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The nanoporous graphene papers (NGPs) was prepared by the hard-template method. The Pt−Pd modified NGPs hybrid was prepared by the self-assembly method. Then a glassy carbon electrode (GCE) modified with Pt−Pd bimetallic nanoparticles-functionalized nanoporous graphene composite has been prepared for the electrochemical determination of Xanthine (XA). The Pt−Pd/NGPs hybrid was characterized by transmission electron microscopy, scanning electron microscope and X-ray diffraction. The electrochemical behavior of XA on Pt−Pd/NGPs/GCE was investigated by cyclic voltammetry and amperometric i-t. The Pt−Pd/NGPs modified electrode exhibited remarkably electrocatalytic activity towards the oxidation reaction of XA in phosphate buffer solution (pH=5.5). Under the optimal conditions, the determination of XA was accomplished by using amperometric i-t, the linear response range from 1.0×10−5∼1.2×10−4 M. The detection limit was 3.0×10−6 M (S/N=3). The proposed modified electrode showed good sensitivity, selectivity, and stability with applied to determine XA in human urine. [ABSTRACT FROM AUTHOR]