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This book is a collection of works that represent the recent advancements in computational and mathematical methods applied to population dynamics. It concentrates on both development of new tools as well as on innovative use of existing tools to obtain new understanding of biological systems. The volume introduces new state-of-the-art techniques for defining and solving numerically control problems in mathematical biology in which the control appears linearly. Such problems produce simpler optimal controls that can be implemented in practice. The book further develops tools for fitting multi-scale models to multi-scale data and studying the practical identifiability of the parameters from multi-scale data. Novel model of Zika with Wolbahia infection in mosquitoes suggests that the most suitable control strategy to control Zika in the absence of Wolbahia is killing mosquitoes but the most suitable strategy when mosquitoes are Wolbahia infected is the treatment of humans.A completely novel methodology of developing discrete-continuous hybrid models of multi-species interactions is also introduced together with avantgarde techniques for discrete-continuous hybrid models analysis. A mathematical model leads to new observations of the within-host virus dynamics and its interplay with the immune responses. In particular, it is observed that the parameters promoting CTL responses need to be boosted over parameters promoting antibody production to obtain a biologically relevant steady state. A novel stochastic model of COVID-19 investigates quarantine and lock down as important strategies for control and elimination of COVID-19.

The Proceedings of the ICM publishes the talks, by invited speakers, at the conference organized by the International Mathematical Union every 4 years. It covers several areas of Mathematics and it includes the Fields Medal and Nevanlinna, Gauss and Leelavati Prizes and the Chern Medal laudatios.

A valuable introduction for newcomers as well as an important reference and source of inspiration for established researchers, this book provides an up-to-date summary of central topics in the field of nonequilibrium statistical mechanics and dynamical systems theory.Understanding macroscopic properties of matter starting from microscopic chaos in the equations of motion of single atoms or molecules is a key problem in nonequilibrium statistical mechanics. Of particular interest both for theory and applications are transport processes such as diffusion, reaction, conduction and viscosity.Recent advances towards a deterministic theory of nonequilibrium statistical physics are summarized: Both Hamiltonian dynamical systems under nonequilibrium boundary conditions and non-Hamiltonian modelings of nonequilibrium steady states by using thermal reservoirs are considered. The surprising new results include transport coefficients that are fractal functions of control parameters, fundamental relations between transport coefficients and chaos quantities, and an understanding of nonequilibrium entropy production in terms of fractal measures and attractors.The theory is particularly useful for the description of many-particle systems with properties in-between conventional thermodynamics and nonlinear science, as they are frequently encountered on nanoscales.

This comprehensive volume is a graduate-level text in human biodynamics, written in the unified categorical language of modern differential geometry and topology. Combining mathematics, physics and robotics with human physiology, this is the first book that describes all levels of human biodynamics, from musculo-skeletal mechanics to the higher brain functions. The book develops and uses a variety of research methods, ranging from chaos theory and Haken's synergetics, through quantum mechanics, to nonlinear control and artificial intelligence, to provide the means to understand, predict and control the behavior of human-like systems in their full neuro-musculo-skeletal complexity. The applications of this unique scientific methodology range from prediction of human neuro-musculo-skeletal injuries to brain-like control of humanoid robots.