18 results
Search Results
2. The Baby-Friendly Hospital Initiative shows positive effects on breastfeeding indicators in Brazil.
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Isoyama Venancio, Sonia, Regina Dias Médici Saldiva, Sílvia, Mercedes Loureiro Escuder, Maria, and Regina Justo Giugliani, Elsa
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BREASTFEEDING promotion ,CHI-squared test ,CONFIDENCE intervals ,EPIDEMIOLOGY ,POLICY sciences ,QUESTIONNAIRES ,RESEARCH funding ,STATISTICS ,DATA analysis ,EVALUATION of human services programs ,DESCRIPTIVE statistics - Abstract
Background The Baby-Friendly Hospital Initiative (BFHI) has been implemented by WHO and Unicef with a view to protect, promote and support breast feeding. This paper aims to assess the influence of the BFHI on breastfeeding indicators in Brazil, using data from the 2nd Survey of Breastfeeding Prevalence, conducted in 2008. Methods Data on 64 municipalities were analysed: a total of 65 936 infants under the age of 1 year who were covered by the 2008 immunisation campaign. The outcomes of interest were breast feeding in the first hour of life in infants under 1 year of age; exclusive breast feeding on the first day after hospital discharge in infants under 4 months of age; exclusive breast feeding in infants under 2, 3 and 6 months of age; and pacifier use in infants under 6 months of age. The influence of birth in baby-friendly hospitals (BFHs) on these end points was analysed by means of Poisson regression with robust variance for complex samples. Findings Infants born in BFHs were 9% more likely to be breast fed in the first hour of life and 6% more likely to be breast fed on the first day at home. Exclusive breast feeding was 13%, 8% and 6% more likely in infants under the ages of 2, 3 and 6 months, respectively, born in BFHs. Birth in a BFH also correlated with significant less pacifier use. Conclusions The BFHI has had an impact on several indicators of breast feeding. The authors hope the results of this study will make policy makers and health professionals aware of the importance and potential of this strategy. [ABSTRACT FROM AUTHOR]
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- 2012
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3. Adolescent blood pressure, body mass index and skin folds: sorting out the effects of early weight and length gains.
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Menezes, Ana M. B., Hallal, Pedro C., Dumith, Samuel C., Matijasevich, Alicia M., Araújo, Cora L. P., Yudkin, John, Osmond, Clive, Barros, Fernando C., and Victora, Cesar G.
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BIRTH weight ,BLOOD pressure ,CONFIDENCE intervals ,HUMAN growth ,LONGITUDINAL method ,REGRESSION analysis ,RESEARCH funding ,SKIN ,STATURE ,WEIGHT gain ,BODY mass index ,DESCRIPTIVE statistics - Abstract
Background Although there is longstanding evidence of the short-term benefits of promoting rapid growth for young children in low-income settings, more recent studies suggest that early weight gain can also increase the risk of chronic diseases in adults. This paper attempts to separate the effects of early life weight and length/height gains on blood pressure, body mass index (BMI), sum of skin folds and subscapular/triceps skin fold ratio at 14-15 years of age. Methods The sample comprised 833 members of a prospective population-based birth cohort from Brazil. Conditional size (weight or height) analyses were used to express the difference between observed size at a given age and expected size based on a regression, including all previous measures of the same anthropometric index. A positive conditional weight or height indicates growing faster than expected given prior size. Results Conditional weights at all age ranges were positively associated with most outcomes; each z-score of conditional weight at 4 years was associated with an increase of 6.1 mm in the sum of skin folds (95% CI 4.5 to 7.6) in adolescence after adjustment for conditional length/height. Associations of the outcomes with conditional length/height were mostly negative or nonsignificant--each z-score was associated with a reduction of 2.4 mm (95% CI -3.8 to -1.1) in the sum of skin folds after adjustment for conditional weight. No associations were found with the skin fold ratio. Conclusion The promotion of rapid length/height gain without excessive weight gain seems to be beneficial for long-term outcomes, but this requires confirmation from other studies. [ABSTRACT FROM AUTHOR]
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- 2012
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4. Estimating the size of illicit tobacco consumption in Brazil: findings from the global adult tobacco survey.
