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Abstract Unlike micro-local studies on turn allocation, this study combines macro- and micro-local (Traverso, 2004) perspectives to explore turn allocation of the multi-participant medical-service-seeking 1 (MSS) party composed of the patient and his/her companion in accompanied medical consultations in China. Through both qualitative and quantitative analyses of the transcription of 20 audio recorded consultations in China, the talk distribution within the MSS party is examined in terms of the structural organization of a medical visit. Features of the talk distribution in different phases of the medical consultation and factors influencing turn allocation are explored. It is found that talk is not equally distributed within the MSS party, and all phases other than the opening and the closing witness a significant or marginally significant difference in talk contribution by the patient and the companion. Factors influencing turn allocation within the MSS party vary from phase to phase: epistemic gradient, sick-role-triggered activity transfer and coalition to offset power asymmetry are among the most important. The paper sheds light on the study of polylogue, enables cross-cultural comparisons of medical consultations, and has methodological implications for further studies of medical conversations. Highlights 1. Turn allocation in accompanied medical consultations operates at two levels: between parties and within a party. 2. The talk distribution within the treatment-seeking party between the patient and the companion varies from phase to phase. 3. The intra-party turn allocation is tacitly or overtly negotiated between the patient and the companion influenced by a range of factors, such as epistemic gradient, sick role-triggered activity transfer, and coalition to offset power asymmetry. [ABSTRACT FROM AUTHOR]

The incidence of hyperuricemia and gout has been increasing year by year, and it is showing a younger trend. However, the first-line drugs currently used for hyperuricemia and gouty arthritis have serious side effects that limit their clinical application. Amomum villosum Lour. has been widely used in China for thousands of years as a traditional medical and edible plant, and previous screening showed that the ethanol extract of Amomum villosum Lour. could effectively inhibit the activity of xanthine oxidase. Based on this discovery, this paper had achieved in-depth mechanism research. The results showed that the ethanol extract of Amomum villosum Lour. could treat hyperuricemia by reducing the production of uric acid via inhibition of xanthine oxidase and increasing the excretion of uric acid via regulation of urate transporters. Meanwhile, the extract also showed a certain protective effect on hepatic and renal damage caused by hyperuricemia. With the formation of extensive uric acid, gouty arthritis will be induced by the deposition of monosodium urate in the joint. The extract could also relieve the inflammation by reducing the expression of inflammatory cytokines. In conclusion, the extract deserves focused research and development as a potential medicine, health care product or supplemented food for the prevention and treatment of hyperuricemia and gouty arthritis. [Display omitted] • The EA could reduce the production of uric acid via inhibition of xanthine oxidase. • The EA could increase the excretion of uric acid via regulation of urate transporters. • The EA showed a certain protective effect on hepatic and renal damage caused by hyperuricemia. • The EA could relieve the gouty arthritis by reducing the expression of inflammatory cytokines. • The EA deserves focused research as a potential medicine for the treatment of hyperuricemia and gouty arthritis. [ABSTRACT FROM AUTHOR]