oncologists and dermatologists in order to cover the complex management of NAFLD in a single volume. It operates under a modern definition of NAFLD that acknowledges the range of presentations related to extrahepatic complications that hepatologists see in daily practice, while also delving into unanswered questions and future directions regarding treatment options. Offering practical, clinical guidance in addition to capturing the new promising therapeutic approaches in the pipeline, this book is an essential reference for clinicians, researchers and students.

ENDOVASCULAR INTERVENTIONS A practical and systematic approach to current endovascular surgical techniques An increasingly popular alternative to open vascular surgery, endovascular intervention offers many advantages, including reduced patient discomfort, smaller incisions, shorter recovery time, and decreased risk of adverse complications. Practitioners and trainees alike require expert guidance on current technologies and up-to-date techniques. Endovascular Interventions provides clinicians with an easy-to-follow guide for minimally invasive treatment of vascular disease. This invaluable resource delivers concise and accurate instructions on a wide range of endovascular interventions, including aorta, renal and mesenteric interventions, lower extremity interventions, venous interventions, and supra-aortic interventions in high-risk patients. Sequential phases of skill development broaden the reader's abilities as they progress through each chapter, supplying step-by-step instructions on when each procedure should be used and how it can be safely and effectively performed. This book offers a complete reference to essential techniques and procedures, suitable for both novice and experienced vascular surgeons, cardiologists, and radiologists. Endovascular Interventions also: Reinforces comprehension of each procedure with templated chapters, equipment lists and boxed key learning points Provides full-color clinical images and detailed illustrations to demonstrate surgical procedures Presents authoritative coverage of modern endovascular technologies and techniques Written by a team of respected experts and practicing surgeons from internationally recognized hospitals and universities Suitable for varying skill levels, Endovascular Interventions is a precise, accessible instruction manual for safe and effective endovascular intervention, helping practicing clinicians sharpen their existing abilities and keep pace with the latest surgical technologies while instructing trainees on this innovative approach to vascular surgery.

The second edition of this critical text features heavily revised chapters detailing how to approach the anesthetic and perioperative management of adult and pediatric patients with congenital heart disease. Initially, a broad overview of relevant concepts in pediatric cardiovascular embryology, physiology, and pharmacology is provided. Subsequently, relevant diagnostic approaches including the use of three-dimensional modeling in surgical planning and preoperative considerations are described. The intraoperative management of a wide range of specific lesions is discussed, with full descriptions of anesthesia plans and the appropriate diagnostic methods and surgical interventions. New topics detailed include the use of hybrid techniques and applications of electrophysiology in patients with congenital heart disease. Postoperative care and potential future approaches are also addressed.Congenital Heart Disease in Pediatric and Adult Patients: Anesthetic and Perioperative Management provide a comprehensive, up-to-date overview of the care of the pediatric patient undergoing cardiac surgery and anesthesia. It is therefore of interest to all practicing and trainee medical professionals who encounter these patients in their day-to-day practice.

The second edition of this book updates, reviews, and discusses the latest findings on the pathophysiology, diagnosis, and management of cardiovascular disease in the older patient. It explains the physiological changes associated with the normal aging process that may lead to the development of disease, to adverse consequences once disease develops, and which alter the risk-benefit equation for medical and other interventions designed to diagnose, assess, and treat cardiovascular disease. Chapters address key issues in the management of cardiovascular disease in the elderly including prevention, coronary artery disease, valvular disease, hypertensive disease, arrhythmias, and interventions. Wherever possible, the authors take an evidence-based approach to recommendations and rely heavily on clinical trials. The value of lifestyle changes in the aging population, the use of primary and secondary prevention strategies, treatments, and complications are also discussed. Cardiovascular Disease in the Elderly offers physicians and other related providers who care for older patients a gold-standard approach to understanding and managing cardiovascular disease in this group.

