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Classroom discussion of scientific articles can be an effective means of teaching scientific principles and methodology to both undergraduate and graduate science students. The availability of classic papers from the American Physiological Society Legacy Project has made it possible to access articles dating back to the early portions of the 20th century. In this article, we discuss a classic paper from the laboratory of Dr. James O. Davis on the regulation of aldosterone synthesis from the adrenal zona glomerulosa cell. Dr. Davis has conducted much of the seminal research investigating the renin-angiotensin system and the regulation of aldosterone release by angiotensin II. In addition to a characterization of the effects of ACTH on aldosterone regulation, this study is useful for discussing the basic principles of negative feedback pathways of the hypothalamic-pituitary axis. This study also provides examples of early bioassay techniques for the detection of angiotensin II and of the importance of quantitative measurements when investigating physiological responses. Three figures and one table are reproduced from the original article along with a series of discussion questions designed to facilitate discovery learning.

Introduction: The article presents the results of a study on scientific collaboration between Spanish universities and private enterprise, measured in terms of the co-authorship of papers published in international journals. Method: Bibliometric analysis of papers published in journals listed in Scopus in 2003-2011. Indicators were calculated for output, collaboration, standardised impact and publication in highly reputed journals. Analysis: A number of dimensions were explored: (1) publication patterns among domestic companies; (2) subject matter distribution and impact of the papers published; (3) university-company partnering based on papers co-authored by university and private sector researchers; and (4) regional differences. Results: The three fields where production was most intense were biochemistry, genetics and molecular biology, engineering and medicine. Research in collaboration with companies had a lower normalised impact than research conducted by universities alone. The highest volumes of private sector collaboration with Spanish universities were recorded for pharmaceutical companies. Conclusions: Companies' output was observed to decline across the period studied and their academic articles appeared to be less visible than the papers published by other institutions.

Presents a list of forthcoming papers for the "European Journal of Biochemistry."

Presents the titles and authors of various research papers that will be published in the "European Journal of Biochemistry."

Presents a listing of papers on biochemistry to be published in the "European Journal of Biochemistry.

Presents forthcoming papers published on the August 1, 1991 issue of the "European Journal of Biochemistry." "Purification and chemical modification of a phosphatidylinositol kinase from sheep brain," by G. Scholz, G. J. Barritt and F. Kwok; "Heat-shock response of rat hepatoma variant cells" by M. Baranyi, A. Hever-Szabo and A. Venetianer; "Structural studies of yeast iso-1 cytochrome c mutants by resonance Raman spectroscopy," by P. Hildebrandt, G. J. Pielak and R. J. P. Williams; "An amplified insect dihydrofolate reductase gene contains a single intron," by F. A. Shotkoski and A. M. Fallon.

Presents a list of papers scheduled to be published in forthcoming issues of the periodical "European Journal of Biochemistry," as of 1990.

Presents a list of forthcoming papers to be published in Volume 181, Number 1, April 1989 issue of the periodical "European Journal of Biochemistry."

Presents the forthcoming research papers to be published in the "European Journal of Biochemistry."

Presents scientific papers to be published in the "European Journal of Biochemistry." Detection and distribution of myosin isozymes in vertebrate smooth muscle," by G. Beckers-Bleukx and G. Marechal; "Experimental evidence for multistability in a photobiochemical system"; "Reductive mobilization of ferritin iron," by F. Funk, J.-P. Lenders, R. R. Crichton and W. Schneider. "

Presents a list of forthcoming papers subsequent to the July 1985 issue of the "European Journal of Biochemistry."

Presents the forthcoming papers to be published in the "European Journal of Biochemistry."

Lists papers due for publication in the "European Journal of Biochemistry" after the January 16, 1984 issue. "Labelling and cross-linking of Escherichia coli penicillin-binding proteins with bis-Beta-lactam antibiotics"; "Sorbitol dehydrogenase. The primary structure of the sheep-liver enzyme"; "Extensive variations and basic features in the alcohol dehydrogenase-sorbitol dehydrogenase family".

