Search

Segmenting anatomical structures in medical images has been successfully addressed with deep learning methods for a range of applications. However, this success is heavily dependent on the quality of the image that is being segmented. A commonly neglected point in the medical image analysis community is the vast amount of clinical images that have severe image artefacts due to organ motion, movement of the patient and/or image acquisition related issues. In this paper, we discuss the implications of image motion artefacts on cardiac MR segmentation and compare a variety of approaches for jointly correcting for artefacts and segmenting the cardiac cavity. The method is based on our recently developed joint artefact detection and reconstruction method, which reconstructs high quality MR images from k-space using a joint loss function and essentially converts the artefact correction task to an under-sampled image reconstruction task by enforcing a data consistency term. In this paper, we propose to use a segmentation network coupled with this in an end-to-end framework. Our training optimises three different tasks: 1) image artefact detection, 2) artefact correction and 3) image segmentation. We train the reconstruction network to automatically correct for motion-related artefacts using synthetically corrupted cardiac MR k-space data and uncorrected reconstructed images. Using a test set of 500 2D+time cine MR acquisitions from the UK Biobank data set, we achieve demonstrably good image quality and high segmentation accuracy in the presence of synthetic motion artefacts. We showcase better performance compared to various image correction architectures. [ABSTRACT FROM AUTHOR]

The aim of this paper is to provide a comprehensive overview of the MICCAI 2020 AutoImplant Challenge. The approaches and publications submitted and accepted within the challenge will be summarized and reported, highlighting common algorithmic trends and algorithmic diversity. Furthermore, the evaluation results will be presented, compared and discussed in regard to the challenge aim: seeking for low cost, fast and fully automated solutions for cranial implant design. Based on feedback from collaborating neurosurgeons, this paper concludes by stating open issues and post-challenge requirements for intra-operative use. The codes can be found at https://github.com/Jianningli/tmi. [ABSTRACT FROM AUTHOR]

Machine learning algorithms can have difficulties adapting to data from different sources, for example from different imaging modalities. We present and analyze three techniques for unsupervised cross-modality feature learning, using a shared autoencoder-like convolutional network that learns a common representation from multi-modal data. We investigate a form of feature normalization, a learning objective that minimizes cross-modality differences, and modality dropout, in which the network is trained with varying subsets of modalities. We measure the same-modality and cross-modality classification accuracies and explore whether the models learn modality-specific or shared features. This paper presents experiments on two public data sets, with knee images from two MRI modalities, provided by the Osteoarthritis Initiative, and brain tumor segmentation on four MRI modalities from the BRATS challenge. All three approaches improved the cross-modality classification accuracy, with modality dropout and per-feature normalization giving the largest improvement. We observed that the networks tend to learn a combination of cross-modality and modality-specific features. Overall, a combination of all three methods produced the most cross-modality features and the highest cross-modality classification accuracy, while maintaining most of the same-modality accuracy. [ABSTRACT FROM AUTHOR]

Reducing the exposure to X-ray radiation while maintaining a clinically acceptable image quality is desirable in various CT applications. To realize low-dose CT (LdCT) imaging, model-based iterative reconstruction (MBIR) algorithms are widely adopted, but they require proper prior knowledge assumptions in the sinogram and/or image domains and involve tedious manual optimization of multiple parameters. In this paper, we propose a deep learning (DL)-based strategy for MBIR to simultaneously address prior knowledge design and MBIR parameter selection in one optimization framework. Specifically, a parameterized plug-and-play alternating direction method of multipliers (3pADMM) is proposed for the general penalized weighted least-squares model, and then, by adopting the basic idea of DL, the parameterized plug-and-play (3p) prior and the related parameters are optimized simultaneously in a single framework using a large number of training data. The main contribution of this paper is that the 3p prior and the related parameters in the proposed 3pADMM framework can be supervised and optimized simultaneously to achieve robust LdCT reconstruction performance. Experimental results obtained on clinical patient datasets demonstrate that the proposed method can achieve promising gains over existing algorithms for LdCT image reconstruction in terms of noise-induced artifact suppression and edge detail preservation. [ABSTRACT FROM AUTHOR]

