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Multiple sclerosis is a complex, autoimmune-mediated disease of the central nervous system characterized by inflammatory demyelination and axonal/neuronal damage. The approval of various disease-modifying therapies and our increased understanding of disease mechanisms and evolution in recent years have significantly changed the prognosis and course of the disease. This update of the Multiple Sclerosis Therapy Consensus Group treatment recommendation focuses on the most important recommendations for disease-modifying therapies of multiple sclerosis in 2021. Our recommendations are based on current scientific evidence and apply to those medications approved in wide parts of Europe, particularly German-speaking countries (Germany, Austria, Switzerland)., (© 2021. The Author(s).)

Background: Spinal muscular atrophy (SMA) is a severe, life-limiting neurodegenerative disease. A disease-modifying and approved therapy with nusinersen has been available in Germany since July 2017. Gene therapies offer another promising treatment option through a once in a lifetime administration. In May 2019 a gene replacement therapy for the treatment of SMA was approved for the first time by the U.S. Food and Drug Administration (FDA). An application for approval in Europe has been submitted and is currently pending., Objective: This consensus paper was compiled at the invitation of the German Society for Muscular Diseases (DGM) with the participation of all potential German neuromuscular treatment centers, the German section of the Society for Pediatric Neurology (GNP) and with the involvement of the medical scientific advisory board of the DGM. The aim was to define and establish the necessary prerequisites for a safe and successful application of the new gene replacement therapy in clinical practice., Conclusion: Gene replacement therapy with onasemnogene abeparvovec has the potential to significantly influence the course of SMA. Long-term data on sustainability of effects and possible adverse effects of gene replacement therapy are not yet available. The application of this innovative therapy must be carried out in specialized and appropriately qualified treatment centers under strict safety conditions. This article makes suggestions for the necessary framework conditions and gives recommendations for a systematic pretreatment and posttreatment assessment schedule under gene therapy. The effectiveness and safety of the therapy should be systematically documented in an industry-independent and disease-specific register.

Copyright of Praehistorische Zeitschrift is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Praehistorische Zeitschrift is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

So far, the history of early Medieval glassmakers has mainly been derived from archaeological sources. Significant in this context was, more than half a century ago, the discovery of a new glass recipe, which began to spread in Europe from the 'deepest' early Middle Ages; the question of how this could develop is still subject of various discussions. A new contribution was published by Alexis Wilkin in 2019. According to this contribution, the early Medieval glass artisans owed the technological foundations of their new recipe to their collaboration with metal artisans. There is some clear evidence for this theory, but besides the technical innovation the social conditions of the artisans should not be forgotten. The glassmakers of the early Middle Ages were not free entrepreneurs, in the historical texts they are dependent on their landlords. This dependency, however, gives rise to a purely historical method of investigation: new finds of early Medieval glassworks manufactured according to the altered glass recipe can be assigned to the territories of specific landlords. This paper examines the extent to which family connections can be made visible in the passing on of glassmakers belonging to these families, perhaps also in the development of the new glass recipe. [ABSTRACT FROM AUTHOR]

Copyright of Historia Ecclesiastica is the property of Vydavatelstvo Presovskej Univerzity and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The aim of this paper is to analyze the image of Europe in the non-fictional texts of Miroslav KRLEŽA and Karl-Markus GAUß, considering the role of the writer as a cultural mediator. Particular attention is paid to the role of Karl-Markus GAUß as central for the reception of works of the Croatian classical writer Miroslav KRLEŽA in the German-speaking area, as well as to his essays Tinte ist bitter. Literarische Porträts aus Barbaropa (1998) and Die Vernichtung Mitteleuropas (1991). The paper also presents a critical attitude towards the European past common to both the authors, especially with regard to the position of both of them on discursive concepts of Central Europe and Europe. [ABSTRACT FROM AUTHOR]

This paper discusses the ecdesiological insights gained in the consultation on church and church fellowship between representatives of the Community of Protestant Churches in Europe (CPCE) and the Pontifical Council for Promoting Christian Unity. In the introduction, the formation of this conversation and its significance for the ecumenical movement in Europe is discussed. Then the approach in the understanding of the church is reflected on the differentiation of the foundation, shape and mission of the church, which proceeds from the implicit reference of the CPCE church study to the understanding of the church in Lume n Ge n tium. The explication is an ecumenical learning process that points the way for further conversations on ecclesiology. [ABSTRACT FROM AUTHOR]

