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This book constitutes the refereed proceedings of the 16th EAI International Conference on Pervasive Computing Technologies for Healthcare, PervasiveHealth 2022, which took place in Thessaloniki, Greece, in December 2022.The 45 full papers included in this volume were carefully reviewed and selected from 120 submissions. The papers are organized in the following topical sections: personal informatics and wearable devices; computer vision; IoT-HR: Internet of things in health research; pervasive health for COVID-19; machine learning, human activity recognition and speech recognition; software frameworks and interoperability; facial recognition, gesture recognition and object detection; machine learning, predictive models and personalised healthcare; human-centred design of pervasive health solutions; personalized healthcare.