Bioluminescence tomography (BLT) is a promising pre-clinical imaging technique for a wide variety of biomedical applications, which can non-invasively reveal functional activities inside living animal bodies through the detection of visible or near-infrared light produced by bioluminescent reactions. Recently, reconstruction approaches based on deep learning have shown great potential in optical tomography modalities. However, these reports only generate data with stationary patterns of constant target number, shape, and size. The neural networks trained by these data sets are difficult to reconstruct the patterns outside the data sets. This will tremendously restrict the applications of deep learning in optical tomography reconstruction. To address this problem, a self-training strategy is proposed for BLT reconstruction in this paper. The proposed strategy can fast generate large-scale BLT data sets with random target numbers, shapes, and sizes through an algorithm named random seed growth algorithm and the neural network is automatically self-trained. In addition, the proposed strategy uses the neural network to build a map between photon densities on surface and inside the imaged object rather than an end-to-end neural network that directly infers the distribution of sources from the photon density on surface. The map of photon density is further converted into the distribution of sources through the multiplication with stiffness matrix. Simulation, phantom, and mouse studies are carried out. Results show the availability of the proposed self-training strategy. [ABSTRACT FROM AUTHOR]

Learning how to capture long-range dependencies and restore spatial information of down-sampled feature maps are the basis of the encoder-decoder structure networks in medical image segmentation. U-Net based methods use feature fusion to alleviate these two problems, but the global feature extraction ability and spatial information recovery ability of U-Net are still insufficient. In this paper, we propose a Global Feature Reconstruction (GFR) module to efficiently capture global context features and a Local Feature Reconstruction (LFR) module to dynamically up-sample features, respectively. For the GFR module, we first extract the global features with category representation from the feature map, then use the different level global features to reconstruct features at each location. The GFR module establishes a connection for each pair of feature elements in the entire space from a global perspective and transfers semantic information from the deep layers to the shallow layers. For the LFR module, we use low-level feature maps to guide the up-sampling process of high-level feature maps. Specifically, we use local neighborhoods to reconstruct features to achieve the transfer of spatial information. Based on the encoder-decoder architecture, we propose a Global and Local Feature Reconstruction Network (GLFRNet), in which the GFR modules are applied as skip connections and the LFR modules constitute the decoder path. The proposed GLFRNet is applied to four different medical image segmentation tasks and achieves state-of-the-art performance. [ABSTRACT FROM AUTHOR]

As the labeled anomalous medical images are usually difficult to acquire, especially for rare diseases, the deep learning based methods, which heavily rely on the large amount of labeled data, cannot yield a satisfactory performance. Compared to the anomalous data, the normal images without the need of lesion annotation are much easier to collect. In this paper, we propose an anomaly detection framework, namely $\mathbb {SALAD}$ , extracting $\mathbb {S}$ elf-supervised and tr $\mathbb {A}$ ns $\mathbb {L}$ ation-consistent features for $\mathbb {A}$ nomaly $\mathbb {D}$ etection. The proposed SALAD is a reconstruction-based method, which learns the manifold of normal data through an encode-and-reconstruct translation between image and latent spaces. In particular, two constraints (i.e., structure similarity loss and center constraint loss) are proposed to regulate the cross-space (i.e., image and feature) translation, which enforce the model to learn translation-consistent and representative features from the normal data. Furthermore, a self-supervised learning module is engaged into our framework to further boost the anomaly detection accuracy by deeply exploiting useful information from the raw normal data. An anomaly score, as a measure to separate the anomalous data from the healthy ones, is constructed based on the learned self-supervised-and-translation-consistent features. Extensive experiments are conducted on optical coherence tomography (OCT) and chest X-ray datasets. The experimental results demonstrate the effectiveness of our approach. [ABSTRACT FROM AUTHOR]

