1. Population-based sero-epidemiological investigation of the dynamics of SARS-CoV-2 infections in the Greater Accra Region of Ghana.
- Author
-
Mensah BA, Ndong IC, Quashie PK, Guichet E, Abuaku B, Effah-Baafi Y, Tapela K, Asiedu K, Appiedu-Addo SNA, Obbeng LB, Amponsah JA, Kusi KA, Ofori M, Ayouba A, Courtin D, Tahar R, Delaporte E, Awandare G, and Ndam NT
- Subjects
- Humans, Aged, SARS-CoV-2, Seroepidemiologic Studies, Ghana epidemiology, Pandemics, Antibodies, Viral, COVID-19 epidemiology
- Abstract
The coronavirus disease 2019 (COVID-19) pandemic devastated countries worldwide, and resulted in a global shutdown. Not all infections are symptomatic and hence the extent of SARS-CoV-2 infection in the community is unknown. The paper presents the dynamics of the SARS-CoV-2 epidemic in the Greater Accra Metropolis, describing the evolution of seroprevalence through time and by age group. Three repeated independent population-based surveys at 6-week intervals were conducted in from November 2020 to July 2021. The global and by age-groups weighted seroprevalences were estimated and the risk factors for SARS-CoV-2 antibody seropositivity were assessed using logistic regression. The overall age-standardized SARS-CoV-2 antibody seroprevalence for both spike and nucleocapsid increased from 13.8% (95% CI 11.9, 16.1) in November 2020 to 39.6% (95% CI 34.8, 44.6) in July 2021. After controlling for gender, marital status, education level, and occupation, the older age group over 40 years had a higher odds of seropositivity than the younger age group (OR 3.0 [95% CI 1.1-8.5]) in the final survey. Pupils or students had 3.3-fold increased odds of seropositivity (OR 3.2 [95% CI 1.1-8.5]) compared to the unemployed. This study reinforces that, SARS-CoV-2 infections have been significantly higher than reported., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF