1. Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition
- Author
-
Yu-Wei Lin, Leslie Y. Yeo, Md. Arifur Rahim, Jiaying Song, Ting Yi Wang, Shuaijun Pan, Christoph E. Hagemeyer, Evelyn Tsantikos, Yizhe Cheng, Nadja Bertleff-Zieschang, Gyeongwon Yun, Frank Caruso, Srinivas Mettu, Jingqu Chen, Andrew J. Mitchell, Christina Cortez-Jugo, Margaret L. Hibbs, and Yi Ju
- Subjects
Materials science ,Biocompatibility ,capsules ,General Chemical Engineering ,pulmonary delivery ,General Physics and Astronomy ,Medicine (miscellaneous) ,Nanoparticle ,02 engineering and technology ,Nanoengineering ,010402 general chemistry ,01 natural sciences ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,medicine ,Deposition (phase transition) ,General Materials Science ,lcsh:Science ,aerodynamic diameter ,Lung ,Full Paper ,nebulization ,metal–phenolic networks ,General Engineering ,Capsule ,Full Papers ,respiratory system ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,medicine.anatomical_structure ,Drug delivery ,Particle ,lcsh:Q ,0210 nano-technology ,Biomedical engineering - Abstract
Particle‐based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. The design of particles with enhanced aerodynamic properties can improve lung distribution and deposition, and hence the efficacy of encapsulated inhaled drugs. This study describes the nanoengineering and nebulization of metal–phenolic capsules as pulmonary carriers of small molecule drugs and macromolecular drugs in lung cell lines, a human lung model, and mice. Tuning the aerodynamic diameter by increasing the capsule shell thickness (from ≈100 to 200 nm in increments of ≈50 nm) through repeated film deposition on a sacrificial template allows precise control of capsule deposition in a human lung model, corresponding to a shift from the alveolar region to the bronchi as aerodynamic diameter increases. The capsules are biocompatible and biodegradable, as assessed following intratracheal administration in mice, showing >85% of the capsules in the lung after 20 h, but 90% of capsules remaining nonassociated with cells. The amenability to nebulization, capacity for loading, tunable aerodynamic properties, high biocompatibility, and biodegradability make these capsules attractive for controlled pulmonary delivery., The aerodynamic diameters of metal–phenolic capsules are nanoengineered by increasing their shell thickness, which facilitates tailored capsule deposition in a mechanical lung model. The engineered capsules are promising for pulmonary delivery owing to their robustness for nebulization, biocompatibility, biodegradability, and their capacity for cargo loading and surface functionalization.
- Published
- 2020