Presents a list of research papers on biochemistry to be published in the "European Journal of Biochemistry."

Presents the forthcoming papers subsequent to the August 1, 1983 issue of the "European Journal of Biochemistry."

Presents a list of research papers to be published in the "European Journal of Biochemistry."

Lists the titles of research papers to be published in the future issues of the "European Journal of Biochemistry." "Relationship between oligosaccharide-lipid synthesis and protein synthesis in mouse LM cells," by S.R. Grant and W.J. Lennarz; "Characterization of a cell line from Chinese Hamster Ovary Resistant to Uncoupler," by K.B. Freeman, et al; "The initiation of glycogen biosynthesis in rat heart," by M.L. Blumenfeld, et al.

The article presents a list of papers that are to be published in future issues of the European Journal of Biochemistry. Some of the articles are: Properties and Reconstruction of a Cytochrome Oxidase Deficient in Subunit III by T. Pentillä The Effects of Octylglucoside on the Interactions of Chloroplast Coupling factor 1 (CF1) With Adenine Nucleotides by U. Pick and S. Bassilian; Localization of Ellipticine Derivatives Interacting With Membranes. A Fluoroscence-Quenching Study by F. Terce, J.-F. Tocanne and G. Laneelle; and Improved Purification and Further Characterization of Acetyl-CoA Carboxylase From Cultures of Cells of Parsley by B. Egin-Bühler and J. Ebel.

Lists forthcoming papers concerning biochemistry, published in the February 1983 issue of the "European Journal of Biochemistry". "Kinetic Properties of Hydrogenase Isolated From Desulfovibrio vulgaris (Hildenborough)," by H.J. Grande, A. van Berkel-Arts, J. Bregh, K. van Dijk; "Sequence Analysis of the Cloned mRNA Coding of for Glyceraldehyde-3-Phosphate Dehydrogenase From Chicken Heart Muscle," by H. Domdey and colleagues; "Mitochondrial Pantetheinephosphate Adenylytransferase and Dephospho-CoA Kinase," by S. Skrede and O. Halvorsen.

Presents the forthcoming papers subsequent to the November 1982 issue of "European Journal of Biochemistry."

Presents a list of research papers related to biochemistry to be published in the "European Journal of Biochemistry."

The article presents a list of forthcoming papers related to biochemistry to be published in the journal.

Presents a list of forthcoming papers to be published in 1980 issues of the "European Journal of Biochemistry." Subjects; Authors.

Presents the list of the forthcoming papers to be published in the "European Journal of Biochemistry."

Lists forthcoming papers subsequent to the August 1, 1979 issue of the "European Journal of Biochemistry."

Lists forthcoming papers subsequent to the July 2, 1979 issue of the "European Journal of Biochemistry."

Lists the forthcoming research articles published in the September 15, 1992 issue of the "European Journal of Biochemistry." "Stoichiometry of interaction between interferon y and its receptor" by M. Fountoulakis, M. Zulauf, A. Lustig and G. Garotta; "Leukotriene uptake by hepatocytes and hepatoma cells" by I. Leier, M. Muller, G. Jedlitschky and D. Keppler; "Regulation of insulin-like-growth-factor-II gene expression in rat liver cells" R. Zarrilli, V. Colantouni and C. B. Bruni; "NMR study of the solution conformation of actionmycin D," by C. Yu, Y.-Y. Tseng.

Presents the articles to be published in the "European Journal of Biochemistry."

Presents research articles on biochemistry to be published in the "European Journal of Biochemistry." "Secondary and Tertiary Structure Characteristic of Megasphaera elsdenii Flavodoxin in the Reduced State as Determined by Two-Dimensional 1H NMR," by C. P. M. van Mierlo, F. M¨ller, and J. Vervoort; "Presence and Characterization of Glycolipid Sulfotransferase in Human Cancer Serum," by S. Gasa, M. -T. Casl, A. Makita, N. Sakakibara, T. Koyanagi, and T. Atsuta; "Interaction of Hemin With Placental Glutathione Transferase," by A. M. Caccuri; A. Aceto, F. Piemonte, C. di Ilio, N. Rosato, and G. Federici.