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Magno Iglesias, Roberto, Salem Szklo, André, Carvalho de Souza, Mirian, and de Almeida, Liz Maria
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TAX laws ,TOBACCO products ,CONFIDENCE intervals ,CRIME ,PROBABILITY theory ,SALES personnel ,SMOKING ,RETROSPECTIVE studies ,DATA analysis software ,DESCRIPTIVE statistics ,ECONOMICS - Published
- 2017
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5. infant up-to-date and timely vaccination.
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Lima de Souza, Evelyn, de Rossi Ferreira, Vinicius Leati, Alves Waldman, Eliseu, and Sayuri Sato, Ana Paula
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IMMUNIZATION ,CONFIDENCE intervals ,IMMUNIZATION of children ,AGE distribution ,CROSS-sectional method ,MEDICAL protocols ,SOCIOECONOMIC factors ,HEALTH literacy ,DESCRIPTIVE statistics ,PUBLIC welfare ,SOCIODEMOGRAPHIC factors ,ODDS ratio ,HEALTH promotion ,SECONDARY analysis ,LONGITUDINAL method - Published
- 2022
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6. Cross- validation of four different survey methods used to estimate illicit cigarette consumption in Brazil.
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Salem Szklo, André, Magno Iglesias, Roberto, Stoklosa, Michal, Carvalho Figueiredo, Valeska, Welding, Kevin, de Souza Junior, Paulo Roberto Borges, Trindade Machado, Alessandra, Leite Martins, Luis Felipe, Nascimento, Hannah, and Drope, Jeffrey
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TAXATION ,CONFIDENCE intervals ,SELF-evaluation ,SURVEYS ,TOBACCO products - Published
- 2022
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7. The effect of São Paulo's smoke-free legislation on carbon monoxide concentration in hospitality venues and their workers.
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Issa, Jaqueline S., Abe, Tania M. O., Pereira, Alexandre C., Megid, Maria Cristina, Shimabukuro, Cristina E., Valentin, Luis Sergio O., Ferreira, Marizete M. da C., Nobre, Moacyr R. C., Lancarotte, Ines, and Barretto, Antonio Carlos Pereira
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SMOKING laws ,INDOOR air pollution ,ANALYSIS of variance ,BREATH tests ,CARBON monoxide ,COMPARATIVE studies ,CONFIDENCE intervals ,FOOD service ,EVALUATION of medical care ,PASSIVE smoking ,PUBLIC spaces ,RESEARCH funding ,SMOKING ,PRE-tests & post-tests ,REPEATED measures design - Abstract
Background Studies have shown that there is no safe level of secondhand smoke (SHS) exposure and there is a close link between SHS and the risk of coronary heart disease and stroke. Carbon monoxide (CO) is one of the most important components present in SHS. Objective To evaluate the impact of the smoking ban law in the city of Sao Paulo, Brazil, on the CO concentration in restaurants, bars, night clubs and similar venues and in their workers. Methods In the present study we measured CO concentration in 585 hospitality venues. CO concentration was measured in different environments (indoor, semi-open and open areas) from visited venues, as well as, in the exhaled air from approximately 627 workers of such venues. Measurements were performed twice, before and 12 weeks after the law implementation. In addition, the quality of the air in the city during the same period of our study was verified. Results The CO concentration pre-ban and pot-ban in hospitality venues was indoor area 4.57 (3.70) ppm vs 1.35 (1.66) ppm (p<0.0001); semi-open 3.79 (2.49) ppm vs 1.16 (1.14) ppm (p<0.0001); open area 3.31(2.2) ppm vs 1.31 (1.39) ppm (p<0.0001); smoking employees 15.78 (9.76) ppm vs 11.50 (7.53) ppm (p<0.0001) and non-smoking employees 6.88 (5.32) ppm vs 3.50 (2.21) ppm (p<0.0001). The average CO concentration measured in the city was lower than 1 ppm during both pre-ban and post-ban periods. Conclusion São Paulo's smoking-free legislation reduced significantly the CO concentration in hospitality venues and in their workers, whether they smoke or not. [ABSTRACT FROM AUTHOR]
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- 2011
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8. Smoke- free legislation and neonatal and infant mortality in Brazil: longitudinal quasiexperimental study.
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Hone, Thomas, Szklo, Andre Salem, Filippidis, Filippos T., Laverty, Anthony A., Sattamini, Isabela, Been, Jasper V., Vianna, Cristiane, Souza, Mirian, de Almeida, Liz Maria, and Millett, Christopher
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SMOKING laws ,CONFIDENCE intervals ,ECOLOGICAL research ,INFANT mortality ,LONGITUDINAL method ,RESEARCH methodology ,PASSIVE smoking ,PUBLIC spaces ,REGRESSION analysis ,DESCRIPTIVE statistics - Published
- 2020
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9. Change in covid-19 risk over time following vaccination with CoronaVac.
