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Dou Ke Jian (The Key of Smallpox) was written by Zhu Xun in the late Ming dynasty,collated and published by Zhu Fengtai in the Qing dynasty.It was rarely studied in China ,but have a far-reaching influence in Japan.By comparing with other works about smallpox and refering to the Japanese Ikeda family's Doukejian Huitong , Doukejian Siheng , Doukejian Shanzhengbuzhu completed on the basis of Dou Ke Jian, this paper systematically reviews the author's life, compilation and publication background, main content, academic characteristics and value, and influence on later generations.The views advocated in this book, such as "toxin hidden in the spleen meridians, attaching importance to qi and blood", "distinguishing between the exterior and interior, deficiency and excess, and take the lips and tongue as the key" have important reference value for the treatment of infectious diseases in later generations.

Shen Shiwan was a translator and physician for both Chinese medicine and western medicine in the period of the Republic of China. This paper examined the life and the main academic contributions of Shen Shiwan. It was found that Shen's main contribution were translating medical works, founding journals and opening the door of Chinese medicine to the world. Additionally, he introduced western medicine, such as pathology, fertility and nutrition to Chinese medical professionals. He also introduced the medical schools of Japanese traditional medicine (Chinese medicine in Japan, Han Yi) into China. Shen's contribution in medicine played an important role for the medical professionals in China in understanding the development of western medicine and Chinese medicine in Japan.

Through literature search in regular database and official websites of relevant countries, this paper combs and summarizes the main characteristics of disease prevention and control systems in five countries, the United States, Germany, South Korea, Australia and Japan, and the European Union at key levels including legal construction, organizational structure, financing, personnel construction and international cooperation, in order to provide decision support for the construction of disease prevention and control system in China in the future.