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Simple Summary: This research paper presents a comprehensive study of the patterns of conflicts between humans and Asiatic black bears (Ursus thibetanus) in the Guthichaur rural municipality, Jumla, Nepal. Through semi-structured interviews with villagers, focus group discussions, and key informant interviews, this study explores the extent of crop damage, livestock depredation, and human injuries caused by black bears from 2009 to 2019. It was found that crop damage was the most significant form of conflict, followed by livestock depredation and human casualties. This study identifies anthropogenic activities, such as human encroachment into bear habitats and agricultural practices near forests, as primary drivers of these conflicts. Importantly, this research proposes measures to mitigate these conflicts, including initiating compensation schemes for losses, establishing electric fences for crop protection, and launching educational programs. These recommendations, rooted in local practices and conservation efforts, show promise for managing conflicts in regions facing similar challenges with black bears. This paper fills a critical gap in understanding the dynamics of human–bear conflicts in Nepal, contributing valuable insights into wildlife management and conservation strategies. Its findings are significant for researchers, policymakers, and conservationists aiming to develop sustainable solutions for human–wildlife coexistence. Our study assessed patterns of Asiatic black bear (Ursus thibetanus)–human conflicts within the Guthichaur rural municipality, Jumla, Nepal. Through semi-structured interviews with villagers, focus group discussions (FGDs), and key informant interviews (KIIs), we gathered black bear–human conflict information from 2009 to 2019. We identified three primary types of black bear–human interactions: crop damage, livestock depredation, and human injuries. Of these, crop damage (77.03%) emerged as the most prevalent issue. Notably, peak occurrences were observed during autumn (September–October) typically between 9 PM and 3 AM. Livestock depredations were more frequent during nighttime in April–August, with cows/ox (70.12%) being the most depredated animal. Our data also revealed five recorded cases of black bear attacks on humans, which transpired from September to October, primarily in farmland areas in varying years. Despite a prevailing negative perception of bears, a notable level of support exists for their conservation efforts among local communities. Furthermore, these conflicts could be mitigated by reinforcing indigenous crop protection methods and implementing targeted mitigation strategies, as observed in other regions with successful black bear–human interaction management. [ABSTRACT FROM AUTHOR]