Anesthesia forCongenital Heart Disease An Extensive Reference Work Detailing the Procedures, Knowledge, and Approaches in Anesthesia for Congenital Heart Disease In this fourth edition of Anesthesia for Congenital Heart Disease, a distinguished group of expert authors in congenital heart disease (CHD) from all over the world provide a thorough, comprehensive, and fully updated overview of the specifics of congenital heart disease and the intricacies involved with administering anesthetic care to patients who suffer from the myriad of lesions encompassed by CHD. In the seven years since the third edition of Anesthesia for Congenital Heart Disease was published, an explosion of new procedures, approaches, and patients eligible for anesthetic care has occurred. The goal of Anesthesia for Congenital Heart Disease, Fourth Edition is to help readers understand all of the recent advancements and developments in the field while also imparting a foundation of essential historical knowledge. The book contains new chapters that reflect exciting new approaches in this rapidly changing field, and also includes: Updated information in the chapter Adult Congenital Heart Disease and Mechanical Support of the Circulation, reflecting the increasing prominence of these patients in CHD care New chapters on Informatics and Artificial Intelligence, Genetic Syndromes, Point of Care Ultrasound, and Cardiopulmonary Resuscitation in Congenital Heart Disease Thorough updates of all chapters with many new figures and tables, and hundreds of new recent references provide up to date information Anesthesia for Congenital Heart Disease, Fourth Edition serves as a thorough and in-depth reference work and is an essential resource for practitioners providing perioperative care to CHD patients.

This book provides a concise, practically applicable guide to the management of patients born with a univentricular heart defect. It describes the anatomy and epidemiology of the univentricular heart, while guidance is provided on how to manage both fetal and neonatal patients with this defect, as well as those in later childhood and adulthood. The utilization of the Fontan operation for patients with a univentricular heart is described in detail. Management of early and late Fontan failure is also discussed, and the pregnant patient is also described, enabling the reader to develop a deep understanding of how to manage these patients in their daily practice. Univentricular Congenital Heart Defects: Practical Manual for Patient Management comprehensively reviews the management of univentricular heart defects and the use of Fontan-type surgery. It is a valuable resource for the experienced practitioner seeking a manual on the latest available techniques andfor trainees who want to develop a thorough understanding of how to manage patients with these congenital heart defects.

Diabetes mellitus has become epidemic on a global scale, and millions of new cases are diagnosed every year. With an estimated 80% of people with diabetes living in disadvantaged regions, and the key roles of lipoproteins in the pathogenesis of the chronic complications of diabetes, this volume will be relevant to many readers globally. It is our intention that the contents will advance knowledge of the readers who will use it to contribute to the reduction of the burden associated with altered lipoproteins in people with diabetes. The second edition of this book provides an updated and comprehensive review of the field. The book, which includes many tables and figures, is presented in three main sections: (i) Lipoprotein metabolism, qualitative changes and measurements; (ii) Lipoproteins and the complications of diabetes; and (iii) the treatment of lipoproteins in diabetes. Each chapter from the first edition has been updated, and new topics added. New topicsinclude the links between glycemia and lipoproteins, the role of lipoproteins in ischemic stroke, the diagnosis and management of statin intolerance (which is thought to be more common in people with diabetes) and the use of PCSK9 inhibitors and fish oils in the management of lipoproteins in people with diabetes. This book is written by an international group of experts in the clinical, laboratory and research aspects of lipoproteins in diabetes. Lipoproteins in Diabetes Mellitus, 2nd Edition is a comprehensive reference on the clinical and scientific aspects of lipoproteins in diabetes. It is a must-have resource for primary care and specialist clinicians, clinical and basic science researchers and to trainees and students.

