377 results
Search Results
2. Critically appraised paper: Participation-focused therapy for children with cerebral palsy improves perception of leisure-time physical activity goal performance, satisfaction and confidence [commentary].
- Author
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Verschuren, Olaf
- Subjects
CEREBRAL palsy treatment ,CEREBRAL palsy ,PATIENT compliance ,QUALITY of life ,PATIENT participation ,PHYSICAL activity ,CHILDREN - Published
- 2020
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3. The effectiveness of taping on children with cerebral palsy: a systematic review.
- Author
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Güçhan, Zehra and Mutlu, Akmer
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PEOPLE with cerebral palsy ,CHILDREN with cerebral palsy ,REHABILITATION ,CHILD consumers ,CHILD mortality ,CEREBRAL palsy treatment ,CEREBRAL palsy ,ORTHOPEDIC apparatus ,PEDIATRICS ,SURGICAL dressings ,SYSTEMATIC reviews ,BIBLIOGRAPHIC databases ,FERRANS & Powers Quality of Life Index - Abstract
Aim: Taping is popular in a variety of paediatric clinical settings. The purpose of this study was to investigate the effectiveness of taping on the rehabilitation of children with cerebral palsy (CP).Method: We used MEDLINE, Embase, PubMed, CINAHL, and the Cochrane Central Register of Controlled Trials as the electronic databases for the review. We reviewed all relevant studies published up to May 2015. We also analysed pertinent secondary references. We used Sackett's Levels of Evidence and the guidelines for critical review of McMaster University to criticize the reviewed articles.Results: Nine papers met the inclusion criteria. Five of these were randomized controlled trials, three were case series, and one was a single case study. Four papers were high quality according to the methodological critical forms of this review, and two of these found that taping was effective in increasing activity in children with CP.Interpretation: Although benefits of taping were found in the population, and functional gains according to the International Classification of Functioning, Disability and Health were obtained, the evidence was not conclusive. Randomized controlled trials with larger sample sizes and with more specific taping procedures are required to strengthen the evidence for the effectiveness of taping on children with CP. [ABSTRACT FROM AUTHOR]- Published
- 2017
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4. Six-month follow-up of a mindfulness yoga program, MiYoga, on attention, executive function, behaviour and physical outcomes in cerebral palsy.
- Author
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Mak, Catherine, Whittingham, Koa, Cunnington, Ross, Chatfield, Mark, and Boyd, Roslyn N.
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CEREBRAL palsy treatment ,MINDFULNESS ,EXECUTIVE function ,EVALUATION of medical care ,WELL-being ,LIFESTYLES ,YOGA ,FUNCTIONAL status ,BEHAVIOR ,CHILDREN with disabilities ,RANDOMIZED controlled trials ,T-test (Statistics) ,PRE-tests & post-tests ,ATTENTION ,QUALITY of life ,RESEARCH funding ,PARENT-child relationships ,STATISTICAL sampling ,LONGITUDINAL method - Abstract
A randomised controlled trial (RCT) of a mindfulness-based yoga program, MiYoga, for cerebral palsy (CP) demonstrated improved attention in children and decreased mindfulness in parents post-intervention. This paper evaluates the retention of treatment effects at 6-months follow-up. 42 children with CP and their parents participated in a RCT with two groups MiYoga (n = 21) and Waitlist control group (n = 21). Waitlist control participants were offered MiYoga following the post-intervention assessment. 23 out of 42 child-parent dyads from both groups completed follow-up assessment 6-months after completing MiYoga. This paper evaluates and reports data from both groups collapsed (n = 23; MiYoga n = 11; and waitlist control n = 12; 47.8% male; mean age = 9:10 ± 2.4 years) to assess retention from post-MiYoga to follow-up and pre-MiYoga to follow-up. The primary outcome was attention, measured by Conner's Continuous Performance Test II (CCPT). Secondary outcomes included child executive function, physical function, behaviour, quality of life, child and parent mindfulness, personal wellbeing, psychological wellbeing and parent-child relationship. Paired t-tests showed no significant changes between post-MiYoga to follow-up and pre-MiYoga to follow-up for variables that showed an intervention effect immediately after MiYoga, namely, children's attention variables and parent's mindfulness. Paired t-tests showed that children's executive function and physical function and parent's wellbeing improved significantly from pre-MiYoga to 6-months follow-up which may potentially reflect sleeper or delayed effects of MiYoga. This study identified possible delayed or sleeper effects in children's executive function and physical function and parent's well-being. 6-month follow-up evidence for retention of effects of MiYoga on children's attention was inconsistent; therefore, booster sessions or continued practice of MiYoga as a lifestyle option are needed to maintain an effect on attention. Because MiYoga can be practised during daily activities, it may provide additional support for children with CP, complementing standard rehabilitation options. By embedding mindfulness in children and parents' daily activities, MiYoga, could provide families with accessible and time-efficient means of learning and practicing mindfulness. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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5. Treatment and re/habilitation of children with cerebral palsy in India: a scoping review.
- Author
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Jindal, Pranay, Macdermid, Joy C, Rosenbaum, Peter, Direzze, Briano, Narayan, Amitesh, and Nayak, Sharada L
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CHILDREN with cerebral palsy ,CEREBRAL palsy ,CEREBRAL palsy treatment ,REHABILITATION ,SCHOLARLY periodicals - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
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- View/download PDF
6. Understanding frames: A qualitative exploration of standing frame use for young people with cerebral palsy in educational settings.
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Goodwin, Jane, Lecouturier, Jan, Smith, Johanna, Crombie, Sarah, Basu, Anna, Parr, Jeremy R., Howel, Denise, McColl, Elaine, Roberts, Andrew, Miller, Keith, and Cadwgan, Jill
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CEREBRAL palsy treatment ,AUTONOMY (Psychology) ,COMMUNICATION ,CONFIDENCE ,FOCUS groups ,HEALTH care teams ,OCCUPATIONAL therapists ,PATIENT positioning ,PEDIATRICIANS ,PHYSICAL therapists ,PROFESSIONAL ethics ,SCHOOL environment ,SPECIAL education ,STANDING position ,QUALITATIVE research ,ASSISTIVE technology ,JOB performance ,SOCIAL boundaries ,THEMATIC analysis ,PARENT attitudes ,COLLEGE teacher attitudes - Abstract
Background: Consensus opinion supports standing frame use as part of postural management for nonambulant young people with cerebral palsy. Most young people with cerebral palsy in the United Kingdom, who use standing frames, use them at nursery or school, rather than at home. In this paper we report professionals' and parents' experiences and views of standing frame use specifically in educational settings. This research was conducted as part of a large mixed methods study to determine the acceptability and inform the design of a future trial of standing frames. Methods: Qualitative methods were used: focus groups with educational professionals, parents and clinicians (paediatricians, physiotherapists and occupational therapists) were convened. Data were analysed thematically using framework analysis. Results: Five focus groups were conducted. The overarching theme "flexibility" encompassed four subordinate themes: (i) "balancing education and therapy," which described the way education professionals had to juggle different priorities from health professionals within a multi‐disciplinary team; (ii) "young people's autonomy," which highlighted participants' belief that standing frame use should be centred on the individual young person and their needs; (iii) "working within logistical boundaries," which demonstrated that "ideal" standing frame use was not always possible due to logistical issues (e.g., staffing and standing frame availability); and (iv) "competence and confidence," which highlighted that educational professionals felt that they lacked the training to confidently position young people in their standing frame. Conclusions: This paper highlights the complexity of standing frame use in the educational setting. If a standing frame programme is prescribed to be delivered in an educational setting, strong multidisciplinary and interagency communication is essential to balance therapy versus education. Training is required to ensure staff are competent in using the standing frame with the young person understanding their individual requirements. A flexible approach—inclusive of the young person's needs, logistical demands and resource—is necessary. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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7. Therapeutic Potency of Cord Blood Stem Cells in Patients with Cerebral Palsy: A Systemic Literature Review.