Offers information on articles scheduled for publication in the "European Journal of Biochemistry". Isolation of a yeast mutant defective in cholinphosphotransferase; Effect of calcium, peroxides, reagents phosphate and aging on the permeability of mitochondrial membranes; Analysis of the puromycin reaction.

Lists articles that will be published in the "European Journal of Biochemistry" periodical.

Presents supplementary information on articles related to biochemistry, which appeared in the July 1985 issue of "European Journal of Biochemistry."

Introduces several forthcoming articles related to biochemistry to be published in the "European Journal of Biochemistry." "Reactivity of Sulphydryl Groups of the Mitochondrial Phosphate Carrier"; "Raman Spectroscopy and Normal Vibrations of Peptides Characteristic Normal Modes of a Type-II β Turn"; "The Effect of Retinoic Acid on Cyclic-AMP-Binding Proteins in Mouse Melanoma Cells"; "Isolation and Characterization of a Precursor Form of M Collagen From Embryonic Chicken Cartilage."

Presents several articles that will be featured in forthcoming issues of "European Journal of Biochemistry."

Lists forthcoming research related to biochemistry published on the March 3, 1980 issue of the "European Journal of Biochemistry."

Presents articles subsequent to the forthcoming issues of the "European Journal of Biochemistry."

The article provides a list of forthcoming papers to be published in "European Journal of Biochemistry." Some of the papers mentioned are: "Isolation and characterization of cDNAs from Atlantic cod encoding two different forms of trypsinogen," "Molecular analysis of chicken embryo SPARC (osteonectin),"

The article lists various papers that will be published in forthcoming issues of the periodical "European Journal of Biochemistry." The list is published in vol. 190, Number 2, June 1990 issue of the periodical. Among various papers are: "Tooth Enamelins Identified Mainly as Serum Proteins--Major Enamelin is Albumin," "Cycloheximide Induces Stromelysin RNA in Cultured Human Fibroblasts," "Recognition of Different Nucleotide-Binding Sites in Primary Structures Using a Properly-Pattern Approach," and "Metabolic Control Analysis--Sensitivity of Control Coefficients to Elasticities."

Lists forthcoming papers to be featured in the "European Journal of Biochemistry."

Presents research papers and related resources on biochemistry published in the "European Journal of Biochemistry."

Presents the lists of the upcoming research papers related to biochemistry published in the November 1992 issue of the "European Journal of Biochemistry."

Presents the forthcoming papers subsequent to the October 1992 issue of "European Journal of Biochemistry."

Presents a list of papers scheduled to be published in the "European Journal of Biochemistry," as of August 15, 1992. Topics; Authors.

Presents the forthcoming papers subsequent to the August 1992 issue of the "European Journal of Biochemistry."

Presents the forthcoming papers subsequent to the July 1992 issue of the "European Journal of Biochemistry."

Lists the forthcoming papers to be published in the "European Journal of Biochemistry."

Lists papers to be published in the "European Journal of Biochemistry" after the March 1992 issue. "Actin and neurofilament binding domain of brain spectrin-Β-subunit," by T. Frappier, et al; "Purification and properties of the mercuric-ion-binding protein MERP," by L. Sahlman and B.-H. Jansson; "Structure of the N-linked oligosaccharides of the human transferrin receptor," by G. Orberger, et al.

Presents a list of research papers related to biochemistry to be published in the issue of "European Journal of Biochemistry."

Presents a list of research papers to be published in the "European Journal of Biochemistry."

Presents the list of forthcoming research papers published on the February 14, 1990 issue of the "European Journal of Biochemistry."