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This two-volume set LNAI 14471-14472 constitutes the refereed proceedings of the 36th Australasian Joint Conference on Artificial Intelligence, AI 2023, held in Brisbane, QLD, Australia during November 28 – December 1, 2023. The 23 full papers presented together with 59 short papers were carefully reviewed and selected from 213 submissions. They are organized in the following topics: computer vision; deep learning; machine learning and data mining; optimization; medical AI; knowledge representation and NLP; explainable AI; reinforcement learning; and genetic algorithm.

This book constitutes the proceedings of the 26th International Conference on Discovery Science, DS 2023, which took place in Porto, Portugal, in October 2023. The 37 full papers and 10 short papers presented in this volume were carefully reviewed and selected from 133 submissions. They were organized in topical sections as follows: Machine learning methods and applications; natural language processing and social media analysis; interpretability and explainability in AI; data analysis and optimization; fairness, privacy and security in AI; control and spatio-temporal modeling; graph theory and network analysis; time series and forecasting; healthcare and biological data analysis; anomaly, outlier and novelty detection.

This book includes high-quality research papers presented at the Fifth International Conference on Innovative Computing and Communication (ICICC 2022), which is held at the Shaheed Sukhdev College of Business Studies, University of Delhi, Delhi, India, on February 19–20, 2022. Introducing the innovative works of scientists, professors, research scholars, students and industrial experts in the field of computing and communication, the book promotes the transformation of fundamental research into institutional and industrialized research and the conversion of applied exploration into real-time applications.

The ten-volume set LNCS 14220, 14221, 14222, 14223, 14224, 14225, 14226, 14227, 14228, and 14229 constitutes the refereed proceedings of the 26th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2023, which was held in Vancouver, Canada, in October 2023. The 730 revised full papers presented were carefully reviewed and selected from a total of 2250 submissions. The papers are organized in the following topical sections: Part I: Machine learning with limited supervision and machine learning – transfer learning; Part II: Machine learning – learning strategies; machine learning – explainability, bias, and uncertainty; Part III: Machine learning – explainability, bias and uncertainty; image segmentation; Part IV: Image segmentation; Part V: Computer-aided diagnosis; Part VI: Computer-aided diagnosis; computational pathology; Part VII: Clinical applications – abdomen; clinicalapplications – breast; clinical applications – cardiac; clinical applications – dermatology; clinical applications – fetal imaging; clinical applications – lung; clinical applications – musculoskeletal; clinical applications – oncology; clinical applications – ophthalmology; clinical applications – vascular; Part VIII: Clinical applications – neuroimaging; microscopy; Part IX: Image-guided intervention, surgical planning, and data science; Part X: Image reconstruction and image registration.

This book is a collection of high-quality peer-reviewed research papers presented at International Conference on Recent Trends in Computing (ICRTC 2022) held at SRM Institute of Science and Technology, Ghaziabad, Delhi, India, during 3 – 4 June 2022. The book discusses a wide variety of industrial, engineering and scientific applications of the emerging techniques. The book presents original works from researchers from academic and industry in the field of networking, security, big data and the Internet of things.

This book primarily aims to discuss emerging topics in statistical methods and to booster research, education, and training to advance statistical modeling on interval-censored survival data. Commonly collected from public health and biomedical research, among other sources, interval-censored survival data can easily be mistaken for typical right-censored survival data, which can result in erroneous statistical inference due to the complexity of this type of data. The book invites a group of internationally leading researchers to systematically discuss and explore the historical development of the associated methods and their computational implementations, as well as emerging topics related to interval-censored data. It covers a variety of topics, including univariate interval-censored data, multivariate interval-censored data, clustered interval-censored data, competing risk interval-censored data, data with interval-censored covariates, interval-censored data from electric medical records, and misclassified interval-censored data. Researchers, students, and practitioners can directly make use of the state-of-the-art methods covered in the book to tackle their problems in research, education, training and consultation.

This book constitutes the Second 3D Head and Neck Tumor Segmentation in PET/CT Challenge, HECKTOR 2021, which was held in conjunction with the 24th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2021. The challenge took place virtually on September 27, 2021, due to the COVID-19 pandemic.The 29 contributions presented, as well as an overview paper, were carefully reviewed and selected form numerous submissions. This challenge aims to evaluate and compare the current state-of-the-art methods for automatic head and neck tumor segmentation. In the context of this challenge, a dataset of 325 delineated PET/CT images was made available for training.

