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This book is the first authoritative and comprehensive text dedicated to the understanding of how cholesterol triggers vascular inflammation and mechanical injury that leads to heart attacks, strokes as well as other organ and tissue pathology. It includes chapters on the background of cholesterol crystal formation and methods for their detection as well as a description of the physiochemical transformation of metastable ‘liquid'cholesterol to a solid flat plate crystalloid within the cellular and extracellular environment resulting in volume expansion. Chapters also discusses cholesterol crystals and other crystalloid molecules found in atherosclerotic plaque. In addition, the book examines how cholesterol crystals can induce similar injurious processes in other organs including the retina of the eye to cause blindness, in solid cancers causing further tumor growth and in the brain of patients with Alzheimer's. And lastly, the book addresses various potential therapeutics that disrupt the physiochemical transformation of cholesterol from a liquid to a solid, inhibit its role in triggering inflammation and tissue injury while ushering a path towards targeted therapies.Cholesterol Crystals in Atherosclerosis and Other Related Diseases will be of interest to cardiologists as well as individuals in various fields of science including crystallography, basic and clinical imaging, cardiac oncology, and drug discovery.

The second edition of this critical text features heavily revised chapters detailing how to approach the anesthetic and perioperative management of adult and pediatric patients with congenital heart disease. Initially, a broad overview of relevant concepts in pediatric cardiovascular embryology, physiology, and pharmacology is provided. Subsequently, relevant diagnostic approaches including the use of three-dimensional modeling in surgical planning and preoperative considerations are described. The intraoperative management of a wide range of specific lesions is discussed, with full descriptions of anesthesia plans and the appropriate diagnostic methods and surgical interventions. New topics detailed include the use of hybrid techniques and applications of electrophysiology in patients with congenital heart disease. Postoperative care and potential future approaches are also addressed.Congenital Heart Disease in Pediatric and Adult Patients: Anesthetic and Perioperative Management provide a comprehensive, up-to-date overview of the care of the pediatric patient undergoing cardiac surgery and anesthesia. It is therefore of interest to all practicing and trainee medical professionals who encounter these patients in their day-to-day practice.

Part of the renowned Braunwald family of references, Clinical Lipidology: A Companion to Braunwald's Heart Disease provides today's clinicians with clear, authoritative guidance on the therapeutic management of patients with high cholesterol levels and other atherogenic lipid disorders. An invaluable resource for cardiologists, lipidologists, endocrinologists, and internal medicine physicians, this one-stop reference covers everything from basic science and the pathogenesis of atherothrombotic disease to risk assessment and the latest therapy options. Now fully updated from cover to cover, the 3rd Edition offers unparalleled coverage of lipidology in an accessible and user-friendly manner. - Thoroughly covers the assessment, diagnosis, and treatment of patients with elevated levels of lipids and lipoproteins, including all the latest research-based recommendations, therapeutic breakthroughs, and related clinical advances. - Presents the latest data on clinical guidelines, risk assessments, and established and emerging pharmacologic and nonpharmacologic therapies—all from internationally recognized experts in the field. - Features condensed, streamlined content that focuses on clinical applications and applying concepts to the practice setting. Chapters have now been completely reorganized into sections on risk assessment; therapy; new and evolving therapeutic targets and platforms; and special populations. - Includes new chapters on Polygenic Risk Scores; Inclisiran; Bempedoic Acid; Selective Peroxisome Proliferator–Activated Receptor–a Modulator: Pemafibrate; Evolving Therapeutic Targets: Lp(a), ANGPTL3, and ApoC-III; New Therapeutic Platforms: Gene Therapy and Genome Editing; and more. - Contains new or expanded content on inflammation; genetic testing; troponins for risk assessment; statins and role of bile acid sequestrants, niacin, and fibrates; mAbs; CANTOS and CIRT; colchicine; IL-6; and cellular, molecular, and genetic therapy. - Provides treatment algorithms throughout, as well as case vignettes that highlight the most common clinical questions in each chapter. - Incorporates the latest guidelines from the AHA, ACC, ESC, and EAS, as well as future directions for ongoing research and emerging applications.