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Farhat, Ahmadshah, Majma, Anahita, Ashrafzadeh, Farah, Akhondian, Javad, Mohammadzadeh, Ashraf, and Ghasemi, Ali
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CORD blood ,STEM cells ,CEREBRAL palsy treatment - Abstract
Background: The main objective of this study was to systematically review the reported potency of cord blood stem cells in treating patients with neurological disorders such as cerebral palsy. Methods: PubMed, Scopus, and Cochrane were searched thoroughly on September 2016 using the following search terms: "Umbilical cord blood stem cells" AND "development" AND "cerebral palsy" to find articles in which the umbilical cord blood stem cells were used to treat patients with cerebral palsy. Only English-language studies conducted on patients with cerebral palsy were included and used for data extraction. Results: Of a total of 77 articles found in the database search, only 6 papers fully met the inclusion criteria. The results showed successful treatment with cord blood stem cells in 165 patients with cerebral palsy. Conclusion: Studies on both human and animal models have shown the beneficial effects of stem cell therapy in the treatment of various neurological diseases. Data presented that cord blood stem cells can be considered as a main therapeutic strategy to treat patients with cerebral palsy. In addition, it is shown that cord blood stem cells significantly improve motor function, cognition, and memory in patients with cerebral palsy.q [ABSTRACT FROM AUTHOR]
- Published
- 2018
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8. Interventions and lower-limb macroscopic muscle morphology in children with spastic cerebral palsy: a scoping review.
- Author
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Walhain, Fenna, Desloovere, Kaat, Declerck, Marlies, Van Campenhout, Anja, Bar‐On, Lynn, and Bar-On, Lynn
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CHILDREN with cerebral palsy ,BOTULINUM toxin ,WHOLE-body vibration ,MUSCLES ,MORPHOLOGY ,VIBRATION therapy ,CEREBRAL palsy treatment ,MUSCLE relaxants ,PHYSICAL therapy ,POSTURAL balance ,SYSTEMATIC reviews ,SPASTICITY ,LEG ,RESEARCH funding ,ELECTROTHERAPEUTICS ,CEREBRAL palsy - Abstract
Aim: To identify and map studies that have assessed the effect of interventions on lower-limb macroscopic muscle-tendon morphology in children with spastic cerebral palsy (CP).Method: We conducted a literature search of studies that included pre- and post-treatment measurements of lower-limb macroscopic muscle-tendon morphology in children with spastic CP. Study quality was evaluated and significant intervention effects and effect sizes were extracted.Results: Twenty-eight articles were identified. They covered seven different interventions including stretching, botulinum neurotoxin A (BoNT-A), strengthening, electrical stimulation, whole-body vibration, balance training, and orthopaedic surgery. Study quality ranged from poor (14 out of 28 studies) to good (2 out of 28). Study samples were small (n=4-32) and studies were variable regarding which muscles and macroscopic morphological parameters were assessed. Inconsistent effects after intervention (thickness and cross-sectional area for strengthening, volume for BoNT-A), no effect (belly length for stretching), and small effect sizes were reported.Interpretation: Intervention studies reporting macroscopic muscle-tendon remodelling after interventions are limited and heterogeneous, making it difficult to generalize results. Studies that include control groups and standardized assessment protocols are needed to improve study quality and data synthesis. Lack or inconclusive effects at the macroscopic level could indicate that the effects of interventions should also be evaluated at the microscopic level.What This Paper Adds: Muscle-targeted interventions to remodel muscle morphology are not well understood. Studies reporting macroscopic muscle remodelling following interventions are limited and heterogeneous. Passive stretching may preserve but does not increase muscle length. The effects of isolated botulinum neurotoxin A injections on muscle volume are inconsistent. Isolated strengthening shows no consistent increase in muscle volume or thickness. [ABSTRACT FROM AUTHOR]- Published
- 2021
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9. Toward modeling locomotion using electromyography-informed 3D models: application to cerebral palsy.
- Author
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Sartori, M., Fernandez, J. W., Modenese, L., Carty, C. P., Barber, L. A., Oberhofer, K., Zhang, J., Handsfield, G. G., Stott, N. S., Besier, T. F., Farina, D., and Lloyd, D. G.
- Subjects
LOCOMOTOR control ,ELECTROMYOGRAPHY ,THREE-dimensional display systems ,CEREBRAL palsy treatment ,NEUROLOGICAL disorders ,THERAPEUTICS ,MAGNETIC resonance imaging - Abstract
This position paper proposes a modeling pipeline to develop clinically relevant neuromusculoskeletal models to understand and treat complex neurological disorders. Although applicable to a variety of neurological conditions, we provide direct pipeline applicative examples in the context of cerebral palsy ( CP). This paper highlights technologies in: (1) patient-specific segmental rigid body models developed from magnetic resonance imaging for use in inverse kinematics and inverse dynamics pipelines; (2) efficient population-based approaches to derive skeletal models and muscle origins/insertions that are useful for population statistics and consistent creation of continuum models; (3) continuum muscle descriptions to account for complex muscle architecture including spatially varying material properties with muscle wrapping; (4) muscle and tendon properties specific to CP; and (5) neural-based electromyography-informed methods for muscle force prediction. This represents a novel modeling pipeline that couples for the first time electromyography extracted features of disrupted neuromuscular behavior with advanced numerical methods for modeling CP-specific musculoskeletal morphology and function. The translation of such pipeline to the clinical level will provide a new class of biomarkers that objectively describe the neuromusculoskeletal determinants of pathological locomotion and complement current clinical assessment techniques, which often rely on subjective judgment. WIREs Syst Biol Med 2017, 9:e1368. doi: 10.1002/wsbm.1368 For further resources related to this article, please visit the . [ABSTRACT FROM AUTHOR]
- Published
- 2017
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10. A STUDY OF CLINICO ETIOLOGICAL PROFILE OF CHILDREN WITH CEREBRAL PALSY IN A TERTIARY CARE CENTRE.
- Author
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Ravula, Chaitanya Jyothi, Kankala, Sirisha, Alladi, Aparna, Thotada, Prasanna Lakshmi, and Kalivela, Santhimayee
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CEREBRAL palsy treatment ,ASPHYXIA neonatorum ,CHILDREN'S health ,SOCIAL status ,TERTIARY care - Abstract
The clinical spectrum of Cerebral palsy (CP) can differ in various places depending upon the knowledge of the people and resources for prevention, diagnosis and management. Although studied extensively in high-resource countries, adequate data related to CP from resource-constraint settings are lacking. The aim: The present study is a descriptive study done on clinical profiles, aetiology, and comorbidities. Materials and methods: Present study is a hospital-based descriptive study of 80 children with Cerebral Palsy from January 2020 to June 2021 (18 months) admitted to Niloufer Hospital for Child Health, cases chosen as per inclusion criteria guided by «The Definition and classification of cerebral palsy, April 2006 International consensus». Clinical history and clinical examination and necessary investigations using a systematically designed proforma. Results: The most common types were spastic type (78.9 %) and hypotonic type (12.5 %). Spastic quadriparesis (55 %) was the most common among subtypes. Males were more affected than females, with more rural than urban distribution. 48.8 % belonged to the lower middle and 37.5 % to the upper lower class of socio-economic status. Consanguinity was observed in 33 %, and 3 % had a similar family history. A high incidence (65 %) was seen in firstborn children. Term gestation was commonest at 87 % and prematurity at 13 %. 91.3 % of the cases were institutional deliveries. For causes of cerebral palsy, 45 % required resuscitation at birth, 2.5 % had neonatal sepsis, 1.25 % had a cerebral malformation, 7.5 % had an intracranial bleed, 7.5 % had post-meaning encephalitic sequelae, 1.3 % had TORCH infection. Comorbidities Like mental retardation were seen in 90 %, seizure disorder in 87.5 %, visual problems in 24.8 %, hearing problems in 13.75 %, 56.25 % of cases were malnourished. Conclusions: Comorbidities are significantly observed in cases of cerebral palsy. Appropriate screening and management of comorbidities, especially vision, hearing, speech, seizures, and nutrition, improve the overall prognosis in cases of Cerebral palsy. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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11. Impairments, functional limitations, and access to services and education for children with cerebral palsy in Uganda: a population-based study.