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Hitchings, M. D. T., Ranzani, O. T., and Lind, M. L.
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REVERSE transcriptase polymerase chain reaction ,COVID-19 ,CONFIDENCE intervals ,COVID-19 vaccines ,CASE-control method ,COMPARATIVE studies ,ODDS ratio ,COVID-19 testing ,LOGISTIC regression analysis - Published
- 2022
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10. Excessive crying at 3 months of age and behavioural problems at 4 years age: a prospective cohort study.
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Santos, Iná S., Matijasevich, Alicia, Capilheira, Marcelo F., Anselmi, Luciana, and Barros, Fernando C.
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BEHAVIOR disorders in children ,APGAR score ,BEHAVIORAL assessment ,CHILD behavior ,CONFIDENCE intervals ,CRYING in children ,LONGITUDINAL method ,QUESTIONNAIRES ,RESEARCH funding ,LOGISTIC regression analysis ,DISEASE prevalence ,DATA analysis software ,DISEASE risk factors - Abstract
Background Excessive crying in early infancy has been associated with behavioural problems among preschool children from high income countries but studies in low income and middle income countries are scarce. Methods The 2004 Pelotas Birth Cohort is a population-based study planned to enroll all live births occurring in Pelotas that year and comprises 4231 children who so far have been followed up at 3, 12, 24, 48 and 72 months of age. Several familial, maternal and child characteristics were gathered in every follow-up. At the 3-month follow-up, infants whose mothers perceived them as crying more than others of the same age were classified as 'crying babies'. Child behavioural problems were assessed through the Child Behavior Checklist (CBCL) applied to the mother at the 48-month follow-up. Crude and adjusted ORs with 95% CIs were calculated by logistic regression. Results Prevalence of excessive crying at 3 months was 11.9% (10.9% to 13.0%). Among children with excessive crying at 3 months the proportion in the clinical range for CBCL total, internalising and externalising problems at 4 years of age was 31.2%, 12.9% and 37.5%, respectively, against 20.6%, 6.8% and 29.6%, respectively, among non-crying babies. After controlling for confounders crying babies presented increased risk of being in clinical range of CBCL total (OR=1.34; 1.03 to 1.74), internalising (OR=1.55; 1.09 to 2.21) and externalising problems (OR=1.29; 1.01 to 1.64) than infants without excessive crying. Conclusions Excessive crying in early infancy may represent one important risk factor for developing behavioural problems in later phases of early childhood. [ABSTRACT FROM AUTHOR]
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- 2015
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11. Social participation and drug use in a cohort of Brazilian sex workers.
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Leslie, Hannah Hogan, Ahern, Jennifer, Chinaglia, Magda, Kerrigan, Deanna, and Lippman, Sheri A
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CONCEPTUAL structures ,CONFIDENCE intervals ,LONGITUDINAL method ,SEX work ,RESEARCH funding ,RISK-taking behavior ,STATISTICAL sampling ,SOCIAL participation ,SUBSTANCE abuse ,LOGISTIC regression analysis ,DATA analysis software ,STATISTICAL models ,DESCRIPTIVE statistics - Abstract
Background Structural interventions focused on community mobilisation to engender an enabling social context have reduced sexual risk behaviours among sex workers. Interventions to date have increased social participation and shown an association between participation and safer sex. Social participation could modify risk for other health behaviours, particularly drug use. We assessed social participation and drug use before and after implementation of a clinical, social and structural intervention with sex workers intended to prevent sexually transmitted infections/HIV infection. Methods We followed 420 sex workers participating in the Encontros intervention in Corumbá, Brazil, between 2003 and 2005. We estimated the association of participation in external social groups with drug use at baseline and follow-up using logistic regression and marginal modelling. Follow-up analyses of preintervention/postintervention change in drug use employed inverse probability weighting to account for censoring and were stratified by exposure to the intervention. Results Social participation showed a protective association with drug use at baseline (1 SD higher level of social participation associated with 3.8% lower prevalence of drug use, 95% CI ?0.1 to 8.3). Among individuals exposed to Encontros, higher social participation was associated with an 8.6% lower level of drug use (95% CI 0.1 to 23.3). No significant association was found among the unexposed. Conclusions A structural intervention that modified sex workers' social environment, specifically participation in external social groups, was associated with reduced drug use. These findings suggest that sexual risk prevention initiatives that enhance social integration among marginalised populations can produce broad health impacts, including reductions in drug use. [ABSTRACT FROM AUTHOR]
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- 2013
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12. Socioeconomic inequalities and vaccination coverage: results of an immunisation coverage survey in 27 Brazilian capitals, 2007-2008.