The editors have placed significant emphasis on conveying succinctly how this knowledge informs both the prevention and treatment of cardiovascular diseases. There are 11 sections covering 140 chapters written by around 250 renowned authors, including 1,000 figures and 400 tables and all the content has been colourfully and digitally enhanced with particular attention to the importance of using appropriate guidelines in the diagnosis and management of cardiovascular diseases. A topic on the latest practice impacting trials has also been incorporated in a dedicated chapter on landmark trials. The editors would like to highlight several exciting changes with a new addition of knowledge on genetics and a section on cardiac oncology.

For over sixty years, McDonald's Blood Flow in Arteries has remained the definitive reference work in the field of arterial hemodynamics, including arterial structure and function with special emphasis on pulsatile flow and pressure. Prestigious, authoritative and comprehensive, this seventh edition has been totally updated and revised with many new chapters. This edition continues to provide the theoretical basis required for a thorough understanding of arterial blood flow in both normal and pathological conditions, while keeping clinical considerations and readability paramount throughout.Key Features The definitive reference work on arterial hemodynamics Fully updated and revised to cover all recent advancements in the field

This book covers the role of statins in all cardiovascular ailments, from prevention to disease management, and brought you the evolving pharmacological interventions. It is an attempt to interference with the cholesterol synthesis pathways through statins and bempedoic acid, and blocking PCSK9 from binding to LDL receptor by intercepting with antibodies or nipping them early by intracellular inhibition of the translation of message to proteins, the monograph brings into focus the ultimate importance of LDL receptors.

This comprehensive text follows an evidence-based approach to thoroughly discuss Atrial septal defects. Since this congenital heart disease mostly presents in adulthood, it becomes imperative to understand the embryology, pathophysiology and anatomy in detail, for effective management of these patients. This book has strong clinical focus on anatomy, natural history, indications, imaging methods and practical aspects of disease management, which inculcates best practice in the day to day management techniques employed by cardiologists, trainees and professionals. Key Features Covers all aspects of atrial septal defects with a logical flow of topics. Serves as a useful guide to clinical cardiologists aiming to specialize in atrial septal defects and professionals entering the field. Explores future directions in diagnosis and treatment, elaborating on the use of 3D echocardiography and Intracardiac echocardiography.

Cardiology: An Illustrated Textbook is the latest edition of this comprehensive two volume textbook, including revised chapters with the latest advances in the field of cardiology. This edition is edited by professors from the Carver College of Medicine, Iowa, and the University of California, San Francisco. This book is comprised of 120 chapters across fifteen sections. The first four sections cover basic cardiology, cardiovascular pharmacology, diagnosis, and electrophysiology. Subsequent sections cover groups of diseases and conditions, including vascular diseases, heart failure, myocardial and pericardial diseases, coronary heart diseases, valvular heart diseases, congenital heart disease, and secondary disorders of the heart. Each section incorporates new advances and step-by-step diagnosis and treatment. The closing sections of the book cover current issues in cardiology, preventive strategies for various cardiac diseases, and a final section on ‘evolving concepts', bringing this edition firmly up to date. Cardiology: An Illustrated Textbook is enhanced by 1600 full colour images and illustrations

This book provides a state-of-the-art overview of the combined use of imaging modalities to obtain important functional and morphological information on intravascular disease and enhance disease detection. It discusses the integration of intravascular ultrasound (IVUS, intravascular optical coherence tomography (OCT), intravascular photoacoustic imaging (IVPA) and acoustic radiation force optical coherence elastography (ARF-OCE), and introduces the integration of multimodality imaging systems, such as IR and florescence. It includes the latest research advances and numerous imaging photos to offer readers insights into current intravascular applications. It is a valuable resource for students, scientists and physicians wanting to gain a deeper understanding of multimodality imaging tools.

This book provides a practically applicable guide to the use of multimodality imaging for managing aortic valve disorders. Details of how to successfully diagnose a range of aortic valve diseases is presented, with detailed information covered on the techniques and relevant criteria for pre-operative screening, surgical and transcatheter planning, intraprocedural imaging and related postoperative follow-up. Multimodality Imaging for Cardiac Valvular Interventions, Volume 1 Aortic Valve: From Diagnosis to Decision-Making enables the reader to develop a thorough understanding and confidence of how to make appropriate clinical decisions when confronted by a range of aortic valve diseases. It is therefore a key resource for practicing cardiac imagers, cardiologists and interventional cardiologists who encounter these patients in their day-to-day clinical practice and trainees in cardiology seeking insight on the appropriate management of these patients.