- Author
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Andrews, Carin, Kakooza‐Mwesige, Angelina, Almeida, Rita, Swartling Peterson, Stefan, Wabwire‐Mangen, Fred, Eliasson, Ann-Christin, Forssberg, Hans, Kakooza-Mwesige, Angelina, and Wabwire-Mangen, Fred
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CHILDREN with cerebral palsy ,RIGHT to education ,CHILD services ,DISABILITIES ,MEDICAL screening ,CEREBRAL palsy treatment ,RESEARCH ,ASSISTIVE technology ,HEALTH services accessibility ,PHYSICAL therapy ,RESEARCH methodology ,EVALUATION research ,MEDICAL cooperation ,SURVEYS ,COMPARATIVE studies ,RESEARCH funding ,CEREBRAL palsy - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
12. Long-term effects of repeated botulinum neurotoxin A, bimanual training, and splinting in young children with cerebral palsy.
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Lidman, Git R M, Nachemson, Ann K, Peny‐Dahlstrand, Marie B, Himmelmann, Kate M E, and Peny-Dahlstrand, Marie B
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BOTULINUM A toxins ,CHILDREN with cerebral palsy ,OCCUPATIONAL therapy for children ,BOTULINUM toxin ,OCCUPATIONAL therapy ,CEREBRAL palsy treatment ,RESEARCH ,MUSCLE relaxants ,RESEARCH methodology ,SPLINTS (Surgery) ,EVALUATION research ,MEDICAL cooperation ,TREATMENT effectiveness ,COMPARATIVE studies ,HAND ,RESEARCH funding ,COMBINED modality therapy ,CEREBRAL palsy ,LONGITUDINAL method ,MOTOR ability - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
13. Prevalence of depression, anxiety, and substance-related disorders in parents of children with cerebral palsy: a systematic review.
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Barreto, Tainara M, Bento, Mayara N, Barreto, Tamiris M, Jagersbacher, João Gabriel, Jones, Nathalia S, Lucena, Rita, and Bandeira, Igor D
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CHILDREN with cerebral palsy ,SUBSTANCE-induced disorders ,META-analysis ,CHILD psychopathology ,CHILD care ,CEREBRAL palsy treatment ,SUBSTANCE abuse ,PSYCHOLOGY of mothers ,SYSTEMATIC reviews ,MENTAL depression ,DISEASE prevalence ,ANXIETY ,PSYCHOLOGY of fathers ,CEREBRAL palsy - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
14. EFFECTIVENESS OF PHYSICAL THERAPY INTERVENTIONS FOR CHILDREN WITH CEREBRAL PALSY.
- Author
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Crăciun, M. D. and Midrigan, N.
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PHYSICAL therapy ,CEREBRAL palsy treatment ,MOTOR ability - Abstract
Cerebral palsy (CP) describes a group of permanent disorders of motor development and posture that cause limiting activity that are attributed to non-progressive dysfunctions occurring in the development of fetal brain or of the child. The main purpose of the paper is to study the clinical and functional aspects with implications in the design and evaluation of the complex recovery therapy of the child with psycho-neuro-motor disabilities diagnosed with infantile cerebral palsy (ICP). The study took place during the period June 2016 - March 2018, is of the type prospectively and comprised 5 children diagnosed with ICP, aged 4 to 12 years. Criteria for inclusion in the recovery group: children diagnosed with infantile cerebral palsy form spastic tetra- spastic, without orthopedic surgery, during the study period. Children have been given a comprehensive assessment of body attitude, upper and lower limb hypertonia, upper limbs functionality, and global motor function. The major objective of recovering the child with infantile cerebral palsy was to improve the quality of life by creating conditions for minimum patient autonomy. The functional recovery program was carried out three times a week using exercises and methods of neuro-motor rehabilitation. Duration of the session was 50-60 min. Due to the results obtained at the initial and final evaluation, a tonus improvement was observed in all the tested muscles, with a decrease in the mobilization resistance of all the muscle groups. In global functional evaluation the total score on the 5 sections of the 5 children with CP had an initial mean value of 34.92 (± 16.60) and a final of 47.72 (± 26.53) Stretching, neuro-motor reeducation methods and active physical exercises help to increase the degree of the functional independence. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
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15. Gait analysis for individually tailored interdisciplinary interventions in children with cerebral palsy: a randomized controlled trial.
- Author
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Rasmussen, Helle M, Pedersen, Niels W, Overgaard, Søren, Hansen, Lars K, Dunkhase‐Heinl, Ulrike, Petkov, Yanko, Engell, Vilhelm, Holsgaard‐Larsen, Anders, Dunkhase-Heinl, Ulrike, and Holsgaard-Larsen, Anders
- Subjects
CHILDREN with cerebral palsy ,RANDOMIZED controlled trials ,ORTHOPEDIC surgery ,QUALITY of life ,PHYSICAL therapy for children ,PHYSICAL therapy ,CEREBRAL palsy treatment ,CEREBRAL palsy ,COMPARATIVE studies ,GAIT in humans ,LONGITUDINAL method ,ORTHOPEDIC apparatus ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,STATISTICAL sampling ,EVALUATION research ,TREATMENT effectiveness - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
- Full Text
- View/download PDF
16. AACPDM systematic review of the effectiveness of therapy for children with cerebral palsy after botulinum toxin A injections.
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Natasha Lannin, Adam Scheinberg, and Kathryn Clark
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CEREBRAL palsy treatment ,CHILDREN with cerebral palsy ,BOTULINUM toxin ,CLOSTRIDIUM botulinum ,GAIT in humans ,HUMAN locomotion - Abstract
The aim of this review was to assess the effectiveness of therapy interventions on improving outcomes in children with cerebral palsy (CP) who have received botulinum toxin A (BTX-A) injections to either upper or lower limb muscles. We searched: the Cochrane Central Register of Controlled Trials; the electronic databases Medline, EMBASE, CINAHL, PEDro, SCI, and SSCI; websites of professional associations; and reference lists in trial reports and other relevant articles. We used studies on the effect of therapy on motor control, functional abilities, contracture, spasticity, and/or pain as the selection criteria. Methodological quality and the strength of evidence was assessed systematically by three independent raters using American Academy for Cerebral Palsy and Developmental Medicine (AACPDM) guidelines. Twenty-four papers met the criteria for inclusion in the content analysis of evidence. Of these, only one randomized controlled trial was available, with results demonstrating that electrical stimulation postinjection did not enhance the effects of BTX-A on gait improvement (insufficient data provided to report size of effect). Remaining papers were of level II evidence (n=2), Level IV evidence (n=5), and level V evidence (n=14). We conclude that there is insufficient evidence to either support or refute the use of therapy interventions after BTX-A injections in children with CP. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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17. Motor function and safety after allogeneic cord blood and cord tissue-derived mesenchymal stromal cells in cerebral palsy: An open-label, randomized trial.