X-ray computed tomography (CT) is of great clinical significance in medical practice because it can provide anatomical information about the human body without invasion, while its radiation risk has continued to attract public concerns. Reducing the radiation dose may induce noise and artifacts to the reconstructed images, which will interfere with the judgments of radiologists. Previous studies have confirmed that deep learning (DL) is promising for improving low-dose CT imaging. However, almost all the DL-based methods suffer from subtle structure degeneration and blurring effect after aggressive denoising, which has become the general challenging issue. This paper develops the Comprehensive Learning Enabled Adversarial Reconstruction (CLEAR) method to tackle the above problems. CLEAR achieves subtle structure enhanced low-dose CT imaging through a progressive improvement strategy. First, the generator established on the comprehensive domain can extract more features than the one built on degraded CT images and directly map raw projections to high-quality CT images, which is significantly different from the routine GAN practice. Second, a multi-level loss is assigned to the generator to push all the network components to be updated towards high-quality reconstruction, preserving the consistency between generated images and gold-standard images. Finally, following the WGAN-GP modality, CLEAR can migrate the real statistical properties to the generated images to alleviate over-smoothing. Qualitative and quantitative analyses have demonstrated the competitive performance of CLEAR in terms of noise suppression, structural fidelity and visual perception improvement. [ABSTRACT FROM AUTHOR]

Differential phase-contrast computed tomography (DPC-CT) is a powerful analysis tool for soft-tissue and low-atomic-number samples. Limited by the implementation conditions, DPC-CT with incomplete projections happens quite often. Conventional reconstruction algorithms face difficulty when given incomplete data. They usually involve complicated parameter selection operations, which are also sensitive to noise and are time-consuming. In this paper, we report a new deep learning reconstruction framework for incomplete data DPC-CT. It involves the tight coupling of the deep learning neural network and DPC-CT reconstruction algorithm in the domain of DPC projection sinograms. The estimated result is not an artifact caused by the incomplete data, but a complete phase-contrast projection sinogram. After training, this framework is determined and can be used to reconstruct the final DPC-CT images for a given incomplete projection sinogram. Taking the sparse-view, limited-view and missing-view DPC-CT as examples, this framework is validated and demonstrated with synthetic and experimental data sets. Compared with other methods, our framework can achieve the best imaging quality at a faster speed and with fewer parameters. This work supports the application of the state-of-the-art deep learning theory in the field of DPC-CT. [ABSTRACT FROM AUTHOR]

Edges tend to be over-smoothed in total variation (TV) regularized under-sampled images. In this paper, symmetric residual convolutional neural network (SR-CNN), a deep learning based model, was proposed to enhance the sharpness of edges and detailed anatomical structures in under-sampled cone-beam computed tomography (CBCT). For training, CBCT images were reconstructed using TV-based method from limited projections simulated from the ground truth CT, and were fed into SR-CNN, which was trained to learn a restoring pattern from under-sampled images to the ground truth. For testing, under-sampled CBCT was reconstructed using TV regularization and was then augmented by SR-CNN. Performance of SR-CNN was evaluated using phantom and patient images of various disease sites acquired at different institutions both qualitatively and quantitatively using structure similarity (SSIM) and peak signal-to-noise ratio (PSNR). SR-CNN substantially enhanced image details in the TV-based CBCT across all experiments. In the patient study using real projections, SR-CNN augmented CBCT images reconstructed from as low as 120 half-fan projections to image quality comparable to the reference fully-sampled FDK reconstruction using 900 projections. In the tumor localization study, improvements in the tumor localization accuracy were made by the SR-CNN augmented images compared with the conventional FDK and TV-based images. SR-CNN demonstrated robustness against noise levels and projection number reductions and generalization for various disease sites and datasets from different institutions. Overall, the SR-CNN-based image augmentation technique was efficient and effective in considerably enhancing edges and anatomical structures in under-sampled 3D/4D-CBCT, which can be very valuable for image-guided radiotherapy. [ABSTRACT FROM AUTHOR]