This book focuses on CSI cardiology update 2018. Cardiology is a medical specialty and a branch of internal medicine concerned with diseases of the heart. It deals with the diagnosis and treatment of such conditions as congenital heart defects, coronary artery disease, heart failure, and valvular heart disease. This book consists of 24 sections that include coronary artery disease risk factors, lipids and diet, diabetes and heart, hypertension, chronic coronary artery disease, acute coronary syndromes, ST-segment elevation myocardial infarction, dual antiplatelet therapy, coronary intervention, intervention in structural heart disease, cardiac imaging, cardiovascular pharmacology, heart failure, syncope, atrial fibrillation, ventricular arrhythmias, cardiac implantable electronic devices, cardiac surgery, stroke, peripheral vascular disease, women and heart disease, systemic diseases and heart, emerging issues in cardiology, and miscellaneous, which are further divided into 154 chapters. This edition of Cardiology Update – 2018 attempts to bring into sharp focus these very controversial yet relevant topics, with views from Indian experts that define approaches and color practices in our sphere of life. This book is useful not only for residents in training, but also for general physicians and general cardiologists as well as for interventional cardiologists and electrophysiologists.

This atlas comprehensively describes the application of computed tomography (CT) and magnetic resonance (MR) imaging in real-world scenarios using 192 illustrative clinical cases. These imaging techniques are revolutionizing the diagnostic and therapeutic approach for cardiovascular patients and are progressively becoming viable sub-specialties among radiologists and cardiologists. Clinical Atlas of Cardiac and Aortic CT and MRI features clinically relevant case-based examples of how CT and MR imaging techniques can be applied to identify the pathological features of a range of acquired and congenital heart diseases. Using more than 1000 high-quality figures of distinctive CT and MR imaging features of most cardiovascular diseases, both acquired and congenital, it therefore provides a valuable resource for both specialist and non-specialist radiology/cardiology practitioners seeking to develop a deep understanding of how to recognize the features of a variety of heart diseases using CT and MR imaging techniques.

This book is a comprehensive and richly-illustrated guide to cardiac CT, its current state, applications, and future directions. While the first edition of this text focused on what was then a novel instrument looking for application, this edition comes at a time where a wealth of guideline-driven, robust, and beneficial clinical applications have evolved that are enabled by an enormous and ever growing field of technology. Accordingly, the focus of the text has shifted from a technology-centric to a more patient-centric appraisal. While the specifications and capabilities of the CT system itself remain front and center as the basis for diagnostic success, much of the benefit derived from cardiac CT today comes from avant-garde technologies enabling enhanced visualization, quantitative imaging, and functional assessment, along with exciting deep learning, and artificial intelligence applications. Cardiac CT is no longer a mere tool for non-invasive coronary artery stenosis detectionin the chest pain diagnostic algorithms; cardiac CT has proven its value for uses as diverse as personalized cardiovascular risk stratification, prediction, and management, diagnosing lesion-specific ischemia, guiding minimally invasive structural heart disease therapy, and planning cardiovascular surgery, among many others. This second edition is an authoritative guide and reference for both novices and experts in the medical imaging sciences who have an interest in cardiac CT.

This book is a fully updated and revised second edition of a highly successful text in which a new concept of knowledge mining, based on explication and transfer of interventional knowledge of experts, has been implemented. The dedicated training program that is set out will serve the needs of all interventional operators, whether cardiologists, vascular surgeons, vascular specialists, or radiologists, enabling them to achieve a consistent expert level across the entire broad spectrum of catheter-based interventions. Operator skills – and in particular decision-making and strategic skills – are the most critical factors for the outcome of catheter-based cardiovascular interventions. Currently, such skills are commonly developed by the empirical trial and error method only. The explicit teaching, training, and learning approach adopted in this book permits the rapid transfer of interventional knowledge and enables individual operators to negotiate steep learning curves and acquire complex skills in a highly efficient manner. It will thereby offer invaluable assistance in meeting successfully the challenges of modern cardiovascular care.

