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In recent years scientists have created genetically modified pigs for the purpose of xenotransplantations. These are transplants of animal organs into human patients. But xenotransplantation has a long history. Since the early twentieth century, many surgeons tried to insert animal organs into human and non-human bodies. This paper examines the controversies that these innovations have caused in the United States and France, including the notion of the objectification of animals. Three phases are described. The historical review shows that far from the choice of pigs being "natural" it turns out to be recent and to follow controversies surrounding the possible use of primates. During the last phase, the scientists have internalized the "animal issue" in their practice: the official donor is now the pig, and the animals are treated respectfully during all the lab manipulations. Since pigs are different from humans they can be objectified and thus absorbed. This objective distance is, however, threatened by new discourses on animal rights, by genetic manipulations that "humanise" pigs, and by scientific practice itself that recognizes a moral proximity between pigs and men. [ABSTRACT FROM AUTHOR]

Though better recognized for its immediate endeavors in human embryo research, the Carnegie Department of Embryology also employed a breeding colony of rhesus macaques for the purposes of studying human reproduction. This essay follows the course of the first enterprise in maintaining a primate colony for laboratory research and the overlapping scientific, social, and political circumstances that tolerated and cultivated the colony's continued operation from 1925 until 1971. Despite a new-found priority for reproductive sciences in the United States, by the early 1920s an unfertilized human ovum had not yet been seen and even the timing of ovulation remained unresolved. Progress would require an organized research approach that could extend beyond the limitations of working with scant and inherently restrictive human subjects or with common lab mammals like mice. In response, the Department of Embryology, under the Carnegie Institution of Washington (CIW), instituted a novel methodology using a particular primate species as a surrogate in studying normal human reproductive physiology. Over more than 40 years the monkey colony followed an unpremeditated trajectory that would contribute fundamentally to discoveries in human reproduction, early embryo development, reliable birth control methods, and to the establishment of the rhesus macaque as a common model organism. [ABSTRACT FROM AUTHOR]

RID=""ID="" Correspondence to: L. C. Fitzpatrick [ABSTRACT FROM AUTHOR]