Before the nineteenth century, philosophical works by women are scarcely documented, if at all, almost everywhere in the world. However, this fact has so far caused little concern to the vast majority of authors of the most diverse narratives of histories of philosophy worldwide. Due to a predominantly masculine perspective in the discipline, the exclusion of women from the canon of the history of philosophy continues to be repeated to this day. This tendency also affects the endeavours since the 1980s to reconstruct and document non-European philosophical traditions as well as to integrate them into a global discourse. A contemporary revision of the canon of the history of philosophy, however, cannot take place solely from an intercultural or global perspective; it must also address and correct patriarchal structures of exclusion - in all regions of the world. The paper discusses the specific challenges of reconstructing the history of women philosophers outside of Europe. [ABSTRACT FROM AUTHOR]

Copyright of Perspektiven der Wirtschaftspolitik is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Cultivated Plants / Journal für Kulturpflanzen is the property of Verlag Eugen Ulmer and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Up till now, Karl-Markus Gauß has published five volumes of what has often been described as “journals”: Mit mir, ohne mich (2002), Von nah, von fern (2003), Zu früh, zu spät (2007), Ruhm am Nachmittag (2012) and Der Alltag der Welt (2015). The emphasis of this paper lies on the first two of these volumes which are labelled respectively as “Ein Journal” and “Ein Jahresbuch”. A special focus lies on thematic continuities, such as the historical and present peripheries of Europe and its populations and questions linked to the construction of identity. Gauß (self-)reflects critically on the historical roots of contemporary phenomena, which are often taken from medial incidents. The study shows aspects of the texts’ construction character. The crossing of boundaries on the thematic level is reflected in the transcending of literary genres: Gauß’ texts merge different genres into new shapes; his narration can be understood as a kind of resistance to cotemporary superficiality. [ABSTRACT FROM AUTHOR]

In the European historiography on social inequality one aspect is strikingly missing: the ecological aspect. Therefore, this paper introduces the concept of "environmental justice" to the discussion. The concept originally stems from a US-social movement that emerged in the 1980s. Today, "environmental justice" is at the same time a social claim, a political principle, as well as an academic concept. While the concept entered the discourse of several academic disciplines from sociology to public-health studies, it is still seldom used in European historiography. This paper argues that "environmental justice" can be employed as an analytic category especially in economic, social, and environmental history, while at the same time being able to connect these disciplines. With the example of the introduction of centralised water infrastructures in European cities, the article explores difficulties and potentials of an application of the "environmental justice"- concept. [ABSTRACT FROM AUTHOR]

Copyright of Praxis der Kinderpsychologie und Kinderpsychiatrie is the property of Vandenhoeck & Ruprecht GmbH & Co. KG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The classicist scholar Gottfried Ernst Groddeck (1762-1825) came into literary history thanks to his students, mainly Adam Mickiewicz. Although a gifted pupil of Christian Gottlieb Heyne, he gained only local fame; neither he nor any of his works was broadly known. Groddeck's professional career, however, deserves careful attention, for it is a conspicuous example of increasing academic mobility in Central Europe at the turn of the 18th and 19th centuries. The paper looks at the biography and work of Groddeck from the network perspective in order to examine the various mechanisms characteristic of networks of savants. In the first part, an analysis of some structuring features of scientific networks is provided. In the second part, the author presents the different roles and spheres in which Groddeck acted, for between 1782 and 1786 he was a student of Heyne in Göttingen, then a librarian and private teacher at the Court of the Prince Czartoryski in Puławy, and eventually Professor for Greek and Latin Languages and Literature at the Imperial University of Vilnius (1803-1825). In all these positions he stayed in contact with other men of letters in Göttingen, Berlin, Leipzig, Wien as well as in Puławy, Vilnius, Dorpat, Moscow and Paris. Among them, there were personal friends, employers as well as pen partners personally unknown to him. Groddeck's correspondence enables us to reconstruct the various dimensions of the international and local networks in which he participated. What is at stake are rules regulating relations, obligations and hierarchies within both informal and more formalized scientific coalitions. [ABSTRACT FROM AUTHOR]

