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1. Neurodevelopmental outcome of nutritional intervention in newborn infants at risk of neurodevelopmental impairment: the Dolphin neonatal double-blind randomized controlled trial.

Author

Andrew, Morag J., Montague‐Johnson, Christine, Laler, Karen, Baker, Bonny, Sullivan, Peter B., Parr, Jeremy R., Holmes, Jane, and Montague-Johnson, Christine

Subjects
NEWBORN infants, NEUROLOGICAL disorders, DOCOSAHEXAENOIC acid, RANDOMIZED controlled trials, BLIND experiment, NUCLEOTIDES, CHOLINE, PREMATURE infant disease prevention, CHILD development, COMPARATIVE studies, DIET therapy, PREMATURE infants, PREMATURE infant diseases, RESEARCH methodology, MEDICAL cooperation, RESEARCH, STATISTICAL sampling, EVALUATION research, THERAPEUTICS
Abstract

Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
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2. Nutritional intervention and neurodevelopmental outcome in infants with suspected cerebral palsy: the Dolphin infant double-blind randomized controlled trial.

Author

Andrew, Morag J., Montague‐Johnson, Christine, Laler, Karen, Baker, Bonny, Sullivan, Peter B., Parr, Jeremy R., Qi, Cathy, and Montague-Johnson, Christine

Subjects
NEURODEVELOPMENTAL treatment for infants, CEREBRAL palsy, DOCOSAHEXAENOIC acid, NUTRITION, RANDOMIZED controlled trials, CEREBRAL palsy treatment, NUCLEOTIDES, CHOLINE, CHILD development, COMPARATIVE studies, DIET therapy, RESEARCH methodology, MEDICAL cooperation, RESEARCH, STATISTICAL sampling, EVALUATION research, BLIND experiment, DISEASE complications, PSYCHOLOGY, THERAPEUTICS
Abstract

Copyright of Developmental Medicine & Child Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
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3. Early Enteral Administration of a Complex Lipid Emulsion Supplement Prevents Postnatal Deficits in Docosahexaenoic and Arachidonic Acids and Increases Tissue Accretion of Lipophilic Nutrients in Preterm Piglets.

Author

Akinsulire, Olajumoke, Perides, George, Anez‐Bustillos, Lorenzo, Cluette‐Brown, Joanne, Nedder, Arthur, Pollack, Elizabeth, Singh, Pratibha, Liu, Yan, Sanchez‐Fernandez, Lady Leidy, Obregon, Evelyn, Bicak, Ece, Kiefer, Savanna, Yakah, William, Gutierrez, Hilda V., Dao, Duy T., Vurma, Mustafa, Ehling, Stefan, Gordon, Douglas, DeMichele, Stephen, and Freedman, Steven D.

Subjects
ARACHIDONIC acid, DOCOSAHEXAENOIC acid, PIGLETS, LIPIDS, FATTY acids, ANIMAL populations, RESEARCH, ANIMAL experimentation, RESEARCH methodology, SWINE, EMULSIONS, EVALUATION research, MEDICAL cooperation, DIETARY supplements, COMPARATIVE studies, FOOD, ENTERAL feeding, STATISTICAL sampling
Abstract

Background: Preterm delivery and current nutrition strategies result in deficiencies of critical long-chain fatty acids (FAs) and lipophilic nutrients, increasing the risk of preterm morbidities. We sought to determine the efficacy of preventing postnatal deficits in FAs and lipophilic nutrients using an enteral concentrated lipid supplement in preterm piglets.Methods: Preterm piglets were fed a baseline diet devoid of arachidonic acid (AA) and docosahexaenoic acid (DHA) and randomized to enteral supplementation as follows: (1) Intralipid (IL), (2) complex lipid supplement 1 (CLS1) with an AA:DHA ratio of 0.25, or (3) CLS2 with an AA:DHA ratio of 1.2. On day 8, plasma and tissue levels of FAs and lipophilic nutrients were measured and ileum histology performed.Results: Plasma DHA levels decreased in the IL group by day 2. In contrast, DHA increased by day 2 compared with birth levels in both CLS1 and CLS2 groups. The IL and CLS1 groups demonstrated a continued decline in AA levels during the 8-day protocol, whereas AA levels in the CLS2 group on day 8 were comparable to birth levels. Preserving AA levels in the CLS2 group was associated with greater ileal villus height and muscular layer thickness. Lipophilic nutrients were effectively absorbed in plasma and tissues.Conclusions: Enteral administration of CLS1 and CLS2 demonstrated similar increases in DHA levels compared with birth levels. Only CLS2 maintained AA birth levels. Providing a concentrated complex lipid emulsion with an AA:DHA ratio > 1 is important in preventing postnatal AA deficits. [ABSTRACT FROM AUTHOR]

Published
2020
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