- Author
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Sun, Jessica M., Case, Laura E., McLaughlin, Colleen, Burgess, Alicia, Skergan, Natalie, Crane, Sydney, Jasien, Joan M., Mikati, Mohamad A., Troy, Jesse, and Kurtzberg, Joanne
- Subjects
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CEREBRAL palsy treatment , *HEMATOPOIETIC stem cell transplantation , *EVALUATION research , *RESEARCH funding , *CELLULAR therapy , *RANDOMIZED controlled trials , *RESEARCH , *RESEARCH methodology , *CORD blood , *COMPARATIVE studies - Abstract
Aim: To evaluate safety and motor function after treatment with allogeneic umbilical cord blood (AlloCB) or umbilical cord tissue-derived mesenchymal stromal cells (hCT-MSC) in children with cerebral palsy (CP).Method: Ninety-one children (52 males, 39 females; median age 3 years 7 months [range 2-5 years]) with CP due to hypoxic-ischemic encephalopathy, stroke, or periventricular leukomalacia were randomized to three arms: (1) the AlloCB group received 10 × 107 AlloCB total nucleated cells (TNC) per kilogram at baseline (n = 31); (2) the hCT-MSC group received 2 × 106 hCT-MSC at baseline, 3 months, and 6 months (n = 28); (3) the natural history control group received 10 × 107 AlloCB TNC per kilogram at 12 months (n = 31). Motor function was assessed with the Gross Motor Function Measure-66 (GMFM-66) and Peabody Developmental Motor Scale, Second Edition.Results: Infusions (n = 143) were well tolerated, with eight infusion reactions (three in the AlloCB group, five in hCT-MSC) and no other safety concerns. At 12 months, the mean differences (95% confidence intervals [CI]) between actual and expected changes in GMFM-66 score were AlloCB 5.8 points (3.4-8.2), hCT-MSC 4.3 (2.2-6.4), and natural history 3.1 (1.4-5.0). In exploratory, post hoc analysis, the mean GMFM-66 score (95% CI) of the hCT-MSC group was 1.4 points higher than natural history (-1.1 to 4.0; p = 0.27), and the AlloCB group was 3.3 points higher than natural history (0.59-5.93; p = 0.02) after adjustment for baseline Gross Motor Function Classification System level, GMFM-66 score, and etiology.Interpretation: High-dose AlloCB is a potential cell therapy for CP and should be further tested in a randomized, blinded, placebo-controlled trial.What This Paper Adds: Unrelated donor allogeneic umbilical cord blood (AlloCB) and human umbilical cord tissue-derived mesenchymal stromal cell infusion is safe in young children with cerebral palsy. Significant changes in motor function were not observed 6 months after treatment. One year later, treatment with AlloCB was associated with greater increases in Gross Motor Function Measure-66 scores. [ABSTRACT FROM AUTHOR]- Published
- 2022
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18. Gait parameters in children with bilateral spastic cerebral palsy: a systematic review of randomized controlled trials.
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Gómez‐Pérez, Cristina, Font‐Llagunes, Josep M, Martori, Joan Carles, Vidal Samsó, Joan, Gómez-Pérez, Cristina, and Font-Llagunes, Josep M
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CEREBRAL palsy ,RANDOMIZED controlled trials ,META-analysis ,NEUROREHABILITATION ,ANATOMICAL planes ,GAIT disorders ,CEREBRAL palsy treatment ,DIAGNOSIS of neurological disorders ,CLINICAL trials ,KINEMATICS ,MEDLINE ,NEUROLOGICAL disorders ,ONLINE information services ,SYSTEMATIC reviews ,DISEASE complications - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
- Full Text
- View/download PDF
19. A case study of developing gaze controlled interface for users with severe speech and motor impairment.
- Author
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Jeevithashree, D.V., Saluja, Kamalpreet Singh, and Biswas, Pradipta
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CEREBRAL palsy treatment ,ANALYSIS of variance ,COMMUNICATION devices for people with disabilities ,EYE movements ,FACILITATED communication ,GAMES ,MOTOR ability ,SPEECH disorders ,USER interfaces ,SOFTWARE architecture - Abstract
BACKGROUND: People with severe speech and motor impairment (SSMI) often depend on electronic user interfaces for communication, learning and many other daily activities. However, these interfaces are often designed assuming the preference and ease of use of end users for different screen regions is the same for people with SSMI as their able bodied counterparts. This paper presents a user study to evaluate whether users can undertake pointing and selection tasks faster if screen elements are organized at their preferred positions. OBJECTIVE: To compare pointing and selection times in an eye gaze controlled interface between two conditions – screen elements randomly organized vs screen elements organized according to preference of users in terms of specific screen locations. METHODS: We designed a word construction game using familiar 4-letter words and users were instructed to select the correct letters to construct words. We compared total times required to construct each correct word. RESULTS: Users with SSMI can statistically significantly construct words faster [F(1,195) = 31.04, p < 0.01, η 2 = 0.14] when letters were organized at their preferred screen positions than random organization. CONCLUSIONS: Users with SSMI prefer middle and right side of screen more than the left side. Pointing and selection times in a gaze controlled interface can be significantly reduced by presenting screen elements at the preferred positions. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
20. Designing AAC Research and Intervention to Improve Outcomes for Individuals with Complex Communication Needs.
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Light, Janice and Mcnaughton, David
- Subjects
AMYOTROPHIC lateral sclerosis treatment ,APHASIA ,TREATMENT of autism ,CEREBRAL palsy treatment ,TREATMENT of communicative disorders ,PEOPLE with intellectual disabilities ,ECOLOGY ,EXPERIMENTAL design ,FACILITATED communication ,LANGUAGE acquisition ,TREATMENT effectiveness ,THERAPEUTICS - Abstract
There is a rapidly growing body of research that demonstrates the positive effects of augmentative and alternative communication (AAC) intervention on the communication of children and adults with complex communication needs. Despite the positive impact of many AAC interventions, however, many individuals with complex communication needs continue to experience serious challenges participating in educational, vocational, healthcare, and community environments. In this paper, we apply the framework proposed by the International Classification of Functioning, Disability and Health (ICF) to illustrate the need to re-think AAC intervention to improve outcomes for individuals with complex communication needs, and to foster a new generation of intervention research that will provide a solid foundation for improved services. Specifically, the paper emphasizes the need to take a more holistic view of communication intervention and highlights the following key principles to guide AAC intervention and research: (a) build on the individual's strengths and focus on the integration of skills to maximize communication, (b) focus on the individual's participation in real-world contexts, (c) address psychosocial factors as well as skills, and (d) attend to extrinsic environmental factors as well as intrinsic factors related to the individual who requires AAC. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
21. Setting a patient-centered research agenda for cerebral palsy: a participatory action research initiative.
- Author
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Gross, Paul H, Bailes, Amy F, Horn, Susan D, Hurvitz, Edward A, Kean, Jacob, Shusterman, Michele, and cerebral palsy research network
- Subjects
NONPROFIT organizations ,PATIENT-centered care ,CEREBRAL palsy ,QUALITY of life ,PUBLIC health administration ,CEREBRAL palsy treatment ,ACTION research ,DELPHI method ,MEDICAL care research ,MEDICAL personnel ,RESEARCH funding ,RESIDENTIAL patterns ,CROSS-sectional method ,PSYCHOLOGY - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
22. Systemic adverse events after botulinum neurotoxin A injections in children with cerebral palsy.
- Author
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Paget, Simon P., Swinney, Caitlyn M., Burton, Karen L. O., Bau, Karen, O'Flaherty, Stephen J., and O'Flaherty, Stephen J
- Subjects
BOTULINUM A toxins ,CEREBRAL palsy treatment ,ADVERSE health care events ,TREATMENT effectiveness ,DRUG side effects ,BOTULINUM toxin ,CEREBRAL palsy ,INJECTIONS ,LONGITUDINAL method ,MULTIVARIATE analysis ,MUSCLE relaxants ,LOGISTIC regression analysis ,SEVERITY of illness index ,DISEASE complications - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
23. Muscle volume alterations after first botulinum neurotoxin A treatment in children with cerebral palsy: a 6-month prospective cohort study.
