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The paper presents the feedback from the project leaders on the management of interdisciplinarity involving 14 scientific projects (3 networks and 11 research projects) that are part of a program on the integrated management of animal health, and from researchers participating in the overall management of the program. The difficulties encountered by the project leaders relate to a need for acculturation among disciplines, to the equilibrium and mutual respect between disciplines within the project, to the lack of time dedicated to the scientific animation of the project, and to the difficulty of publishing interdisciplinary work. The level of interdisciplinarity varies among projects, from juxtaposition of several disciplines to their actual integration. Recommendations proposed to future project leaders at the various steps of a projet involve the co-design step, in order to facilitate the decentering of disciplinary questioning, the implementation step requiring an agile management, and the report step, in order to analyse how interdisciplinarity has shifted disciplinary lines and modified initial questions. Strengthening of interdisciplinary programs should prioritize the training of researchers in interdisciplinarity, provide support for the conception of interdisciplinary projects, and analyse the degree to which integration of disciplines was achieved in the projects. [ABSTRACT FROM AUTHOR]