T1-weighted image (T1WI) and T2-weighted image (T2WI) are the two routinely acquired magnetic resonance (MR) modalities that can provide complementary information for clinical and research usages. However, the relatively long acquisition time makes the acquired image vulnerable to motion artifacts. To speed up the imaging process, various algorithms have been proposed to reconstruct high-quality images from under-sampled k-space data. However, most of the existing algorithms only rely on mono-modality acquisition for the image reconstruction. In this paper, we propose to combine complementary MR acquisitions (i.e., T1WI and under-sampled T2WI particularly) to reconstruct the high-quality image (i.e., corresponding to the fully sampled T2WI). To the best of our knowledge, this is the first work to fuse multi-modal MR acquisitions through deep learning to speed up the reconstruction of a certain target image. Specifically, we present a novel deep learning approach, namely Dense-Unet, to accomplish the reconstruction task. The proposed Dense-Unet requires fewer parameters and less computation, while achieving promising performance. Our results have shown that Dense-Unet can reconstruct a three-dimensional T2WI volume in less than 10 s with an under-sampling rate of 8 for the k-space and negligible aliasing artifacts or signal-noise-ratio loss. Experiments also demonstrate excellent transferring capability of Dense-Unet when applied to the datasets acquired by different MR scanners. The above-mentioned results imply great potential of our method in many clinical scenarios. [ABSTRACT FROM AUTHOR]

Compressive sensing (CS) has proved effective for tomographic reconstruction from sparsely collected data or under-sampled measurements, which are practically important for few-view computed tomography (CT), tomosynthesis, interior tomography, and so on. To perform sparse-data CT, the iterative reconstruction commonly uses regularizers in the CS framework. Currently, how to choose the parameters adaptively for regularization is a major open problem. In this paper, inspired by the idea of machine learning especially deep learning, we unfold the state-of-the-art “fields of experts”-based iterative reconstruction scheme up to a number of iterations for data-driven training, construct a learned experts’ assessment-based reconstruction network (LEARN) for sparse-data CT, and demonstrate the feasibility and merits of our LEARN network. The experimental results with our proposed LEARN network produces a superior performance with the well-known Mayo Clinic low-dose challenge data set relative to the several state-of-the-art methods, in terms of artifact reduction, feature preservation, and computational speed. This is consistent to our insight that because all the regularization terms and parameters used in the iterative reconstruction are now learned from the training data, our LEARN network utilizes application-oriented knowledge more effectively and recovers underlying images more favorably than competing algorithms. Also, the number of layers in the LEARN network is only 50, reducing the computational complexity of typical iterative algorithms by orders of magnitude. [ABSTRACT FROM AUTHOR]

The continuous development and extensive use of computed tomography (CT) in medical practice has raised a public concern over the associated radiation dose to the patient. Reducing the radiation dose may lead to increased noise and artifacts, which can adversely affect the radiologists’ judgment and confidence. Hence, advanced image reconstruction from low-dose CT data is needed to improve the diagnostic performance, which is a challenging problem due to its ill-posed nature. Over the past years, various low-dose CT methods have produced impressive results. However, most of the algorithms developed for this application, including the recently popularized deep learning techniques, aim for minimizing the mean-squared error (MSE) between a denoised CT image and the ground truth under generic penalties. Although the peak signal-to-noise ratio is improved, MSE- or weighted-MSE-based methods can compromise the visibility of important structural details after aggressive denoising. This paper introduces a new CT image denoising method based on the generative adversarial network (GAN) with Wasserstein distance and perceptual similarity. The Wasserstein distance is a key concept of the optimal transport theory and promises to improve the performance of GAN. The perceptual loss suppresses noise by comparing the perceptual features of a denoised output against those of the ground truth in an established feature space, while the GAN focuses more on migrating the data noise distribution from strong to weak statistically. Therefore, our proposed method transfers our knowledge of visual perception to the image denoising task and is capable of not only reducing the image noise level but also trying to keep the critical information at the same time. Promising results have been obtained in our experiments with clinical CT images. [ABSTRACT FROM AUTHOR]