- Author
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Alexander, Caroline, Elliott, Catherine, Valentine, Jane, Stannage, Katherine, Bear, Natasha, Donnelly, Cyril J., Shipman, Peter, and Reid, Siobhan
- Subjects
BOTULINUM A toxins ,CEREBRAL palsy treatment ,MUSCLE abnormalities ,TREATMENT effectiveness ,COHORT analysis ,ANTHROPOMETRY ,BOTULINUM toxin ,CEREBRAL palsy ,COMPARATIVE studies ,EXERCISE tests ,HYPERTROPHY ,INTRAMUSCULAR injections ,LEG ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,MUSCLE relaxants ,RESEARCH ,SPASTICITY ,EVALUATION research ,ATROPHY ,SKELETAL muscle ,DISEASE complications - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
24. Responsiveness of the ACTIVLIM-CP questionnaire: measuring global activity performance in children with cerebral palsy.
- Author
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Paradis, Julie, Arnould, Carlyne, Thonnard, Jean‐Louis, Houx, Laëtitia, Pons‐Becmeur, Christelle, Renders, Anne, Brochard, Sylvain, Bleyenheuft, Yannick, Thonnard, Jean-Louis, and Pons-Becmeur, Christelle
- Subjects
PEDIATRIC intensive care ,ACTIVITIES of daily living ,BOTULINUM A toxins ,QUESTIONNAIRES ,QUALITY of life ,CEREBRAL palsy treatment ,BOTULINUM toxin ,CEREBRAL palsy ,COMPARATIVE studies ,INJECTIONS ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,MOTOR ability ,MUSCLE relaxants ,PHYSICAL therapy ,RESEARCH ,RESEARCH funding ,EVIDENCE-based medicine ,PROFESSIONAL practice ,EVALUATION research ,TREATMENT effectiveness ,SEVERITY of illness index ,DIAGNOSIS - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
25. Use of virtual reality intervention to improve reaction time in children with cerebral palsy: A randomized controlled trial.
- Author
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Pourazar, Morteza, Mirakhori, Fatemeh, Hemayattalab, Rasool, and Bagherzadeh, Fazlolah
- Subjects
CEREBRAL palsy treatment ,ANALYSIS of variance ,MULTIVARIATE analysis ,REACTION time ,T-test (Statistics) ,VIRTUAL reality ,RANDOMIZED controlled trials ,TREATMENT effectiveness ,CHILDREN - Abstract
Purpose: The purpose of this study was to investigate the training effects of Virtual Reality (VR) intervention program on reaction time in children with cerebral palsy. Methods: Thirty boys ranging from 7 to 12 years (mean = 11.20; SD = .76) were selected by available sampling method and randomly divided into the experimental and control groups. Simple Reaction Time (SRT) and Discriminative Reaction Time (DRT) were measured at baseline and 1 day after completion of VR intervention. Multivariate analysis of variance (MANOVA) and paired sample t-test were performed to analyze the results. Results: MANOVA test revealed significant effects for group in posttest phase, with lower reaction time in both measures for the experimental group. Based on paired sample t-test results, both RT measures significantly improved in experimental group following the VR intervention program. Conclusions: This paper proposes VR as a promising tool into the rehabilitation process for improving reaction time in children with cerebral palsy. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
26. Diagnosing cerebral palsy in full-term infants.
- Author
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Morgan, Catherine, Fahey, Michael, Roy, Bithi, and Novak, Iona
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CHILDREN with cerebral palsy ,CEREBRAL palsy treatment ,CEREBRAL palsy ,MOVEMENT disorders ,BRAIN damage ,DIAGNOSIS - Abstract
More than 50% of infants with cerebral palsy (CP) are born at or near term, with the vast majority having pre- or perinatally acquired CP. While some have a clinical history predictive of CP, such as neonatal encephalopathy or neonatal stroke, others have no readily identifiable risk factors. Paediatricians are often required to discriminate generalised motor delay from a variety of other diagnoses, including CP. This paper outlines known causal pathways to CP in term-born infants with a focus on differential diagnosis. Early and accurate diagnosis is important as it allows prompt access to early intervention during the critical periods of brain development. A combination of clinical history taking, standard clinical examination, neuroimaging and genetic testing should be started at the time of referral. Attention to the investigation of common comorbidities of CP, including feeding and sleep difficulties, and referral to early intervention are recommended. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
27. Early diagnosis and early intervention in cerebral palsy.
- Author
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Hadders-Algra, Mijna
- Subjects
CEREBRAL palsy treatment ,EARLY diagnosis ,PEOPLE with cerebral palsy ,BRAIN damage ,NEUROLOGICAL disorders ,NEUROPLASTICITY - Abstract
This paper reviews the opportunities and challenges for early diagnosis and early intervention in cerebral palsy (CP). CP describes a group of disorders of the development of movement and posture, causing activity limitation that is attributed to disturbances that occurred in the fetal or infant brain.Therefore, the paper starts with a summary of relevant information from developmental neuroscience. Most lesions underlying CP occur in the second half of gestation, when developmental activity in the brain reaches its summit. Variations in timing of the damage not only result in different lesions but also in different neuroplastic reactions and different associated neuropathologies. This turns CP into a heterogeneous entity.This may mean that the best early diagnostics and the best intervention methods may differ for various subgroups of children with CP. Next, the paper addresses possibilities for early diagnosis. It discusses the predictive value of neuromotor and neurological exams, neuroimaging techniques, and neurophysiological assessments. Prediction is best when complementary techniques are used in longitudinal series. Possibilities for early prediction of CP differ for infants admitted to neonatal intensive care and other infants. In the former group, best prediction is achieved with the combination of neuroimaging and the assessment of general movements, in the latter group, best prediction is based on carefully documented milestones and neurological assessment.The last part reviews early intervention in infants developing CP. Most knowledge on early intervention is based on studies in high-risk infants without CP. In these infants, early intervention programs promote cognitive development until preschool age; motor development profits less.The few studies on early intervention in infants developing CP suggest that programs that stimulate all aspects of infant development by means of family coaching are most promising. More research is urgently needed. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
28. Nutritional intervention and neurodevelopmental outcome in infants with suspected cerebral palsy: the Dolphin infant double-blind randomized controlled trial.
- Author
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Andrew, Morag J., Montague‐Johnson, Christine, Laler, Karen, Baker, Bonny, Sullivan, Peter B., Parr, Jeremy R., Qi, Cathy, and Montague-Johnson, Christine
- Subjects
NEURODEVELOPMENTAL treatment for infants ,CEREBRAL palsy ,DOCOSAHEXAENOIC acid ,NUTRITION ,RANDOMIZED controlled trials ,CEREBRAL palsy treatment ,NUCLEOTIDES ,CHOLINE ,CHILD development ,COMPARATIVE studies ,DIET therapy ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,STATISTICAL sampling ,EVALUATION research ,BLIND experiment ,DISEASE complications ,PSYCHOLOGY ,THERAPEUTICS - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
29. Economic evaluation and cost of interventions for cerebral palsy: a systematic review.
- Author
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Shih, Sophy T. F., Tonmukayakul, Utsana, Imms, Christine, Reddihough, Dinah, Graham, H. Kerr, Cox, Liz, and Carter, Rob
- Subjects
CEREBRAL palsy ,MEDICAL care costs ,META-analysis ,RANDOMIZED controlled trials ,BOTULINUM toxin ,CEREBRAL palsy treatment ,QUALITY of life ,MENTAL health ,ALGORITHMS ,COST effectiveness ,HEALTH outcome assessment ,SYSTEMATIC reviews ,DISEASE management ,PSYCHOLOGY - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
30. Intrathecal baclofen therapy in children: an analysis of individualized goals.
- Author
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Liew, Peck Yee, Stewart, Kirsty, Khan, Debra, Arnup, Sarah Jane, and Scheinberg, Adam
- Subjects
BACLOFEN ,GROSS motor ability ,CHILDREN with cerebral palsy ,CEREBRAL palsy treatment ,SPASTICITY ,CEREBRAL palsy ,COMPARATIVE studies ,GOAL (Psychology) ,SPINAL infusions ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,MUSCLE relaxants ,MUSCLE rigidity ,HEALTH outcome assessment ,RESEARCH ,TIME ,EVALUATION research ,PSYCHOLOGY - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