This textbook is a readily accessible educational tool for all fellows undertaking subspecialty training in interventional cardiology, while also serving as a refresher to early career interventional cardiologists. The key objective is to equip the reader with an evidence-based expert-led resource focussed primarily on pre-procedural planning, peri-procedural decision-making, and the salient technical aspects of performing safe and effective coronary intervention, the intention being to support the therapeutic decision-making process in the emergency room, coronary care unit or cath lab in order to optimize patient outcome. The Interventional Cardiology Training Manual provides readers with a step-by-step guide to the basic principles underpinning coronary intervention and facilitates rapid access to best practice from the experts, presented in a pragmatic, digestible and concise format. Uniquely, each chapter has been written in a heart center-specificmanner, affording the reader an opportunity to learn how individual institutions perform a specific procedure, which algorithms and guidelines they follow and what evidence they draw on to instigate the best possible care for their patients.

This book is intended as a guide for all cardiologists who are interested in coronary imaging and physiology, a sound understanding of which is vital for the optimal performance of appropriate coronary interventions. The basics of each relevant modality are presented, with clear explanation of clinical utility and evaluation of the evidence regarding clinical outcomes. All technical methods are described in detail, and the text is complemented by numerous helpful tables and illustrations.The effectiveness of intravascular coronary imaging in improving clinical outcomes is proven, and it is widely used for this purpose. Two modalities for intravascular coronary imaging are available in clinical practice: intravascular ultrasound (IVUS) and optical coherence tomography (OCT). For coronary physiology, the pressure wire-derived fractional flow reserve (FFR) provides information on the functional status of coronary trees. This technique and its clinical applications receive particular attention in the book, which also looks beyond FFR to FFR-CT, a method using computational fluid dynamics, and to invasive assessment of the microcirculation.

This book presents general measures and offers a comprehensive overview of anesthetic considerations for specific serious medical problems in pregnant patients, with a focus on the anesthetic management of non-obstetric disorders during pregnancy and pregnancy-induced diseases. Although many books on this topic are available, this unique volume addresses specific disorders that may be encountered in daily obstetric anesthesia practice and discusses in detail serious medical problems during pregnancy. As such it is a valuable tool, providing targeted information particularly on the anesthetic considerations and management of not only non-obstetric diseases during pregnancy but also pregnancy- induced diseases.

Expert guidance from internationally recognized authorities, who provide clear and current updates on all aspects of interventional cardiology. This new edition; Contains a radically expanded chapter contents list presented in four clear sections; coronary interventions, interventional pharmacology, structural heart interventions, and endovascular therapy Includes 46 new chapters, including the latest advances in bioresorbable coronary stents, advanced transcatheter aortic valve replacement, MitraClip, new transcatheter mitral valve interventions, and more Chapters are templated for rapid referral, beginning with pathophysiological background and relevant pathology, moving to mechanisms of treatment, device description, procedural techniques, follow-up care, and ending with risks, contraindications and complications Multiple choice questions at the end of each chapter for self-assessment, a total of more than 400 MCQs in the book Features 19 procedural videos, hosted on a companion website

This book outlines the state of the art in transradial intervention and illustrates case-based learning for the transradial access (TR access) technique, especially in complex lesions. Offering a practical guide, it includes essential tips and tricks on how to overcome anatomical complexities, how to avoid radial complications, multiple case-based learning for very complex PCI, etc. It also discusses the advantages of the TR intervention, such as reduced vascular access site complications and immediate patient mobilization. The authors, who work at respected transradial centers, share their extensive experience with TR intervention, providing a comprehensive review of current percutaneous interventions for cardiac surgeons and cardiothoracic surgical residents. Editor Yujie Zhou is a Professor at the department of Cardiology, Anzhen Hospital, Beijing, China. Editor Wei Liu is a physician at the same department. Editor Ferdinand Kiemeneij is an interventional cardiologist at Department of Cardiology, Tergooi Hospital, Blaricum, the Netherlands. Editor Shigeru Saito, FACC, FSCAI, FJCC, is the director of cardiology and Catheterization Laboratories, Shonan Kamakura General Hospital, Kamakura, Japan.