Ultrafast ultrasound (US) revolutionized biomedical imaging with its capability of acquiring full-view frames at over 1 kHz, unlocking breakthrough modalities such as shear-wave elastography and functional US neuroimaging. Yet, it suffers from strong diffraction artifacts, mainly caused by grating lobes, sidelobes, or edge waves. Multiple acquisitions are typically required to obtain a sufficient image quality, at the cost of a reduced frame rate. To answer the increasing demand for high-quality imaging from single unfocused acquisitions, we propose a two-step convolutional neural network (CNN)-based image reconstruction method, compatible with real-time imaging. A low-quality estimate is obtained by means of a backprojection-based operation, akin to conventional delay-and-sum beamforming, from which a high-quality image is restored using a residual CNN with multiscale and multichannel filtering properties, trained specifically to remove the diffraction artifacts inherent to ultrafast US imaging. To account for both the high dynamic range and the oscillating properties of radio frequency US images, we introduce the mean signed logarithmic absolute error (MSLAE) as a training loss function. Experiments were conducted with a linear transducer array, in single plane-wave (PW) imaging. Trainings were performed on a simulated dataset, crafted to contain a wide diversity of structures and echogenicities. Extensive numerical evaluations demonstrate that the proposed approach can reconstruct images from single PWs with a quality similar to that of gold-standard synthetic aperture imaging, on a dynamic range in excess of 60 dB. In vitro and in vivo experiments show that trainings carried out on simulated data perform well in experimental settings. [ABSTRACT FROM AUTHOR]

Medical imaging denoising faces great challenges, yet is in great demand. With its distinctive characteristics, medical imaging denoising in the image domain requires innovative deep learning strategies. In this study, we propose a simple yet effective strategy, the content-noise complementary learning (CNCL) strategy, in which two deep learning predictors are used to learn the respective content and noise of the image dataset complementarily. A medical image denoising pipeline based on the CNCL strategy is presented, and is implemented as a generative adversarial network, where various representative networks (including U-Net, DnCNN, and SRDenseNet) are investigated as the predictors. The performance of these implemented models has been validated on medical imaging datasets including CT, MR, and PET. The results show that this strategy outperforms state-of-the-art denoising algorithms in terms of visual quality and quantitative metrics, and the strategy demonstrates a robust generalization capability. These findings validate that this simple yet effective strategy demonstrates promising potential for medical image denoising tasks, which could exert a clinical impact in the future. Code is available at: https://github.com/gengmufeng/CNCL-denoising. [ABSTRACT FROM AUTHOR]

Deep learning (DL) is bringing a big movement in the field of computed tomography (CT) imaging. In general, DL for CT imaging can be applied by processing the projection or the image data with trained deep neural networks (DNNs), unrolling the iterative reconstruction as a DNN for training, or training a well-designed DNN to directly reconstruct the image from the projection. In all of these applications, the whole or part of the DNNs work in the projection or image domain alone or in combination. In this study, instead of focusing on the projection or image, we train DNNs to reconstruct CT images from the view-by-view backprojection tensor (VVBP-Tensor). The VVBP-Tensor is the 3D data before summation in backprojection. It contains structures of the scanned object after applying a sorting operation. Unlike the image or projection that provides compressed information due to the integration/summation step in forward or back projection, the VVBP-Tensor provides lossless information for processing, allowing the trained DNNs to preserve fine details of the image. We develop a learning strategy by inputting slices of the VVBP-Tensor as feature maps and outputting the image. Such strategy can be viewed as a generalization of the summation step in conventional filtered backprojection reconstruction. Numerous experiments reveal that the proposed VVBP-Tensor domain learning framework obtains significant improvement over the image, projection, and hybrid projection–image domain learning frameworks. We hope the VVBP-Tensor domain learning framework could inspire algorithm development for DL-based CT imaging. [ABSTRACT FROM AUTHOR]

In positron emission tomography (PET), gating is commonly utilized to reduce respiratory motion blurring and to facilitate motion correction methods. In application where low-dose gated PET is useful, reducing injection dose causes increased noise levels in gated images that could corrupt motion estimation and subsequent corrections, leading to inferior image quality. To address these issues, we propose MDPET, a unified motion correction and denoising adversarial network for generating motion-compensated low-noise images from low-dose gated PET data. Specifically, we proposed a Temporal Siamese Pyramid Network (TSP-Net) with basic units made up of 1.) Siamese Pyramid Network (SP-Net), and 2.) a recurrent layer for motion estimation among the gates. The denoising network is unified with our motion estimation network to simultaneously correct the motion and predict a motion-compensated denoised PET reconstruction. The experimental results on human data demonstrated that our MDPET can generate accurate motion estimation directly from low-dose gated images and produce high-quality motion-compensated low-noise reconstructions. Comparative studies with previous methods also show that our MDPET is able to generate superior motion estimation and denoising performance. Our code is available at https://github.com/bbbbbbzhou/MDPET. [ABSTRACT FROM AUTHOR]