31. Demographic and modifiable factors associated with knee contracture in children with cerebral palsy.
- Author
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Cloodt, Erika, Rosenblad, Andreas, Rodby‐Bousquet, Elisabet, and Rodby-Bousquet, Elisabet
- Subjects
CHILDREN with cerebral palsy ,CEREBRAL palsy treatment ,CONTRACTURE (Pathology) ,GROSS motor ability ,KNEE diseases - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
32. Pharmacological and neurosurgical interventions for managing dystonia in cerebral palsy: a systematic review.
- Author
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Fehlings, Darcy, Brown, Leah, Harvey, Adrienne, Himmelmann, Kate, Lin, Jean‐Pierre, Macintosh, Alexander, Mink, Jonathan W., Monbaliu, Elegast, Rice, James, Silver, Jessica, Switzer, Lauren, Walters, Ilana, and Lin, Jean-Pierre
- Subjects
NEUROSURGERY ,TREATMENT of dystonia ,CEREBRAL palsy treatment ,SYSTEMATIC reviews ,TREATMENT effectiveness ,MUSCLE relaxants ,BACLOFEN ,CEREBRAL palsy ,COMPARATIVE studies ,DYSTONIA ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,EVALUATION research ,DEEP brain stimulation ,DISEASE complications ,THERAPEUTICS - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
33. Educational outcomes for children with cerebral palsy: a linked data cohort study.
- Author
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Gillies, Malcolm B., Bowen, Jennifer R., Patterson, Jillian A., Roberts, Christine L., and Torvaldsen, Siranda
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CHILDREN with cerebral palsy ,CEREBRAL palsy ,EDUCATIONAL outcomes ,CEREBRAL palsy treatment ,COHORT analysis ,DIAGNOSIS ,AGE distribution ,COMPARATIVE studies ,HEALTH planning ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,EVALUATION research ,EDUCATIONAL attainment ,PSYCHOLOGY - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
34. Development of the Hand Assessment for Infants: evidence of internal scale validity.
- Author
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Krumlinde‐Sundholm, Lena, Ek, Linda, Sicola, Elisa, Sjöstrand, Lena, Guzzetta, Andrea, Sgandurra, Giuseppina, Cioni, Giovanni, and Eliasson, Ann‐Christin
- Subjects
CEREBRAL palsy treatment ,CHILDREN with cerebral palsy ,NEURAL development ,CEREBRAL cortex development ,INFANT health ,DISEASES ,CEREBRAL palsy ,COMPARATIVE studies ,HAND ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,RESEARCH evaluation ,EVALUATION research ,SEVERITY of illness index ,DIAGNOSIS - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
35. Efficacy of oral pharmacological treatments in dyskinetic cerebral palsy: a systematic review.
- Author
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Masson, Riccardo, Pagliano, Emanuela, and Baranello, Giovanni
- Subjects
CEREBRAL palsy treatment ,DEVELOPMENTAL neurobiology ,AUDITORY perception in children ,NEURAL development ,CEREBRAL cortex development ,ANTICONVULSANTS ,CEREBRAL palsy ,DRUGS ,MOVEMENT disorders ,NEUROTRANSMITTERS ,HEALTH outcome assessment ,SYSTEMATIC reviews ,DISEASE complications ,PHARMACODYNAMICS - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
36. Therapy access among children with autism spectrum disorder, cerebral palsy, and attention-deficit-hyperactivity disorder: a population-based study.
- Author
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Benevides, Teal W, Carretta, Henry J, Ivey, Carole K, and Lane, Shelly J
- Subjects
ALTERNATIVE treatment for autism spectrum disorders ,PERVASIVE child development disorders ,NEURAL development ,CEREBRAL cortex development ,CEREBRAL palsy treatment ,TREATMENT of attention-deficit hyperactivity disorder ,HEALTH insurance statistics ,HEALTH services accessibility ,MEDICAL needs assessment ,POVERTY ,RESEARCH funding ,CHILDREN with disabilities ,CROSS-sectional method - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
37. Functional electrical stimulation of the ankle dorsiflexors during walking in spastic cerebral palsy: a systematic review.
- Author
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Moll, Irene, Vles, Johannes S H, Soudant, Dan L H M, Witlox, Adhiambo M A, Staal, Heleen M, Speth, Lucianne A W M, Janssen‐Potten, Yvonne J M, Coenen, Marcel, Koudijs, Suzanne M, and Vermeulen, R Jeroen
- Subjects
CEREBRAL palsy treatment ,ELECTRIC stimulation ,ELECTRICITY in medicine ,BRAIN damage ,DEVELOPMENTAL disabilities ,ANKLE ,ELECTROTHERAPEUTICS ,WALKING ,SYSTEMATIC reviews ,SKELETAL muscle - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
38. Coaction of individual and environmental factors: a review of intensive therapy paradigms for children with unilateral spastic cerebral palsy.
- Author
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Ferre, Claudio L and Gordon, Andrew M
- Subjects
CHILDREN with cerebral palsy ,BRAIN damage ,PYRAMIDAL tract ,CEREBRAL palsy treatment ,CAREGIVERS ,ARM physiology ,CEREBRAL palsy ,NEURAL pathways ,CEREBRAL dominance ,ECOLOGY ,PHYSICAL therapy ,SOCIAL skills ,PSYCHOLOGY ,PHYSIOLOGY - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
39. Comparing emergency department presentations among children with cerebral palsy with general childhood presentations: a data linkage study.
- Author
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Meehan, Elaine, Williams, Katrina, Reid, Susan M, Freed, Gary L, Babl, Franz E, Sewell, Jillian R, Vidmar, Suzanna, Donath, Susan, and Reddihough, Dinah S
- Subjects
CHILDREN with cerebral palsy ,EMERGENCY medical services ,HOSPITAL admission & discharge ,PRIMARY care ,MEDICAL triage ,CEREBRAL palsy treatment ,CEREBRAL palsy ,CHILDREN'S hospitals ,DIGESTIVE system diseases ,HOSPITAL emergency services ,LONGITUDINAL method ,MUSCULOSKELETAL system diseases ,NEUROLOGICAL disorders ,RESPIRATORY diseases ,ACQUISITION of data ,DISEASE complications - Abstract
Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
40. Mastery of manual skills: recent insights into typical and atypical development of manual ability.
- Author
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Hadders-Algra, Mijna
- Subjects
CHILDREN with cerebral palsy ,CEREBRAL palsy treatment ,MOVEMENT disorders in children - Abstract
An introduction is presented in which the editor discusses various articles within the issue on topics including the role of vision in manual activities of children with cerebral palsy (CP), various aspects of developmental coordination disorder (DCD), and the treatment of children with CP.
- Published
- 2013
- Full Text
- View/download PDF
41. Evaluation of cervical posture improvement of children with cerebral palsy after physical therapy based on head movements and serious games.