Part of the renowned Braunwald family of references, Clinical Arrhythmology and Electrophysiology: A Companion to Braunwald's Heart Disease provides today's clinicians with clear, authoritative guidance on every aspect of the latest diagnosis and management options for patients with arrhythmias. This comprehensive reference on cardiac arrhythmias lays a solid foundation of the underlying mechanisms of cardiac electrophysiology with an emphasis on identifying, understanding, and treating individual arrhythmias. Now fully updated from cover to cover, and carefully written to provide continuity and a consistent message throughout, the 4th Edition offers unparalleled coverage of cardiac arrhythmias in an accessible and user-friendly manner. - Grounds clinical techniques in basic science for managing patients with complex arrythmia disorders. - Offers increased clinical content with complete diagnostic and management options, including the latest drug-based, device-based, and device-drug therapies. - Covers new tools and techniques for atrial transseptal and percutaneous pericardial access, new ablation energies and tools, and new ACC/HRS guidelines for bradyarrhythmias. - Contains a new chapter on stroke prevention in atrial arrhythmias. - Includes significant content updates on macro-reentrant atrial tachycardias in an era of ultra-high-resolution mapping, new mapping and ablation technologies for ventricular tachycardia, new genetic mechanisms underlying arrhythmia syndromes, and much more. - Provides access to dozens of videos depicting key mapping techniques, and fluoroscopy images illustrating techniques for electrophysiologic catheter positioning, and atrial septal puncture, as well as pericardial access, cryoablation, and left atrial appendage exclusion procedures. - Uses a consistent format throughout, showing every arrhythmia in a similar manner for quick reference. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

This is the ultimate revision guide for candidates who are preparing to take the European Diploma in Anaesthesiology and Intensive Care (EDAIC) Part I and Part II examinations. This resource provides 303 practice questions and model answers for a complete guide to both parts of the examination. For Part I: Paper A, there are 135 example questions and model answers on physiology, pharmacology, anatomy, physics, and statistics. For Part I: Paper B, another 127 example questions and model answers cover general anaesthesia, regional anaesthesia, special anaesthesia, intensive care, internal medicine, and emergency medicine. To help candidates prepare for the Part II: the Oral part of the exam, there are five SOE-type questions and detailed worked answers addressing applied physiology, applied pharmacology, applied anatomy, clinical measurement, general anaesthesia, critical incidents, intensive care, and image interpretation for a total of 41 practice questions. Written by top quality authors who are or were previously experienced examiners within the European Society of Anesthesiology and Intensive Care (ESAIC), this is an authoritative guide to the EDAIC exam.

Körperliche Erkrankungen gehen in ihrem Verlauf mit einer hohen psychischen Komorbidität einher. Vor allem eine koexistente Depression und Angst, ein chronischer oder traumatischer Stress üben einen relevanten negativen Einfluss auf das dynamische Krankheitsgeschehen aus. Sie sind nicht nur häufig mit einer erhöhten Morbidität, einer ungünstigeren Lebensqualität und belasteten psychosozialen Integration assoziiert. Sie sind oft auch mit einem erhöhten Mortalitätsrisiko und einem bedenkenswerten Suizidrisiko verbunden. Depression, Angst, chronischer und posttraumatischer Stress können auch die Entwicklung von körperlichen Krankheiten beeinflussen, indem sie allgemeine somatische Krankheitsrisiken vermitteln. Sowohl eine psycho-somatische als auch ein somato-psychische Perspektive ist notwendig, um die komplexen Interaktionen zwischen psychologischer, psychosozialer und biologischer Ebene zu erfassen. Ein allgemeiner Teil nimmt das Thema von psychischer und somatischer Komorbidität in einer bidirektionalen Wirkrichtung auf. Er befasst sich mit theoretischen Konzepten und empirischen Befunden zu möglichen Beziehungen zwischen somatischer Krankheit und medizinischer Behandlungsmodalität einerseits und psychischer Vulnerabilität und Störung andererseits, die traditionellerweise einer „psychosomatischen Perspektive“ in der Medizin zugeordnet werden. In einem speziellen Teil werden diese allgemeinen Aspekte einer biopsychosozialen Betrachtung von Depression, Angst und traumatischem Stress in ihrem potentiellen Einfluss auf definierte internistische Krankheitsrisiken bzw. von koexistenter depressiver, Angst- und posttraumatischer Belastungsstörung bei internistischen Erkrankungen in ihren möglichen Auswirkungen auf Krankheitsdynamik und Krankheitsverlauf jeweils nach traditionellen Organsystemen bzw. nach speziellen medizinischen Behandlungskontexten je gesondert dargestellt. Dieses umfangreiche Werk richtet sich gleichermaßen an die Kolleg•innenaus Psychiatrie und Psychotherapie wie aus den medizinischen Fächern, sowie an alle Leser•innen, die an einer psychosomatischen und somatopsychischen Perspektive auf die komplexen wechselseitigen Beziehungen zwischen psychischen Störungen und körperlichen Krankheiten interessiert sind.