This book focuses on the coronary bioresorbable scaffold, a new interventional treatment for coronary artery disease, differentiated from a permanent metallic stent. The book provides an overview of the technology including non-clinical studies and clinical evidences in order to help clinicians understand the appropriate application of the technology and the optimal techniques of implantation. It covers the basics of bioresorbable scaffolds; bench test results; preclinical studies; clinical evidences; and tips and tricks of implantation.

The first and only interventional cardiology reference with a global perspective. This comprehensive, clinically oriented resource offers readers around the world superb practical guidance based on the best evidence available today and integrates the latest advances in devices, techniques, imaging, and collaboration with surgical subspecialties. Its authors are world-renowned leaders in their fields, who offer invaluable insights into how interventional cardiology is practiced in a wide range of countries. Broad issues in the practice of interventional cardiology are considered, with chapters on working with the multidisciplinary heart team, the appropriateness of intervention, reporting and monitoring of outcomes, the critical appraisal of clinical trials, and more. Puts practical, real-life examples at readers fingertips with extensive chapters dedicated solely to clinical cases at the end of each section. Illustrated important concepts, techniques, and information with more than 1000 clinical photographs, imaging studies, illustrations, tables and more. Digests key points with a synopsis written by the section editor at the beginning of each chapter. Identifies important gaps in our understanding of interventional cardiology for future investigations.

This book collates all the current knowledge of cardiac CT and presents it in a clinically relevant and practical textbook format appropriate for both cardiologists and radiologists. The images have been supplied by an experienced set of contributing authors and represent the full spectrum of cardiac CT.The field of Cardiovascular CT has experienced continued rapid evolution due to: 1) advances in technology, 2) expanded spectrum of cardiovascular applications and 3) significant growth in published data including large prospective multicenter studies. As increasing numbers have access to cardiac CT scanners, this book provides all the relevant information on this modality. This is an extensive update of the previous edition bringing the reader up-to-date with the immense amount of updated content in the discipline.

Ideal for cardiologists, surgeons, and referring physicians who need a clinical guide to interventional procedures, Textbook of Interventional Cardiology focuses on the latest treatment protocols for managing heart disorders at every level of complexity. In this updated edition, Dr. Topol continues to bring together experts in the field who present the current state of knowledge and clinical practice in interventional cardiology, including cutting-edge theories, trends, and applications of diagnostic and interventional cardiology, as well as peripheral vascular techniques and practices.Offers an in-depth understanding of cardiology, making it well suited for cardiology and interventional cardiology exam preparation. Expert guidance from leading authorities ensures a fresh and balanced perspective on every aspect of interventional cardiology.Presents the most recent genetic information and clinical trials related to interventional cardiology.Highlights the latest treatment advances, procedures, devices, and techniques, including transcatheter aortic valve implantation (TAVI).Brand-new chapters include Radiation Safety, Renal Denervation for Resistant Hypertension, Post PCI Hospitalization, Length of Stay and Discharge Planning, and Interventional Heart Failure. Offers balanced coverage of the entire scope of technologies available, without favoring one particular device over another. Integrates the latest trial data into discussions on clinical practice and recommendations. Multiple images of devices and intra-procedural imaging enhance your visual understanding of the material. Key Points boxes at the beginning of each chapter summarize the most important facts.

Coronary artery bypass surgery has been developed since 1960s to overcome proximal coronary artery disease. Worldwide, the number of patients that are undergoing coronary artery bypass surgery is steadily increasing. Depending on diverse risk factors, one fifth of grafts are occluded at 1 year. For the remaining, graft patency last usually 8–15 years. This book brings together the main specialists in the field to review the current evidence on epidemiology, pathophysiology, diagnostic, new imaging techniques and specific therapeutic modalities. This volume aims to update a complex subject represented by coronary graft failure. The authors of this monograph are interventional cardiologists, cardiovascular surgeons and research scientists, who will be creating four parts and 71 chapters that are divided in order to give a uniform interpretation of this condition including all aspects of coronary graft failure This book not only provides the most up-to-dated scientific evidence in the field but in a two-step manner. Each chapter is divided into a at a glance part that reflects the basic evidence on the topic, and a “full picture” part that brings all what the advanced reader should be brought with.