- Author
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Velasco, Miguel, Raya, Rafael, Muzzioli, Luca, Morelli, Daniela, Otero, Abraham, Iosa, Marco, Cincotti, Febo, Rocon, Eduardo, and Velasco, Miguel A
- Subjects
POSTURE ,CEREBRAL palsy ,EXERCISE ,VIDEO games ,KINEMATICS ,PHYSICAL therapy ,CEREBRAL palsy treatment ,CONVALESCENCE ,BODY movement ,CERVICAL cord - Abstract
Background: This paper presents the preliminary results of a novel rehabilitation therapy for cervical and trunk control of children with cerebral palsy (CP) based on serious videogames and physical exercise.Materials: The therapy is based on the use of the ENLAZA Interface, a head mouse based on inertial technology that will be used to control a set of serious videogames with movements of the head.Methods: Ten users with CP participated in the study. Whereas the control group (n = 5) followed traditional therapies, the experimental group (n = 5) complemented these therapies with a series of ten sessions of gaming with ENLAZA to exercise cervical flexion-extensions, rotations and inclinations in a controlled, engaging environment.Results: The ten work sessions yielded improvements in head and trunk control that were higher in the experimental group for Visual Analogue Scale, Goal Attainment Scaling and Trunk Control Measurement Scale (TCMS). Significant differences (27% vs. 2% of percentage improvement) were found between the experimental and control groups for TCMS (p < 0.05). The kinematic assessment shows that there were some improvements in the active and the passive range of motion. However, no significant differences were found pre- and post-intervention.Conclusions: Physical therapy that combines serious games with traditional rehabilitation could allow children with CP to achieve larger function improvements in the trunk and cervical regions. However, given the limited scope of this trial (n = 10) additional studies are needed to corroborate this hypothesis. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
42. USE AND ADVERSE EFFECTS OF BOTULINUM TOXIN IN MANAGEMENT OF CHILDREN WITH SPASTIC CEREBRAL PALSY.
- Author
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ULICI, ALEXANDRU, STERIAN, ALIN-GABRIEL, TEVANOV, IULIA, and POPESCU, MIHAI-BOGDAN
- Subjects
CHILDREN with cerebral palsy ,CEREBRAL palsy treatment ,BOTULINUM toxin ,CLINICAL indications ,MEDICAL care costs - Abstract
Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
43. Effect of early intervention in infants at very high risk of cerebral palsy: a systematic review.
- Author
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Hadders‐Algra, Mijna, Boxum, Anke G, Hielkema, Tjitske, Hamer, Elisa G, and Hadders-Algra, Mijna
- Subjects
EARLY medical intervention ,CEREBRAL palsy ,INFANT health services ,CHILDREN with cerebral palsy ,NEURODEVELOPMENTAL treatment for infants ,MEDICAL quality control ,META-analysis ,DISEASE risk factors ,CEREBRAL palsy treatment ,SYSTEMATIC reviews ,BIBLIOGRAPHIC databases ,EARLY intervention (Education) ,FERRANS & Powers Quality of Life Index - Abstract
Aim: First, to systematically review the evidence on the effect of intervention applied during the first postnatal year in infants with or at very high risk of cerebral palsy (CP) on child and family outcome. Second, to assess whether type and dosing of intervention modify the effect of intervention.Method: Relevant literature was identified by searching the PubMed, Embase, and CINAHL databases. Selection criteria included infants younger than 12 months corrected age with or at very high risk of CP. Methodological quality including risk of bias was scrutinized.Results: Thirteen papers met the inclusion criteria. Seven studies with moderate to high methodological quality were analysed in detail; they evaluated neurodevelopmental treatment only (n=2), multisensory stimulation (n=1), developmental stimulation (n=2), and multifaceted interventions consisting of a mix of developmental stimulation, support of parent-infant interaction, and neurodevelopmental treatment (n=2). The heterogeneity precluded conclusions. Yet, two suggestions emerged: (1) dosing may be critical for effectiveness; (2) multifaceted intervention may offer best opportunities for child and family.Interpretation: The literature on early intervention in very high-risk infants with sufficient methodological quality is limited, heterogeneous, and provides weak evidence on the effect. More studies are urgently needed. Suggestions for future research are provided. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
44. Family adaptation to cerebral palsy in adolescents: A European multicenter study.
- Author
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Guyard, Audrey, Michelsen, Susan I., Arnaud, Catherine, and Fauconnier, Jerome
- Subjects
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BEHAVIOR disorders in adolescence , *CEREBRAL palsy treatment , *PEOPLE with cerebral palsy , *MENTAL illness , *CAREGIVERS , *PSYCHOLOGICAL distress , *CEREBRAL palsy , *FAMILIES & psychology , *ADAPTABILITY (Personality) , *PSYCHOLOGY of caregivers , *COMPARATIVE studies , *HEALTH attitudes , *RESEARCH methodology , *MEDICAL cooperation , *PSYCHOLOGY of parents , *RESEARCH , *RESEARCH funding , *PSYCHOLOGICAL stress , *EVALUATION research , *SEVERITY of illness index , *PSYCHOLOGICAL factors , *PSYCHOLOGY - Abstract
Background and Aim: Factors promoting family adaptation to child's disability are poorly studied together. The aim of the study was to describe the family adaptation to disability and to identify determinants associated with using a global theoretical model.Materials and Methods: 286 families of teenagers [13-17 years] with cerebral palsy (CP) from 4 European disability registers were included and visited at home. Face to face interviews were performed in order to measure parental distress, perceived impact in various dimensions of family life, family resources and stressors. Relationships were modelled with structural equations.Results: 31.8% of parents living with an adolescent with CP showed clinically significant high stress requiring professional assistance. The main stressors were the level of motor impairment and behavioural disorders in adolescent. A good family functioning was the best protective factor. Respite in care and a parents' positive attitude were significantly related to less parental distress. Material support, socioeconomical level, marital status or parental qualifications did not appear to be significant protector factors.Conclusions: Particular attention must be paid not only on physical condition but also on adolescent psychological problems to improve family adaptation. Families at risk of experiencing severe distress should be targeted early and proactive caregiver interventions on the whole family should be performed.What This Paper Adds: Family is a dynamic system: facing disability, it tries to recover its balance with available resources and its perception of the situation. Literature highlights potential stressors and protecting factors that could affect the disabled child's family adaptation but few papers study a global model including most of these factors. This study validated a global theoretical model of family adaptation to disability at adolescence. It identified behaviour disorders and motor impairment level as main stressors, family functioning as the largest protecting factors, and equipment and financial support as non significant protective factors. [ABSTRACT FROM AUTHOR]- Published
- 2017
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45. Infant constraint induced movement therapy: Lessons learned from clinical implementation.
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Reidy, Teressa Garcia, Carney, Joan, Whiston, Nicole, and Naber, Erin
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CEREBRAL palsy treatment ,HEMIPLEGIA ,CONSTRAINT-induced movement therapy ,EARLY medical intervention - Abstract
Current evidence supports the efficacy of pediatric constraint induced movement therapy (CIMT) for toddlers and children but little has been published about its use in early intervention with children eighteen months and younger. This paper and case report describes the clinical experience of developing and executing a modified pediatric CIMT intervention with infants under 18 months old. This is an emerging area of practice that is showing positive trends with initial cases. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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46. Effectiveness of routine physical therapy with or without home-based intensive bimanual training on clinical outcomes in cerebral palsy children: a randomised controlled trial.
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Ejaz, Fatima, Tanveer, Fahad, Shoukat, Filza, Fatima, Nida, and Ahmad, Ashfaq
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PHYSICAL therapy ,CEREBRAL palsy treatment ,RANDOMIZED controlled trials ,ACTIVITIES of daily living ,CHILD patients ,FOLLOW-up studies (Medicine) - Abstract
Introduction. This study aimed to test how normal physical treatment, with or without home-based intense bimanual training, affected hand coordination and daily living activities in children with cerebral palsy. Methods. A randomised controlled experiment was carried out at DHQ Hospital in Kasur, Pakistan. Thirty children with unilateral spastic cerebral palsy took part in the study. The first group received standard physical treatment, whereas the second group received bimanual training along with routine physical therapy. Follow-ups were performed in the fourth and sixth weeks. The paediatric motor log activity scale and the ABILHAND questionnaire were used to assess daily activities and coordination, respectively. Results. At baseline, no significant association was seen between treatment groups and hand coordination outcome among the patients (p = 0.0450) and no significant difference was seen in patients in both treatment groups regarding their activities of daily living. In group A, no significant improvement was seen in hand coordination from baseline until the 6th week (p = 0.257) while in group B, a significant difference was seen in hand coordination from baseline until the 6th week follow-up (p = 0.000). Conclusions. This study concluded that the combined effect of home-based bimanual exercises and routine physical therapy shows significant achievements in hand coordination and activities of daily living. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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47. The Relationship Between Manual Ability and Selfcare in Children Aged 1-8 Years With Spastic Cerebral Palsy: A Cross-sectional Study.
