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Traditional Chinese Medicine (TCM) contains an extensive knowledge that the Chinese nation has accumulated through practical experimentation and theoretical research in treating diseases and promoting health over a period of thousands of years. Throughout the history, many TCM theorists, experts, and pharmacists have contributed valuable works. The most representative of them was Li Shizhen with his Ben Cao Gang Mu (Compendium of Materia Medica), which was praised by Charles Darwin as an'encyclopaedia'of ancient China and was selected into Memory of the World Register by UNESCO in 2011.This book is divided into two parts: the introduction and the selected reading of the original work of Ben Cao Gang Mu. In the introductory part, the life story, academic characteristics and main contributions of Li Shizhen are illustrated, and suggested learning methods of the book are recommended. In the selected reading part, five aspects are mainly discussed: original preface and memorial to the throne, essence of Li Shizhen's medical theories, treatment of various diseases, Li Shizhen's medical records and medical notes, and health preservation. Apart from the selected reading from Ben Cao Gang Mu, theoretical exposition and modern application are supplemented in each chapter so as to improve readers'theoretical knowledge and ability of practical problem-solving.