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“[A] remarkable journey.”—The Telegraph The incredible life story of legendary cardiac surgeon and scientist Magdi Yacoub, an outsider who succeeded against the odds Veteran journalists Simon Pearson and Fiona Gorman follow the remarkable life of heart surgeon Magdi Yacoub from his formative years in Egypt, through spectacular success at Cairo University, to his long and distinguished career in Britain. Although at times he clashed with the medical establishment in London, Yacoub pioneered great advances in heart surgery. He was knighted in 1992, and in 2014, he was awarded the highest honor in the gift of the Queen, the Order of Merit.Written with unprecedented access and drawing on extensive interviews and research, the biography recounts how Yacoub transformed the treatment of children with congenital heart disease. He performed some of the first heart transplants in Britain and the first heart-lung transplants in Europe. At London's Harefield Hospital, he created the greatest heart transplant center in the world. Among his patients are men and women who are still thriving more than thirty-five years after he gave them new hope. This story is also about science, the development of new medical techniques, and a deeper understanding of how the human body works. Today, at an age when most people have long since retired, Yacoub is still pushing the boundaries of scientific understanding and surgical know-how. He is also taking heart surgery to places that until now have had little access to cardiac treatment, developing centers of excellence across Africa, including in Egypt, where his hospital in Aswan has an international reputation, and a new center is rising in Cairo.Yacoub's life is one of triumph and tragedy, success and failure, fierce criticism and high praise—it is also an enthralling journey through the worlds of scientific research and medical politics and ethics at the highest levels.

Great innovations take place within great institutions. Founded in 1819, Toronto General Hospital (TGH) is one of Canada's oldest hospitals and has created a nurturing environment for early Canadian innovations in heart surgery. The Heartbeat of Innovation tells the story of the brilliant surgeons who worked there and the hospital environment that provided an incubator to the many people – skilled perfusionists, dedicated nurses, and pioneering cardiologists – who participated in the revolution in heart surgery that took place along University Avenue in Toronto. Supported by historical records, hospital archives, personal memoirs, and interviews, this book is an extensive and descriptive account of the seemingly inexorable development of cardiac surgery at this leading academic health science centre. It pursues several themes: the complexity of this surgical specialty, its generally male-dominated nature, the trend toward teamwork in practice, and the evolution and incorporation of original research into this branch of healthcare. These strands are woven together to demonstrate how the TGH has evolved into such a dominant leader in the competitive and demanding field of cardiac surgery. Canadian hearts may beat with pride at the knowledge that one of the major stories in modern medicine took place here – and continues here.

This engaging book covers a multitude of topics related to heart rhythm disorders (HRDs) and uniquely familiarizes readers with the development of treatment modalities over the past several decades, including the evolution of anti-arrhythmic drugs, pacemakers, defibrillators, and catheter ablation. Organized in ten sections, this title serves as both an archival and a contemporary resource for clinicians. The first section describes the discovery of the circulatory system by William Harvey in 1628 and outlines the development and understanding of HRD since the advent of intra-cardiac electrophysiology. Subsequent sections discuss the historical evolution of abnormal heart rhythms, such as supra and ventricular rhythms and sudden cardiac death, their treatment with drugs, surgery, pacemakers, implantable defibrillators and catheter ablation. Section nine offers a fascinating narration of the clinical evolution of overcoming heart attacks and its impact on HRDs. Thefinal section explores potential new frontiers in HRD and the factors that may contribute to the prospective rise of cardiovascular diseases. A ground-breaking and invaluable addition to the clinical literature, Heart Rhythm Disorders: History, Mechanisms and Management Perspectives details the pervasive nature of cardiovascular diseases in human history, their ramifications, and their projected effects on at-risk demographic populations and human health in general.

