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Kevin Dooley (1997), defined Complex Adaptive System (CAS) as a group of semi-autonomous agents who interact in interdependent ways to produce system-wide patterns, such that those patterns then influence behavior of the agents. A healthcare system is considered as a Complex Adaptive System of system (SoS) with agents composed of strategies, people, process, and technology. Healthcare systems are fragmented with independent systems and information. The enterprise architecture (EA) aims to address these fragmentations by creating boundaries around the business strategy and key performance attributes that drive integration across multiple systems of processes, people, and technology. This paper uses a SoS Explorer to select an optimal architecture that provide the necessary capabilities to meet key performance attributes (KPAs) in a dynamic, complex healthcare business environment. The SoS Explorer produced an optimal meta-architecture where all but two systems (disease and facility processes) participated with many of the systems having at least four interfaces. The healthcare meta-architecture produced in this study is not a solution to address the challenges of the healthcare enterprise architecture but provides insight on the areas – systems, capabilities, characteristics, and interfaces – to pay attention to where agility is an important attribute and not to be severely compromised. [ABSTRACT FROM AUTHOR]

No comprehensive review of Bayesian networks (BNs) in healthcare has been published in the past, making it difficult to organize the research contributions in the present and identify challenges and neglected areas that need to be addressed in the future. This unique and novel scoping review of BNs in healthcare provides an analytical framework for comprehensively characterizing the domain and its current state. A literature search of health and health informatics literature databases using relevant keywords found 3810 articles that were reduced to 123. This was after screening out those presenting Bayesian statistics, meta-analysis or neural networks, as opposed to BNs and those describing the predictive performance of multiple machine learning algorithms, of which BNs were simply one type. Using the novel analytical framework, we show that: (1) BNs in healthcare are not used to their full potential; (2) a generic BN development process is lacking; (3) limitations exist in the way BNs in healthcare are presented in the literature, which impacts understanding, consensus towards systematic methodologies, practice and adoption; and (4) a gap exists between having an accurate BN and a useful BN that impacts clinical practice. This review highlights several neglected issues, such as restricted aims of BNs, ad hoc BN development methods, and the lack of BN adoption in practice and reveals to researchers and clinicians the need to address these problems. To map the way forward, the paper proposes future research directions and makes recommendations regarding BN development methods and adoption in practice. [ABSTRACT FROM AUTHOR]