The fifth edition of Mayo Clinic Cardiology: Concise Textbook follows from other previous editions providing a comprehensive overview of the field of cardiology. This textbook is designed for physicians-in-training, be they budding cardiologists, internists, or related disciplines. It caters particularly to those preparing for qualifying boards and examinations who want a manageable amount of high-value information about the heart in an easily digestible format. This revised edition is updated to reflect current practice guidelines and includes key information that all cardiologists should know is presented in a brief and interesting manner. This textbook is not, nor is it intended to be, a definitive or exhaustive guide to cardiology.

The book provides a comprehensive overview of the medical implications, pathophysiology, and treatment of Obstructive Sleep Apnea (OSA), a disease that creates increased health risks, most notably those related to the cardiovascular and cerebrovascular systems.The opening chapters are dedicated to the definition of OSA, its diagnosis, and the treatment options. The following chapters address primary forms of disease presentation in each medical field, with the latest evidence.Given its characteristics, the book will enable the reader to adopt a broad strategy for evaluating and managing OSA patients. In addition, it will be a valuable resource for all the clinicians who treat sleep-disordered breathing, including otolaryngologists, pulmonologists, cardiologists, neurologists, etc.

Volume 2 of the 5th Edition of the Handbook of Obesity spotlights on clinical applications for evaluation, diagnosis, prevention, and treatment of obesity. It covers on the several major developments occurred between the previous and the new edition, including the effect of SARS-CoV-2 on people with obesity, the concept of “Precision Medicine”, and new medications approved by USFDA aiding patients with obesity weight loss of 15 to 20%. This volume is structured into 5 parts: Part 1 provides insights from evolution on changes in diet and physical activity, and the implications and results for preventing obesity, health care costs associated with obesity and the cost-effectiveness of obesity prevention and treatment Part 2 deals with evaluation of overweight patients, approaches for classifying obesity and using this knowledge to evaluate patients, and addressing ethnic and racial considerations in evaluating patients with obesity Part 3 explains the impact of lifestyle in managing obesity, which include behavioural management, diet, dietary composition, and meal timing, and the effects of physical activity and exercise in weight loss and weight loss maintenance Part 4 is focused on medications in the management of obesity. This includes drug selection, various classes of drugs, combination of drugs affecting weight loss, effect of herbal agents on weight loss and treatment of obesity in pediatric populations, genetic diseases causing obesity and the role of drugs in treating the dyslipidemias Part 5 discusses bariatric surgery, its history, procedure and effects in details, and other surgical techniques including electric stimulation of the vagus nerve, gastric balloons, intestinal liners, and liposuction