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Barradas Barata, Rita, Carlos Sampaio De Almeida Ribeiro, Manoel, Cássio De Moraes, José, and Flannery, Brendan
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CENSUS ,CHI-squared test ,CONFIDENCE intervals ,EPIDEMIOLOGY ,HEALTH services accessibility ,HEALTH status indicators ,IMMUNIZATION of children ,MULTIVARIATE analysis ,QUESTIONNAIRES ,RESEARCH funding ,STATISTICS ,LOGISTIC regression analysis ,DATA analysis ,SOCIOECONOMIC factors ,DATA analysis software - Abstract
Background Since 1988, Brazil's Unified Health System has sought to provide universal and equal access to immunisations. Inequalities in immunisation may be examined by contrasting vaccination coverage among children in the highest versus the lowest socioeconomic strata. The authors examined coverage with routine infant immunisations from a survey of Brazilian children according to socioeconomic stratum of residence census tract. Methods The authors conducted a household cluster survey in census tracts systematically selected from five socioeconomic strata, according to average household income and head of household education, in 26 Brazilian capitals and the federal district. The authors calculated coverage with recommended vaccinations among children until 18 months of age, according to socioeconomic quintile of residence census tract, and examined factors associated with incomplete vaccination. Results Among 17 295 children with immunisation cards, 14 538 (82.6%) had received all recommended vaccinations by 18 months of age. Among children residing in census tracts in the highest socioeconomic stratum, 77.2% were completely immunised by 18 months of age versus 81.2%e86.2% of children residing in the four census tract quintiles with lower socioeconomic indicators (p<0.01). Census tracts in the highest socioeconomic quintile had significantly lower coverage for bacille Calmette-Guérin, oral polio and hepatitis B vaccines than those with lower socioeconomic indicators. In multivariable analysis, higher birth order and residing in the highest socioeconomic quintile were associated with incomplete vaccination. After adjusting for interaction between socioeconomic strata of residence census tract and household wealth index, only birth order remained significant. Conclusions Evidence from Brazilian capitals shows success in achieving high immunisation coverage among poorer children. Strategies are needed to reach children in wealthier areas. [ABSTRACT FROM AUTHOR]
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- 2012
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13. Contextual factors associated with smoking among Brazilian adolescents.
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Barreto, Sandhi Maria, Giatti, Luana, Casado, Leticia, de Moura, Lenildo, Crespo, Claudio, and Malta, Deborah
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SMOKING prevention ,CHI-squared test ,CLUSTER analysis (Statistics) ,CONFIDENCE intervals ,STATISTICAL correlation ,EPIDEMIOLOGY ,FAMILIES ,HIGH school students ,QUESTIONNAIRES ,RESEARCH funding ,STATISTICAL sampling ,SCHOOLS ,SMOKING ,ADOLESCENT health ,MATHEMATICAL variables ,SAMPLE size (Statistics) ,DATA analysis ,MULTIPLE regression analysis ,SOCIOECONOMIC factors ,DISEASE prevalence ,CROSS-sectional method ,DATA analysis software ,ADOLESCENCE - Abstract
Background: Very few studies have examined the role of school, household and family contexts in youth smoking in middle-income countries. Methods: This work describes smoking exposure among59 992 high school students who took part in the Brazilian Survey of School Health and investigatescontextual factors associated with regular smoking, defined as smoking cigarettes at least once in the past 30 days. The explaining variables were grouped into: socio-demographic characteristics, school context, household context and family rapport. Variables independently associated with smoking in each context were identified by multiple logistic regression analysis. Results: 53% of the total sample were girls, 89% were aged 13-15 years. 24% had already experimented with cigarettes, 50% before the age of 12 years. The prevalence of regular smoking was 6.3% (95% CI 5.87 to 6.74), with no sex variation. Smoking was not associated with either the mother's education or the index of household assets. In the multivariable analysis, studying at a private school, the possibility of purchasing cigarettes at school and skipping of classes without parents' consent increased the chances of smoking. In the household context, living with both parents was negatively associated with smoking, while having smoking parents and exposure to other people's smoking was positively related to smoking. In the family context, parental unawareness of what the adolescent was doing increased smoking, but having meals with the mother one or more days per week and parents' negative reactions to adolescent smoking reduced the chances of smoking. Conclusion: The results reinforce the role of school, household and family contexts in youth smoking behaviours and will help improve public health policies aimed at preventing smoking and health promotion in adolescents. [ABSTRACT FROM AUTHOR]
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- 2012
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14. Propensity score matching approach to test the association of income inequality and mortality in São Paulo, Brazil.
