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Innovation is changing. Traditionally viewed as a tool for financial return and market growth, there is mounting pressure to rethink and reframe the theory and practice of innovation for the pressing sustainability and inequality challenges of our era. This textbook provides students with a research-informed dive into the emerging space of innovation for systems/transformative change. Combining real-world case studies with interdisciplinary theory, it shows how and why innovation for urgent global challenges requires a systems-based approach. Relevant for students and instructors of business and management, particularly innovation studies, development studies and related fields, this book is the first to provide a comprehensive, interdisciplinary and research-informed overview of alternative approaches to innovation focused on systemic change.