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In Advances in Medicine and Biology. Volume 127, the authors discuss Parkinson's disease (PD), a neurological disorder characterized by the death of dopaminergic neurons in the substantia nigra pars compacta and reduced dopamine levels in the striatum. Currently, there are few pharmacological treatments for PD and although Levodopa has frequently been used, it is not a viable treatment option for all patients. Thus, this book presents experimental evidence supporting the claim that endocannabinoid signaling may represent a promising therapeutic target for PD, inducing a reduction in neurodegeneration with minimal psychotropic effects. Subsequently, it presents findings that free-hydroxyproline observed in a physiological system must be resulted from a degradation of protein molecules. Variations in free-hydroxyproline concentrations in the plasma and white muscle of fishes, with genetic differences in growth rates and with different feedings, could indicate differences in protein degradation rates for tissue remodeling and growth. Since the synthesis of the connective tissue framework of muscle is a rate-limiting step in muscle growth, the concentrations of white muscle free-hydroxyproline could be reliable for growth studies, as its levels are correlated with fish specific growth rates (SGR) and feed efficiency. Next, the authors analyze the results of umbilical hernia repair using Ventralex® Hernia Patch, a bilayer prosthesis. Preoperative characteristics, surgical procedure details, postoperative complications and recurrence rate were studied. An overview of the most up-to-date findings on the association of NGF with development of schizophrenia is presented, based on literature data as well as the authors'own findings. The contributions of other research groups are provided and discussed in the context of prominent existing hypothesis of psychiatric disorder development. Next, the authors exhibit a retrospective cohort study to assess the impact of 6-hour versus 4-hour HD sessions in end-stage renal disease (ESRD) patients treated with three times per week, daytime, in-center HD. Using data from a cohort of forty-three, stable chronic ESRD patients, the authors compared twenty-one patients undergoing 6-hour HD sessions with twenty-two patients on conventional 4-hour HD sessions. The following chapter begins with an introduction to collagen and the function of Hyp in the collagen molecule, followed by a description of sources of various Hyp fractions in tissues and body fluids. The effects of different toxins on various Hyp fractions in the serum and tissues are also discussed. Then, soy isoflavones or soy derivatives (supplements containing S-equol) are recommended for relieving vasomotor symptoms. The evidences for standardized cohosh preparations are effective and are also be recommended. This book also discusses DNA damage repair, a very important biological process commonly associated with human health and diseases, because a detailed elucidation of DNA repair mechanism is essential for a better understanding of health and disease. Afterwards, the current information on collagen PTMs and their alteration under different pathological conditions are examined. It has been reported that collagen undergoes polyubiquitination in response to S-adenosyl-L-methionine. The polyubiquitination inhibits Collagen processing leading to decreased collagen secretion in hepatic stellate cells (HSCs). In closing, a critical review about the impact of changes in lifestyle and diet supplementation with natural phytochemicals on cancer statistics is given. This review highlights the new advances in understanding the anticancer activity of flavonoids based on its ability to damage DNA in cancer cells.

The chapters in this volume present the latest developments in medicine and biology. Chapters One reviews on m-Health in prehospital emergency medicine. Chapter Two analyzes regional telemedicine network for the diagnosis and care of cardiac malformations. Chapter Three describes a computational fluid dynamic (CFD) approach with the aim to simulate the flow of blood with cardiac pulse through the aorta artery with aneurysm disease. In Chapter Four, a CFD study was carried out for real geometries of one specific patient and was resolved numerically the Navier-Stokes equations for the blood flow in abdominal aortic aneurysms with a pulsatile inlet condition in the ascending aorta. Chapter Five reviews a CFD of the blood flow using pulsatile inlet condition in the ascending aorta with aneurysm disease. Chapter Six examines a CDF methodology in order to analyze the features of the pulsatile blood flow in patients with exovascular Stent Devices in abdominal aortic aneurysms. Chapter Seven focuses on hyponatremia in heart failure. Chapter Eight discusses neuroglial potassium channels in health and disease. Chapter Nine discusses the impact of preventing and treating periodontal and peri-implant inflammation on peri-implantitis risks reduction, and highlights the importance of managing periodontal and early peri-implant biological complications in order to prevent occurrence or progression of peri-implantitis. Chapter Ten studies the application of direct analysis in real time mass spectrometry on designer drug identification. Chapter Eleven reviews current understanding of tick antioxidant defense with emphasis on its potential as a target for tick and tick-borne pathogen control.

The chapters in this volume present the latest developments in medicine and biology. Chapter One reviews creatinine in obstetrics. Chapter Two studies urinary creatinine analysis by liquid chromatography tandem mass spectrometry. Chapter Three discusses hormonal and metabolic disorders as links between obesity and cancer risk in men and women. Chapter Four presents and discusses a review of intraocular pressure (IOP) fluctuations in diverse animal models and humans in the context of aqueous humor dynamics and glaucoma. Chapter Five discusses phytochemical and pharmacological properties of Scabiosa L. genus. Chapter Six discusses new candidate biomarkers, their role in pathogenesis and describes future directions in developing algorithms that will improve the ability to predict the development of clinically relevant graft versus host disease (GVHD). Chapter Seven reviews the literature that informs our understanding on how trypanosomes monitor and respond to nutrients in their environment, with a focus on a key metabolite, glucose. The goal of this chapter is to address mechanisms that enable the parasites to respond to differences in availability of this critical nutrient in the suite of niches they occupy. Chapter Eight discusses bovine trypanosomosis prevalence and its vectors density in the major cattle rearing regions of Cameroon. Chapter Nine presents a short review of the current situation of ecological-genetic research with the use of environmental DNA.