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Amiri, Mohammad, Dalvand, Hamid, Rassafiani, Mehdi, and Almasi, Amir
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CEREBRAL palsy treatment ,STATISTICS ,KRUSKAL-Wallis Test ,FUNCTIONAL status ,CROSS-sectional method ,AGE distribution ,ONE-way analysis of variance ,ACTIVITIES of daily living ,CLINICS ,MANN Whitney U Test ,REGRESSION analysis ,FISHER exact test ,OCCUPATIONAL therapy ,T-test (Statistics) ,RESEARCH funding ,CHI-squared test ,PHYSICAL mobility ,QUESTIONNAIRES ,STATISTICAL sampling ,DATA analysis software ,DATA analysis ,COGNITIVE testing ,MOTOR ability ,HEALTH self-care ,EDUCATIONAL attainment - Abstract
Objectives: Limitations in the ability to perform manual functions decrease the individual's participation in activities of daily living (ADLs). Thus, it is required to study the relationship between manual skills and self-care activities in children. This study aims to investigate the relationship between manual ability and self-care in children with spastic cerebral palsy at the ages of 1 to 8 years. Methods: In this cross-sectional study, 125 children aged 1-8 years with spastic cerebral palsy who were chosen by the convenience sampling method from 8 occupational therapy clinics in Tehran City, Iran, in 2022 were studied. The evaluation tools were manual ability classification system (MACS), mini-manual ability classification system (Mini-MACS), pediatric evaluation of disability inventory (PEDI), and cognitive level form designed in the SPARCLE project. After collecting the data, Stata software, version 14 was used to analyze data using chi-square, Spearman correlation coefficient, Mann-Whitney, Kruskal-Wallis, and regression. Results: In this research, the mean age of the children was 54.2±15 months and 43.2% had a cognitive level >70. The mean self-care and mobility in children were 49.65±30.60 and 40.78±26.97, respectively. With increasing age, self-care and mobility of children showed a significant increase (P<0.001). No significant difference was observed between boys and girls in self-care and mobility (P<0.05). By changing the education level of the main caregiver, no significant difference was found in self-care and mobility (P<0.05). With the increase in children's cognitive ability level and MACS level, self-care and mobility improved significantly (P<0.001). Moreover, the level of MACS and mobility with the highest beta values (-0.530 and 0.512, respectively) showed a greater contribution to the prediction of self-care. Discussion: The results showed that with increasing age, cognitive ability level, and MACS level, self-care and mobility improve significantly in children with spastic cerebral palsy. Therefore, it is suggested to pay more attention to manual ability to improve self-care and mobility in these children. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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48. Stem cell therapy for neonatal hypoxic-ischemic encephalopathy.
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Gonzales-Portillo, Gabriel S., Reyes, Stephanny, Aguirre, Daniela, Pabon, Mibel M., and Borlongan, Cesar V.
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STEM cell treatment ,CHILDREN with cerebral palsy ,CEREBRAL palsy treatment ,HYPOTHERMIA ,NEONATAL diseases - Abstract
Treatments for neonatal hypoxic-ischemic encephalopathy (HIE) have been limited.The aim of this paper is to offer translational research guidance on stem cell therapy for neonatal HIE by examining clinically relevant animal models, practical stem cell sources, safety and efficacy of endpoint assays, as well as a general understanding of modes of action of this cellular therapy. In order to do so, we discuss the clinical manifestations of HIE, highlighting its overlapping pathologies with stroke and providing insights on the potential of cell therapy currently investigated in stroke, for HIE. To this end, we draw guidance from recommendations outlined in stem cell therapeutics as an emerging paradigm for stroke or STEPS, which have been recently modified to Baby STEPS to cater for the "neonatal" symptoms of HIE. These guidelines recognized that neonatal HIE exhibit distinct disease symptoms from adult stroke in need of an innovative translational approach that facilitates the entry of cell therapy in the clinic. Finally, new information about recent clinical trials and insights into combination therapy are provided with the vision that stem cell therapy may benefit from available treatments, such as hypothermia, already being tested in children diagnosed with HIE. [ABSTRACT FROM AUTHOR]
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- 2014
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49. Clinical study on the efficacy of Rajayapana Basti and Baladi Yoga in motor disabilities of cerebral palsy in children.
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Shailaja U., Rao, Prasanna N., Girish K. J., and G. R., Arun Raj
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CEREBRAL palsy treatment ,CEREBRAL palsy ,YOGIC therapy ,PEDIATRIC research ,AYURVEDIC medicine - Abstract
Background: Cerebral palsy is a static encephalopathy that may be defined as a non-progressive disorder of posture and movement often associated with epilepsy and abnormalities in speech, vision and intellect resulting from a defect or lesion of the developing brain. There are 25 lakhs cerebral palsy affected children in India. Aim: To assess the efficacy of Rajayapana Basti (RB) and Baladi Yoga in motor disabilities of cerebral palsy in children. Materials and Methods: Total 98 children satisfying diagnostic criteria and between the age group of 2-10 years were included and randomly divided into two groups. In RB with Baladi group (n = 40) patients were treated with Mustadi Rajayapana Basti for 8 days, followed by oral administration of Baladi Yoga with honey and ghee for 60 days. Before administering Basti, patients were subjected to Sarvanga Abhyanga and Sastikashali Pinda Sveda. In the control group (n = 40), patients were given tablets of Godhuma Choorna for 60 days. Before administering the placebo tablet, the patients of the control group were given Sarvanga Abhyanga and Sastikashali Pinda Sveda for 8 days. The patients of the control group were given Basti with lukewarm water for 8 days. Results: RB group has shown improvements in understanding ability (13.43%), speech (10%) and performance skill (11.11%), in fine motor functions such as putting small object in to a container (14.3%), throws the ball in all direction (21.8%), use of thumb and index finger (10.93%), retaining 2 inch cube in fist (19.04%), folds paper and inserts into envelope (10.30%), in gross motor functions such as in crawling (26.7%), sitting (31.7%), standing (13.75%), walking (9.5%) and claps hands (13.9%) respectively. Conclusion: Mustadi RB along with Baladi Yoga provided a significant improvement in all the parameters and has promising result in managing motor disabilities of cerebral palsy in children. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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50. Impact of Caring for a Child with Cerebral Palsy on the Quality of Life of Parents: A Systematic Review of the Literature.
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Pousada, Modesta, Guillamón, Noemí, Hernández-Encuentra, Eulàlia, Muñoz, Elena, Redolar, Diego, Boixadós, Mercè, and Gómez-Zúñiga, Beni
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CEREBRAL palsy treatment ,PSYCHOLOGY information storage & retrieval systems ,MEDLINE ,PARENTS ,PEDIATRICS ,QUALITY of life ,RESEARCH funding ,SYSTEMATIC reviews ,BURDEN of care - Abstract
The implications of caring for a child with cerebral palsy (CP) are considerable, and parents have to cope with many changing demands related to the specific needs of their child. A new research field, devoted to the consequences of these caring tasks, has recently emerged. However, an overall vision is lacking, one that would enable us to understand how research is evolving and the relevant data that should be taken into account when planning interventions with these families. In this paper, we review the literature on the effects of caregiving on parents of children with CP, and summarize the factors related to these effects. A systematic search of online databases was performed and further studies were identified based on the reference lists of selected articles. Forty six articles that met the inclusion criteria were analysed. The review shows that caregivers of children with CP tend to have high levels of stress and depression and lower quality of life than parents of healthy children. We identify child behaviour and cognitive problems, low caregiver self-efficacy and low social support as factors that are consistently related with higher levels of stress and depression. The implications of these findings are discussed, especially those related to interventions that should be addressed to the family as a whole and which should aim to enhance parents' competence and resources to better cope with the demands of the caring task. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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