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Despite an abundant use of the term "Out of the loop" (OOTL) in the context of automated driving and human factors research, there is currently a lack of consensus on its precise definition, how it can be measured, and the practical implications of being in or out of the loop during automated driving. The main objective of this paper is to consider the above issues, with the goal of achieving a shared understanding of the OOTL concept between academics and practitioners. To this end, the paper reviews existing definitions of OOTL and outlines a set of concepts, which, based on the human factors and driver behaviour literature, could serve as the basis for a commonly-agreed definition. Following a series of working group meetings between representatives from academia, research institutions and industrial partners across Europe, North America, and Japan, we suggest a precise definition of being in, out, and on the loop in the driving context. These definitions are linked directly to whether or not the driver is in physical control of the vehicle, and also the degree of situation monitoring required and afforded by the driver. A consideration of how this definition can be operationalized and measured in empirical studies is then provided, and the paper concludes with a short overview of the implications of this definition for the development of automated driving functions. [ABSTRACT FROM AUTHOR]

Wireless vehicular communications are gaining momentum, mainly to improve road safety through the use of cooperative systems. Such visionary cooperative applications are based on recently established families of standards, notably the IEEE Wireless Access for Vehicular Environment (WAVE) and the ETSI ITS G5. Despite some relevant differences, both family of standards share the same physical and MAC layers, described in the IEEE 802.11:2012 - amendment 6, also know as IEEE 802.11p. Due to the characteristics of the wireless communications in vehicular environment, e.g., high-speed mobility causing unpredictable time-varying changes in connectivity, IP protocols are not suitable for safety communications as they require channel scanning, authentication and association under strict time limits. Safety vehicular communications rely, instead on non-IP protocols, either the WAVE Short Message Protocol (WSMP) or the FAST Network and Transport Protocol (FNTP). In this paper, we explore some of the challenges of implementing such protocols, and designed an architecture for a stack capable of handling both standards. The proposed architecture, including the communication and transport layers of the stack, was implemented in a custom ETSI ITS G5 compliant platform (IT2S), and its performance was assessed using a prototype. [ABSTRACT FROM AUTHOR]

Bibliometric analysis was carried out for champion data comparisons among prestigious nuclear research institutes (PNRI) existed in Japan, the U. S., France, and Germany. The analysis was relied on database INIS (IAEA), ECD (DOE), WOS (Thomson), and SCOPUS (Elsevier). INIS is advanced, key ex-post evaluating tool for determining general research paper-based champion. Over the 30-year time span of research paper publication, the world champion among 11 PNRI is JAERI confirmed by INIS but ORNL confirmed by ECD, WOS, and SCOPUS, the latter two collected journal submitted research paper. Five years ago JAERI is the 3rd ranked institutes following ORNL and ANL. INIS database results revealed that CEA/Grenoble is the French domestic champion regarding research paper publication. Five years ago it was CEA/Saclay. Results from analytical tools used in bibliometric studies should be viewed with careful consideration to learn of any influencing factors because different characteristics exhibited by individual databases can sometimes generate conflicting bibliometric results. This was true among INIS, ECD, WOS, and SCOPUS when looking at trends especially between 5-year periods. [ABSTRACT FROM AUTHOR]

Pharmacovigilance science has traditionally been a discipline focussed on the postmarketing or post-authorisation period, with due attention directed towards pre-clinical safety data, clinical trials and adverse events. As the biological sciences have evolved, pharmacovigilance has slowly shifted toward earlier, proactive consideration of risks and potential benefits of drugs in the pre- and peri-approval stages of drug development, leading to a maturing of drug safety risk management. Further advances in biology, pharmacology and improvements in computational applications to medicine have led to the development of more complex medicines previously unobtainable and have also permitted a more thorough assessment of risks and potential benefits even earlier in the development process. Elevated public concern with the safety of more sophisticated medicines, combined with new science, have led pharmaceutical innovators, regulators and healthcare professionals to collaborate to develop guidelines, which drive enhanced pharmacovigilance and safety risk management earlier in drug development.In this paper, we review international guidelines on pharmacovigilance planning applicable to the pre-approval phases of medicines development and provide author opinion on these guidelines’ potential drug safety implications. We discuss the possible evolution of a pharmaceutical industry model to respond to these guidelines; a view on multidisciplinary safety management teams is provided to encourage refinement of safety-signal identification and risk assessment early in drug development and to communicate important safety concerns to internal research efforts, patients, investigators and regulators. We further describe these functions in the context of the complexities of vulnerable populations, including the example of medicines research for paediatric populations. We also discuss the special role of epidemiology in pre-approval drug development and the impact on epidemiological science of changes to the pharmacovigilance paradigm. [ABSTRACT FROM AUTHOR]

The author analyzes the growth of nanotechnology on a geographical basis according to the scientific papers presented, patent applications filed and funding received. Based on public funding, United States leads the research and development followed by Japan and European Community. Total number of patent applications filed between 1995 and 2003 are presented. The author concludes that relatively high public funding and infrastructure will contribute to the growth of nanotechnology in Europe.

The article cites a U.S. report that states that Asian nations are catching up with Europe and the United States in terms of scientific output. According to the report, in 2004, countries from the Asia Pacific region including China, South Korea, Taiwan, Japan, Singapore and India produced 25 percent of the world's research papers. By comparison, Europe produced 38 percent of the world's scientific papers, and the United States produced 33 percent. Within Asia, China, South Korea, Singapore and Taiwan grew the most. In China, some institutions even pay researchers extra for publications in indexed journals, especially ones that carry widely cited articles.