In State of the Heart, Dr. Haider Warraich takes readers inside the ER, inside patients'rooms, and inside the history and science of cardiac disease.State of the Heart traces the entire arc of the heart, from the very first time it was depicted on stone tablets, to a future in which it may very well become redundant. While heart disease has been around for a while, the type of heart disease people have, why they have it, and how it's treated is changing. Yet, the golden age of heart science is only just beginning. And with treatments of heart disease altering the very definitions of human life and death, there is no better time to look at the present and future of heart disease, the doctors and nurses who treat it, the patients and caregivers who live with it, and the stories they hold close to their chests.More people die of heart disease than any other disease in the world and when any form of heart disease progresses, it can result in the development of heart failure. Heart failure affects millions and can affect anyone at anytime, a child recovering from a viral infection, a woman who has just given birth or a cancer patient receiving chemotherapy. Yet new technology to treat heart failure is fundamentally changing just what it means to be human. Mechanical pumps can be surgically sown into patients'hearts and when patients with these pumps get really sick, sometimes they don't need a doctor or a surgeon—they need a mechanic. In State of the Heart, the journey to rid the world of heart disease is shown to be reflective of the journey of medical science at large. We are learning not only that women have as much heart disease as men, but that the type of heart disease women experience is diametrically different from that in men. We are learning that heart disease and cancer may have more in common than we could have imagined. And we are learning how human evolution itself may have led to the epidemic of heart disease. In understanding how our knowledge of the heart evolved, State of the Heart traces the twisting and turning road that science has taken—filled with potholes and blind turns—all the way back to its very origin.

This book is a valuable tool to assist both cardiovascular physicians and scientists learning the intricacies of hypertension research and its milestone studies. All major hypertension trials have been reviewed in this book in chronological order with extensive discussion of the study population, study design, and outcomes and with a special focus on what knowledge they offered, their strengths and weaknesses, statistical errors, impact on international guidelines and unmet needs. Importantly, the book also offers physicians and young scientists with basic knowledge regarding medical biostatistics. It is of critical importance for a scientist involved in the field to understand deeply the process of analyzing medical data. Moreover, the accurate interpretation of the results is central for applying evidence-based medicine in everyday clinical practice. Management of Hypertension: Current Practice and the Application of Landmark Trials is a critical tool to assist in the education of physicians and researchers in the field, providing a separate section on pioneer researchers in hypertension and urging readers to become bright exemplars for scientists wishing to pursue a career in academic medicine and hypertension research.

A comprehensive history of the development of artificial hearts in the United States.Artificial hearts are seductive devices. Their promissory nature as a cure for heart failure aligned neatly with the twentieth-century American medical community's view of the body as an entity of replacement parts. In Artificial Hearts, Shelley McKellar traces the controversial history of this imperfect technology beginning in the 1950s and leading up to the present day. McKellar profiles generations of researchers and devices as she traces the heart's development and clinical use. She situates the events of Dr. Michael DeBakey and Dr. Denton Cooley's professional fall-out after the first artificial heart implant case in 1969, as well as the 1982–83 Jarvik-7 heart implant case of Barney Clark, within a larger historical trajectory. She explores how some individuals—like former US Vice President Dick Cheney—affected the public profile of this technology by choosing to be implanted with artificial hearts. Finally, she explains the varied physical experiences, both negative and positive, of numerous artificial heart recipients. McKellar argues that desirability—rather than the feasibility or practicality of artificial hearts—drove the invention of the device. Technical challenges and unsettling clinical experiences produced an ambivalence toward its continued development by many researchers, clinicians, politicians, bioethicists, and the public. But the potential and promise of the artificial heart offset this ambivalence, influencing how success was characterized and by whom. Packed with larger-than-life characters—from dedicated and ardent scientists to feuding Texas surgeons and brave patients—this book is a fascinating case study that speaks to questions of expectations, limitations, and uncertainty in a high-technology medical world.

“More than a litany of medical advances—it's the story of the gritty, bloody and deadly experiences that underlie scientific progress.” —Washington PostAn eye-opening and heroic story of pioneering heart surgeons, structured around eleven operations.For thousands of years the human heart remained the deepest of mysteries; both home to the soul and an organ too complex to touch, let alone operate on.Then, in the late nineteenth century, medics began going where no one had dared go before. The following decades saw the mysteries of the heart exposed, thanks to pioneering surgeons, brave patients and even sacrificial dogs.In eleven landmark operations, Thomas Morris tells us stories of triumph, reckless bravery, swaggering arrogance, jealousy and rivalry, and incredible ingenuity: the trail-blazing ‘blue baby'procedure that transformed wheezing infants into pink, healthy children; the first human heart transplant, which made headline news around the globe. And yet the heart still feels sacred: just before the operation to fit one of the first artificial hearts, the patient's wife asked the surgeon if he would still be able to love her.The Matter of the Heart gives us a view over the surgeon's shoulder, showing us the heart's inner workings and failings. It describes both a human story and a history of risk-taking that has ultimately saved millions of lives.“A thoroughly engaging history.” —The Wall Street Journal“Morris's expert guided tour of cardiac surgery and its quirky, brilliant innovators covers a dazzling and dizzying array of procedures and hints at tantalizing prospects for future surprises.” —Publishers Weekly, starred review“A well-developed narrative with no end of heroes.'“ —Kirkus Reviews“Gripping.” —John Crace, The Guardian

