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Climate change may cause adverse impact on agricultural production that could jeopardize food availability and security. In this paper, we investigate how changes in mean values and variability of weather variables may affect rice yield using panel data for 30 districts of Tamil Nadu State from 1971 to 2018. We estimate a fixed-effects regression model with panel-corrected standard errors. Results show that rainfall and temperature have a statistically significant impact on rice yield. Furthermore, weather variability, measured as standard deviations of temperature and rainfall, has a negative effect on rice yields. We use the Coupled Model Inter-comparison Project-5 outputs and dynamically downscaled the weather outputs using the regional climate model. The results of the climate model showed that the rise in temperature and disruptions in rainfall patterns including both excessive and deficient rainfall events in Tamil Nadu will continue in the future under different climate scenarios. Projected changes in the weather variables are likely to decrease rice yield in Tamil Nadu from 0.7 to 6.3% under the low emission scenario and 4.1 to 20.1% in the high emission scenario during 2022–2050 (relative to 1971–2018). These projections have implications for the planning and targeting of climate adaptation technologies such as drought-tolerant and flood-tolerant varieties to lessen the adverse impact of weather variability due to climate change in the future. [ABSTRACT FROM AUTHOR]