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Artificial intelligence (AI) algorithms are playing a crucial role in transforming healthcare by enhancing the quality, accessibility, and efficiency of medical care, research, and operations. These algorithms enable healthcare providers to offer more accurate diagnoses, predict outcomes, and customize treatments to individual patient needs. AI also improves operational efficiency by automating routine tasks and optimizing resource management. However, there are challenges to adopting AI in healthcare, such as data privacy concerns and potential biases in algorithms. Collaboration among stakeholders is necessary to ensure ethical use of AI and its positive impact on the field. AI also has applications in medical research, preventive medicine, and public health. It is important to recognize that AI should augment, not replace, the expertise and compassionate care provided by healthcare professionals. The ethical implications and societal impact of AI in healthcare must be carefully considered, guided by fairness, transparency, and accountability principles. Several research papers in this special issue explore the application of AI algorithms in various aspects of healthcare, such as gait analysis for Parkinson's disease diagnosis, human activity recognition, heart disease prediction, compliance assessment with clinical protocols, epidemic management, neurological complications identification, fall prevention, leukemia diagnosis, and genetic clinical pathways. These studies demonstrate the potential of AI in improving medical diagnostics, patient monitoring, and personalized care. [Extracted from the article]