‘Jauhar weaves his own personal and family story into his history of the heart…very effectively… This gives a certain dramatic tension to the book, as it tells the fascinating and rather wonderful history of cardiology.'–Henry Marsh, New StatesmanA Mail on Sunday Book of the Year The heart lies at the centre of life. For cardiologist Sandeep Jauhar it is an obsession. In this fascinating history he interweaves gripping scenes from the operating theatre with the moving tale of his family's history of heart problems – from the death of his grandfather to the ominous signs of how he himself might die. Jauhar looks at the pioneers who risked patients'lives and their own careers, and confronts the limits of medical technology, arguing that how we live is more important than any device or drug we may invent. Heart is the all-encompassing story of the engine of life.

This book provides a comprehensive account of vascular biology and pathology and its significance for health and disease. It systematically and chronologically explains how we came to our current understanding of the vasculature and it´s function today, and describes in an entertaining way the diverse flaws and turns in science and medicine from the past. It thereby offers a complete and well-studied history on vascular biology and medicine. The book has an easy-to-read style and is written for students as well as scientists, physicians and lecturers in the field of biomedicine, human physiology, cardiology and hematology.

This special issue of Heart Failure Clinics examines heart failure with a truly global perspective, exposing health inequities in the treatment of heart failure.

From a renowned surgeon, “a stunning survey of cardiology's ‘Golden Age'and the ‘misfits'who made it so... a book of marvels” (Publishers Weekly, starred review).By the middle of the twentieth century, heart disease was killing millions and, as with the Black Death centuries before, physicians stood helpless. Visionaries, though, had begun to make strides decades earlier, daring to defy the medical wisdom of their day.On Sept. 7, 1895, Ludwig Rehn successfully sutured the heart of a living man with a knife wound to the chest for the first time. Once it was deemed possible to perform surgery on the heart, others followed. In 1929, Dr. Werner Forssman inserted a cardiac catheter in his own arm and forced the x-ray technician on duty to take a photo as he successfully threaded it down the vein into his own heart... and lived. On June 6, 1944—D-Day—another momentous event occurred far from the Normandy beaches: Dr. Dwight Harken sutured the shrapnel-injured heart of a young soldier, saving his life, and the term “cardiac surgeon” born.In The Heart Healers, world-renowned cardiac surgeon Dr. James Forrester tells the story of these rebels and the risks they took with their own lives and the lives of others to heal the most elemental of human organs. The result is a compelling chronicle of a disease and its cure, a disease that is still with us—but that is slowly being conquered by healers.“Forrester brings history to life and explains complex procedures for lay readers in this excellent book.” —Library Journal (starred review)“One of the great medical storytellers of our era.” —Eric Topol, cardiologist and author of Deep Medicine

In The Big Fat Surprise, investigative journalist Nina Teicholz reveals the unthinkable: everything we thought we knew about dietary fat is wrong. For the past 60 years, we have been told that the best possible diet involves cutting back on fat, especially saturated fat. But what if the low-fat diet is itself the problem? What if the very foods we've been denying ourselves — the creamy cheeses, the sizzling steaks — are the key to reversing the epidemics of obesity, diabetes, and heart disease? In this captivating, vibrant, and convincing narrative, based on a nine-year-long investigation, Teicholz shows how the misinformation about saturated fats took hold in the scientific community and the public imagination, and how recent findings have overturned these beliefs. She explains why the Mediterranean diet is not the healthiest, and how we might be replacing trans fats with something even worse. With eye-opening scientific rigour, The Big Fat Surprise makes the ground-breaking claim that more, not less, dietary fat — including saturated fat — is what leads to better health and wellness. Science shows that we have been needlessly avoiding meat, cheese, whole milk, and eggs for decades, and that we can now, guilt-free, welcome these delicious foods back into our lives.