Synthetic digital mammography (SDM), a 2D image generated from digital breast tomosynthesis (DBT), is used as a potential substitute for full-field digital mammography (FFDM) in clinic to reduce the radiation dose for breast cancer screening. Previous studies exploited projection geometry and fused projection data and DBT volume, with different post-processing techniques applied on re-projection data which may generate different image appearance compared to FFDM. To alleviate this issue, one possible solution to generate an SDM image is using a learning-based method to model the transformation from the DBT volume to the FFDM image using current DBT/FFDM combo images. In this study, we proposed to use a deep convolutional neural network (DCNN) to learn the transformation to generate SDM using current DBT/FFDM combo images. Gradient guided conditional generative adversarial networks (GGGAN) objective function was designed to preserve subtle MCs and the perceptual loss was exploited to improve the performance of the proposed DCNN on perceptual quality. We used various image quality criteria for evaluation, including preserving masses and MCs which are important in mammogram. Experiment results demonstrated progressive performance improvement of network using different objective functions in terms of those image quality criteria. The methodology we exploited in the SDM generation task to analyze and progressively improve image quality by designing objective functions may be helpful to other image generation tasks. [ABSTRACT FROM AUTHOR]

Fetal cortical plate segmentation is essential in quantitative analysis of fetal brain maturation and cortical folding. Manual segmentation of the cortical plate, or manual refinement of automatic segmentations is tedious and time-consuming. Automatic segmentation of the cortical plate, on the other hand, is challenged by the relatively low resolution of the reconstructed fetal brain MRI scans compared to the thin structure of the cortical plate, partial voluming, and the wide range of variations in the morphology of the cortical plate as the brain matures during gestation. To reduce the burden of manual refinement of segmentations, we have developed a new and powerful deep learning segmentation method. Our method exploits new deep attentive modules with mixed kernel convolutions within a fully convolutional neural network architecture that utilizes deep supervision and residual connections. We evaluated our method quantitatively based on several performance measures and expert evaluations. Results show that our method outperforms several state-of-the-art deep models for segmentation, as well as a state-of-the-art multi-atlas segmentation technique. We achieved average Dice similarity coefficient of 0.87, average Hausdorff distance of 0.96 mm, and average symmetric surface difference of 0.28 mm on reconstructed fetal brain MRI scans of fetuses scanned in the gestational age range of 16 to 39 weeks (28.6± 5.3). With a computation time of less than 1 minute per fetal brain, our method can facilitate and accelerate large-scale studies on normal and altered fetal brain cortical maturation and folding. [ABSTRACT FROM AUTHOR]

Non-rigid motion-corrected reconstruction has been proposed to account for the complex motion of the heart in free-breathing 3D coronary magnetic resonance angiography (CMRA). This reconstruction framework requires efficient and accurate estimation of non-rigid motion fields from undersampled images at different respiratory positions (or bins). However, state-of-the-art registration methods can be time-consuming. This article presents a novel unsupervised deep learning-based strategy for fast estimation of inter-bin 3D non-rigid respiratory motion fields for motion-corrected free-breathing CMRA. The proposed 3D respiratory motion estimation network (RespME-net) is trained as a deep encoder-decoder network, taking pairs of 3D image patches extracted from CMRA volumes as input and outputting the motion field between image patches. Using image warping by the estimated motion field, a loss function that imposes image similarity and motion smoothness is adopted to enable training without ground truth motion field. RespME-net is trained patch-wise to circumvent the challenges of training a 3D network volume-wise which requires large amounts of GPU memory and 3D datasets. We perform 5-fold cross-validation with 45 CMRA datasets and demonstrate that RespME-net can predict 3D non-rigid motion fields with subpixel accuracy (0.44 ± 0.38 mm) within ~10 seconds, being ~20 times faster than a GPU-implemented state-of-the-art non-rigid registration method. Moreover, we perform non-rigid motion-compensated CMRA reconstruction for 9 additional patients. The proposed RespME-net has achieved similar motion-corrected CMRA image quality to the conventional registration method regarding coronary artery length and sharpness. [ABSTRACT FROM AUTHOR]