Copyright of Jahrbuch der Europäischen Integration is the property of Nomos Verlagsgesellschaft mbH & Co. KG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Savings banks succeeded in a breakthrough across many parts of North, Central and Western Europe at the beginning of the 19th century. This wave of foundations was based on the imitation of the first savings banks from the continent, and in particular, the early British savings banks. Nevertheless, different patterns in terms of organisation and investment of deposits were rapidly formed due to local conditions. This paper explores the experiences that were gained with the concepts of private and public management as well as with central and local investment schemes in a short and a long term perspective. The international comparison shows that in the long run major disadvantages emerged for savings banks with central deposit management but without loan services. Furthermore, the fate of savings banks during the 19th and 20th century can be explained with path dependencies that derive from the policy decisions that were made during the wave of foundations. [ABSTRACT FROM AUTHOR]

In the 1960s and 1970s, political debates in East Central Europe and Western Europe were influenced by the idea of convergence between the capitalist and the socialist systems that dominated Europe. After 1989, the idea of convergence was replaced by ideas that revolved around the one-sided adaptation of “Europeanization" and “transformation". Despite the great political and economic success of the transformation process, the concept of an “ever closer European Union" has lost its attractiveness in East Central Europe. Drawing on current political and cultural debates in East Central Europe, the paper argues that it is the asymmetrical nature of the transformation and the process of Europeanization that is causing new divergences in Europe today. [ABSTRACT FROM AUTHOR]

Intelligence offices emerged in European urban centers beginning in the seventeenth century. Most were privately run institutions and procured work, goods, real estate, and capital. They registered requests in protocol ledgers and sometimes published them in advertising papers. The registration procedures that intelligence offices imposed on job seekers contributed to surveillance and disciplinary power. The data stored by information offices were coveted by the authorities, and in some cases, the existence of intelligence offices inspired far-reaching fantasies of control that aimed to transform them into registration or credit information offices. [ABSTRACT FROM AUTHOR]

In the fourteenth and fifteenth centuries, so called monarchical orders were founded at many European courts. These orders cultivated a splendid knightly culture, although the great age of chivalry seemed long to be over. By comparing two of these orders, the Order of the Golden Fleece and the Order of the Crescent, this paper examines the role of their founders, Philipp of Burgundy and René of Anjou, and their relationship towards the other members based on the statutes of both institutions. Therefore this paper focusses on the constitutional shaping of the orders as well as on different processes of decision-making and symbolic semantics, which played an essential role at different events. It is argued that while René of Anjou emphasized the aspect of equality by different means, Philipp of Burgundy presented himself as a primus inter pares, being both a brother and a lord. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Applied & Regional Geology / Zeitschrift der Deutschen Gesellschaft für Geowissenschaften (ZDGG) is the property of E. Schweizerbart'sche Verlagsbuchhandlung and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and Aim: Due to its strong economy and a well-developed healthcare system, Germany is well positioned to achieve above-average reductions in mortality. Nevertheless, in terms of life expectancy, Germany is increasingly falling behind Western Europe. We compare mortality trends in Germany with other Western European countries, covering the period from 1960 to 2019. The focus is on long-term trends in Germany's ranking in international mortality trends. In addition, we conduct a detailed mortality analysis by age., Methods: Our analysis is mostly based on mortality data from the Human Mortality Database (HMD). Cause-specific mortality data originate from the database of the World Health Organization (WHO). For the international comparison of mortality trends, we use conventional mortality indicators (age-standardized mortality rate, period life expectancy)., Results: Compared to other Western European countries, Germany has higher mortality in the middle and older age groups. Germany's life expectancy gap compared to Western Europe has grown during the past 20 years. In 2000, Germany was 0.73 years behind for men and 0.74 years behind for women. By 2019, these figures had risen to 1.43 and 1.34 years, respectively. This is mainly due to mortality from non-communicable diseases., Conclusion: For Germany to catch up with other Western European countries, a stronger focus on further reducing mortality at ages 50+ is crucial. This also requires further research to understand the factors behind Germany's disadvantageous position., (© 2024. The Author(s).)