T​his book teaches the key knowledge required for the use of ultrasound to guide many catheter based cardiac therapies. While live CME courses are now covering this material there are very few textbooks on this topic. A unique aspect of this book is that it has many images to illustrate the teaching points. The use of minimally invasive treatments of many cardiac diseases especially by catheter based therapies and devices is a rapidly expanding discipline in cardiology and radiology. Cardiac ultrasound particularly echocardiography is utilized extensively to guide these therapies. Many echocardiographers are being called upon to guide these therapies but they have not been trained in this unique use of echocardiography.

This heavily revised second edition comprehensively reviews the use of optical coherence tomography (OCT) in cardiovascular practice. It provides detailed guidance on how to properly interpret OCT images and successfully utilise it in daily clinical practice Chapters cover the development and physics associated with OCT, relevant interpretation skills, OCT imaging artifacts, plaque erosion, bioabsorbable stent, the detection of vulnerable plaque, and the use of OCT imaging in unison with other modalities such as phase contrast imaging (PCI). Areas of potential future development are also covered Cardiovascular OCT Imaging enables interventional cardiologists and cardiologists to quickly become both familiar and develop a detailed understanding of this technology to improve patient care and treatment outcome. It is a valuable reference for all practising and trainee medical professionals in cardiology, and in particular those who specialize in interventional cardiology.

This book presents a thorough review of coronary angioscopy, ranging from instructions on its use to the latest advances. Starting with the structure and fundamental principles of angioscopy, it shows readers how to apply the image to comprehensive care of coronary-artery patients. Plentiful color photos and illustrations will enable readers to investigate and classify plaques and thrombi and to evaluate coronary stent- and drug-based therapies. The authors are leading researchers on angioscopy. This book offers the perfect guide not only for new clinicians but also for cardiologists who have already adopted this technique for medical examination and treatment. Angioscopy is a unique medical technique for visualizing the interior of blood vessels and helps physicians not only to diagnose the pathology but also to measure the effectiveness of Percutaneous coronary intervention (PCI) or antiarteriosclerotic drugs. Furthermore, the recently developed molecular angioscopy approach allows us to observe Low-density lipoprotein (LDL) oxide, collagen, and macrophages, and is rapidly growing in importance.

Freshly updated and expanded, Grossman & Baim's Cardiac Catheterization, Angiography, and Intervention, 8th edition, proves it's still the leading go-to textbook for cardiac catheterization. Whether you're an experienced practitioner, resident or cardiology fellow, you'll find this an irreplaceable cardiac reference. The authors offer expert overviews of the theoretical and practical aspects of clinical issues, with increased stress given to hemodynamic data and tracings and interventional procedures. The clear, succinct text is illuminated by summary tables, illustrations and real-life images. Perfectly designed for quick access and easy reference! Features • New color graphs, tables, illustrations and real-life photos illustrate procedures, complications and bailout methods • Companion website with 171 cases and more than 900 videos • Online cases include a summary of important teaching points, with reference to relevant chapters in the print edition • Eight sections, covering: General Principles; Basic Techniques; Hemodynamic Principles; Angiographic Techniques; Evaluation of Cardiac Function; Special Catheter Techniques; Interventional Techniques; and Clinical Profiles • 12 new chapters cover: Integrated Imaging Modalities in the Cardiac Catheterization Lab; Radial Artery Approach; Complications; Pitfalls in the Evaluation of Hemodynamic Data; Evaluation of Tamponade, Constrictive, and Restrictive Physiology; Coronary Artery Anomalies; Interventions for Acute Myocardial Infarction; Pericardial Interventions: Pericardiocentisis, Balloon Pericardiotomy, and Epicardial Approach to Cardiac Procedures; General Overview of Interventions for Structural Heart Disease; Interventions for Cardiac Arrhythmias; Interventions with Cell Therapies; and Aortic Endovascular Grafting

This issue of Interventional Cardiology Clinics, edited by Matthew J. Price, is devoted to Intravascular Imaging. Dr. Price assembled a group of expert contributors to review the following topics: IVUS for the assessment of coronary lesion severity and optimization of PCI; IVUS for the diagnosis and treatment of left main coronary artery disease; Fundamentals of OCT: image acquisition and interpretation; Technique and Best Practices for Intracoronary OCT; Assessment and quantitation of stent results by intracoronary OCT; PCI planning and optimization with intracoronary OCT; Advances in Automated Assessment of Intracoronary OCT and Their Clinical Application; Diagnosis and evaluation of stent thrombosis using OCT; Acute and long-term evaluation of bioresorbable scaffolds by OCT; Role of OCT in the diagnosis, evaluation, and management of spontaneous coronary artery dissection; and Neointimal Coverage after Drug-Eluting Stent Implantation: Insights from Optical Coherence Tomography.

