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1. Berberine as a promising natural compound for the treatment of periodontal disease: A focus on anti‐inflammatory properties

Author

Saeed Mohammadian Haftcheshmeh and Amir Abbas Momtazi-Borojeni

Subjects
Berberine, medicine.drug_class, Short Communication, Anti-Inflammatory Agents, Drug Evaluation, Preclinical, Inflammation, Disease, Pharmacology, Anti-inflammatory, chemistry.chemical_compound, Immune system, In vivo, Medicine, Animals, Humans, Periodontitis, Periodontal Diseases, Biological Products, Clinical Trials as Topic, biology, business.industry, Cell Biology, medicine.disease, Treatment Outcome, chemistry, RANKL, inflammation, biology.protein, Molecular Medicine, medicine.symptom, business
Abstract

Accumulating evidence during the last two decades has addressed the potential anti‐inflammatory properties of berberine (BBR), a bioactive alkaloid compound isolated from Coptidis rhizoma, in controlling or treating several inflammatory diseases. Periodontitis is one of the most common chronic and serious inflammatory diseases, in which uncontrolled and unabated host immune responses against periodontopathic pathogens play critical and crucial roles in the disease pathogenesis. Hence, regulating inflammatory responses in periodontitis has a valuable approach and holds promise in treating periodontitis. For the first time, this paper reviews the evidence from in vitro and in vivo experimental models to explore the anti‐inflammatory effects of BBR in periodontitis and exhibits that BBR has the high potency to exert anti‐inflammatory effects by reducing expression and secretion of pro‐inflammatory mediators including TNF‐α, IL‐1β, IL‐17, RANKL, MMP‐2, MMP‐9 and MCP‐1. The BBR‐mediated anti‐inflammatory actions could translate into the inhibition of the periodontal tissues and alveolar bone destruction and the control of the disease in vivo. As the second aim of this paper, we also paid attention to the therapeutic potential of BBR in treating human diseases regarding its anti‐inflammatory properties.

Published
2021

2. Pyrolae herba: A review on its botany, traditional uses, phytochemistry, pharmacology and quality control.

Author

He, Chunjiao, Liu, Junyu, Ke, Tongwei, Luo, Yawen, Zhang, Shaowu, Mao, Ting, Li, Zulun, Qin, Xuhua, and Jin, Shenrui

Subjects
*PHYTOTHERAPY, *MEDICINAL plants, *ANTI-inflammatory agents, *ANTI-infective agents, *ANTIVIRAL agents, *ANTINEOPLASTIC agents, *ANTIOXIDANTS, *OSTEOBLASTS, *BIOLOGY, *PHYTOCHEMICALS, *CELL proliferation, *TOXICOLOGY, *CARDIOTONIC agents
Abstract

Pyrolae herba is the dried whole plant of Pyrola calliantha H. Andres or Pyrola decorata H. Andres (Pyrolaceae). Pyrolae herba has a long history of medicinal use in China. In ancient times, it was often used to treat pain in tendons and bones, swollen sore, cough, expectoration, bleeding, and other diseases. and was commonly used in ancient times to treat pain in the tendons and bones, swollen sore, cough, expectoration, bleeding and other diseases. This paper summarizes the botany, traditional uses, phytochemistry, pharmacology, quality control and toxicology of Pyrolae herba , with a view to providing reference for further development and research. The relevant information on Pyrolae herba was collected from the scientific databases including PubMed, CNKI, ScienceDirect, Wiley, Springer, Web of Science, Google Scholar, Baidu Scholar, Pharmacopoeia of the People's Republic of China and Flora Republicae Popularis Sinicae, etc. At present, more than 70 compounds have been identified from Pyrolae herba , including flavonoids, phenolic glycosides, quinones, terpenoids, volatile oils and other compounds. Pharmacological studies have shown that Pyrolae herba has a variety of pharmacological activities, such as anti-inflammatory, anti-bacterial, anti-viral, anti-tumor, anti-oxidation, reducing blood lipids, protective on cardiovascular and cerebrovascular, promoting osteoblast proliferation, and so on. It is used clinically in modern times to treat rheumatic arthritis, rheumatoid arthritis, bone hyperplasia, sciatica, cervical spondylosis, lumbar spondylosis, acute and chronic bronchitis, mammary gland hyperplasia, tumor, hypertension, coronary heart disease and bleeding diseases. Pyrolae herba is rich in chemical constituents, diverse in pharmacological activities and abundant in resources, which is widely used in clinics from traditional to modern. However, there is a lack of research on the relationship between chemical constituents and pharmacodynamics of Pyrolae herba. In addition, the existing clinical applications suggest that Pyrolae herba has a certain therapeutic potential in the treatment of hemorrhagic diseases, but there is a lack of information on experimental studies. It is worthwhile to further investigate the Pyrolae herba in depth in the hope of making discoveries and breakthroughs. [Display omitted] • Systematically sorted out the clinical application of Pyrolae herba. • Put forward a promising research direction for Pyrolae herba. • The hemostatic effect of Pyrolae herba has been widely used in clinical medicine in traditional Chinese medicine. [ABSTRACT FROM AUTHOR]

Published
2022
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