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Filho, Alexandre Dias Porto Chiavegatto, Kawachi, Ichiro, and Gotlieb, Sabina Léa Davidson
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INCOME ,MORTALITY ,COMPARATIVE studies ,CONFIDENCE intervals ,CULTURE ,ECONOMICS ,LITERACY ,POPULATION ,POVERTY ,PROBABILITY theory ,PUBLIC health ,RESIDENTIAL patterns ,SOCIOECONOMIC factors - Abstract
Background Support for the adverse effect of high income inequality on population health has come from studies that focus on larger areas, such as the US states, while studies at smaller geographical areas (eg, neighbourhoods) have found mixed results. Methods We used propensity score matching to examine the relationship between income inequality and mortality rates across 96 neighbourhoods (distritos) of the municipality of São Paulo, Brazil. Results Prior to matching, higher income inequality distritos (Gini ≥0.25) had slightly lower overall mortality rates (2.23 per 10 000, 95% CI- 23.92 to 19.46) compared to lower income inequality areas (Gini <0.25). After propensity score matching, higher inequality was associated with a statistically significant higher mortality rate (41.58 per 10 000, 95% CI 8.85 to 73.3). Conclusion In São Paulo, the more egalitarian communities are among some of the poorest, with the worst health profiles. Propensity score matching was used to avoid inappropriate comparisons between the health status of unequal (but wealthy) neighbourhoods versus equal (but poor) neighbourhoods. Our methods suggest that, with proper accounting of heterogeneity between areas, income inequality is associated with worse population health in São Paulo. [ABSTRACT FROM AUTHOR]
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- 2012
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15. How much do smoking and alcohol consumption explain socioeconomic inequalities in head and neck cancer risk?
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Boing, A. F., Ferreira Antunes, J. L., Brasilino de Carvalho, M., Francisco de Góis Filho, J., Kowalski, L. P., Michaluart Jr., P., Eluf-Neto, J., Boffetta, P., and Wüsch-Filho, V.
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ANALYSIS of variance ,CONFIDENCE intervals ,STATISTICAL correlation ,ALCOHOL drinking ,EMPLOYMENT ,EPIDEMIOLOGY ,MEDICAL cooperation ,METROPOLITAN areas ,MULTIVARIATE analysis ,RESEARCH ,RESEARCH funding ,SMOKING ,LOGISTIC regression analysis ,DATA analysis ,SOCIOECONOMIC factors ,EDUCATIONAL attainment ,DISEASE incidence ,CASE-control method - Abstract
Background A higher burden of head and neck cancer has been reported to affect deprived populations. This study assessed the association between socioeconomic status and head and neck cancer, aiming to explore how this association is related to differences of tobacco and alcohol consumption across socioeconomic strata. Methods We conducted a case-control study in São Paulo, Brazil (1998-2006), including 1017 incident cases of oral, pharyngeal and laryngeal cancer, and 951 sex- and age-matched controls. Education and occupation were distal determinants in the hierarchical approach; cumulative exposure to tobacco and alcohol were proximal risk factors. Outcomes of the hierarchical model were compared with fully adjusted ORs. Results Individuals with lower education (OR 2.27; 95% CI 1.61 to 3.19) and those performing manual labour (OR 1.55; 95% CI 1.26 to 1.92) had a higher risk of disease. However, 54% of the association with lower education and 45% of the association with manual labour were explained by proximal lifestyle exposures, and socioeconomic status remained significantly associated with disease when adjusted for smoking and alcohol consumption. Conclusions Socioeconomic differences in head and neck cancer are partially attributable to the distribution of tobacco smoking and alcohol consumption across socioeconomic strata. Additional mediating factors may explain the remaining variation of socioeconomic status on head and neck cancer. [ABSTRACT FROM AUTHOR]
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- 2011
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16. The family health system: analysis of a health survey in São Paulo, Brazil.