This sixth edition is enriched by over 300 figures, 150 tables and a video-companion collecting more than 100 cases also presented in the format of short movies and teaching cartoons. This extensively revised and enlarged edition of this long-seller documents the very significant advances made since the fifth (2009) edition and is entirely written by Eugenio Picano, a pioneer in the field sharing his lifetime experience with the help of an international panel of 50 contributors from 22 countries representing some of the best available knowledge and expertise in their respective field. In a societal and economic climate of increasing pressure for appropriate, justified and optimized imaging, stress echocardiography offers the great advantages of being radiation-free, relatively low cost, and with a staggering versatility: we can get more (information) with less (cost and risk). For a long time, the scope and application of stress echo remained focused on coronary artery disease. In the last ten years, it has exploded in its breadth and variety of applications. From a black-and-white, one-fits-all approach (wall motion by 2D-echo in the patient with known or suspected coronary artery disease) now we have moved on to a omnivorous, next-generation laboratory employing a variety of technologies (from M-Mode to 2D and pulsed, continuous, color and tissue Doppler, to lung ultrasound and real time 3D echo, 2D speckle tracking and myocardial contrast echo) on patients covering the entire spectrum of severity (from elite athletes to patients with end-stage heart failure) and ages (from children with congenital heart disease to the elderly with low-flow, low-gradient aortic stenosis).

This book provides comprehensive reviews on our most recent understanding of the molecular and cellular mechanisms underlying atherosclerosis and calcific aortic valve disease (CAVD) as visualized in animal models and patients using optical molecular imaging, PET-CT, ultrasound and MRI. In addition to presenting up-to-date information on the multimodality imaging of specific pro-inflammatory or pro-calcification pathways in atherosclerosis and CAVD, the book addresses the intriguing issue of whether cardiovascular calcification is an inflammatory disease, as has been recently supported by several preclinical and clinical imaging studies. In order to familiarize researchers and clinicians from other specialties with the basic mechanisms involved, chapters on the fundamental pathobiology of atherosclerosis and CAVD are also included. The imaging chapters, written by some of the foremost investigators in the field, are so organized as to reveal the nature of the involved mechanisms as disease progresses.

OCT is rapidly being adopted in cardiology practice. However, gap exists between the speed of technology development and the knowledge of cardiologists. Many cardiologists are not familiar with image interpretation and don't have enough background/knowledge to use the information in clinical practice. This book will be designed for busy interventional cardiologists to become quickly familiar with this emerging technology so that they can take advantage of its power improve patient care and outcome.

The 6th Edition of the indispensable Textbook of Interventional Cardiology, by Drs. Eric Topol and Paul S. Teirstein, offers you comprehensive, seasoned clinical advice on all aspects of this rapidly evolving subspecialty. You'll find balanced, expert perspectives on the scientific and clinical advances established over the last few decades so you can better decide which procedures deliver optimal results in any given situation. You'll also get an updated look at promising new techniques like transcatheter aortic valve implantation; new interventional approaches for left mainstem disease and thrombus-containing lesions; transradial intervention; and optical coherence tomography (OCT). At www.expertconsult.com you can access the complete contents of the book, plus additional case discussions and procedural videos to enhance your knowledge and skills. Rely on Dr. Topol's premier text to provide unmatched leadership in the ever-evolving practice of interventional cardiology. Achieve the best outcomes for your patients with dependable, objective advice on both proven and emerging procedures and devices. Perform effective interventions for heart disorders with the expert guidance of leading authorities who offer a fresh and balanced perspective on all aspects of interventional cardiology. Keep up with emerging procedures including transcatheter aortic valve implantation (TAVI), transradial intervention, and optical coherence tomography (OCT), as well as new interventional approaches for left mainstem disease and thrombus-containing lesions. Stay current with the latest genetic information and clinical trials. Search the complete text plus additional case discussions, download all the images, and watch procedural videos online at www.expertconsult.com.