Advanced Statistics in Regulatory Critical Clinical Initiatives is focused on the critical clinical initiatives introduced by the 21st Century Cure Act passed by the United States Congress in December 2016. The book covers everything from the outline of the initiatives to analysis on the effect on biopharmaceutical research and development. Advanced Statistics in Regulatory Critical Clinical Initiatives provides innovative ways to resolve common challenges in statistical research of rare diseases such small sample sizes and provides guidance for combined use of data. With analysis from regulatory and scientific perspectives this book is an ideal companion for researchers in biostatistics, pharmaceutical development, and policy makers in related fields.Key Features: Provides better understanding of innovative design and analysis of each critical clinical initiatives which may be used in regulatory review/approval of drug development. Makes recommendations to evaluate submissions accurately and reliably. Proposes innovative study designs and statistical methods for oncology and/or rare disease drug development. Provides insight regarding current regulatory guidance on drug development such as gene therapy and rare diseases.

Statistical Design, Monitoring, and Analysis of Clinical Trials, Second Edition concentrates on the biostatistics component of clinical trials. This new edition is updated throughout and includes five new chapters.Developed from the authors'courses taught to public health and medical students, residents, and fellows during the past 20 years, the text shows how biostatistics in clinical trials is an integration of many fundamental scientific principles and statistical methods. The book begins with ethical and safety principles, core trial design concepts, the principles and methods of sample size and power calculation, and analysis of covariance and stratified analysis. It then focuses on sequential designs and methods for two-stage Phase II cancer trials to Phase III group sequential trials, covering monitoring safety, futility, and efficacy. The authors also discuss the development of sample size reestimation and adaptive group sequential procedures, phase 2/3 seamless design and trials with predictive biomarkers, exploit multiple testing procedures, and explain the concept of estimand, intercurrent events, and different missing data processes, and describe how to analyze incomplete data by proper multiple imputations. This text reflects the academic research, commercial development, and public health aspects of clinical trials. It gives students and practitioners a multidisciplinary understanding of the concepts and techniques involved in designing, monitoring, and analyzing various types of trials. The book's balanced set of homework assignments and in-class exercises are appropriate for students and researchers in (bio)statistics, epidemiology, medicine, pharmacy, and public health.

This book analyzes the development of medical big data projects in Japan.Japan is experiencing unprecedented population aging, and labor productivity has decreased accordingly. Big data analysis of the Japanese medical real-world database (RWD) has the potential to tackle this issue.To allow readers to gain an understanding of Japanese medical big data analysis, the book discusses the original Japanese system that generates medical RWDs in the hospital medical records system, the nationwide standardized health checkup system, and the public medical insurance system in Japan.After introducing four major big data projects in the healthcare–medical field in Japan, the book explains the importance of creating information standards to maintain data quality and to analyze medical big data. It enables readers to analyze which standards are installed in which RWDs, how the standards are maintained, and which issues are prevalent in Japan.This book also describes the ethical processes involved in big data projects involving medical RWDs in Japan.

The eight-volume set LNCS 13431, 13432, 13433, 13434, 13435, 13436, 13437, and 13438 constitutes the refereed proceedings of the 25th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2022, which was held in Singapore in September 2022.The 574 revised full papers presented were carefully reviewed and selected from 1831 submissions in a double-blind review process. The papers are organized in the following topical sections:Part I: Brain development and atlases; DWI and tractography; functional brain networks; neuroimaging; heart and lung imaging; dermatology;Part II: Computational (integrative) pathology; computational anatomy and physiology; ophthalmology; fetal imaging;Part III: Breast imaging; colonoscopy; computer aided diagnosis;Part IV: Microscopic image analysis; positron emission tomography; ultrasound imaging; video data analysis; image segmentation I;Part V: Image segmentation II; integration of imaging with non-imaging biomarkers;Part VI: Image registration; image reconstruction;Part VII: Image-Guided interventions and surgery; outcome and disease prediction; surgical data science; surgical planning and simulation; machine learning – domain adaptation and generalization;Part VIII: Machine learning – weakly-supervised learning; machine learning – model interpretation; machine learning – uncertainty; machine learning theory and methodologies.

Das Buch enthält die Abstracts der eingeladenen bzw. angenommenen Vorträge der 6. Konferenz der Deutschen Arbeitsgemeinschaft Statistik (DAGStat), welche vom 28. März bis 1. April 2022 am Universitätsklinikum Hamburg-Eppendorf (UKE) in Kooperation mit der Universität Hamburg sowie der Helmut-Schmidt-Universität stattfand. Die Konferenz stellte ebenfalls das 68. Biometrische Kolloquium der Deutschen Region der International Biometric Society (IBS-DR) dar, sowie die 45. Jahrestagung der Gesellschaft für Klassifikation (GfKl/Data Science Society). Die Vorträge behandelten dabei ein breites Spektrum sowohl angewandter als auch eher methodischer/theoretischer Themen aus dem Bereich Statistik und Data Science.