The fifth edition of Volume 1 of Handbook of Obesity written by global experts covers the basic science aspects under the broad topic areas of epidemiology, etiology, and pathophysiology of obesity. Divided into 5 sections and detailed in 66 chapters, this edition covers the important advances occurring over the past decades. With a focus on science of obesity and factors participating in the etiology of obesity, this topic is studied from biological, behavioural, and environmental perspectives.Volume 1 is structured into 5 parts: Part 1 focuses on the history, definitions, and prevalence of the obesity. It identifies the historical references to excess weight, obesity in art and literature, direct and surrogate measurements of adiposity and obesity related traits, epidemiology of obesity around the globe, and age, sex, and ethnic variation completes this part of the volume Part 2 explains the biological determinants of obesity. It explains the bioenergetics, energy dissipation mechanisms and exposure to experimental overfeeding, genetic and epigenetic evidence, metabolic rates, energy expenditure and energy partitioning, and the evidence on infections and adiposity Part 3 describes the behavioral determinants of obesity. It deals with chapters related to food, beverages, and ingestive behavior, dealing with smoking, breast-feeding, and sleep duration and pattern, and sedentary behavior, occupational work, and leisure-time physical activity and obesity Part 4 comprises of chapters explaining the environmental, social, and cultural determinants of obesity. The chapters in this section focus on the role of agriculture and the food industry in the current obesity epidemic, social and economic aspects of obesity, and ethnic and cultural differences, and environmental pollutants Part 5 of this volume discusses the health consequences of obesity. The chapters address important topics such obesity and heart disease, lipoprotein metabolism, insulin resistance and diabetes, metabolic syndrome, cancer, hepatic biology, pulmonary functions, and arthritis and gout, mental health and quality of life, growth and health disorders in pediatric populations, and on bias and discrimination affecting the obese persons.

This book is an illustration-rich practically focused resource on the use of cardiopulmonary point of care ultrasound (POCUS). It focuses on the applications of POCUS in a wide range of medical specialties especially critical care medicine, cardiology, emergency and respiratory medicine. Topics covered include the application of POCUS in diagnostics, monitoring of various cardiorespiratory conditions such as pulmonary edema, and the role it can perform in guiding interventions for pleural and pericardial effusion. Stunning illustrations and instructive accompanying video clips ensure that the reader can develop a deep understanding of how to properly apply the technology into day-to-day clinical practice. Cardiopulmonary Point of Care Ultrasound is edited and authored by a group of world-renowned experts in the field of critical care echocardiography and POCUS from critical care medicine, cardiology, respiratory medicine, emergency medicine, surgery, radiology and cardiac physiology with a powerful multi-specialty and multi-disciplinary collaboration. It offers detailed insight into the applications of this technique and associated technologies across medical specialties with a focus on cardiorespiratory disorders. The user-focused emphasis in this resource makes it an ideal bedside manual for both experienced practitioners and trainees in these fields.

This state-of-the-art book concentrates in one volume our current knowledge on the cardiovascular complications of liver disease. This easy-to-read work provides a better understanding of the pathogenesis and consequences of portal hypertension and establishes a physiological basis for its pharmacological treatment. It examines the effect of liver disease on volume regulation, the activity of the sympathetic nervous system, and the processes involved in capillary fluid exchange. It includes a discussion on volume and sodium regulation, as well as atrial natriuretic peptide. It also covers the effects of different classes of drugs such as alcohol, sympathomimetics, diuretics, and hormones on the cardiovascular system in liver disease. This reference manual is an absolute must for all clinicians and researchers with an interest in the cardiovascular system in liver disease.

Cardiovascular Endocrinology and Metabolism: Theory and Practice of Cardiometabolic Medicine discusses the close intersection between metabolic disorders and cardiovascular disease, covering the basic science and pathophysiology of disease and the latest research in pharmacological approaches and translational therapeutic options. This book is a valuable resource for the vascular and endocrinology clinical and research communities in need of knowledge and potential outcomes. The global increase in the prevalence of cardiometabolic disorders, and the introduction of therapeutic options for treating metabolic disease that also lower cardiovascular risk, is bringing endocrinologists and cardiologists together in a shared clinical experience. - Discusses the intersection between metabolic disorders and cardiovascular diseases - Provides a comprehensive understanding of the relevant pathophysiology of diseases as a basis for the evidence-based management of cardiometabolic disorders - Offers a comprehensive reference, ranging from basic science and pathophysiology to clinical diagnostics and management