Therapeutic hypothermia has emerged as a very important treatment option for patients with cardiac arrest as it provides significant protection from developing neurologic injury once the patient has been successfully resuscitated. Studies have demonstrated over 15% absolute risk reduction in death and neurologic injury using this therapy. Although hospitals and medical centers have become familiar with this important intervention it still remains greatly under utilized due to an experience and lack of resources to safely and effectively deploy such a program. The objective of this book is to educate and familiarize both providers and institutions as to how to develop and deploy and provide therapeutic hypothermia to their patients. The current knowledge for this is provided by speakers and national experts and also by literature review. There are several courses being provided on this as well throughout the US. These are good venues for people to come and see and get hands on experience, but there still needs to be a concrete book with references on how to go about getting this program started.

Despite recent advances in the diagnosis and treatment of symptomatic atherosclerosis, available traditional screening methods for early detection and treatment of asymptomatic coronary artery disease are grossly insufficient and fail to identify the majority of victims prior to the onset of a life-threatening event. In Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment, Dr. Morteza Naghavi and leading authorities from the Society for Heart Attack Prevention and Eradication (SHAPE) present a new paradigm for the screening and primary prevention of asymptomatic atherosclerosis. The text focuses on accurate, yet underutilized, measures of subclinical atherosclerosis, notably coronary artery calcium scanning and carotid intima-media thickness measurement. The authors introduce a comprehensive approach to identifying the vulnerable patients (asymptomatic individuals at risk of a near future adverse event). Additional chapters discuss future directions towards containing the epidemic of atherosclerotic cardiovascular disease using innovative solutions such as preemptive interventional therapies (bioabsorbable stents) for stabilization of vulnerable atherosclerotic plaques, mass unconditional Polypill therapy for population-based risk reduction, and ultimately vaccination strategies to prevent the development of atherosclerosis. Up-to-date and authoritative, Asymptomatic Atherosclerosis: Pathophysiology, Detection, and Treatment is a must-have for any cardiologist or primary care physician who wishes to practice modern preventive cardiology and manage the increasing number of asymptomatic atherosclerotic patients. Outlines more accurate measures of risk (coronary artery calcium and carotid intima-media thickness) than traditional risk factors (total cholesterol, LDL cholesterol, HDL cholesterol) Presents new multipronged strategies to aid in the early detection and treatment of high risk asymptomatic patients

Leslie T. Cooper, Jr., MD, and a panel of leading clinical and scientific experts comprehensively review both advances in basic scientific understanding and current clinical knowledge of inflammatory heart disease. On the clinical side they discuss the diagnosis, prognosis, and treatment of nonspecific and specific myocarditis in separate chapters devoted to such major idiopathic clinical entities as cardiac sarcoidosis, giant cell myocarditis, eosinophilic myocarditis, Chagas disease, rheumatic fever, and human immunodeficiency virus-related cardiomyopathy. Research articles complete the picture with discussions of the role of apoptosis in viral myocarditis, rat and mouse models of autoimmune giant cell and lymphocytic myocarditis, and the latest available data on enteroviral proteases and cardiomyopathy.

Although distant metastases are the most dreaded situation in the evolution of cancer of every organ, the medical literature has surprisingly given little attention to the anatomical relationship between the primary tumor and metastasic sites. Only risk factors, treatment possibilities, and survival results are extensively examined. Stimulated by the occurrence in his practice of some puzzling and unexpected metastases, the author reviewed more than 12,000 references. He looked for anatomical relationships highlighting the relation between the location of the primary tumors and the particular patterns of metastasis observed. It would seem that the `pathways and flows'are apparently a more decisive factor in the implantation of the metastases than the `seed and soil'properties of the cancer cells and the metastatic site. Aided by his colleague Dr. T. Geukens, M.D., the author includes original anatomical drawings, illustrating the sometimes unexpected pathways the cancer cells follow in order to reach the organs where they will become lodged and give rise to metastatic tumors. The subject has apparently not been exhausted in the literature and several ideas are given for further research.