Reliable MRI is crucial for accurate interpretation in therapeutic and diagnostic tasks. However, undersampling during MRI acquisition as well as the overparameterized and non-transparent nature of deep learning (DL) leaves substantial uncertainty about the accuracy of DL reconstruction. With this in mind, this study aims to quantify the uncertainty in image recovery with DL models. To this end, we first leverage variational autoencoders (VAEs) to develop a probabilistic reconstruction scheme that maps out (low-quality) short scans with aliasing artifacts to the diagnostic-quality ones. The VAE encodes the acquisition uncertainty in a latent code and naturally offers a posterior of the image from which one can generate pixel variance maps using Monte-Carlo sampling. Accurately predicting risk requires knowledge of the bias as well, for which we leverage Stein’s Unbiased Risk Estimator (SURE) as a proxy for mean-squared-error (MSE). A range of empirical experiments is performed for Knee MRI reconstruction under different training losses (adversarial and pixel-wise) and unrolled recurrent network architectures. Our key observations indicate that: 1) adversarial losses introduce more uncertainty; and 2) recurrent unrolled nets reduce the prediction uncertainty and risk. [ABSTRACT FROM AUTHOR]

Limitations on bandwidth and power consumption impose strict bounds on data rates of diagnostic imaging systems. Consequently, the design of suitable (i.e. task- and data-aware) compression and reconstruction techniques has attracted considerable attention in recent years. Compressed sensing emerged as a popular framework for sparse signal reconstruction from a small set of compressed measurements. However, typical compressed sensing designs measure a (non)linearly weighted combination of all input signal elements, which poses practical challenges. These designs are also not necessarily task-optimal. In addition, real-time recovery is hampered by the iterative and time-consuming nature of sparse recovery algorithms. Recently, deep learning methods have shown promise for fast recovery from compressed measurements, but the design of adequate and practical sensing strategies remains a challenge. Here, we propose a deep learning solution termed Deep Probabilistic Sub-sampling (DPS), that enables joint optimization of a task-adaptive sub-sampling pattern and a subsequent neural task model in an end-to-end fashion. Once learned, the task-based sub-sampling patterns are fixed and straightforwardly implementable, e.g. by non-uniform analog-to-digital conversion, sparse array design, or slow-time ultrasound pulsing schemes. The effectiveness of our framework is demonstrated in-silico for sparse signal recovery from partial Fourier measurements, and in-vivo for both anatomical image and tissue-motion (Doppler) reconstruction from sub-sampled medical ultrasound imaging data. [ABSTRACT FROM AUTHOR]

In this work we reduce undersampling artefacts in two-dimensional (2D) golden-angle radial cine cardiac MRI by applying a modified version of the U-net. The network is trained on 2D spatio-temporal slices which are previously extracted from the image sequences. We compare our approach to two 2D and a 3D deep learning-based post processing methods, three iterative reconstruction methods and two recently proposed methods for dynamic cardiac MRI based on 2D and 3D cascaded networks. Our method outperforms the 2D spatially trained U-net and the 2D spatio-temporal U-net. Compared to the 3D spatio-temporal U-net, our method delivers comparable results, but requiring shorter training times and less training data. Compared to the compressed sensing-based methods kt-FOCUSS and a total variation regularized reconstruction approach, our method improves image quality with respect to all reported metrics. Further, it achieves competitive results when compared to the iterative reconstruction method based on adaptive regularization with dictionary learning and total variation and when compared to the methods based on cascaded networks, while only requiring a small fraction of the computational and training time. A persistent homology analysis demonstrates that the data manifold of the spatio-temporal domain has a lower complexity than the one of the spatial domain and therefore, the learning of a projection-like mapping is facilitated. Even when trained on only one single subject without data-augmentation, our approach yields results which are similar to the ones obtained on a large training dataset. This makes the method particularly suitable for training a network on limited training data. Finally, in contrast to the spatial 2D U-net, our proposed method is shown to be naturally robust with respect to image rotation in image space and almost achieves rotation-equivariance where neither data-augmentation nor a particular network design are required. [ABSTRACT FROM AUTHOR]