1. Agreement of primary outcomes in chiropractic-related clinical trials registered in clinicaltrials.gov with corresponding publication.
- Author
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Coté, Robert M., Perle, Stephen M., and Martin, Derek S.
- Subjects
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PUBLISHING , *CLINICAL trials , *CHIROPRACTIC , *SERIAL publications , *HEALTH outcome assessment , *DESCRIPTIVE statistics , *STATISTICAL correlation , *CLINICAL trial registries , *AUTHORSHIP - Abstract
Introduction: Previous analysis of registered clinical trials has found a number of protocols result in changes in the registered primary outcome measures. This investigation determined if reported primary outcomes in chiropractic-related clinical trials registered in clinicaltrials.gov match their published results. Additionally, we assessed secondary outcomes, publication status and whether raw data were posted to the registry. Methods: Clinicaltrials.gov was searched for chiropractic-related trials and having a completed status. If the study was published, outcome measures were compared between the clinicaltrials.gov entry and the published paper to assess for consistency. Results: Within clinicaltrials.gov 171 chiropracticrelated protocols were identified with 102 of those published (59.6% publication rate). Ninety-two of the published papers (90.2%) had agreement between their primary outcome and the entry on clinicaltrials.gov and 82 (80.4%) agreed with the secondary outcomes. Conclusion: A modest rate of agreement between clinicaltrails.gov entries and the published papers was found. While chiropractic-related clinical trials are fewer compared to medical trials, chiropractic-related research has a substantially better rate of primary and secondary outcome concordance with registered protocols. [ABSTRACT FROM AUTHOR]
- Published
- 2021