This book contains all of Leonardo Da Vinci's drawings on the heart and its physiology, accompanied by re-translations of all of the associated notes. All Leonardo's drawings have been interpreted in the light of modern knowledge by a practicing cardiac clinician and anatomist. The veracity of his work is proven against contemporary dissections of cardiac structure and comparison of his illustrations with contemporary images generated by Magnetic Resonance scanners and high definition ultrasound will astound the reader. Perhaps the most interesting element is the re-dissection of the Ox heart set against Leonardo's own drawings. His place in the greater scheme of anatomical development will be put into context with his ideas of man's place in the microcosm/macrocosm continuum.

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

Sir Thomas Lewis has become one of the greatest cardiologists of this century. He was foremost in using the newly invented electrocardiograph to diagnose heart disease and was a pioneer of cardiac electro-physiology. This is the first biography of Sir Thomas Lewis, who became famous, whilst still quite young, for his outstanding pioneer work in electrocardiography. It recounts the scientific career of Lewis, together with accounts of his hospital work and teaching, and his familiy life and hobbies. There are over 100 illustrations including Lewis and his co-workers, and much of the information about Lewis has been derived from first hand accounts by his former associates. This biography appeal to cardiologists and to those physicians, surgeons and research workers with a special interest in the skin, pain and vascular disease, as well as clinical physiologists and medical historians.

The book provides a clear overview of the various research stages of cardiac surgery, interventional cardiology, and cardiac anesthesia. It also deals with recent advances in minimally invasive surgery, robotic surgery, and many other innovations introduced in this field. However, aim of this volume is not only to describe the evolution of the discipline, but also to give the occasion of revisiting old and forgotten ideas that could be used successfully also nowadays if supported by modern technologies. With contributions by renowned international experts, the volume will be a very useful tool for students, residents, cardiac surgery and anesthesia professionals, cardiologists, biomedical engineers, and researchers.

Blood in Motion is a textbook in Cardiovascular Science. It sets out to introduce, entice and explain the cardiovascular system to the reader using a classical system in teaching anatomy, physiology, general operation and specific systems. It is specifically designed to support the interests of students, experienced physiologists and clinicians. The book is subdivided into three parts, comprising a total of 11 chapters. Part I presents an historical perspective of cardiovascular knowledge and complements it with current insight into the physiology of the cardiovascular system. Part II explores sections of the circulatory loop, starting with an in-depth treatment of the veins, and including the lymphatic, the microcirculation, the arterial system and the heart. Part III incorporates approaches to the cardiovascular system as a whole, both in physiology and in science, such as modeling. This section introduces impedance-defined flow and offers the reader its application in mathematical modeling. At the end of each chapter, the reader will find questions designed to reinforce the information presented. Each chapter can be read or studied as an independent unit.

“Only once in a great while does a book come along that really does the job in addressing a major medical issue. When this happens, all can be joyful… Readers will find ALL their favorite dietary puzzlements dealt with… With consummate scholarship, clarity and brevity, Truswell sifts out the chaff and identifies the critical questions, the responsible investigators, and the key studies.” So says Emeritus Professor Henry Blackburn from the University of Minnesota in the foreword to this remarkable concise book on the history of research on diet and heart disease. This was a theme of scientific, medical and public interest in the 20th Century, a century marked by the rise and fall of coronary heart disease as the major cause of death in the first world, followed by the rise of this cause of death in the developing world. There is obviously much to learn, and this book is an excellent starting point, tracing dietary factors and their role in heart disease one by one: fats, sugar, salt, alcohol, coffee, trans-fats, etc. Without an understanding of the role of diet and the changes that have been seen in the North American and NW European diet, the story of the decline in the heart disease death rate may have been very different.

The story told in this book begins in about 1700, when the first attempts were made to study the diseased heart in life (the subject matter of cardiology), as distinct from its appearance after death; it ends, rather arbitrarily, in 1970. The account of the development of knowledge of heart disease is mainly chronological with emphasis on the fruitful consequences of the cross-fertilization of clinical practice with pathological anatomy at the beginning of the nineteenth century and with physiology at the end. In addition, shorter chapters deals with such topics as specific disease entities, methods of investigation, cardiac surgery and the work of two individuals - Peter Latham, an example of a physician practising with today's clinical skills but a very imperfect knowledge of the pathogenesis of heart disease and Etienne Marey, an early exponent of the clinical physiology which would, in time, throw light on that pathogenesis.