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Brandão, José Ricardo Mello, Gianini, Reinaldo José, Novaes, Hilegonda Maria Dutilh, and Goldbaum, Moisés
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ANALYSIS of variance ,CHI-squared test ,CLUSTER analysis (Statistics) ,COMMUNITY health workers ,COMPARATIVE studies ,CONFIDENCE intervals ,CORONARY disease ,DIABETES ,HEALTH care teams ,HEALTH services accessibility ,HYPERTENSION ,INTERVIEWING ,RESEARCH methodology ,EVALUATION of medical care ,MULTIVARIATE analysis ,PRIMARY health care ,QUALITY assurance ,RESEARCH funding ,STATISTICAL sampling ,STATISTICS ,SURVEYS ,CONTROL groups ,HEALTH literacy - Abstract
Background The Family Health Strategy (FHS) has been implemented as a strategy for primary care improvement in Brazil. Working with teams that include one doctor, one nurse, auxiliary nurses and community health workers in predefined areas, the FHS began in 1994 (known then as the Family Health Program) and has since grown considerably. The programme has only recently undergone assessment of outcomes, in contrast to more routine evaluations of infrastructure and process. Methods In 2001, a health survey was carried out in two administrative districts (with 190 000 inhabitants) on the outskirts of the city of São Paulo, both partially served by the FHS. Chronic morbidity (hypertension, diabetes and ischaemic heart disease) of individuals aged 15 or older was studied in areas covered and not covered by the programme. Stratified univariate analysis was applied for sex, age, education, income, working status and social insurance of these populations. Multivariate analysis was applied where applicable. Results There was a distinct pattern in the morbidity profile of these populations, suggesting differentiated self-knowledge on chronic disease status in the areas served by the FHS. Conclusion The FHS can increase population awareness of chronic diseases, possibly through increasing access to primary care. [ABSTRACT FROM AUTHOR]
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- 2011
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17. Weight-for-age z-score as a proxy marker for diarrhoea in epidemiological studies.
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Schmidt, Wolf-Peter, Boisson, Sophie, Genser, Bernd, Barreto, Mauricio L., Baisley, Kathy, Filteau, Suzanne, and Cairncross, Sandy
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EPIDEMIOLOGY research methodology ,AGE distribution ,ANALYSIS of variance ,BIOMARKERS ,BODY weight ,CLINICAL trials ,CONFIDENCE intervals ,STATISTICAL correlation ,DIARRHEA in children ,REGRESSION analysis ,RESEARCH funding ,TIME ,SECONDARY analysis ,RESEARCH bias ,DISEASE incidence - Abstract
Background The validity of unblinded randomised trials testing interventions against diarrhoea is severely compromised by the potential for bias. Objective proxy markers for diarrhoea not relying on self-report are needed to assess the effect of interventions that cannot be blinded. Short-term changes in weight-for-age z-score (WAZ) may (due to catch-up growth) not be a clinically important marker for nutritional status. However, even a transient decrease in WAZ could indicate recent diarrhoea, and be interpreted as the effect of an intervention. Methods Using data from two large vitamin A trials from Ghana and Brazil, the immediate effect of the cumulative diarrhoea occurrence over 14 and 28 day time windows on WAZ was explored. Results A very strong linear association was found between the number of days with diarrhoea over the last 14-28 days and WAZ. In both trials, differences in diarrhoea between the trial arms were associated with corresponding differences in WAZ. Conclusion Repeated WAZ measures appear to be a suitable proxy marker for diarrhoea in children, but have disadvantages in terms of specificity and study power. [ABSTRACT FROM AUTHOR]
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- 2010
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18. Antipsychotic adjunctive therapy to mood stabiliser should be continued for 6 months after remission of a manic episode.
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Hatta, Kotaro
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THERAPEUTIC use of lithium ,RISPERIDONE ,VALPROIC acid ,OLANZAPINE ,DISEASE relapse prevention ,CONFIDENCE intervals ,LONGITUDINAL method ,BIPOLAR disorder ,STATISTICAL sampling ,RANDOMIZED controlled trials ,TREATMENT effectiveness ,SEVERITY of illness index ,TREATMENT duration ,THERAPEUTICS - Published
- 2017
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