This book is a practical guide to the evidence-based medicine (EBM) research methods that are applicable to Chinese medicine (CM). It includes 3 parts: clinical research, healthcare data research and laboratory research. In each chapter, it explains how to acquire, analyze and evaluate a specific kind of CM research result. Authors exemplify the most important methods with successful cases in transforming reliable data into new knowledge of CM. This book emphasizes the requirements for CM researchers to design and conduct CM studies by following the best available principles, standards and guidelines.

This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed in this book include central nervous system manifestations of TSC; methadone; dietary aspects, weight issues and bone health at and post-menopause; Stevens-Johnson syndrome and toxic epidermal necolysis; biosensors and their applications in healthcare; study on riboflavin encapsulation by cyclodextrins; thyroid goitres; anti-cyclic citrullinated peptide (anti-CCP) antibodies in different autoimmune diseases; and the role of flaxseed on non-alcoholic fatty liver disease (NAFLD) in rabbits submitted to a hypercholesterolemic diet.

This book will enable the reader to gain a sound understanding of contemporary and futuristic evidence-based interventions and assessment procedures for pelvic floor disorders. It gathers the experiences of some of the most important experts on electrical stimulation techniques, offering a multidisciplinary and problem-oriented approach organized according to therapeutic goals. Interventions are recommended that are consistent with theory and display clinical efficacy for specific disorders, including urinary incontinence or retention, fecal incontinence, constipation, pelvic pain, sexual dysfunction and neurological diseases involving the pelvic floor. All of the surgical or rehabilitative techniques requiring electrical stimulation for the treatment of these disorders are explored and essential background information is provided on functional anatomy, neurophysiology and concepts in electrotherapy. This volume will be a very useful tool for urologists, general or colorectal surgeons, gynecologists and anesthesiologists and also physiotherapists and alternative medicine practitioners (a specific chapter focuses on electroacupuncture). It will assist in their clinical practice as they seek to help the very many patients who suffer from any of the wide range of functional pelvic floor disorders.

This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed include polyclonal antibodies; non-steroidal anti-inflammatory drugs in oral health care; pneumonia risk factors and prevention; polyisoprenylated methylated protein methylesterase and the fulcrum of chemopreventive effects of NSAIDs and PUFAs; mammalian target of rapamycin (mTOR); in-depth review of ANCA-associated vasculitis; use of NSAIDs as part of an adjuvant or palliative therapy in animal cancer; effect of antiretroviral therapy in children of HIV positive mothers; mTOR complexes in GM3 mediated melanoma metastasis and as a strategy in oncology; and the role of fluoride and pH in titanium corrosion in the oral cavity.

Quelle que soit la discipline concernée, le diagnostic et le traitement des cancers du sein reposent sur des acquis dont la remise en cause, en dehors de véritables révolutions, est fort rare. Mais qu'il s'agisse de disciplines fondamentales ou cliniques, les connaissances ont des limites et au-delà de celles-ci des perspectives nouvelles se dessinent. Au cours de ces 34es journées, ces Acquis et Limites, ouvrant la porte à de nouvelles voies sont discutés. Sont ainsi abordées les classifications anatomopathologiques et de biologie moléculaire, les méthodes d'imagerie et les méthodes thérapeutiques qu'elles soient chirurgicales, médicales ou de radiothérapie. Cet ouvrage présente l'état de l'art, présent et futur, de sa discipline sous l'oeil critique des autres acteurs concernés dans la prise en charge de la pathologie du sein et du cancer en particulier.

Esta obra describe las diferentes situaciones que se pueden presentar en un paciente con trauma de alta energia, la descripcion acertada de las lesiones, las prioridades y el tipo de tratamiento que se debe realizar, tomando en cuenta los grandes adelantos que nos permiten hacer un mejor diagnostico y un tratamiento mas eficaz a corto plazo.

This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed include infant HIV and nanotechnology; self-expansion as an aid in smoking abstinence and cessation; gene silencing; the plausible role of antimicrobial peptides in periodontal disease; periodic leg movements in narcolepsy; the role of steroid hormones in brain development and visuospatial processing of adolescence and the future direction of cataract surgery.

This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. This compilation focuses on the impact of depression during pregnancy on a newborn's health; chromosome mapping in the era of dense marker sets; the importance of parent physical activity levels and their expectations for their children's health; the autonomic nervous system and glucose and lipid metabolism; smoke-related lung disease and the role of metal ion in inorganic biochemistry.

This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed in this compilation include the effects of hypertension in patients with epistaxis; chronic supportive otitis media in children; the effect of menopausal hormone therapy on breast atrophy; therapeutic targets for Huntington's Disease; catheter-related infections and mortality from congenital malformations in newborns and infants. (Imprint: Nova Biomedical Press)

This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed in this compilation include bone marrow stromal cell transplantation in spinal cord injury; DNA tumor viruses; contraception methods and implications; pediatric palliative care; health care costs from diabetes in Latin America and vitamin K as a ligand of steroid and xenobiotic receptors.

This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. This compilation focuses on: Vitamin B; smoking cessation; exercise performance; blood coagulation; and others.

This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. This compilation focuses on stem cell-like cells and plant regeneration; amputations in patients with diabetes mellitus; patient education in the internet age; diet, weight loss and nonalcoholic fatty liver disease; Fcy receptors on human neutrophils; virtual nursing care; and digital dermatological photography.

Esta obra presenta temas de gran interes para el anestesiologo interesado en el trasplante de organos. Discute los principios anestesicos para el trasplante de rinon, corazon e higado y el manejo perioperatorio del paciente trasplantado para procedimientos quirurgicos no involucrados con el trasplante.