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This book describes classical and potential PET radiopharmaceuticals (PET-RPs) which can provide high-resolution 5D images in-vivo to simultaneously diagnose and treat the patient. This novel (theranostic) approach avoids futile therapies, unnecessary radiation exposure, and saves a lot of time, money, and energy. The most significant challenge is to properly build Cyclotron & PET RPs labs. Existing books offer insufficient knowledge to accomplish the full potential of these highly specialized, expansive, and sophisticated labs, demanding in-depth knowledge, confidence, cooperation, a mutual understanding, adjustment, time management, team effort, patience, resilience, and dedication. A systematic approach is provided to integrate Cyclotron and PET-RPS labs, run the cyclotron properly, resolve technical problems efficiently, and maintain quality control (QC) without being exposed to an unnecessary radiation hazard due to repetitive run failure, innocence, ignorance, negligence, misconception, misunderstanding, and/or overconfidence. Described QC experiments can be globally reproduced in other labs. The contents provided are thought-provoking and motivate cyclotron engineers, basic scientists, radiopharmaceutical scientists, radiopharmacists, and physicians to develop novel PET-RPs in this challenging the era of Nanotheranostics. The most recent knowledge of potential PET-RPs in the early theranostics of cancer, cardiovascular diseases, neurodegenerative diseases, drug addiction, obesity, neurobehavioral disorders, rheumatoid arthritis, and chronic inflammatory illnesses is provided with currently limited treatment options. This unique, informative, and timely released book will act as a helpful guide; it is an applied textbook for basic biomedical students, scientists, researchers, teachers, doctors, administrators, and affiliated staff involved in current and future development of novel PET-RPs to accomplish personalized theranostics.

This encyclopedia presents important research on dermatological advances. This six set volume includes discussions on the structure and composition of the dermis layer of the skin; the biosynthesis, functions and health benefits of melanin; the genetics, as well as the geographic variation and disorders, of skin pigmentation; the causes, diagnosis and treatment of alopecia, rosacea, candidiasis, cyanosis, psoriasis, and bullous pemphigoid; new research on skin aging; risk factors, protection practices and health effects of sun exposure; skin cancer prevention; the use of sunscreen; skin cancer prevention guidance for schools and youth; and the epidemiology, management and impact on muscle and joint functions of burns.

The book discusses multiple aspects of sepsis syndrome seen in all age groups of patients and by all specialties in medicine. The syndrome is the aftermath of the dissemination of an infectious process into and through the blood stream. This allows the bacteria, bacterial products and cytokines to reach multiple organs, resulting in their dysfunction. In spite of the advances in supportive care and antibiotic therapy, the outcome of sepsis has not changed significantly. The inadequacies in the current diagnostic modalities and conflicting inconclusive results of investigations on novel treatments have contributed significantly to the lack of progress in the management of sepsis. Antibiotic overuse in and outside the intensive care unit driven by the lack of microbiological data and definitive diagnosis lends to the creation and transmission of antibiotic resistant bacteria, which has added to the challenges and poor outcomes of sepsis syndrome. The nine chapters in this book are authored by experts in various aspects of sepsis from North America, South America, Europe and Asia. State of the art information is provided in the areas of pathogenesis, epidemiology, diagnosis and management of sepsis. Each chapter has a contribution on the role of various evidence-based preventive strategies to reduce the incidence and subsequent poor outcomes of sepsis syndrome.

Fluconazole is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. In this book, the authors present current research in the study of the pharmacology, clinical uses and health effects of fluconazole. Topics discussed include the utilization of fluconazole in adult intensive care units; the use of fluconazole in veterinary species and a description of variances from the human experience as well as findings in veterinary species which may have applicability in human medicine; common clinical uses and in vitro activity features on fluconazole; and the discovery and development of medically-important antifungal agents, particularly the azole derivatives and the development of fluconazole and its clinical applications.

This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed in this compilation include the cell cycle alteration in down syndrome; TLR agonists as immune adjuvants; heart rate variability in eating disorders; current trends in glaucoma; pharmacological aspects of borates; phage display technology and the quantitative determination of oxytocin.